Fish schooling as a basis for vertical axis wind turbine farm design

Most wind farms consist of horizontal axis wind turbines (HAWTs) due to the high power coefficient (mechanical power output divided by the power of the free-stream air through the turbine cross-sectional area) of an isolated turbine. However when in close proximity to neighbouring turbines, HAWTs suffer from a reduced power coefficient. In contrast, previous research on vertical axis wind turbines (VAWTs) suggests that closely-spaced VAWTs may experience only small decreases (or even increases) in an individual turbine's power coefficient when placed in close proximity to neighbours, thus yielding much higher power outputs for a given area of land. A potential flow model of inter-VAWT interactions is developed to investigate the effect of changes in VAWT spatial arrangement on the array performance coefficient, which compares the expected average power coefficient of turbines in an array to a spatially-isolated turbine. A geometric arrangement based on the configuration of shed vortices in the wake of schooling fish is shown to significantly increase the array performance coefficient based upon an array of 16x16 wind turbines. Results suggest increases in power output of over one order of magnitude for a given area of land as compared to HAWTs.Comment: Submitted for publication in BioInspiration and Biomimetics. Note: The technology described in this paper is protected under both US and international pending patents filed by the California Institute of Technolog

Potential Vorticity Evolution of a Protoplanetary Disk with An Embedded Protoplanet

We present two-dimensional inviscid hydrodynamic simulations of a protoplanetary disk with an embedded planet, emphasizing the evolution of potential vorticity (the ratio of vorticity to density) and its dependence on numerical resolutions. By analyzing the structure of spiral shocks made by the planet, we show that progressive changes of the potential vorticity caused by spiral shocks ultimately lead to the excitation of a secondary instability. We also demonstrate that very high numerical resolution is required to both follow the potential vorticity changes and identify the location where the secondary instability is first excited. Low-resolution results are shown to give the wrong location. We establish the robustness of a secondary instability and its impact on the torque onto the planet. After the saturation of the instability, the disk shows large-scale non-axisymmetry, causing the torque on the planet to oscillate with large amplitude. The impact of the oscillating torque on the protoplanet's migration remains to be investigated.Comment: 17 pages total with 9 figures (Fig.4,5,9 are in .jpg), accepted to Ap

Hot-Lithography SLA-3D Printing of Epoxy Resin

The hot-lithography stereolithography 3D printing technology is used to print epoxy resins with high reactivity in order to achieve 3D printed structures. Different hydroxyl containing compounds are investigated as chain transfer agents and the viscoelastic properties of UV-cured materials are fully characterized. The most promising formulations are studied at a high temperature, the 3D printing process parameters are defined and the printed object is fully characterized. By combining the suitable precursor materials in the photocurable formulation with the advanced hot-lithography process, it is possible to produce 3D printed structures that are characterized by outstanding thermomechanical properties and good printability precision

Discovery of Five New Pulsars in Archival Data

Reprocessing of the Parkes Multibeam Pulsar Survey has resulted in the discovery of five previously unknown pulsars and several as-yet-unconfirmed candidates. PSR J0922-52 has a period of 9.68 ms and a DM of 122.4 pc cm^-3. PSR J1147-66 has a period of 3.72 ms and a DM of 133.8 pc cm^-3. PSR J1227-6208 has a period of 34.53 ms, a DM of 362.6 pc cm^-3, is in a 6.7 day binary orbit, and was independently detected in an ongoing high-resolution Parkes survey by Thornton et al. and also in independent processing by Einstein@Home volunteers. PSR J1546-59 has a period of 7.80 ms and a DM of 168.3 pc cm^-3. PSR J1725-3853 is an isolated 4.79-ms pulsar with a DM of 158.2 pc cm^-3. These pulsars were likely missed in earlier processing efforts due to their high DMs and short periods and the large number of candidates that needed to be looked through. These discoveries suggest that further pulsars are awaiting discovery in the multibeam survey data.Comment: 12 pages, 2 figures, 2 tables, accepted to Ap

