70 research outputs found
Drugs foresight 2020: a Delphi expert panel study
- Author
- AJ McBride
- Anne Konu
- AT Shulgin
- B Kelly
- B Svensson
- CD Burrell
- DJ Nutt
- DS Scheele
- Elina Kotovirta
- Government Office for Science
- Government Office for Science
- H Tanhua
- HA Linstone
- HA Linstone
- HP McKenna
- IA Mitroff
- J Aschemann-Witzel
- KG Loughlin
- M Frisher
- M Turoff
- M Turoff
- N McKeganey
- National Institute for Health and Welfare
- National Institute for Health and Welfare
- NC Dalkey
- Sanna Rönkä
- T Gordon
- T Tammi
- TF Nelson
- The European Monitoring Centre for Drugs and Drug Addiction
- Tomi Lintonen
- Publication venue
- Publication date
- 01/01/2014
- Field of study
Peer reviewe
Developing the specifications of an Open Angle Glaucoma screening intervention in the United Kingdom : a Delphi approach
- Author
- A Behrens
- A Bowling
- A Iwase
- A Raffle
- Alexandra C Greene
- Augusto Azuara-Blanco
- C Powell
- Craig R Ramsay
- D Pascolini
- F Hasson
- FA Medeiros
- G Mowatt
- H Vaahtoranta-Lehtonen
- HA Linstone
- HA Quigley
- J Burr
- J Jones
- Jennifer M Burr
- Jillian J Francis
- KG Loughlin
- M Lester
- M Toth
- Marion K Campbell
- PC Maier
- RB Akins
- S Hatt
- S Keeney
- SL Mansberger
- Susan E Campbell
- The Glaucoma screening Platform Study (GPS) Group
- UK National Screening Committee
- World Glaucoma Association
- YX Wang
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/01/2012
- Field of study
PMID: 23216983 [PubMed - indexed for MEDLINE] PMCID: PMC3563574 Free PMC Article Acknowledgements We thank all the glaucoma specialists who took part in the Delphi process. We thank the Glaucoma screening Platform Study advisory panel including R Bativala, D Crabb, D Garway-Heath, M Griffiths, R Hitchings; S McPherson, A Tuulonen, A Viswanathan, H Waterman, R Wormald, D Wright for their guidance and contribution to the Delphi process and Luke Vale and Rodolfo Hernandez for their advice on development of the Delphi questionnaires. This paper was developed from the first phase of a project funded by the MRC (project reference G0701759) Developing the intervention & outcome components of a proposed randomized controlled trial of screening for open angle glaucoma. The Health Services Research Unit is core funded by the Chief Scientist Office of the Scottish Government Health Directorates. The views expressed in this report are those of the authors and not necessarily those of the funders.Peer reviewedPublisher PD
One-Day vs Two-Day Epidural Analgesia for Total Knee Arthroplasty (TKA): A Retrospective Cohort Study
- Author
- Adams HA
- Bachyen Dang
- Block BM
- Capdevila X
- Carolyn Beagan
- Charlson ME
- Chu CP
- Corbett Corbett
- Elena Losina
- Granger CV
- Hantler C
- Horlocker TT
- Jeffrey N. Katz
- John Wright
- Kurtz S
- Kurtz S
- Loughlin J
- Mahoney OM
- Markel DC
- Moraca RJ
- Parvizi J
- Paul Corsello
- Ravaud JF
- Regina Mikulinsky
- Rodgers A
- Roya Ghazinouri
- Sharrock NE
- Singelyn FJ
- William M. Reichmann
- Williams-Russo P
- Publication venue
- Bentham Open
- Publication date
- Field of study
Noncanonical G recognition mediates KSRP regulation of let-7 biogenesis
- Author
- Andres Ramos
- C Bartels
- CD Cukier
- D Hollingworth
- David Hollingworth
- EF Pettersen
- EP Nikonowicz
- F Delaglio
- FE Loughlin
- G Michlewski
- G Michlewski
- G Varani
- Geoff Kelly
- Giuseppe Nicastro
- HA Lewis
- I Büssing
- I Heo
- J Krol
- JP Hagan
- JP Linge
- M Trabucchi
- María Flor García-Mayoral
- MF García-Mayoral
- MF García-Mayoral
- MF García-Mayoral
- NJ Baxter
- P Briata
- Paola Briata
- PH Backe
- R Gherzi
- R Koradi
- R Valverde
- Roberto Gherzi
- SR Martin
- SR Viswanathan
- Stephen R Martin
- T Cierpicki
- VN Kim
- Y Nam
- Z Liu
- Publication venue
- Publication date
- 11/11/2012
- Field of study
Let-7 is an important tumor-suppressive microRNA (miRNA) that acts as an on-off switch for cellular differentiation and regulates the expression of a set of human oncogenes. Binding of the human KSRP protein to let-7 miRNA precursors positively regulates their processing to mature let-7, thereby contributing to control of cell proliferation, apoptosis and differentiation. Here we analyze the molecular basis for KSRP-let-7 precursor selectivity and show how the third KH domain of the protein recognizes a G-rich sequence in the pre-let-7 terminal loop and dominates the interaction. The structure of the KH3-RNA complex explains the protein recognition of this noncanonical KH target sequence, and we demonstrate that the specificity of this binding is crucial for the functional interaction between the protein and the miRNA precursor
Impact of clinical phenotypes on management and outcomes in European atrial fibrillation patients: a report from the ESC-EHRA EURObservational Research Programme in AF (EORP-AF) General Long-Term Registry
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- ?liwi?ski A.
