Open Innovation in firms located in an intermediate technology developed country

Open Innovation is a flow of inputs and outputs of knowledge and technology which favours, at the firm level, the acceleration of the innovation process, as well as the establishment and penetration of firms in new markets. This type of innovation incorporates technological innovation from internal and external sources, as well as different ways to access markets. The empirical studies in the area reveal that there is a significant bias in favour of countries of technological frontier, such as the United States, Finland, the Netherlands, Germany or Sweden. The present study aims at covering this gap in literature by examining firms in a country of intermediate technology development – Portugal. Based on 70 innovative firms located in Portugal we found that open innovation is only partially diffused throughout these firms. In addition, open innovation is more widespread in terms of external absorption of knowledge/ technology rather than in terms of knowledge/technology transfer. This result may indicate lack of awareness about the economic potential of making available to third parties the technologies internally created. This may require a different approach to organization/management of R&D, in particular, and of innovation, in general.Open Innovation; Intermediate technology development; Portugal.

Rosuvastatin and vascular dysfunction markers in pulmonary arterial hypertension: a placebo-controlled study

We investigated whether chronic rosuvastatin administration could improve the abnormalities of the circulating levels of vascular dysfunction markers in pulmonary arterial hypertension (PAH). Sixty patients, aged 13 to 60 years, with idiopathic (N = 14) or congenital heart disease-associated PAH (N = 46) were equally but randomly assigned to rosuvastatin treatment (10 mg a day, orally) or placebo for 6 months in a blind fashion. Plasma levels of P-selectin, tissue-plasminogen activator and its inhibitor as well as von Willebrand factor antigen were measured by enzyme-linked immunoassay before and after 1, 3, and 6 months of treatment. Baseline levels of biomarkers were elevated (68, 16, 45 and 46% increase relative to controls, for P-selectin, von Willebrand factor antigen, tissue-plasminogen activator and its inhibitor, respectively; P < 0.001). P-selectin values at baseline, 1, 3, and 6 months were 39.9 ± 18.5, 37.6 ± 14.6, 34.8 ± 14.6, and 35.4 ± 13.9 ng/mL, respectively, for the rosuvastatin group and 45.7 ± 26.8, 48.0 ± 26.9, 48.1 ± 25.7, and 45.7 ± 25.6 ng/mL for the placebo group. The P-selectin level was lower in the rosuvastatin group compared with placebo throughout treatment (P = 0.037, general linear model). A trend was observed towards a decrease in tissue-plasminogen activator in the statin group (16% reduction, P = 0.094), with no significant changes in the other markers. Since P-selectin is crucial in inflammation and thrombosis, its reduction by rosuvastatin is potentially relevant in the pathophysiological scenario of PAH.FAPES

THREE-DIMENSIONAL RECONSTRUCTION OF THE HUMAN MOTION BASED ON IMAGES FROM A SINGLE CAMERA

It is widely accepted that the photograms of two or more cameras are required for the spatial reconstruction of the human motion. Each projection of the spatial coordinates of a given anatomical point of the human body is described by two equations. Consequently, two or more cameras are necessary for at least three independent linear equations required to obtain the original three coordinates of the point from its projected positions. If n cameras are used in the reconstruction process 2n equations are available for that purpose. In this case more equations than unknowns are available, and the solution for the reconstruction must minimize the error in those equations. Regardless of the number of cameras available, no information of the biomechanical model is generally used during the reconstruction process. In this work, a biomechanical model of 16 segments is used to support the motion reconstruction. The kinematic equations that characterize the dependency between the Cartesian coordinates of the points describing each component of the biomechanical model are used together with the two equations describing their projection in each frame. The single triangle describing the lower torso is defined by three points corresponding to nine spatial coordinates. For a given frame of a single camera six independent linear equations are defined. The remaining three equations needed to the spatial reconstruction of the triangle are the kinematic constraint equations ensuring that the distance between each two points remains constant throughout the motion. The system of nonlinear equations defined in this form has multiple solutions. For each subsequent camera frame the same process is followed to obtain the multiple solutions of the triangle reconstruction. The motion of the triangle representing the lower torso is selected as the combination of the solutions of the independent frames that minimizes a given function, defined as a measure of the smoothness of the triangle motion, variation of its angular orientation or increment of its distance between frames. Only the two solutions for the motion corresponding to the lower values of the functional, evaluated during four frames, are kept. Assuming that the motion for both solutions is feasible for the remaining frames, the method proceeds with the reconstruction of the segments adjacent to the lower torso, followed by the segments adjacent to the first set and so forth. A branch of solutions is eliminated if it cannot proceed from one frame to the next, either because no solution is possible or because the reconstructed motion develops behind the camera. Finally the reconstruction of the full motion is obtained in an automatic form. The methodology is applied to a case of complex human body motion demonstrating that it is feasible to reconstruct the three dimensional human motion using the photograms of a single stationary camera and a consistent biomechanical model