Macropinocytotic uptake and infection of human epithelial cells with species B2 adenovirus type 35

The human adenovirus serotype 35 (HAdV-35, short Ad35) causes kidney and urinary tract infections, and infects respiratory organs of immunocompromised individuals. Unlike other adenoviruses, Ad35 has a low seroprevalence which makes Ad35-based vectors promising candidates for gene therapy. Ad35 utilizes CD46 and integrins as receptors for infection of epithelial and hematopoietic cells. Here, we show that infectious entry of Ad35 into HeLa, human kidney HK-2 cells and normal human lung fibroblasts strongly depended on CD46 and integrins but not heparan sulfate, and variably required the large GTPase dynamin. Ad35 infections were independent of expression of the carboxy-terminal domain of AP180 which effectively blocks clathrin-mediated uptake. Ad35 infections were inhibited by small chemicals against the serine/threonine kinase Pak1 (p21-activated kinase), protein kinase C (PKC), sodium-proton exchangers, actin and acidic organelles. Remarkably, the F-actin inhibitor jasplakinolide, the Pak1 inhibitor IPA-3 or the sodium-proton exchange inhibitor EIPA blocked the endocytic uptake of Ad35. Dominant-negative proteins or small interfering RNAs against factors driving macropinocytosis, including the small GTPase Rac1, Pak1 or the Pak1 effector C-terminal binding protein 1 (CtBP1) potently inhibited Ad35 infection. Confocal laser scanning microscopy, electron microscopy and live cell imaging showed that Ad35 colocalized with fluid phase markers in large endocytic structures that were positive for CD46, alpha v integrins and also CtBP1. Our results extend earlier observations with HAdV-3 (Ad3), and establish macropinocytosis as an infectious pathway for species B human adenoviruses in epithelial and hematopoietic cells

Introducing intravascular microdialysis for continuous lactate monitoring in patients undergoing cardiac surgery:a prospective observational study

Introduction: Lactate is a marker of hypoperfusion and may be used for risk assessment in critically ill patients. Although evidence suggests that repeated lactate measurements are of clinical interest, how and when lactate should be analyzed is controversial. Intravascular microdialysis provides a novel method for the continuous monitoring of lactate, which may be clinically beneficial in critically ill patients. Methods: Circulating lactate levels were continuously monitored in 80 patients undergoing cardiac surgery using either a separate single-lumen microdialysis catheter or a triple-lumen central venous catheter with an integrated microdialysis function. The catheter was placed with the tip positioned in the superior vena cava. Arterial blood gas samples were taken every hour to obtain reference values, and the lactate levels were analyzed in a blood gas analyzer. Results: A total of 1,601 paired microdialysis-arterial blood gas lactate samples were obtained. Bland-Altman analysis showed a bias (mean difference) +/- limits of agreement (+/- 1.96 SD) of 0.02 +/- 0.42 mmol/L. The regression coefficient was 0.98 (P = 0.0001). Conclusions: Central venous microdialysis is an accurate and reliable method for continuous blood lactate monitoring in patients undergoing cardiac surgery. The system may be useful for early lactate-guided therapy in critically ill patients

Application of Compromise Programming to a semi-detached housing development in order to balance economic and environmental criteria

