« La musique... L’expérience même de l’appropiation impossible ». Quelques variations sur un thème de Jacques Derrida

Desde sus comienzos, la relación de la filosofía con la música ha sido sin duda problemática. ¿Qué herencia nos ha dejado Jacques Derrida al respecto? Aunque no mantuvo ninguna tesis sobre la música «como tal», ha abierto un camino –otro camino– hacia la misma, hacia su escucha. Frente a la primacía óptico-háptica de la ontología y su logofonocentrismo, Derrida nos acerca, a través de la escucha, a la experiencia como apropiación imposible de la différance que encierra la variación modulada del material sonoro y, más allá de toda presencia, a la experiencia inaccesible de la luz de un duelo originario, donde, en la velocidad infinita de un presente sin pasado y siempre por venir, se entrecruzan la vida y la muerte, la memoria y la espera. La cadencia con la que termina el Concierto de Brandenburgo nº 5 en Re Mayor de J. S. Bach y el finale de la Sonata en do menor de Schubert pueden ser dos bellos ejemplos para esa experiencia indecidible.From its beginnings, the relationship between philosophy and music has always been problematic. What is Derrida’s legacy to us on this subject? Although he did not develop a thesis about music “as such”, he opened up a path –another path– to music, and its listening. Against the optical-haptical primacy of ontology and its logo-phono-centrism, Derrida leads us, through this process of listening, to experience as impossible appropriation of the différance which entails the modulated variation of sonorous matter, and, beyond all presence, to the inaccessible experience of light of an original mourning which, at the infinite speed of a present with no past and yet to come, life and death, memory and wait, intertwine. The ending cadence of the first movement of J. S. Bach’s Brandenburg Concerto No 5 in D major, and the Finale of Schubert’s Sonata in C minor are two fine examples of this undecidible experience.Desde sus comienzos, la relación de la filosofía con la música ha sido sin duda problemática. ¿Qué herencia nos ha dejado Jacques Derrida al respecto? Aunque no mantuvo ninguna tesis sobre la música «como tal», ha abierto un camino –otro camino– hacia la misma, hacia su escucha. Frente a la primacía óptico-háptica de la ontología y su logofonocentrismo, Derrida nos acerca, a través de la escucha, a la experiencia como apropiación imposible de la différance que encierra la variación modulada del material sonoro y, más allá de toda presencia, a la experiencia inaccesible de la luz de un duelo originario, donde, en la velocidad infinita de un presente sin pasado y siempre por venir, se entrecruzan la vida y la muerte, la memoria y la espera. La cadencia con la que termina el Concierto de Brandenburgo nº 5 en Re Mayor de J. S. Bach y el finale de la Sonata en do menor de Schubert pueden ser dos bellos ejemplos para esa experiencia indecidible

A model of workplace safety incorporating worker interactions and simple interventions

