Synthesis and characterization of a trifunctional aminoamide cellulose derivative

As part of an effort to synthesize a dendronized cellulose, we have synthesized a trifunctional aminoamide derivative, which is the first generation of a dendron substituent. We anticipate that a dendronized cellulose would have applications in complexing metals and could be employed as an adjuvant for drugs. The trifunctional aminoamide substituent was introduced by coupling di-tert-butyl 4-[2-(tert-butoxycarbonyl)ethyl]-4-aminoheptanedicarboxylate, BA, directly to a (carboxymethyl)cellulose (CMC) backbone and converting the tert-butyl ester peripheral groups to aminoamide substituents by use of N,N-dimethyl-1,3-propanediamine. Confirmation of the proposed chemical structure of the intermediates as well as the water-soluble aminoamide derivative (CMCBADMPDA) was obtained by Fourier transform infrared (FT-IR) and NMR spectroscopy. The degree of substitution (DS) was determined to be 0.40 +/- 0.01 by thermogravimetric analysis. Typical weight average molecular weight (M(w)), molecular weight distribution (MWD), and molecular size of the dendronized polymers were found to be 97,000, 1.7, and 17.4 nm for derivatives of a CMC with corresponding M(w), MWD, and root-mean-square radius (RMS) of 230 000, 3.2, and 24 nm. A differential refractive index (dn/dc) for the aminoamide derivative measured in aqueous 0.40 N ammonium acetate-0.01 N NaOH was found to be 0.1473. The intrinsic viscosity of the dendronized cellulose decreased significantly when compared with that of CMC, that is, 0.40 dL/g relative to 5.60 dL/g. The hydrophobicity of the CMCBADMPDA microenvironment in aqueous solution was probed by evaluating the relative fluorescence intensities of the I(373)/I(384) pyrene bands; a slightly more hydrophobic environment was observed

Tectonic Activity and Plate Boundaries along the Northern Flank of the Fiji Platform

Recent volcanic activity along the northern flank of the Fiji Platform, revealed for the first time from new GLORIA imagery, suggests that the loci of interplate motion in this region have migrated rapidly since the switch from Vitiaz to New Hebridean subduction at 5–8 Ma. At present the plate boundaries along the northern flank of the Fiji Platform consist of two major strike-slip faults of opposing sense: the sinistral Fiji Transform Fault along the northwest flank of the platform, and at least one (or possibly two) zones of dextral strike slip (including Peggy Ridge) along the northeast flank. The tectonic relation-ships of these two fault systems lies north of Fiji and is not determined

COSPAR Task Group for Constellation of Small Satellites (TGCSS): Mission Objectives, Design, and Implementation Plan for a space weather observing constellation

International audienceThe Committee on Space Research (COSPAR) in 2020 established a new Task Group to develop an "actionable" plan for an international constellation of small satellites. COSPAR will play the role of an honest broker in assembling an international consortium that will develop, launch, and acquire data from a constellation of small satellites contributed from voluntary participants. The COSPAR team, known formally as the Task Group on establishing a Constellation of Small Satellites (TGCSS), identified space weather monitoring from a constellation of LEO small satellites as one of its primary objectives from the constellation. TGCSS will facilitate development of mission concepts, constellation architecture, coordinate launch opportunities, as well as reference payloads and supporting ground facilities. The preliminary scientific objectives focus on measuring plasma conditions in the ionosphere, and atmospheric drag with sufficient measurement density to substantially improve space weather forecasts. In this presentation, we will report on the presently defined mission objectives and constellation design, as well as plans on implementation. It is hoped that through collaboration with the scientific community, the COSPAR constellation will help to address pertinent scientific objectives, while also serving as a platform for capacity building and international collaboration

Pyrazolobenzotriazinone derivatives as COX inhibitors: synthesis, biological activity, and molecular-modeling studies.

Pyrazolylbenzotriazinones are endowed with a structural analogy with the COX-2 selective inhibitor celecoxib. Considering that our research group has long been interested in the 3-pyrazolyl-substituted benzotriazinones as anti-inflammatory agents, six new pyrazolylbenzotriazinone derivatives 16a-c and 18a-c have been prepared by reacting the opportune ethyl 5-(2-aminobenzamido)-1-(pyridin-2-yl)-1H-pyrazole-4-carboxylate or 5-(2-aminobenzamido)-1-(pyridin-2-yl)-1H-pyrazole-4-carboxyic acid with sodium nitrite in glacial acetic acid. The biological studies revealed a good pharmacological profile for some pyrazolylbenzotriazinones and, in the case of the ethyl 5-(4-oxo-1,2,3-benzotriazin-3(4H)-yl)-1-pyridin-2-yl-1H-pyrazole-4-carboxylate, a good COX-1/COX-2 selectivity. Molecular modeling studies confirmed the obtained biological results