Unique Organization of Extracellular Amylases into Amylosomes in the Resistant Starch-Utilizing Human Colonic Firmicutes Bacterium Ruminococcus bromii

ACKNOWLEDGMENTS We acknowledge support from BBSRC grant no. BB/L009951/1, from the Scottish government Food, Land and People program, and from the Society for Applied Microbiology. E.A.B. is supported by a grant (no. 1349/13) from the Israel Science Foundation (ISF), Jerusalem, Israel, and by a grant from the United States-Israel Binational Science Foundation (BSF). E.A.B. is the incumbent of the Maynard I. and Elaine Wishner Chair of Bio-organic Chemistry. Thanks are due to Fergus Nicol for proteomic analysis and to Auriane Bernard for enzyme assays on stationary-phase cultures. We also thank Julian Parkhill and Keith Turner (Wellcome Trust Sanger Institute, Cambridge, United Kingdom) for making the R. bromii L2-63 genome sequence available for analysis.Peer reviewedPublisher PD

No metastable de Sitter vacua in N=2 supergravity with only hypermultiplets

We study the stability of vacua with spontaneously broken supersymmetry in N = 2 supergravity theories with only hypermultiplets. Focusing on the projection of the scalar mass matrix along the sGoldstino directions, we are able to derive a universal upper bound on the lowest mass eigenvalue. This bound only depends on the gravitino mass and the cosmological constant, but not on the details of the quaternionic manifold spanned by the scalar fields. Comparing with the Breitenlohner-Freedman bound shows that metastability requires the cosmological constant to be smaller than a certain negative critical value. Therefore, only AdS vacua with a sufficiently negative cosmological constant can be stable, while Minkowski and dS vacua necessarily have a tachyonic direction

La fiabilité : une voie vers l’équité ?

Ce ne sont pas les bonnes idées et les innovations qui manquent dans le champ éducatif. Pourtant, l’école actuelle demeure largement incapable de répondre aux besoins de l’ensemble des élèves, s’agissant notamment des élèves de couleur et des élèves pauvres. Pourquoi nos innovations ne parviennent-elles pas à créer une pression positive en faveur de l’équité ? Face à une trop grande variété des résultats dans une même situation, il est illusoire de vouloir prescrire ce qui a marché ailleurs. C’est au contraire en créant une grande « vigilance et conscience situationnelle » que l’on pourra, de façon fiable, faire face à la diversité des besoins et assurer plus d’équité.There is no shortage of good ideas and innovations in the education field. And yet schooling remains grossly unable to meet the needs of all students, particularly students of colour and poor students. Why do our innovations fail to create a positive press on equity? Faced with too great a variety of results in the same situation, it is illusory to want to prescribe what has worked elsewhere. On the contrary, it is by creating great “vigilance and situational awareness” that we will be able to reliably meet the diversity of needs and ensure more equity.Se puede decir que no faltan las ideas buenas y las innovaciones en el campo educativo. Sin embargo, la escuela actual sigue siendo en gran parte incapaz de contestar a las necesidades de la totalidad de los alumnos, sobre todo cuando se trata de alumnos de color y de alumnos pobres. ¿Por qué nuestras innovaciones no permiten crear una presión positiva a favor de la equidad? Frente a una variedad demasiado grande de resultados en una misma situación, resulta ser ilusorio querer preconizar lo que ha funcionado en otros lugares. Por lo contrario, es por la creación de una gran “vigilancia y conciencia situacional” como se podrá enfrentar de manera fiable con la diversidad de las necesidades y asegurar más equidad

Barrier breakdown in a multiple quantum well structure

We explore a regime of unipolar electronic transport in a multiple quantum well structure with very large current discontinuities - up to five orders of magnitude. Magneto-transport experiments reveal different transport regimes. Quantum well impact ionization shifts the structure from a resistive down state, where the current flows through inter-well quantum tunneling, to a highly conductive up state. In the latter regime, the current leaks through a barrier suddenly broken down because of an efficient ionization of the first quantum well.Comment: 16 pages, 5 figure