Although there was substantial research into the occupational health and safety sector over the past forty years, this generally focused on statistical analyses of data related to costs and/or fatalities and injuries. There is a lack of mathematical modelling of the interactions between workers and the resulting safety dynamics of the workplace. There is also little work investigating the potential impact of different safety intervention programs prior to their implementation. In this article, we present a fundamental, differential equation-based model of workplace safety that treats worker safety habits similarly to an infectious disease in an epidemic model. Analytical results for the model, derived via phase plane and stability analysis, are discussed. The model is coupled with a model of a generic safety strategy aimed at minimising unsafe work habits, to produce an optimal control problem. The optimal control model is solved using the forward-backward sweep numerical scheme implemented in Matlab. References Australian Bureau of Statistics. Forms of employment. Commonwealth of Australia, 2010. http://www.abs.gov.au/AUSSTATS/[email protected]/DetailsPage/6359.0November%202010?OpenDocument Bahn, S. Power and Influence: Examining the Communication Pathways that Impact on Safety in the Workplace. J. Occup. Health Safety–-Aust. N.Z., 25(3):213–222, 2009. Bird, P. Reducing Manual Handling Workers Compensation Claims in a Public Health Facility. J. Occup. Health Safety–-Aust. N.Z., 25(6):451–459, 2009. Breslin, P. Improving ohs Standards in the Building and Construction Industry through safe design. J. Occup. Health Safety–-Aust. N.Z., 23(4):89–99, 2007. Breslin, P. National Harmonisation: Designers' Duties of Care in the Australian Building and Construction Industry. J. Occup. Health Safety–-Aust. N.Z., 25(6):495–504, 2009 . Driscoll, T., Mitchell, T., Mandryk, J., Healey, S., Hendrie, L. and Hull, B. Trends in Work-Related Fatalities in Australia, 1982 to 1992. J. Occup. Health Safety–-Aust. N.Z., 18(1):21–33, 2002. Driscoll, T. Fatal Injury of young workers in Australia. J. Occup. Health Safety–-Aust. N.Z., 22(2):151–161, 2006. Foley, G., Gale, J. and Gavenlock, L. The Cost of Work-Related Injury and Disease. J. Occup. Health Safety–-Aust. N.Z., 11(2):171–194, 1995. Glendon, I. and Waring, A. Risk management as a framework for occupational health and safety. J. Occup. Health Safety–-Aust. N.Z., 13(6):525–532, 1997. Gunningham, N. and Healy, P. Agricultural ohs Policy: Towards Systemic Reform. J. Occup. Health Safety–-Aust. N.Z., 20(4):311–318, 2004. Hawkins, A., Eather, J. and Fragar, L. Improving Health and Safety in the Farm Workshop. J. Occup. Health Safety–-Aust. N.Z., 24(2):155–160, 2008. Heads of Workers' Compensation Authorities. 2008/09 Australia and New Zealand Return to Work Monitor. http://www.hwca.org.au/documents/Australia%20and%20New%20Zealand%20Return%20to%20Work%20Monitor%202008-2009.pdf Kermack, W. O. and McKendrick, A. G. A Contribution to the Mathematical Theory of Epidemics. Proc. R. Soc. Lond. A., 115(772):700–721, 1927. doi:10.1098/rspa.1927.0118 Lenhart, S. and Workman, J. T. Optimal control applied to biological models. Chapman and Hall CRC Mathematical and Computational Biology Series, 2007. Mallet, D. G., Bagher-Oskouei, M., Farr, A. C., Simpson, D. P. and Sutton, K-J. A mathematical model of Chlamydial infection incorporating movement of Chlamydial particles. B. Math. Biol., 75(11):2257–2270, 2013. doi:10.1007/s11538-013-9891-9 Murray, J. D. Mathematical Biology, I: An Introduction. Springer, 2002. Raggett, G. F. Modelling the Eyam plague. B. I. Math. Appl., 18:221–226, 1982. Safe Work Australia. The cost of work-related injury and illness for australian employers, workers and the community:2008-2009. Commonwealth of Australia, 2012. http://www.safeworkaustralia.gov.au/sites/SWA/about/Publications/Documents/660/Cost%20of%20Work-related%20injury%20and%20disease.pdf Shulgin, B., Stone, L. and Agur, Z. Pulse vaccination strategy in the sir Epidemic Model. B. Math. Biol., 60(6):1123–1148, 1998. doi:10.1006/S0092-8240(98)90005-2 Vanderkruk, R. Workplace health and safety officers: a Queensland success story. J. Occup. Health Safety–-Aust. N.Z., 15(6):557–563, 1999. Winder, C. The development of ohs legislation in Australia. J. Occup. Health Safety–-Aust. N.Z., 25(4):277–287, 2009

Tell me if you prefer bovine or poultry sectors and I’ll tell you who you are: Characterization of Salmonella enterica subsp. enterica serovar Mbandaka in France

IntroductionIn north-western France, Salmonella enterica susp. enterica serovar Mbandaka (S. Mbandaka) is most frequently isolated from bovine and dairy samples. While this serovar most often results in asymptomatic carriage, for a number of years it has caused episodes of abortions, which have serious economic consequences for the sector. Interestingly, this serovar is also isolated from Gallus gallus in the same geographic zone. Despite its prevalence in bovines in north-western France, S. Mbandaka has not been broadly studied at the genomic level, and its prevalence and host adaptation are still not fully understood.MethodsIn this study, we analyzed the genomic diversity of 304 strains of S. Mbandaka isolated from the bovine and poultry sectors in this area over a period of 5 years. A phylogenetic analysis was carried out and two approaches were followed to identify conserved genes and mutations related to host associations. The first approach targeted the genes compiled in the MEGARESv2, Resfinder, VFDB and SPI databases. Plasmid and phage contents were also investigated. The second approach refers to an in-house algorithm developed for this study that computes sensitivity, specificity, and accuracy of accessory genes and core variants according to predefined genomes groups.Results and discussionAll the analyzed strains belong to the multi-locus sequence type profile ST413, and the phylogenomic analysis revealed main clustering by host (bovine and poultry), emphasizing the circulation of 12 different major clones, of which seven circulate in poultry and five in the bovine sector in France and a likely food production chain adaptation of these clones. All strains present resistance determinants including heavy metals and biocides that could explain the ability of this serovar to survive and persist in the environment, within herds, and in food processing plants. To explore the wild animal contribution to the spread of this serovar in north-western France, we retrieved S. Mbandaka genomes isolated from wild birds from EnteroBase and included them in the phylogenomic analysis together with our collection. Lastly, screening of accessory genes and major variants allowed us to identify conserved specific mutations characteristic of each major cluster. These mutations could be used to design useful probes for food safety surveillance

