Peranan Orang Tua dalam Mengatasi Kenakalan Remaja Akibat Meminum Alkhohol Cap Tikus (Studi Kasus di Desa Talawaan Kecamatan Talawaan Kabupaten Minahasa Utara)”

Kids Teens who commit crimes were generally lacking self-control, or the control ofabusing themselves instead, and likes to enforce its own rules without regard to the presence of others in thevicinity. The incidence of such behaviour can also be caused by factors in socialization; they often hang outwith friends without looking at his background. And in general, these children very selfish, and likesto abuse or even exaggerate the price themselves. On the basis of a sense of glad they did it without regardto the effects that will be accepted. In rural areas, many acts of juvenile delinquency are very differentwith that occurs in urban areas, one of the causes of juvenile delinquency in rural areas is the drinking ofliquor among other drinks which high levels of alcohol such as the rat Stamp. Based on the backgroundof the issue that became a goal in this research is to know the role of parents in addressing the rateof juvenile delinquency as a result of the rat Stamp liquor in the village of Talawaan.The methods used in this research is qualitative research methods. In this study to understand aphenomenon in social context by nature with emphasis on the process ofdeep communication interaction between researchers with the phenomena examined. Techniquesof collection and processing of data in the research carried out in the form,namely: Observation/observation. Interview. Primary data and secondary data, the study documents.Results of the study prove that the forms of delinquency are experienced by teens affected by lackof parental control, the influence of the environment both in the school environment aswell as social environments, as well as the impact of globalization, among others, the influence of the massmedia such as television, Computer Media, and others. Results of the study prove that the forms of juveniledelinquency are extremely diverse and complex, where the offences and crimes committedby teenagers have already violated the rules and values of decency that occurred in the community suchas violating legal norms and customs

Nerve growth factor and bromocriptine: a sequential therapy for human bromocriptine-resistant prolactinomas.

Nerve growth factor (NGF) administration to athymic mice with transplanted human bromocriptine-resistant prolactinoma, results in the expression of dopamine D-2 receptors in the tumour and restores sensitivity to subsequent treatment with bromocriptine, which then produces normalisation of plasma prolactin and tumour regression. Sequential administration of NGF and bromocriptine thus may be a promising therapy for patients refractory to bromocriptine

Linear response of light deformed nuclei investigated by self-consistent quasiparticle random-phase-approximation

We present a calculation of the properties of vibrational states in deformed, axially--symmetric even--even nuclei, within the framework of a fully self--consistent Quasparticle Random Phase Approximation (QRPA). The same Skyrme energy density and density-dependent pairing functionals are used to calculate the mean field and the residual interaction in the particle-hole and particle-particle channels. We have tested our software in the case of spherical nuclei against fully self consistent calculations published in the literature, finding excellent agreement. We investigate the consequences of neglecting the spin-orbit and Coulomb residual interactions in QRPA. Furthermore we discuss the improvement obtained in the QRPA result associated with the removal of spurious modes. Isoscalar and isovector responses in the deformed ${}^{24-26}$Mg, $^{34}$Mg isotopes are presented and compared to experimental findings

Associations between sedentary time, physical activity and bone health among older people using compositional data analysis

Introduction : Aging is associated with a progressive decrease in bone mass (BM), and being physical active is one of the main strategies to combat this continuous loss. Nonetheless, because daily time is limited, time spent on each movement behavior is co-dependent. The aim of this study was to determine the relationship between BM and movement behaviors in elderly people using compositional data analysis. Methods : We analyzed 871 older people [395 men (76.9 +/- 5.3y) and 476 women (76.7 +/- 4.7y)]. Time spent in sedentary behavior (SB), light physical activity (LPA) and moderate-to-vigorous physical activity (MVPA), was assessed using accelerometry. BM was determined by bone densitometry (DXA). The sample was divided according to sex and bone health indicators. Results : The combined effect of all movement behaviors (PA and SB) was significantly associated with whole body, leg and femoral region BM in the whole sample (p<0.05), with leg and pelvic BM (p<0.05) in men and, with whole body, arm and leg BM (p<0.05) in women. In men, arm and pelvic BM were negatively associated with SB and whole body, pelvic and leg BM were positively associated with MVPA (p<0.05). In women, whole body and leg BM were positively associated with SB. Arm and whole body BM were positively associated and leg BM was negatively associated with LPA and arm BM was negatively associated with MVPA (p<0.05). Women without bone fractures spent less time in SB and more in LPA and MVPA than the subgroup with bone fractures. Conclusion : We identified that the positive effect of MVPA relative to the other behaviors on bone mass is the strongest overall effect in men. Furthermore, women might decrease bone fracture risk through PA increase and SB reduction, despite the fact that no clear benefits of PA for bone mass were found

Sexual Dimorphism in Cellular and Molecular Features in Human ACTH-Secreting Pituitary Adenomas.