Scalar geometry and masses in Calabi-Yau string models

We study the geometry of the scalar manifolds emerging in the no-scale sector of Kahler moduli and matter fields in generic Calabi-Yau string compactifications, and describe its implications on scalar masses. We consider both heterotic and orientifold models and compare their characteristics. We start from a general formula for the Kahler potential as a function of the topological compactification data and study the structure of the curvature tensor. We then determine the conditions for the space to be symmetric and show that whenever this is the case the heterotic and the orientifold models give the same scalar manifold. We finally study the structure of scalar masses in this type of geometries, assuming that a generic superpotential triggers spontaneous supersymmetry breaking. We show in particular that their behavior crucially depends on the parameters controlling the departure of the geometry from the coset situation. We first investigate the average sGoldstino mass in the hidden sector and its sign, and study the implications on vacuum metastability and the mass of the lightest scalar. We next examine the soft scalar masses in the visible sector and their flavor structure, and study the possibility of realizing a mild form of sequestering relying on a global symmetry.Comment: 36 pages, no figure

Characterizing, modelling and understanding the climate variability of the deep water formation in the North-Western Mediterranean Sea

Observing, modelling and understanding the climate-scale variability of the deep water formation (DWF) in the North-Western Mediterranean Sea remains today very challenging. In this study, we first characterize the interannual variability of this phenomenon by a thorough reanalysis of observations in order to establish reference time series. These quantitative indicators include 31 observed years for the yearly maximum mixed layer depth over the period 1980–2013 and a detailed multi-indicator description of the period 2007–2013. Then a 1980–2013 hindcast simulation is performed with a fully-coupled regional climate system model including the high-resolution representation of the regional atmosphere, ocean, land-surface and rivers. The simulation reproduces quantitatively well the mean behaviour and the large interannual variability of the DWF phenomenon. The model shows convection deeper than 1000 m in 2/3 of the modelled winters, a mean DWF rate equal to 0.35 Sv with maximum values of 1.7 (resp. 1.6) Sv in 2013 (resp. 2005). Using the model results, the winter-integrated buoyancy loss over the Gulf of Lions is identified as the primary driving factor of the DWF interannual variability and explains, alone, around 50 % of its variance. It is itself explained by the occurrence of few stormy days during winter. At daily scale, the Atlantic ridge weather regime is identified as favourable to strong buoyancy losses and therefore DWF, whereas the positive phase of the North Atlantic oscillation is unfavourable. The driving role of the vertical stratification in autumn, a measure of the water column inhibition to mixing, has also been analyzed. Combining both driving factors allows to explain more than 70 % of the interannual variance of the phenomenon and in particular the occurrence of the five strongest convective years of the model (1981, 1999, 2005, 2009, 2013). The model simulates qualitatively well the trends in the deep waters (warming, saltening, increase in the dense water volume, increase in the bottom water density) despite an underestimation of the salinity and density trends. These deep trends come from a heat and salt accumulation during the 1980s and the 1990s in the surface and intermediate layers of the Gulf of Lions before being transferred stepwise towards the deep layers when very convective years occur in 1999 and later. The salinity increase in the near Atlantic Ocean surface layers seems to be the external forcing that finally leads to these deep trends. In the future, our results may allow to better understand the behaviour of the DWF phenomenon in Mediterranean Sea simulations in hindcast, forecast, reanalysis or future climate change scenario modes. The robustness of the obtained results must be however confirmed in multi-model studies

Molecular Characterization of the Gastrula in the Turtle Emys orbicularis: An Evolutionary Perspective on Gastrulation