- ?zin B.
- Aalborg University
- Aalborg University Hospital
- Aarup A.
- Abalea J.
- Abela E.
- Acimovic T.
- Adamczewski J.
- Adams C.
- Adams L.
- Adams M.
- Adrag?o P.
- Ahadi N.
- Ahmad S.
- Ahyt B.
- Akin Serdar Serdar O.
- Alam I.
- Alcalde O.
- Alin D.
- Alina-Ramona N.
- Allison J.
- Almeida S.
- Alves M.
- Andersen K.
- Andersen M.
- Andrews N.
- Andric A.
- Anguita M.
- Anneken L.
- Antoniades L.
- Antovski A.
- Arandjelovic A.
- Arend C.
- Arhipova T.
- Ari H.
- Aring J.
- Arnaud D.
- Arnault I.
- Arnold M.
- Asanin M.
- Asanovic D.
- Ashton A.
- Atar D.
- Atar D.
- Atmaca Y.
- Austin R.
- Axthelm C.
- Ayarra M.
- Azhari A.
- B?aszczyk H.
- Badenco N.
- Bader H.
- Badila E.
- Bahadur S.
- Bairamukova A.
- Bajraktarova Proseva Proseva T.
- Bakalska-Georgieva S.
- Bakrecheski N.
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- Belcher G.
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- Carol Davila University of Medicine and Pharmacy
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- Clinical Center of Serbia
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- Department of Anaesthesiology and Intensive Care
- Department of Cardiology
- Department of Clinical Medicine
- Department of Gastroenterology and Hepatology
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- Hvilsted Rasmussen Rasmussen L.
- Hôpital Trousseau CHU de Tours
- Ilic S.
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- Ingram T.
- Investigators on behalf of the ESC-EHRA EORP-AF Long-Term General Registry
- Ionac A.
- Ionescu G.
- Iqbal R.
- IRCCS Istituti Clinici Scientifici Maugeri S.p.A. SB - Pavia
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- Klinik Anæstesi Børn, Kredsløb og Kvinder
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- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/01/2021
- Field of study
Background: Epidemiological studies in atrial fibrillation (AF) illustrate that clinical complexity increase the risk of major adverse outcomes. We aimed to describe European AF patients\u2019 clinical phenotypes and analyse the differential clinical course. Methods: We performed a hierarchical cluster analysis based on Ward\u2019s Method and Squared Euclidean Distance using 22 clinical binary variables, identifying the optimal number of clusters. We investigated differences in clinical management, use of healthcare resources and outcomes in a cohort of European AF patients from a Europe-wide observational registry. Results: A total of 9363 were available for this analysis. We identified three clusters: Cluster 1 (n = 3634; 38.8%) characterized by older patients and prevalent non-cardiac comorbidities; Cluster 2 (n = 2774; 29.6%) characterized by younger patients with low prevalence of comorbidities; Cluster 3 (n = 2955;31.6%) characterized by patients\u2019 prevalent cardiovascular risk factors/comorbidities. Over a mean follow-up of 22.5 months, Cluster 3 had the highest rate of cardiovascular events, all-cause death, and the composite outcome (combining the previous two) compared to Cluster 1 and Cluster 2 (all P <.001). An adjusted Cox regression showed that compared to Cluster 2, Cluster 3 (hazard ratio (HR) 2.87, 95% confidence interval (CI) 2.27\u20133.62; HR 3.42, 95%CI 2.72\u20134.31; HR 2.79, 95%CI 2.32\u20133.35), and Cluster 1 (HR 1.88, 95%CI 1.48\u20132.38; HR 2.50, 95%CI 1.98\u20133.15; HR 2.09, 95%CI 1.74\u20132.51) reported a higher risk for the three outcomes respectively. Conclusions: In European AF patients, three main clusters were identified, differentiated by differential presence of comorbidities. Both non-cardiac and cardiac comorbidities clusters were found to be associated with an increased risk of major adverse outcomes
