Incidencia de bacteriemia en la Gerencia de Gestión Integrada de Ferrol: tasa anual y agentes etiológicos principales

Objetivos. El propósito de este estudio es analizar el impacto de las bacteriemias en la población atendida en la Gerencia de Gestión Integrada (GGI) de Ferrol y detectar los principales agentes etiológicos. Metodología. Mediante la base de datos perteneciente al laboratorio de microbiología del Complejo Hospitalario Universitario de Ferrol, se realiza un estudio observacional de cohortes basado en la población. Resultados. Se recogieron 1070 casos de bacteriemia durante el periodo del 1 de enero de 2011 hasta el 31 de diciembre de 2013 en todo el área sanitaria competencia de la GGI de Ferrol. La incidencia de bacteriemias fue de 143 casos por 100.000 habitantes/año en el 2011 y aumentó en los dos años posteriores hasta 194 casos por 100.000 habitantes y año. La media de edad superó los 60 años para todos los años estudiados. Los principales agentes etiológicos causantes de bacteriemia fueron Escherichia coli, Staphylococcus aureus y Staphylococcus epidermidis con un 40, 9 y 7 por ciento respectivamente del total de casos. Las enfermedades de base asociadas a las bacteriemias más prevalentes fueron cardiopatías, neoplasias y diabetes mellitus con porcentajes aproximados de 28, 27 y 24 respectivamente frente a otras enfermedades. Discusión. En pacientes comprometidos inmunológicamente de edad avanzada o de patologías de gravedad es más común adquirir una bacteriemia lo que agrava significativamente la salud. Las mejoras en la prevención y protección de la salud del paciente están justificadas así como la concienciación de los profesionales sanitarios implicados.Traballo fin de grao (UDC.FEP). Enfermaría. Curso 2014-201

Transición epitelio- mesenquimal como diana terapéutica en modelos experimentales de diálisis peritoneal

Tesis doctoral inédita. Universidad Autónoma de Madrid, Facultad de Ciencias. Fecha de lectura: 05-10-201

Study of basic vector operations on Intel Xeon Phi and NVIDIA Tesla using OpenCL

The present work is an analysis of the performance of the basic vector operations AXPY, DOT and SpMV using OpenCL. The code was tested on the NVIDIA Tesla S2050 GPU and Intel Xeon Phi 3120A coprocessor. Due to the nature of the AXPY function, only two versions were implemented, the routine to be executed by the CPU and the kernel to be executed on the previously mentioned devices. It was studied how they perform for different vector’s sizes. Their results show the NVIDIA architecture better suited for the smaller vectors sizes and the Intel architecture for the larger vector’s sizes. For the DOT and SpMV functions, there are three versions implemented. The first is the CPU routine, the second one is an OpenCL kernel that uses local memory and the third one is an OpenCL kernel that only uses global memory. The kernels that use local memory are tested by varying the size of the work-group; the kernels that only uses global memory are tested by varying the arrays size. In the case of the first ones, the results show the optimum work-group size and that the NVIDIA architecture benefits from the use of local memory. For the latter kernels, the results show that larger computational loads benefits the Intel architectureThis work has been supported by FEDER funds and Xunta de Galicia under contract GRC 2014/008, and by Spanish Government (MCYT) under project TEC2010-17320 and TIN-2013-41129-PS

Spin-polarized transport in a full magnetic pn tunnel junction

Simulations of the tunneling current as a function of voltage and temperature for a Zener diode where both sides are ferromagnetic have been performed. The current is evaluated as a function of the applied bias, the magnetization, and the temperature on the diode. The tunneling magnetoresistance is also analyzed. Mn doped GaAs parameters were used to simulate a highly asymmetric doped diode, which leads to a large difference on the magnetization values between the p and n sidesThis work was supported by Spanish Government Grant Nos. TIN2007-67537-C03-01 and TEC2010-17320 and by Xunta de Galicia Grant Nos. DXIDI09TIC001CT and INCITE08PXIB206094PRS

Vertical-Tunnel-Junction (VTJ) Solar Cell for Ultra-High Light Concentrations (>2000 Suns)

A novel architecture of cell structure tailored to ultra-high (>2000 suns) concentration ratios is proposed. The basic solar cell consists of two p-n junctions connected in series by a highly doped tunnel diode with the metallic contacts located laterally. The tunneling connection allows using direct band-gap semiconductor compounds aiming to optimize the absorption of the spectrum. The performance of the novel architecture is investigated up to ultra-high concentration using TCAD software. Simulations show its viability for developing a new generation of solar cells to increase the potential in terms of efficiency and cost reduction of ultra-high concentrator systems. The solar cell does not show any degradation with concentration and efficiency as high as 28.4% at 15000 suns has been obtained for a preliminary designThe work of E. F. Fernández and F. Almonacid was supported by the Spanish Economy Ministry and FEDER funds under Project ENE2016-78251-R. The work of N. Seoane and A. J. García-Loureiro was supported in part by the Spanish Ministry of Economy and Competitiveness and FEDER funds under Grants TEC2014-59402-JIN and TIN2016-76373-P and in part by the Xunta de Galicia and FEDER funds under Grant GRC 2014/008S