Due to the presence of a blastopore as in amphibians, the turtle has been suggested to exemplify a transition form from an amphibian- to an avian-type gastrulation pattern. In order to test this hypothesis and gain insight into the emergence of the unique characteristics of amniotes during gastrulation, we have performed the first molecular characterization of the gastrula in a reptile, the turtle Emys orbicularis. The study of Brachyury, Lim1, Otx2 and Otx5 expression patterns points to a highly conserved dynamic of expression with amniote model organisms and makes it possible to identify the site of mesoderm internalization, which is a long-standing issue in reptiles. Analysis of Brachyury expression also highlights the presence of two distinct phases, less easily recognizable in model organisms and respectively characterized by an early ring-shaped and a later bilateral symmetrical territory. Systematic comparisons with tetrapod model organisms lead to new insights into the relationships of the blastopore/blastoporal plate system shared by all reptiles, with the blastopore of amphibians and the primitive streak of birds and mammals. The biphasic Brachyury expression pattern is also consistent with recent models of emergence of bilateral symmetry, which raises the question of its evolutionary significance

A Business Plan On TeHuiGou Co.,Ltd.

随着支付技术的快速发展以及消费者购物习惯的日益改变，我国支付市场已经被众多商家视为新的“聚宝盆”；而随着第三方牌照的发放，第三方支付市场将迎来新的“井喷期”。而POS收单业务，作为支付体系运作终端环节，也是支付受理环境最重要的组成部分，同时新技术的发展，催生了手机现场支付与特定行业的小额支付等新的支付手段，推动的POS收单业务带来新的业务增长点。 本论文应用创业管理相关理论，提出了特惠购有限公司的创业计划书。研究表明，特惠购公司依托于多年从事移动支付的技术背景以及1000多家联盟商家客户资源，与F市社保卡发卡行紧密合作，专注于特定行业小额支付收单业务，并通过不断创新业务模式，大力发展增值业务...As the rapid development of payment technology and changing of consumers’s shopping habits, China payment market has been taken as a new "cornucopia" by many businessman; and as the third party license issuance, the third party payment market will usher in a new "blowout period". While POS bill-received business, as payment system operation terminal link, is also the most important part of payment...学位：工程管理硕士院系专业：管理学院工商管理教育中心（MBA中心）_工商管理硕士(MBA)学号：1792009115079

De Sitter vacua in no-scale supergravities and Calabi-Yau string models

We perform a general analysis on the possibility of obtaining metastable vacua with spontaneously broken N = 1 supersymmetry and non-negative cosmological constant in the moduli sector of string models. More specifically, we study the condition under which the scalar partners of the Goldstino are non-tachyonic, which depends only on the Kahler potential. This condition is not only necessary but also sufficient, in the sense that all of the other scalar fields can be given arbitrarily large positive square masses if the superpotential is suitably tuned. We consider both heterotic and orientifold string compactifications in the large-volume limit and show that the no-scale property shared by these models severely restricts the allowed values for the 'sGoldstino' masses in the superpotential parameter space. We find that a positive mass term may be achieved only for certain types of compactifications and specific Goldstino directions. Additionally, we show how subleading corrections to the Kahler potential which break the no-scale property may allow to lift these masses

Moduli Stabilization and Cosmology of Type IIB on SU(2)-Structure Orientifolds

We consider type IIB flux compactifications on six-dimensional SU(2)-structure manifolds with O5- and O7-planes. These six-dimensional spaces allow not only for F_3 and H_3 fluxes but also for F_1 and F_5 fluxes. We derive the four-dimensional N=1 scalar potential for such compactifications and present one explicit example of a fully stabilized AdS vacuum with large volume and small string coupling. We then discuss cosmological aspects of these compactifications and derive several no-go theorems that forbid dS vacua and slow-roll inflation under certain conditions. We also study concrete examples of cosets and twisted tori and find that our no-go theorems forbid dS vacua and slow-roll inflation in all but one of them. For the latter we find a dS critical point with \epsilon numerically zero. However, the point has two tachyons and eta-parameter \eta \approx -3.1.Comment: 35 pages + appendices, LaTeX2e; v2: numerical dS extremum added, typos corrected, references adde