Novel non-invasive biomarkers that distinguish between benign prostate hyperplasia and prostate cancer
- Author
- A Jemal
- A Thathiah
- A Thathiah
- Adam Curatolo
- Andrej Jedinak
- BD Westerveld
- C Teasdale
- CC Yang
- CM Coley
- CY Lin
- D Faraggi
- D Zurakowski
- David Zurakowski
- DG Ward
- E Basch
- EA Rakha
- ER DeLong
- GL Andriole
- GS Arul
- H Pandha
- HA Guess
- I Gritti
- IM Thompson
- IV Shilov
- J Shuster
- J Yang
- JL Bosch
- Kevin R Loughlin
- KL Greene
- L Gooren
- L Hemmingsen
- LM McShane
- M Abdul
- M Afkarian
- M Gross
- M Ichinose
- M Rigau
- MA Hollingsworth
- MA Moses
- Manoj K Bhasin
- Marsha A Moses
- MD Eckhardt
- Monisha Sachdev
- P Abrams
- R Mazzucchelli
- R Roy
- R Roy
- R Siegel
- R Siegel
- Roopali Roy
- RP Pal
- RQ Wang
- Simon Dillon
- T Jamaspishvili
- TA Haj-Ahmad
- TJ Duncan
- Towia A Libermann
- WJ Catalona
- Y Tani
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- Field of study
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- Patel NA
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- Ramakrishnan V
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- Publication date
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- Field of study
Background: The 5 years since the publication of the first International Consensus Statement on Allergy and Rhinology: Rhinosinusitis (ICAR‐RS) has witnessed foundational progress in our understanding and treatment of rhinologic disease. These advances are reflected within the more than 40 new topics covered within the ICAR‐RS‐2021 as well as updates to the original 140 topics. This executive summary consolidates the evidence‐based findings of the document. Methods: ICAR‐RS presents over 180 topics in the forms of evidence‐based reviews with recommendations (EBRRs), evidence‐based reviews, and literature reviews. The highest grade structured recommendations of the EBRR sections are summarized in this executive summary. Results: ICAR‐RS‐2021 covers 22 topics regarding the medical management of RS, which are grade A/B and are presented in the executive summary. Additionally, 4 topics regarding the surgical management of RS are grade A/B and are presented in the executive summary. Finally, a comprehensive evidence‐based management algorithm is provided. Conclusion: This ICAR‐RS‐2021 executive summary provides a compilation of the evidence‐based recommendations for medical and surgical treatment of the most common forms of RS
Observation of gravitational waves from the coalescence of a 2.5−4.5 M⊙ compact object and a neutron star
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- Abac Adrian
- Abbott R.
- Abouelfettouh I.
- Acernese F.
- Ackley Kendall
- Adhicary S.
- Adhikari Naresh
- Adhikari Rana X.
- Adkins V. K.
- Afif Ismail M.
- Agarwal Deepali
- Agathos Michalis
- Aghaei Abchouyeh Maryam
- Aguiar Odylio D.
- Aguilar I.
- Aiello Lorenzo
- Ain Anirban
- Ajith Parameswaran
- Akcay Sarp
- Akseli Hannuksela Otto
- Akutsu Tomotada
- Al-Jodah Ammar
- Al-Shammari S.
- Albanesi Simone
- Alex iandolo Guido
- Alfaidi Reem Atallah E
- Allocca Annalisa
- Alléné C.
- Altin Paul
- Alvarez-Lopez Sofia
- Amato Alex
- Amez-Droz L.
- Amorosi A.
- Amra C.
- Ananyeva A.
- Anderson Stuart
- Anderson Warren G.
- Andia Manuel
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- Virtuoso Andrea
- Vitale Salvatore
- Vives A.
- Vocca Helios
- Voigt Daniel
- von Reis E. R. G.
- von Wrangel J. S. A.
- Vyatchanin Sergey P.
- Wade L. E.
- Wade Madeline
- Wagner Katelyn
- Wajid A.
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- Wu Hsun-Chung
- Wuchner E.
- Wysocki Daniel
- Xu Victoria
- Xu Yumeng
- Yaala M. Ben
- Yadav Nikesh
- Yamamoto Hiroaki
- Yamamoto Kazuhiro
- Yamamoto Takahiro
- Yamamoto Takahiro S.
