The Dusty Nuclear Torus in NGC 4151: Constraints from Gemini Near-Infrared Integral Field Spectrograph Observations

We have used a near-infrared nuclear spectrum (covering the Z, J, H and K bands) of the nucleus of NGC 4151 obtained with the Gemini Near-infrared Integral Field Spectrograph (NIFS) and adaptive optics, to isolate and constrain the properties of a near-IR unresolved nuclear source whose spectral signature is clearly present in our data. The near-IR spectrum was combined with an optical spectrum obtained with the Space Telescope Imaging Spectrograph which was used to constrain the contribution of a power-law component. After subtraction of the power-law component, the near-IR continuum is well fitted by a blackbody function, with $T=1285\pm50$K, which dominates the nuclear spectrum -- within an aperture of radius 0\farcs3 -- in the near-IR. We attribute the blackbody component to emission by a dusty structure, with hot dust mass $M_{\rm HD}=(6.9\pm 1.5) \times10^{-4} {\rm M_\odot}$, not resolved by our observations, which provide only an upper limit for its distance from the nucleus of 4 pc. If the reddening derived for the narrow-line region also applies to the near-IR source, we obtain a temperature $T=1360\pm50$K and a mass $M_{\rm HD}=(3.1\pm 0.7) \times10^{-4} {\rm M_\odot}$ for the hot dust. This structure may be the inner wall of the dusty torus postulated by the Unified Model or the inner part of a dusty wind originating in the accretion disk.Comment: 5 pages, 1 figure; ApJ, 698, 176

The continuum and narrow line region of the NLS1 galaxy Mrk 766

We present the first spectroscopic observations in the interval 0.8-4.0 microns, complemented with HST/UV and optical spectroscopy, of the narrow line Seyfert 1 galaxy Mrk766. The NIR spectrum is characterized by permitted lines of HI, HeI, HeII and FeII, and forbidden lines of [SII], [SIII] and [FeII] among others. High ionized species such as [SiIX], [SiX], [SIX] and [MgVII] are also observed. The continuum has a complex shape, with contribution of the central engine, circumnuclear stellar population and dust. This last component is evidenced by the presence of an excess of emission peaking at 2.25 microns, fitted by blackbody function with T_bb=1200K. That temperature is close to the evaporation temperature of graphite grains. As such, it provides strong evidence of hot dust, probably very close to the nucleus. Consistent modeling of the line and broad band continuum spectrum by composite models, which account for the photoionizing flux of the central engine and shocks, shows that the shock velocities are between 100 and 500 km/s, the preshock densities between 100 and 1000 cm^-3 and the radiation fluxes from the active centre between 10^9 and 5x10^12 photons cm^-2 s^-1 eV^-1 at 1 Ryd with spectral indices $\alpha_{UV}$=-1.5 and $\alpha_X$=-0.4. Adopting silicon grains, dust-to-gas ratios are between 10^-{6} and 4x10$^{-4}$ by mass. The emitting clouds are at an average distance of 160 pc from the centre, with high velocity clouds closer and low velocity clouds farther from the centre. The N/H relative abundance could be twice solar. In constrast, Fe is depleted from the gaseous phase by a factor >2. Ratios of calculated to observed line ratios to Hbeta indicate an average contribution of the broad line region to the observed Hbeta of about 40%.Comment: 15 pages, 6 figures. Accepted to MNRA

AGN-Starburst connection in NGC7582: Gemini near-infrared spectrograph integral field unit observations

We analyse two-dimensional near-IR K-band spectra from the inner 660x315 pc^2 of the Seyfert galaxy NGC7582 obtained with the Gemini GNIRS IFU. The nucleus harbors an unresolved source well reproduced by a blackbody of temperature T 1050 K, which we attribute to emission by circumnuclear dust located closer than 25 pc from the nucleus, with total mass of ~3x10^{-3}M_Sun. Surrounding the nucleus, we observe a ring of active star formation with radius of ~190 pc, an age of ~5 Myr. The radiation of the young stars in the ring accounts for at least 80 % of the ionization observed in the Brgamma emitting gas, the remaining being due to radiation emitted by the active nucleus. The stellar kinematics reveals: (1) a distorted rotation pattern in the radial velocity field with kinematic center apparently displaced from the nuclear source by a few tens of parsecs; (2) a high velocity dispersion in the bulge of sigma=170 km/s; (3) a partial ring of sigma=50 km/s interpreted as due to stars formed from cold gas in a previous burst of star formation. The kinematics of the ionized gas shows an additional blueshifted component with velocities > 100 km/s interpreted as due to an outflow along the ionization cone. The mass outflow rate in the ionized gas was estimated as ~0.05 M_Sun/yr, which is one order of magnitude larger than the accretion rate to the AGN. The flux distribution and kinematics of the hot molecular gas, traced by the H2l2.22um emission line, suggests that most of this gas is in the galactic plane. An excess blueshift along PA~-70 can be interpreted as an inflow towards the nucleus. An AGN-Starburst connection in the nucleus of NGC7582 is supported by the ratio between the mass accretion rate and the star formation rate in the circumnuclear region of ~0.26%, which is close to the Magorrian relation.Comment: 16 pages, 11 figures, accepted for publication in MNRA

Validation of plasma proteomic biomarkers relating to brain amyloid burden in the EMIF-Alzheimer's disease multimodal biomarker discovery cohort

We have previously investigated, discovered, and replicated plasma protein biomarkers for use to triage potential trials participants for PET or cerebrospinal fluid measures of Alzheimer's disease (AD) pathology. This study sought to undertake validation of these candidate plasma biomarkers in a large, multi-center sample collection. Targeted plasma analyses of 34 proteins with prior evidence for prediction of in vivo pathology were conducted in up to 1,000 samples from cognitively healthy elderly individuals, people with mild cognitive impairment, and in patients with AD-type dementia, selected from the EMIF-AD catalogue. Proteins were measured using Luminex xMAP, ELISA, and Meso Scale Discovery assays. Seven proteins replicated in their ability to predict in vivo amyloid pathology. These proteins form a biomarker panel that, along with age, could significantly discriminate between individuals with high and low amyloid pathology with an area under the curve of 0.74. The performance of this biomarker panel remained consistent when tested in apolipoprotein E ɛ4 non-carrier individuals only. This blood-based panel is biologically relevant, measurable using practical immunocapture arrays, and could significantly reduce the cost incurred to clinical trials through screen failure