Background. Cushing\u2019s disease presents gender disparities in prevalence and clinical course. Little is known, however, about sexual dimorphism at the level of the corticotrope adenoma itself. The aim of the present study was to evaluate molecular features of ACTH-secreting pituitary adenomas collected from female and male patients with Cushing\u2019s disease. (2) Methods. We analyzed 153 ACTH-secreting adenomas collected from 31 men and 122 women. Adenomas were established in culture and ACTH synthesis and secretion assessed in basal conditions as well as during incubation with CRH or dexamethasone. Concurrently, microarray analysis was performed on formalin-fixed specimens and differences in the expression profiles between specimens from male and female patients identified. (3) Results. ACTH medium concentrations in adenomas obtained from male patients were significantly lower than those observed in adenomas from female patients. This could be observed for baseline as well as modulated secretion. Analysis of corticotrope transcriptomes revealed considerable similarities with few, selected differences in functional annotations. Differentially expressed genes comprised genes with known sexual dimorphism, genes involved in tumour development and genes relevant to pituitary pathophysiology. (4) Conclusions. Our study shows for the first time that human corticotrope adenomas present sexual dimorphism and underlines the need for a gender-dependent analysis of these tumours. Differentially expressed genes may represent the basis for gender-tailored target therapy

Derecho y control 1

Se reúnen en el presente libro diversos textos producto del trabajo en un grupo de investigación. El trabajo grupal giró en torno al análisis de las ideas de derecho y su relación con el control individual o social. Se abordaron lecturas con enfoques conceptuales, sociológicos y normativos

Effect of CRINA RUMINANTS AF, a Mixture of Essential Oil Compounds, on Ruminal Fermentation and Digestibility

Eight ruminally fistulated steers were used in a metabolism experiment to determine effects of an essential oil feed additive in altering steer ruminal fermentation characteristics and nutrient digestibilities. Yearling steers were fed three treatments: 1) Control (CON) 2) CRINA RUMINANTS AF (CRINA) and 3) Rumensin® (RUM). There were no differences in DMI, OM intake, total tract DM and OM digestibilities, or pH among treatments. Steers receiving the CRINA treatment consumed 24.5% fewer meals than CON. Ruminal acetate was greatest and total VFA concentrations tended to be greatest for CRINA treatment. Acetate:propionate was 1.68, 1.49, and 1.43 for CON, CRINA, and RUM, respectively, suggesting addition of CRINA RUMINANTS AF favorably alters rumen fermentation end products without negatively affecting intake or rumen pH

Aspectos florísticos y ecológicos del Cerro de Huenes (Sierra Nevada, Granada)

El Cerro de Huenes constituye una estribación montañosa importante de la vertiente Noroccidental de Sierra Nevada. Como macizo presenta una notable complejidad geomorfológica, lo que unido a la diferencia altitudinal entre las zonas basales y la cumbre, configura un territorio de una gran variedad florística y paisajística. Dos pisos bioclimáticos pueden diferenciarse en él, mesomediterráneo y supramediterráneo, en ambos predominan materiales geológicos de tipo básico, siendo muy limitados los de tipo ácido. La vegetación presente en el piso mesomediterráneo queda incluida en la serie bética basófilade la encina: Paeonio coriaceae-Querceto rotundifoliae S. La del piso supramediterráneo se incluye en la serie: Berberido hispanicae-Querceto rotundifoliae S. En la actualidad son escasos los restos de las formaciones naturales, ocupando amplias extensiones del territorio las repoblaciones forestales de Pinus sylvestris.Huenes hill is an important mountain spur on the north-western slope of Sierra Nevada. It has a particularly complex geomorfology. This together with the difference between the base and the summit, makes it a territory with a very varied flora and landscape. There are two distinct bioclimatic layers: mesomediterranean and supramediterranean, in both of them basic gelogic material predominates. There is a great limitation to the acid materials. The mesomediterranean vegetation is included in the Andalusian serie of basic material Paeonio coriaceae-Qllercefo rofLlndijoliae S. The supramediterranean layer is included in the series Berberido hispanicae-Qllercefo rofundijoliae S. Today remains of natural formations are scarce tghe forest repopulations of Pinlls sylvesfris occupy extensive territories

Aspectos florísticos y ecológicos del Cerro de Huenes (Sierra Nevada, Granada)

El Cerro de Huenes constituye una estribación montañosa importante de la vertiente Noroccidental de Sierra Nevada. Como macizo presenta una notable complejidad geomorfológica, lo que unido a la diferencia altitudinal entre las zonas basales y la cumbre, configura un territorio de una gran variedad florística y paisajística. Dos pisos bioclimáticos pueden diferenciarse en él, mesomediterráneo y supramediterráneo, en ambos predominan materiales geológicos de tipo básico, siendo muy limitados los de tipo ácido. La vegetación presente en el piso mesomediterráneo queda incluida en la serie bética basófilade la encina: Paeonio coriaceae-Querceto rotundifoliae S. La del piso supramediterráneo se incluye en la serie: Berberido hispanicae-Querceto rotundifoliae S. En la actualidad son escasos los restos de las formaciones naturales, ocupando amplias extensiones del territorio las repoblaciones forestales de Pinus sylvestris

SEOM clinical guideline on unknown primary cancer (2017)

Cancer of unknown primary site is a histologically confirmed cancer that manifests in advanced stage, with no identifiable primary site following standard diagnostic procedures. Patients are initially categorized based on the findings of the initial biopsy: adenocarcinoma, squamous-cell carcinoma, neuroendocrine carcinoma, and poorly differentiated carcinoma. Appropriate patient management requires understanding several clinical and pathological features that aid in identifying several subsets of patients with more responsive tumors