- Yamamura S.
- Yamazaki Ryo
- Yan S.
- Yan T.
- Yang F.
- Yang Fengwei
- Yang Kate Z.
- Yang Yi
- Yarbrough Zach
- Yasui H.
- Yeh S. -W.
- Yelikar A. B.
- Yin X.
- Yokoyama Jun'ichi
- Yokozawa T.
- Yoo Jooheon
- Yu Hang
- Yuan S.
- Yuzurihara Hirotaka
- Zadrożny A.
- Zanolin M.
- Zeeshan M.
- Zelenova T.
- Zendri J. -P.
- Zeoli M.
- Zerrad M.
- Zevin Michael
- Zhang A. C.
- Zhang L.
- Zhang Rui
- Zhang T.
- Zhang Ya
- Zhao C.
- Zhao Yue
- Zhao Yuhang
- Zheng Yanyan
- Zhong Haowen
- Zhou R.
- Zhu Xingjiang
- Zhu Zong-Hong
- Zimmerman Aaron
- Zucker M. E.
- Zweizig John
- Árpád Gergely László
- 劉 國欽
- 都丸 隆行
- Publication venue
- Publication date
- 23/04/2024
- Field of study
Search for eccentric black hole coalescences during the third observing run of LIGO and Virgo
- Author
- Abac A. G.
- Abbott R.
- Abe H.
- Acernese F.
- Ackley Kendall
- Adamcewicz C.
- Adhicary S.
- Adhikari Naresh
- Adhikari Rana X.
- Adkins V. K.
- Adya V. B.
- Affeldt C.
- Afif Ismail M.
- Agarwal D.
- Agathos Michalis
- Aguiar Odylio D.
- Aguilar I.
- Aiello Lorenzo
- Ain Anirban
- Ajith Parameswaran
- Akseli Hannuksela Otto
- Akutsu Tomotada
- Al-Jodah Ammar
- Albanesi S.
- Alberto Trani Alessandro
- Alfaidi Reem Atallah E
- Allocca Annalisa
- Alléné C.
- Almualla M.
- Altin Paul
- Amato Alex
- Amez-Droz L.
- Amorosi A.
- Anand S.
- Ananyeva A.
- Andersen R.
- Anderson Stuart
- Anderson Warren G.
- Andia Manuel
- Ando M.
- Andrade T.
- Andrea Prodi Giovanni
- Andres Nicolas
- Andric Tomislav
- Andrés-Carcasona Marc
- Anne Bizouard Marie
- Ansoldi S.
- Antelis Javier M.
- Antier Sarah
- Antonio Font Roda Jose
- Aoumi M.
- Apostolatos T.
- Appavuravther E. Z.
- Appert S.
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- Arai Koji
- Araya Akito
- Araya Melody
- Areeda Joseph
- Arif Shaikh Md
- Aritomi Naoki
- Armato F.
- Arnaud Nicolas
- Arogeti Megan
- Aronson Scott
- Arun K. G.
- Ashton Gregory
- Aso Yoichi
- Assiduo M.
- Aston S. M.
- Astone Pia
- Aubin Florian
- Babak Stanislav
- Badalyan A.
- Badaracco Francesca
- Badger C.
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- Yokozawa T.
- Yoo Jooheon
- Yu Hang
- Yuzurihara Hirotaka
- Zadrożny A.
- Zahoor Jan Aasim
- Zannelli A. J.
- Zanolin M.
- Zeeshan M.
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- Zevin Michael
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- Zhao Yue
- Zhao Yuhang
- Zheng Yanyan
- Zhong Haowen
- Zhou R.
- Zhu Zong-Hong
- Zimmerman Aaron
- Zucker M. E.
- Zweizig John
- Álvarez-López S.
- Árpád Gergely László
- 劉 國欽
- 曹周键
- 都丸 隆行
- Publication venue
- Publication date
- 01/08/2023
- Field of study
Despite the growing number of confident binary black hole coalescences observed through gravitational waves so far, the astrophysical origin of these binaries remains uncertain. Orbital eccentricity is one of the clearest tracers of binary formation channels. Identifying binary eccentricity, however, remains challenging due to the limited availability of gravitational waveforms that include effects of eccentricity. Here, we present observational results for a waveform-independent search sensitive to eccentric black hole coalescences, covering the third observing run (O3) of the LIGO and Virgo detectors. We identified no new high-significance candidates beyond those that were already identified with searches focusing on quasi-circular binaries. We determine the sensitivity of our search to high-mass (total mass M>70 M⊙) binaries covering eccentricities up to 0.3 at 15 Hz orbital frequency, and use this to compare model predictions to search results. Assuming all detections are indeed quasi-circular, for our fiducial population model, we place an upper limit for the merger rate density of high-mass binaries with eccentricities 0<e≤0.3 at 0.33 Gpc−3 yr−1 at 90\% confidence level
Ultralight vector dark matter search using data from the KAGRA O3GK run
- Author
- Abac A. G.