Temperature evaluation in ex-vivo bovine bones submitted to drilling processes

A necrose óssea induzida durante o processo de furação é um fenómeno frequente que contribui para problemas pós-operatórios. O calor de fricção gerado pelo contato entre a broca e a parede do furo é inevitável. No entanto, a utilização de técnicas avançadas para a obtenção do registo térmico durante a furação óssea é importante para a garantia da qualidade durante a furação. O objetivo deste estudo é apresentar dois métodos experimentais diferentes para analisar as condições de furação que geram as temperaturas mais baixas, evitando a ocorrência da necrose óssea. Foram utilizados ossos de bovino ex-vivo para simular o processo de furação considerando os efeitos do diâmetro da broca, velocidade de rotação e velocidade de avanço. Foram realizados diferentes testes experimentais para avaliar a sua repetibilidade. Os resultados identificaram o diâmetro da broca como o parâmetro mais crítico na indução de temperaturas mais elevadas durante a furação óssea.This research was supported by the Portuguese Foundation of Science and Technology under the research project UID/EMS/50022/2013. The third author acknowledges the funding of Project NORTE-01-0145-FEDER-000022-SciTech -Science and Technology for Competitive and Sustainable Industries, co-financed by Programa Operacional Regional do Norte (NORTE2020), through Fundo Europeu de Desenvolvimento Regional (FEDER).info:eu-repo/semantics/publishedVersio

Nonintegrable Interaction of Ion-Acoustic and Electromagnetic Waves in a Plasma

In this paper we re-examine the one-dimensional interaction of electromagnetic and ion acoustic waves in a plasma. Our model is similar to one solved by Rao et al. (Phys. Fluids, vol. 26, 2488 (1983)) under a number of analytical approximations. Here we perform a numerical investigation to examine the stability of the model. We find that for slightly over dense plasmas, the propagation of stable solitary modes can occur in an adiabatic regime where the ion acoustic electric field potential is enslaved to the electromagnetic field of a laser. But if the laser intensity or plasma density increases or the laser frequency decreases, the adiabatic regime loses stability via a transition to chaos. New asymptotic states are attained when the adiabatic regime no longer exists. In these new states, the plasma becomes rarefied, and the laser field tends to behave like a vacuum field.Comment: 19 pages, REVTeX, 6 ps figures, accepted for publication in Phys. Rev.

Impact of active power curtailment on overvoltage prevention and energy production of PV inverters connected to low voltage residential feeders

As non-controllable power sources, photovoltaics (PV) can create overvoltage in low voltage (LV) distribution feeders during periods of high generation and low load. This is usually prevented passively by limiting the penetration level of PV to very conservative values, even if the critical periods rarely occur. Alternatively, one can use active power curtailment (APC) techniques, reducing the amount of active power injected by the PV inverters, as the voltage at their buses increase above a certain value. In this way, it is possible to increase the installed PV capacity and energy yield while preventing overvoltage. This paper investigates a number of approaches for sizing and controlling the PV power generated by 12 net-zero energy houses equipped with large rooftop PV systems in a typical 240 V/75 kVA Canadian suburban radial distribution feeder. Simulations of a one year period with typical solar irradiance and load profiles are conducted with PSCAD to assess the performance of the different approaches in terms of overvoltage occurrence, sharing of the burden for overvoltage prevention per house and total energy yield of the residential PV feeder

Fatores prognósticos em câncer de cólon localmente avançado tratado com ressecção extendida