Caveolin-1 deficiency induces a MEK-ERK1/2-Snail-1-dependent epithelial-mesenchymal transition and fibrosis during peritoneal dialysis

Peritoneal dialysis (PD) is a form of renal replacement therapy whose repeated use can alter dialytic function through induction of epithelial-mesenchymal transition (EMT) and fibrosis, eventually leading to PD discontinuation. The peritoneum from Cav1-/- mice showed increased EMT, thickness and fibrosis. Exposure of Cav1-/- mice to PD fluids further increased peritoneal membrane thickness, altered permeability and increased the number of FSP-1/cytokeratin-positive cells invading the sub-mesothelial stroma. High-throughput quantitative proteomics revealed increased abundance of collagens, FN and laminin, as well as proteins related to TGF- activity in matrices derived from Cav1-/- cells. Lack of Cav1 was associated with hyperactivation of a MEK-ERK1/2-Snail-1 pathway that regulated the Smad2-3/Smad1-5-8 balance. Pharmacological blockade of MEK rescued E-cadherin and ZO-1 inter-cellular junction localization, reduced fibrosis and restored peritoneal function in Cav1-/- mice. Moreover, treatment of human PD-patient-derived MCs with drugs increasing Cav1 levels, as well as ectopic Cav1 expression, induced reacquisition of epithelial features. This study demonstrates a pivotal role of Cav1 in the balance of epithelial versus mesenchymal state and suggests targets for the prevention of fibrosis during PD

Análisis del Proyecto de Educación Digital (E-DIXGAL): la visión del profesorado de Educación Primaria

El presente artículo analiza la visión del profesorado sobre el proyecto E-DIXGAL en la Comunidad Autónoma de Galicia. Este proyecto se trata de la primera iniciativa desde la Administración para la implantación del libro digital en los centros educativos. Así, toma como referente el proyecto Abalar —denominación autonómica del Programa Escuela 2.0—el cual busca la integración plena de las TIC en la práctica educativa gallega.El análisis de carácter cualitativo se realiza a través de la técnica de la entrevista aplicada a ocho profesores/as que pertenecen a centros de carácter urbano y rural de todas las provincias gallegas. Los resultados obtenidos manifiestan un nivel de inclusión de las TIC insuficiente, corroboran los antecedentes teóricos y retratan nuevas problemáticas relacionadas con el desarrollo futuro del proyecto E-DIXGAL

Analysis of the digital education project (E-DIXGAL): the views of primary school teachers

El presente artículo analiza la visión del profesorado sobre el proyecto E-DIXGAL en la Comunidad Autónoma de Galicia. Este proyecto se trata de la primera iniciativa desde la Administración para la implantación del libro digital en los centros educativos. Se toma como referente el proyecto Abalar —denominación autonómica del Programa Escuela 2.0—el cual busca la integración plena de las TIC en la práctica educativa gallega. El análisis de carácter cualitativo se realiza a través de la técnica de la entrevista aplicada a ocho docentes que pertenecen a centros de carácter urbano y rural de todas las provincias gallegas. Los resultados obtenidos manifiestan un nivel de inclusión de las TIC insuficiente, corroboran los antecedentes teóricos y retratan nuevas problemáticas relacionadas con el desarrollo futuro del proyecto E-DIXGAL.The following article assesses the vision of teachers about the E-DIXGAL project in the Autonomous Community of Galicia. This project is the first initiative from the Administration for the implementation of the digital book in schools. Thus, it takes as a reference the Abalar project —the autonomic designation of the School 2.0 Program—, which seeks the full integration of ICT in the Galician educational system. The qualitative analysis is carried out through the technique of the interview applied to eight teachers who belong to urban and rural schools of all the Galician provinces. The results obtained show an insufficient level of ICT inclusion, corroborate the theoretical background and bring new problems related to the future development of the EDIXGAL project.S

Vacuum annealing effect on physical properties and electrical circuit model of ZnO:Sn/SnO2:F bilayer structure

Tin doped Zinc oxide/Fluorine doped tin dioxide bilayer films (ZnO:Sn/SnO2:F) were deposited on glass substrates using spray pyrolysis technique. The effect of vacuum annealing at different temperatures was investigated. Both structural and morphological analysis have shown that there is a significant modification in the bilayer film structure and surface following the vacuum annealing process at 450 °C. Electrical properties have been investigated using the Hall Effect measurements as well as the impedance spectroscopy at room temperature. The circuit parameters were determined using an equivalent circuit model fitted from the impedance spectra and suggesting the presence of grain and grain boundary conductions in the bilayer structure. It was found that the film annealed in vacuum for 1 h at 350 °C is optimal in all respects, as it possesses all the desirable characteristics including the lowest resistivity, high porosity and better grain boundary conductivityS