- Abbott R.
- Abe H.
- Abouelfettouh I.
- Acernese F.
- Ackley Kendall
- Adamcewicz Christian
- Adhicary S.
- Adhikari Naresh
- Adhikari Rana X.
- Adkins V. K.
- Adya V. B.
- Affeldt C.
- Afif Ismail M.
- Agarwal Deepali
- Agathos Michalis
- Aguiar Odylio D.
- Aguilar I.
- Aiello Lorenzo
- Ain Anirban
- Ajith Parameswaran
- Akseli Hannuksela Otto
- Akutsu Tomotada
- Al-Jodah Ammar
- Al-Shammari S.
- Albanesi S.
- Alberto Trani Alessandro
- Alfaidi Reem Atallah E
- Allocca Annalisa
- Alléné C.
- Altin Paul
- Alvarez-Lopez Sofia
- Amato Alex
- Amez-Droz L.
- Amorosi A.
- Amra C.
- Anand S.
- Ananyeva A.
- Anderson Stuart
- Anderson Warren G.
- Andia Manuel
- Ando M.
- Andrade T.
- Andrea Prodi Giovanni
- Andres Nicolas
- Andric Tomislav
- Andrés-Carcasona Marc
- Anglin J.
- Anne Bizouard Marie
- Ansoldi S.
- Antelis Javier M.
- Antier Sarah
- Antoni Ramis Vidal Felip
- Antonietta Palaia Maria
- Antonio Font Roda Jose
- Aoumi M.
- Appavuravther E. Z.
- Appert S.
- Apple S. K.
- Arai Koji
- Araya Akito
- Araya Melody
- Areeda Joseph
- Argianas L. Granda
- Arif Shaikh Md
- Aritomi Naoki
- Armato F.
- Arnaud Nicolas
- Arogeti Megan
- Aronson Scott
- Arun K. G.
- Ashton Gregory
- Aso Yoichi
- Assiduo M.
- Aston S. M.
- Astone Pia
- Aubin Florian
- AVALLONE Guerino
- Babak Stanislav
- Badaracco Francesca
- Badger C.
- Bae Sangwook
- Bagnasco Stefano
- Bagui E.
- Bai Y.
- Baier Jeremy
- Bajpai Rishabh
- Baka T.
- Ball M.
- Ballardin G.
- Ballmer S. W.
- Banagiri Sharan
- Banerjee Biswajit
- Bankar Deepak
- Baral Pratyusava
- Barayoga J. C.
- Barish B. C.
- Barker D.
- Barneo Pablo
- Barone Fabrizio
- Barr Bryan
- Barsotti Lisa
- Barsuglia Matteo
- Barta Dániel
- Barthelmy S. D.
- Barton Mark Andrew
- Bartos I.
- Basak Soummyadip
- Basalaev Artem
- Bassiri Riccardo
- Basti Andrea
- Bawaj Mateusz
- Baxi P.
- Bayley Joseph
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- MORALES ESTER. RUIZ.
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- Zhao Yuhang
- Zheng Yanyan
- Zhong Haowen
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- Zhu Zong-Hong
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- Zweizig John
- Árpád Gergely László
- 劉 國欽
- 曹周键
- 都丸 隆行
- Publication venue
- Publication date
- 01/03/2024
- Field of study
Among the various candidates for dark matter (DM), ultralight vector DM can be probed by laser interferometric gravitational wave detectors through the measurement of oscillating length changes in the arm cavities. In this context, KAGRA has a unique feature due to differing compositions of its mirrors, enhancing the signal of vector DM in the length change in the auxiliary channels. Here we present the result of a search for U(1)B−L gauge boson DM using the KAGRA data from auxiliary length channels during the first joint observation run together with GEO600. By applying our search pipeline, which takes into account the stochastic nature of ultralight DM, upper bounds on the coupling strength between the U(1)B−L gauge boson and ordinary matter are obtained for a range of DM masses. While our constraints are less stringent than those derived from previous experiments, this study demonstrates the applicability of our method to the lower-mass vector DM search, which is made difficult in this measurement by the short observation time compared to the auto-correlation time scale of DM
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