Erratum to: Methods for evaluating medical tests and biomarkers

[This corrects the article DOI: 10.1186/s41512-016-0001-y.]

Mapping genomic loci implicates genes and synaptic biology in schizophrenia

Schizophrenia has a heritability of 60-80%1, much of which is attributable to common risk alleles. Here, in a two-stage genome-wide association study of up to 76,755 individuals with schizophrenia and 243,649 control individuals, we report common variant associations at 287 distinct genomic loci. Associations were concentrated in genes that are expressed in excitatory and inhibitory neurons of the central nervous system, but not in other tissues or cell types. Using fine-mapping and functional genomic data, we identify 120 genes (106 protein-coding) that are likely to underpin associations at some of these loci, including 16 genes with credible causal non-synonymous or untranslated region variation. We also implicate fundamental processes related to neuronal function, including synaptic organization, differentiation and transmission. Fine-mapped candidates were enriched for genes associated with rare disruptive coding variants in people with schizophrenia, including the glutamate receptor subunit GRIN2A and transcription factor SP4, and were also enriched for genes implicated by such variants in neurodevelopmental disorders. We identify biological processes relevant to schizophrenia pathophysiology; show convergence of common and rare variant associations in schizophrenia and neurodevelopmental disorders; and provide a resource of prioritized genes and variants to advance mechanistic studies

Drying colloidal systems: laboratory models for a wide range of applications

The drying of complex fluids provides a powerful insight into phenomena that take place on time and length scales not normally accessible. An important feature of complex fluids, colloidal dispersions and polymer solutions is their high sensitivity to weak external actions. Thus, the drying of complex fluids involves a large number of physical and chemical processes. The scope of this review is the capacity to tune such systems to reproduce and explore specific properties in a physics laboratory. A wide variety of systems are presented, ranging from functional coatings, food science, cosmetology, medical diagnostics and forensics to geophysics and art

Evidence synthesis to inform model-based cost-effectiveness evaluations of diagnostic tests: a methodological systematic review of health technology assessments

Background: Evaluations of diagnostic tests are challenging because of the indirect nature of their impact on patient outcomes. Model-based health economic evaluations of tests allow different types of evidence from various sources to be incorporated and enable cost-effectiveness estimates to be made beyond the duration of available study data. To parameterize a health-economic model fully, all the ways a test impacts on patient health must be quantified, including but not limited to diagnostic test accuracy. Methods: We assessed all UK NIHR HTA reports published May 2009-July 2015. Reports were included if they evaluated a diagnostic test, included a model-based health economic evaluation and included a systematic review and meta-analysis of test accuracy. From each eligible report we extracted information on the following topics: 1) what evidence aside from test accuracy was searched for and synthesised, 2) which methods were used to synthesise test accuracy evidence and how did the results inform the economic model, 3) how/whether threshold effects were explored, 4) how the potential dependency between multiple tests in a pathway was accounted for, and 5) for evaluations of tests targeted at the primary care setting, how evidence from differing healthcare settings was incorporated. Results: The bivariate or HSROC model was implemented in 20/22 reports that met all inclusion criteria. Test accuracy data for health economic modelling was obtained from meta-analyses completely in four reports, partially in fourteen reports and not at all in four reports. Only 2/7 reports that used a quantitative test gave clear threshold recommendations. All 22 reports explored the effect of uncertainty in accuracy parameters but most of those that used multiple tests did not allow for dependence between test results. 7/22 tests were potentially suitable for primary care but the majority found limited evidence on test accuracy in primary care settings. Conclusions: The uptake of appropriate meta-analysis methods for synthesising evidence on diagnostic test accuracy in UK NIHR HTAs has improved in recent years. Future research should focus on other evidence requirements for cost-effectiveness assessment, threshold effects for quantitative tests and the impact of multiple diagnostic tests

Erratum to: Methods for evaluating medical tests and biomarkers

[This corrects the article DOI: 10.1186/s41512-016-0001-y.]