Health Outcomes of Exposure to Biological and Chemical Components of Inhalable and Respirable Particulate Matter

Particulate matter (PM) is a key indicator of air pollution and a significant risk factor for adverse health outcomes in humans. PM is not a self-contained pollutant but a mixture of different compounds including chemical and biological fractions. While several reviews have focused on the chemical components of PM and associated health effects, there is a dearth of review studies that holistically examine the role of biological and chemical components of inhalable and respirable PM in disease causation. A literature search using various search engines and (or) keywords was done. Articles selected for review were chosen following predefined criteria, to extract and analyze data. The results show that the biological and chemical components of inhalable and respirable PM play a significant role in the burden of health effects attributed to PM. These health outcomes include low birth weight, emergency room visit, hospital admission, respiratory and pulmonary diseases, cardiovascular disease, cancer, non-communicable diseases, and premature death, among others. This review justifies the importance of each or synergistic effects of the biological and chemical constituents of PM on health. It also provides information that informs policy on the establishment of exposure limits for PM composition metrics rather than the existing exposure limits of the total mass of PM. This will allow for more effective management strategies for improving outdoor air quality

The complex hybrid origins of the root knot nematodes revealed through comparative genomics

Meloidogyne root knot nematodes (RKN) can infect most of the world's agricultural crop species and are among the most important of all plant pathogens. As yet however we have little understanding of their origins or the genomic basis of their extreme polyphagy. The most damaging pathogens reproduce by mitotic parthenogenesis and are suggested to originate by interspecific hybridizations between unknown parental taxa. We sequenced the genome of the diploid meiotic parthenogen Meloidogyne floridensis, and use a comparative genomic approach to test the hypothesis that it was involved in the hybrid origin of the tropical mitotic parthenogen M. incognita. Phylogenomic analysis of gene families from M. floridensis, M. incognita and an outgroup species M. hapla was used to trace the evolutionary history of these species' genomes, demonstrating that M. floridensis was one of the parental species in the hybrid origins of M. incognita. Analysis of the M. floridensis genome revealed many gene loci present in divergent copies, as they are in M. incognita, indicating that it too had a hybrid origin. The triploid M. incognita is shown to be a complex double-hybrid between M. floridensis and a third, unidentified parent. The agriculturally important RKN have very complex origins involving the mixing of several parental genomes by hybridization and their extreme polyphagy and agricultural success may be related to this hybridization, producing transgressive variation on which natural selection acts. Studying RKN variation via individual marker loci may fail due to the species' convoluted origins, and multi-species population genomics is essential to understand the hybrid diversity and adaptive variation of this important species complex. This comparative genomic analysis provides a compelling example of the importance and complexity of hybridization in generating animal species diversity more generally

Multi-Dimensional, Compressible Viscous Flow on a Moving Voronoi Mesh

Numerous formulations of finite volume schemes for the Euler and Navier-Stokes equations exist, but in the majority of cases they have been developed for structured and stationary meshes. In many applications, more flexible mesh geometries that can dynamically adjust to the problem at hand and move with the flow in a (quasi) Lagrangian fashion would, however, be highly desirable, as this can allow a significant reduction of advection errors and an accurate realization of curved and moving boundary conditions. Here we describe a novel formulation of viscous continuum hydrodynamics that solves the equations of motion on a Voronoi mesh created by a set of mesh-generating points. The points can move in an arbitrary manner, but the most natural motion is that given by the fluid velocity itself, such that the mesh dynamically adjusts to the flow. Owing to the mathematical properties of the Voronoi tessellation, pathological mesh-twisting effects are avoided. Our implementation considers the full Navier-Stokes equations and has been realized in the AREPO code both in 2D and 3D. We propose a new approach to compute accurate viscous fluxes for a dynamic Voronoi mesh, and use this to formulate a finite volume solver of the Navier-Stokes equations. Through a number of test problems, including circular Couette flow and flow past a cylindrical obstacle, we show that our new scheme combines good accuracy with geometric flexibility, and hence promises to be competitive with other highly refined Eulerian methods. This will in particular allow astrophysical applications of the AREPO code where physical viscosity is important, such as in the hot plasma in galaxy clusters, or for viscous accretion disk models.Comment: 26 pages, 21 figures. Submitted to MNRA

The Living Planet Index: using species population time series to track trends in biodiversity.

