7 research outputs found

    Microeconometrics with Partial Identification

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    This chapter reviews the microeconometrics literature on partial identification, focusing on the developments of the last thirty years. The topics presented illustrate that the available data combined with credible maintained assumptions may yield much information about a parameter of interest, even if they do not reveal it exactly. Special attention is devoted to discussing the challenges associated with, and some of the solutions put forward to, (1) obtain a tractable characterization of the values for the parameters of interest which are observationally equivalent, given the available data and maintained assumptions; (2) estimate this set of values; (3) conduct test of hypotheses and make confidence statements. The chapter reviews advances in partial identification analysis both as applied to learning (functionals of) probability distributions that are well-defined in the absence of models, as well as to learning parameters that are well-defined only in the context of particular models. A simple organizing principle is highlighted: the source of the identification problem can often be traced to a collection of random variables that are consistent with the available data and maintained assumptions. This collection may be part of the observed data or be a model implication. In either case, it can be formalized as a random set. Random set theory is then used as a mathematical framework to unify a number of special results and produce a general methodology to carry out partial identification analysis

    The ratio of cardiac troponin T to troponin I may indicate non-necrotic troponin release among COVID-19 patients

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    Background: Although cardiac troponin T (cTnT) and troponin I(cTnI) are expressed to similar amount in cardiac tissue, cTnI often reach ten-times higher peak levels compared to cTnT in patients with myocardial necrosis such as in acute myocardial infarction (MI). In contrast, similar levels of cTnT and cTnI are observed in other situations such as stable atrial fibrillation and after strenuous exercise.Objective: Examine cTnT and cTnI levels in relation to COVID-19 disease and MI. Methods: Clinical and laboratory data from the local hospital from an observational cohort study of 27 patients admitted with COVID-19 and 15 patients with myocardial infarction (MI) that were analyzed with paired cTnT and cTnI measurement during hospital care.Results: Levels of cTnI were lower than cTnT in COVID-19 patients (TnI/TnT ratio 0.3, IQR: 0.1-0.6). In contrast, levels of cTnI were 11 times higher compared to cTnT in 15 patients with MI (TnI/TnT ratio 11, IQR: 7-14). The peak cTnI/cTnT ratio among the patients with MI following successful percutaneous intervention were 14 (TnI/ TnT ratio 14, IQR: 12-23). The 5 COVID-19 patient samples collected under possible necrotic events had a cTnI/ cTnT ratio of 5,5 (IQR: 1,9-8,3).Conclusions: In patients with COVID-19, cTnT is often elevated to higher levels than cTnI in sharp contrast to patients with MI, indicating that the release of cardiac troponin has a different cause in COVID-19 patients
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