This is a post-peer-review, pre-copyedit version of an article published in Journal of the Operational Research Society. The definitive publisher-authenticated version: Ruá Aguilar, MJ.; Guadalajara Olmeda, MN. (2012). Application of Compromise Programming to a semi-detached housing development in order to balance economic and environmental criteria. Journal of the Operational Research Society. 64(3):459-468, is available online at: http://www.palgrave-journals.com/jors/journal/v64/n3/full/jors201276a.html.European Energy Performance of Buildings Directives DE promote energy efficiency in buildings. Under these Directives, the European Union States must apply minimum requirements regarding the energy performance of buildings and ensure the certification of their energy performance. The Directives set only the basic principles and requirements, leaving a significant amount of room for the Member States to establish their specific mechanisms, numeric requirements and ways to implement them, taking into account local conditions. With respect to the Spanish case, the search for buildings that are more energy efficient results in a conflict between users¿ economic objectives and society's environmental objectives. In this paper, Compromise Programming is applied to help in the decision-making process. An appropriate distribution of types of dwellings, according to their energy performance and to the climatic zone considered in Spain, will be suggested. Results provide a compromise solution between both objectives.Ruá Aguilar, MJ.; Guadalajara Olmeda, MN. (2012). Application of Compromise Programming to a semi-detached housing development in order to balance economic and environmental criteria. Journal of the Operational Research Society. 64(3):459-468. doi:10.1057/jors.2012.76S459468643Andaloro, A. P. F., Salomone, R., Ioppolo, G., & Andaloro, L. (2010). Energy certification of buildings: A comparative analysis of progress towards implementation in European countries. Energy Policy, 38(10), 5840-5866. doi:10.1016/j.enpol.2010.05.039André, F. J., Cardenete, M. A., & Romero, C. (2008). Using compromise programming for macroeconomic policy making in a general equilibrium framework: theory and application to the Spanish economy. Journal of the Operational Research Society, 59(7), 875-883. doi:10.1057/palgrave.jors.2602415Baja, S., Chapman, D. M., & Dragovich, D. (2006). Spatial based compromise programming for multiple criteria decision making in land use planning. Environmental Modeling & Assessment, 12(3), 171-184. doi:10.1007/s10666-006-9059-1Ballestero, E., & Romero, C. (1991). A theorem connecting utility function optimization and compromise programming. Operations Research Letters, 10(7), 421-427. doi:10.1016/0167-6377(91)90045-qBallestero, E., & Romero, C. (1993). Weighting in compromise programming: A theorem on shadow prices. Operations Research Letters, 13(5), 325-329. doi:10.1016/0167-6377(93)90055-lDavies, H., & Wyatt, D. (2004). Appropriate use of the ISO 15686-1 factor method for durability and service life prediction. Building Research & Information, 32(6), 552-553. doi:10.1080/0961321042000291938Diakaki, C., Grigoroudis, E., Kabelis, N., Kolokotsa, D., Kalaitzakis, K., & Stavrakakis, G. (2010). A multi-objective decision model for the improvement of energy efficiency in buildings. Energy, 35(12), 5483-5496. doi:10.1016/j.energy.2010.05.012Dı́az-Balteiro, L., & Romero, C. (2003). Forest management optimisation models when carbon captured is considered: a goal programming approach. Forest Ecology and Management, 174(1-3), 447-457. doi:10.1016/s0378-1127(02)00075-0Diaz-Balteiro, L., & Rodriguez, L. C. E. (2006). Optimal rotations on Eucalyptus plantations including carbon sequestration—A comparison of results in Brazil and Spain. Forest Ecology and Management, 229(1-3), 247-258. doi:10.1016/j.foreco.2006.04.005Fattahi, P., & Fayyaz, S. (2009). A Compromise Programming Model to Integrated Urban Water Management. Water Resources Management, 24(6), 1211-1227. doi:10.1007/s11269-009-9492-4Hamdy, M., Hasan, A., & Siren, K. (2011). Applying a multi-objective optimization approach for Design of low-emission cost-effective dwellings. Building and Environment, 46(1), 109-123. doi:10.1016/j.buildenv.2010.07.006Johnstone, I. M. (2001). Energy and mass flows of housing: a model and example. Building and Environment, 36(1), 27-41. doi:10.1016/s0360-1323(99)00065-7Johnstone, I. M. (2001). Energy and mass flows of housing: estimating mortality. Building and Environment, 36(1), 43-51. doi:10.1016/s0360-1323(99)00066-9Linares, P., & Romero, C. (2000). A multiple criteria decision making approach for electricity planning in Spain: economic versus environmental objectives. Journal of the Operational Research Society, 51(6), 736-743. doi:10.1057/palgrave.jors.2600944Rey, F. J., Velasco, E., & Varela, F. (2007). Building Energy Analysis (BEA): A methodology to assess building energy labelling. Energy and Buildings, 39(6), 709-716. doi:10.1016/j.enbuild.2006.07.009Rudbeck, C. (2002). Service life of building envelope components: making it operational in economical assessment. Construction and Building Materials, 16(2), 83-89. doi:10.1016/s0950-0618(02)00003-xSan-José, J. T., Losada, R., Cuadrado, J., & Garrucho, I. (2007). Approach to the quantification of the sustainable value in industrial buildings. Building and Environment, 42(11), 3916-3923. doi:10.1016/j.buildenv.2006.11.013Yu, P. L. (1973). A Class of Solutions for Group Decision Problems. Management Science, 19(8), 936-946. doi:10.1287/mnsc.19.8.936Zelany, M. (1974). 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H-AMR: A New GPU-accelerated GRMHD Code for Exascale Computing With 3D Adaptive Mesh Refinement and Local Adaptive Time-stepping