The impact of clinical, pathologic, and surgical variables on the postoperative morbidity, mortality, and survival of patients undergoing extended resections of colon carcinoma were evaluated. METHODS: The medical records of 95 patients who underwent extended resections for colon carcinoma between 1953 and 1996 were reviewed. In all cases, in addition to colectomy, 1 or more organs and/or structures were resected en bloc due to a macroscopically based suspicion of tumor invasion. The clinical, pathologic, and surgical parameters were analyzed. Overall survival rates were analyzed according to the method of Kaplan and Meier. Multivariate analysis was performed using the Cox proportional hazards model. RESULTS: Eighty-six patients were treated by curative surgeries and the remaining by palliative resections. Invasion of the organs and/or adjacent structures and regional lymph nodes was found microscopically in 48 and 31 patients, respectively. The median follow-up without postoperative mortality was 47.7 months. The 5-year overall survival rates was 52.6%. The 5-year overall survival rates for patients undergoing curative and palliative surgeries was 58.3% and 0%, respectively. The mean survival time in the palliative surgery group was 3.1 months. Multivariate analysis showed that Karnofsky performance status was strongly related to the risk of postoperative complications (P = .01), and postoperative deaths were associated with the type of surgery and Karnofsky performance status at the time of admission (P = .001). CONCLUSIONS: Some patients with locally advanced colon adenocarcinomas undergoing extended resections have a 5-year overall survival rates of 58.3%. Patients could benefit from palliative-intent procedures, but these measures should cautiously be indicated and avoided in patients with low Karnofsky performance status due to high rates of postoperative mortality and poor survival.Foi avaliado o impacto de variáveis clínicas, patológicas e cirúrgicas na morbidade e mortalidade pós operatórias de pacientes submetidos à ressecção extendida de carcinoma do cólon. MÉTODOS: Prontuários médicos de 95 pacientes submetidos á ressecção extendida de carcinoma de cólon entre os anos de 1953 e 1996 foram revisados. Em todos os casos, além de colectomia, um ou mais órgãos e/ou estruturas foram ressecados em bloco devido á suspeição de invasão tumoral macroscópica. As variáveis clínicas, patológicas e cirúrgicas foram analizadas. As taxas de sobrevida global foram analizadas de acordo com o método de Kaplan and Meier. A análise multivariada foi realizada empregando-se o modelo de risco proporcional de Cox. RESULTADOS: Oitenta e seis pacientes foram tratados com cirurgia curativa e o restante com ressecção paliativa. Invasão microscópica de órgãos e/ou estruturas adjacentes e linfonodos regionais foi encontrada em 48 e 31 pacientes respectivamente. O tempo de seguimento mediano, sem mortalidade pós operatória, foi de 47.7 meses. A taxa de sobrevida global em 5 anos foi de 52.6%. A taxa de sobrevida global para pacientes submetidos à cirurgia curativa e paliativa foi de 58.3% e zero, respectivamente. A sobrevida mediana no grupo de pacientes com cirurgia paliativa foi de 3.1 meses. A análise multivariada mostrou que a performance status de Karnofsky fortemente correlacionou com risco de complicações pós operatórias (p=0.01), e que o risco de morte pós operatória estava associada com o tipo de cirurgia e a performance status de Karnofsky na admissão (p=0.001) CONCLUSÕES: Pacientes com adenocarcinoma de cólon localmente avançados submetidos à ressecção extendida têm taxa de sobrevida global em 5 anos de 58.3% Este tipo de cirurgia pode ser empregada com intuito paliativo, mas deve ter indicação criteriosa e ser evitada em pacientes com baixa performance status de Karnofsky devido às altas taxas de mortalidade pós operatória e baixa sobrevida

Seropositivity of Coxiella burnetii in wild boar (Sus scrofa) and red deer (Cervus elaphus) in Portugal

Coxiella burnetii is a zoonotic microorganism that infects a wide range of wild and domestic species, causing the disease Q fever, frequently involving ticks as vectors. To better understand the occurrence of C. burnetii infection in wild boar (Sus scrofa) and red deer (Cervus elaphus), an epidemiological study was conducted in the Centre region of Portugal.info:eu-repo/semantics/publishedVersio

Perceptions in Living Kidney Donation: What ProtagonistsThink and Feel

Abstract Background Although donor perceptions of donation have been evaluated in several programs, evaluation of associated recipients has not been as frequent. Purpose Our aim was to evaluate and compare after transplantation, donor and recipient perceptions of donation. Methods After transplantation 35 recipients and 45 donors completed a sociodemographic and a donation perception questionnaire. We applied the Fisher test to descriptive (absolute and relative frequency) data. Results 57.8% of donors were female and 62.9% of recipients male. 53.3% of donors were siblings, 44.5% parents, and 2.2% a daughter. Most recipients (71.9%) thought that the donation was the donors' initiative and 21.9% that it was suggested by medical team. 96.4% responded that it was the donor's wish that determined their decision; 51.4% had serious or some doubts about accepting the option, but for 48.6% it was an easy decision. Among the donors, 88.9% decided by themselves and 8.9% were asked for donation. For 91.1%, their wish was the main reason of the decision, but 8.9% felt a moral obligation; 77.8% thought it was an easy decision, and 17.8% hesitated a little 84.4% were not worried about their future health. Conclusions Altruistic motivations were predominant in both groups. Most recipients thought that the motivation for donation was self-determined, a finding that agreed with donor perceptions. Perceptions about the quality of and changes in emotional relationship were the same in both groups. Donors and recipients referred to the donation process as positive, but there were some negative emotions and perceptions