The Living Planet Index was developed to measure the changing state of the world's biodiversity over time. It uses time-series data to calculate average rates of change in a large number of populations of terrestrial, freshwater and marine vertebrate species. The dataset contains about 3000 population time series for over 1100 species. Two methods of calculating the index are outlined: the chain method and a method based on linear modelling of log-transformed data. The dataset is analysed to compare the relative representation of biogeographic realms, ecoregional biomes, threat status and taxonomic groups among species contributing to the index. The two methods show very similar results: terrestrial species declined on average by 25% from 1970 to 2000. Birds and mammals are over-represented in comparison with other vertebrate classes, and temperate species are over-represented compared with tropical species, but there is little difference in representation between threatened and non-threatened species. Some of the problems arising from over-representation are reduced by the way in which the index is calculated. It may be possible to reduce this further by post-stratification and weighting, but new information would first need to be collected for data-poor classes, realms and biomes

The uses of foreigners in Mao-era China: ‘Techniques of Hospitality’ and international image-building in the People’s Republic, 1949-1976

This article focuses on the inner workings of Mao-era China’s ‘Foreign Affairs’ system (waishi xitong): the complex, comprehensive web of bureaucracy woven after 1949 to monitor and control Chinese contact with the outside world. It explores one of the channels along which the People’s Republic between 1949 and 1976 tried to project international, soft-power messages beyond conventional diplomatic channels: the inviting of so-called ‘foreign guests’ (waibin) on carefully planned tours around China, often with all or at least some expenses paid. Earlier accounts of this hospitality have evoked a machine of perfect control, carefully judged to manipulate visitors and rehearsed to ensure flawless performances by Chinese hosts. Using memoirs and Chinese archival documents, the article discusses the attitude of top-level leaders to such visits, the way in which trips were prepared and planned, and the successes and weaknesses of the system. It argues that the PRC’s hosting programme had a domestic as well as an international purpose. Although foreigners were the official target (and indeed, Maoist China’s ‘techniques of hospitality’ garnered some rich international political dividends) the government also used the preparation for and execution of hosting duties to underscore at home the triumph of the revolution

Upper Bounds on the Neutrino-Nucleon Inelastic Cross Section

Extraterrestrial neutrinos can initiate deeply developing air showers, and those that traverse the atmosphere unscathed may produce cascades in the ice or water. Up to now, no such events have been observed. This can be translated into upper limits on the diffuse neutrino flux. On the other hand, the observation of cosmic rays with primary energies > 10^{10} GeV suggests that there is a guaranteed flux of cosmogenic neutrinos, arising from the decay of charged pions (and their muon daughters) produced in proton interactions with the cosmic microwave background. In this work, armed with these cosmogenic neutrinos and the increased exposure of neutrino telescopes we bring up-to-date model-independent upper bounds on the neutrino-nucleon inelastic cross section. Uncertainties in the cosmogenic neutrino flux are discussed and taken into account in our analysis. The prospects for improving these bounds with the Pierre Auger Observatory are also estimated. The unprecedented statistics to be collected by this experiment in 6 yr of operation will probe the neutrino-nucleon inelastic cross section at the level of Standard Model predictions.Comment: To be published in JCA

Social Integration and the Mental Health of Black Adolescents

Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/106936/1/cdev12182.pd

The Particle Physics Reach of High-Energy Neutrino Astronomy

We discuss the prospects for high-energy neutrino astronomy to study particle physics in the energy regime comparable to and beyond that obtainable at the current and planned colliders. We describe the various signatures of high-energy cosmic neutrinos expected in both neutrino telescopes and air shower experiments and discuss these measurements within the context of theoretical models with a quantum gravity or string scale near a TeV, supersymmetry and scenarios with interactions induced by electroweak instantons. We attempt to access the particle physics reach of these experiments.Comment: Mini-review article for New Journal of Physics, "Focus on Neutrinos" issue. 27 pages, 11 figure