Es pot desenvolupar el capital psicològic en el dia a dia de les organitzacions?

En el present estudi realitzem una reflexió sobre el potencial que té el capital psicològic, per a ser desenvolupat a partir de les pràctiques comunes en les organitzacions, i com això pot ajudar a explicar i millorar el comportament de les persones en el treball. Així mateix, s’avancen algunes de les preguntes que això podria plantejar, i les respostes que podrien resultar de gran valor, tant en el camp acadèmic com en l’aplicat

Programa educativo sobre hábitos saludables en jóvenes jugadores de fútbol – Revisión, evaluación y reorientación.

El sobrepeso y la obesidad son enfermedades crónicas multifactoriales que se caracterizan por una acumulación excesiva de grasa corporal. Dichas enfermedades son generalmente causadas por la inactividad física y la mala alimentación causando un importante problema en la salud pública. Durante los últimos años han aumentado las cifras de prevalencia de obesidad infantil, las cuales son predictores de una obesidad en edad adulta y los problemas que derivan de ella. En este estudio se comenzó a realizar una intervención con niños y adolescentes que padecían sobrepeso y obesidad en una escuela de futbol el cual no se pudo finalizar y se tuvo que complementar con una revisión sistemática de artículos sobre este tema en los últimos 10 años. En el programa participaron 17 niños de 8 a 14 años y a los que se les realizaron mediciones de talla, peso, IMC y porcentaje graso además de una prueba de salto y de agilidad. Esta intervención tuvo una duración de 3 meses en la que se recogían las mediciones cada mes y se realizaba un seguimiento con reorientación nutricional y de actividad física. Los resultados obtenidos no son del todo significativos debido a la interrupción causada por el confinamiento del COVID-19. <br /

Real space manifestations of coherent screening in atomic scale Kondo lattices

The interaction among magnetic moments screened by conduction electrons drives quantum phase transitions between magnetically ordered and heavy-fermion ground states. Here, starting from isolated magnetic impurities in the Kondo regime, we investigate the formation of the finite size analogue of a heavy Fermi liquid. We build regularly-spaced chains of Co adatoms on a metallic surface by atomic manipulation. Scanning tunneling spectroscopy is used to obtain maps of the Kondo resonance intensity with sub-atomic resolution. For sufficiently small interatomic separation, the spatial distribution of Kondo screening does not coincide with the position of the adatoms. It also develops enhancements at both edges of the chains. Since we can rule out any other interaction between Kondo impurities, this is explained in terms of the indirect hybridization of the Kondo orbitals mediated by a coherent electron gas, the mechanism that causes the emergence of heavy quasiparticles in the thermodynamic limit.Financial support was provided by the Spanish Plan Nacional de I+ D+ i (grants MAT 2013-46593-C6-3-P, MAT2016-78293-C6-6-R, MAT2015-66888-C3-2-R, and FIS2015-64886-C5-3-P), Charles University (programme PRIMUS/Sci/09) and the European Union through programmes Interreg-POCTEFA (grant TNSI/EFA194/16) and H2020-EINFRA-5-2015 MaX Center of Excellence (grant no. 676598). M. M.-L., M. P., and D. S. acknowledge the use of SAI at Universidad de Zaragoza. R. R. acknowledges The Severo Ochoa Centers of Excellence Program (grant no. SEV-2017-0706) and Generalitat de Catalunya (grant no. 2017SGR1506 and the CERCA Programme)

The effect of ageing on the ocular surface parameters

Received 11 July 2017, Revised 18 September 2017, Accepted 19 September 2017, Available online 10 October 2017.Depto. de Optometría y VisiónFac. de Óptica y OptometríaTRUEinpres

Filaggrin gene mutations and new SNPs in asthmatic patients: a cross-sectional study in a Spanish population

[EN] Background: Several null-mutations in the FLG gene that produce a decrease or absence of filaggrin in the skin and predispose to atopic dermatitis and ichthyosis vulgaris have been described. The relationship with asthma is less clear and may be due to the influence of atopy in patients with associated asthma. Methods: Four hundred individuals were included, 300 patients diagnosed with asthma divided into two groups according to their phenotype (allergic and non-allergic asthma) and 100 strictly characterized controls. The coding region and flanking regions of the FLG gene were amplified by PCR. We proceeded to the characterization of potential gene variants in that region by RFLP and sequencing and analysed their association with lung function parameters, asthma control and severity, and quality of life. Results: We identified two null-mutations (R501X and 2282del4), seven SNPs previously described in databases and three SNPs that had not been previously described. One of the SNP identified in this study (1741A > T) was more frequently detected in patients with non-allergic asthma, worse FVC, FEV1 and PEF values and a higher treatment step. In addition, lowered spirometric values were observed in the non-allergic group carrying any of the nonsynonymous SNPs. Conclusions: In the association study of genetic variants of the FLG gene in our population the 1741A > T polymorphism seems to be associated with non-allergic asthma

Increased TPSAB1 Copy Number in a Family With Elevated Basal Serum Levels of Tryptase

[EN]Background: Some recent familial studies have described a pattern of autosomal dominant inheritance for increased basal serum tryptase (BST), but no correlation with mRNA expression and gene dose have been reported. Objective: We analyzed TPSAB1 mRNA expression and gene dose in a four-member family with high BST and in two control subjects. Methods: Blood samples were collected from the family and control subjects. Complete morphologic, immunophenotypical, and molecular bone marrow mast cell (MC) studies were performed. mRNA gene expression and gene dose were performed in a LightCycler 480 instrument. Genotype and CNV were performed by quantitative real-time digital PCR (qdPCR). Results: CNV analysis revealed a hereditary copy number gain genotype (3β2α) present in all the family members studied. The elevated total BST in the family members correlated with a significant increase in tryptase gene expression and dose. Conclusions and Clinical Relevance: We present a family with hereditary α-tryptasemia and elevated BST which correlated with a high expression of tryptase genes and an increased gene dose. The family members presented with atypical MC-mediator release symptoms or were even asymptomatic. Clinicians should be aware that elevated BST does not always mean an MC disorder.Spanish Foundation of the Spanish Association of Allergy and Clinical Immunology (Sociedad Española de Alergologia e Inmunologia Clínica); the Council of Castilla y León; European Social Fund, the Immunoallergic Association of Salamanca; Asthma, Allergic, and Adverse Reactions networks for Cooperative Research in Health (ARADyAL); Instituto de Salud Carlos III; European Regional Development Fund (ERDF)

Update in collecting duct carcinoma: Current aspects of the clinical and molecular characterization of an orphan disease

Bellini carcinoma; Clear-cell carcinoma; Collecting ductCarcinoma de Bellini; Carcinoma de cèl·lules clares; Conducte col·lectorCarcinoma de Bellini; Carcinoma de células claras; Conducto colectorCollecting duct renal cell carcinoma (cdRCC), which until recently was thought to arise from the collecting ducts of Bellini in the renal medulla, is a rare and aggressive type of non-clear renal cell carcinoma (ncRCC), accounting for 1% of all renal tumors and with nearly 50% of patients being diagnosed with Stage IV disease. The median overall survival in this setting is less than 12 months. Several regimens of chemotherapies had been used based on morphologic and cytogenetic similarities with urothelial cell carcinoma described previously, although the prognosis still remains poor. The use of targeted therapies also did not result in favorable outcomes. Recent works using NGS have highlighted genomic alterations in SETD2, CDKN2A, SMARCB1, and NF2. Moreover, transcriptomic studies have confirmed the differences between urothelial carcinoma and cdRCC, the possible true origin of this disease in the distal convoluted tubule (DCT), differentiating from other RCC (e.g., clear cell and papillary) that derive from the proximal convoluted tubule (PCT), and enrichment in immune cells that may harbor insights in novel treatment strategies with immunotherapy and target agents. In this review, we update the current aspects of the clinical, molecular characterization, and new targeted therapeutic options for Collecting duct carcinoma and highlight the future perspectives of treatment in this setting

Patients and healthcare professionals’ voice on preventable readmissions

Introduction Currently, about 10% of patients required unplanned readmissions within 30 days after discharge.1 2 This proportion has not changed substantially over the past several years despite intense efforts to improve the discharge process. Although several studies3 4 have been performed, including patients’ and physicians’ opinion on the preventability of readmissions and factors that would predict preventability, only a few studies have included nurses’ opinions and the consensus with all stakeholders.5 We aimed to determine the patient’s opinion on preventable readmission, associated factors and the extent to which patients, nurses and physicians agree on readmission preventability. Methods To achieve the proposed objectives, a descriptive transversal correlational multicentre study was developed. This study was approved by the Clinical Research Ethics Committee (reference number: PR114/17). From 2 April 2017 to 18 January 2019, all patients readmitted within 30 days to 2 medical and 2 surgical departments (internal medicine, pneumology, trauma and digestive surgery) at 4 university hospitals were identified. Patients who provided written informed consent were interviewed within 72 hours of readmission. Four research nurses were trained to deliver the interviews. The patient’s interview involved 23 questions6 about functional status at discharge, discharge process and follow-up care, including readmission preventability (online supplemental material). Two independent physicians and nurses of the research team concurrently reviewed electronic health records to identify factors contributing to potentially preventable readmissions.7 Clinical and demographic patients’ characteristics were also collected. We estimated that a total sample size of 276 patients was needed for a proportion of 11% of preventable readmission,7 95% confidence level and 0.04 precision and assuming 15% potentially missed cases. A logistic regression model has been used to assess the association between the patient profile and his answer to the main question of his readmission preventability. The conditions of application of the models have been validated and CIs at 95% of the estimator have been calculated whenever possible. Cohen’s kappa statistic has been calculated to assess the concordance between physicians’, nurses’ and patients’ answer to this preventability readmission question. All the analysis has been done with the statistic package R V.3.5.3 (11 March 2019) for Windows. Patients were not involved in the design, conduct, reporting or dissemination plans of this study. Results We assessed 805 consecutive patients for eligibility, of whom 529 were excluded refused or unavailable (314 presented haemodynamic instability, 107 were discharged early, 104 refused to participate and four had language barrier). Among 276 patients included, 44.2% were admitted to internal medicine, 13.8% pneumology, 8% trauma and 34.1% digestive surgery department, respectively. The mean age was 68 years and 65.9% were men. The median (IQR) time between discharge and readmission was 11 days (5–17 days) and the median (IQR) Charlson comorbidity index was 5 (3–6). Ninety-six (34.8%) patients reported that their readmission was preventable, 69 (25.0%) were undecided and 111 (40.2%) reported that their readmission was not preventable. Comparing patients who reported non-preventable readmissions to those who reported preventable readmissions or were undecided, the latter had less time between discharge and readmission, did not have a follow-up appointment scheduled with primary care or specialist at discharge, no medication reviewed and felt concerns were not addressed before discharge. Also, patients who were less satisfied with the hospital’s discharge team, who felt were discharged before being ready and felt concern during follow-up care were more likely to report preventable readmission or undecidednes