General-relativistic magnetohydrodynamic (GRMHD) simulations have revolutionized our understanding of black-hole accretion. Here, we present a GPU-accelerated GRMHD code H-AMR with multi-faceted optimizations that, collectively, accelerate computation by 2-5 orders of magnitude for a wide range of applications. Firstly, it involves a novel implementation of a spherical-polar grid with 3D adaptive mesh refinement that operates in each of the 3 dimensions independently. This allows us to circumvent the Courant condition near the polar singularity, which otherwise cripples high-res computational performance. Secondly, we demonstrate that local adaptive time-stepping (LAT) on a logarithmic spherical-polar grid accelerates computation by a factor of $\lesssim10$ compared to traditional hierarchical time-stepping approaches. Jointly, these unique features lead to an effective speed of $\sim10^9$ zone-cycles-per-second-per-node on 5,400 NVIDIA V100 GPUs (i.e., 900 nodes of the OLCF Summit supercomputer). We demonstrate its computational performance by presenting the first GRMHD simulation of a tilted thin accretion disk threaded by a toroidal magnetic field around a rapidly spinning black hole. With an effective resolution of $13$,$440\times4$,$608\times8$,$092$ cells, and a total of $\lesssim22$ billion cells and $\sim0.65\times10^8$ timesteps, it is among the largest astrophysical simulations ever performed. We find that frame-dragging by the black hole tears up the disk into two independently precessing sub-disks. The innermost sub-disk rotation axis intermittently aligns with the black hole spin, demonstrating for the first time that such long-sought alignment is possible in the absence of large-scale poloidal magnetic fields.Comment: 10 pages, 5 figures, submitted to MNRAS, for the YouTube playlist, see https://youtu.be/rIOjKUfzcv

Digital intervention increases influenza vaccination rates for people with diabetes in a decentralized randomized trial

People with diabetes (PWD) have an increased risk of developing influenza-related complications, including pneumonia, abnormal glycemic events, and hospitalization. Annual influenza vaccination is recommended for PWD, but vaccination rates are suboptimal. The study aimed to increase influenza vaccination rate in people with self-reported diabetes. This study was a prospective, 1:1 randomized controlled trial of a 6-month Digital Diabetes Intervention in U.S. adults with diabetes. The intervention group received monthly messages through an online health platform. The control group received no intervention. Difference in self-reported vaccination rates was tested using multivariable logistic regression controlling for demographics and comorbidities. The study was registered at clinicaltrials.gov: NCT03870997. A total of 10,429 participants reported influenza vaccination status (5158 intervention, mean age (±SD) = 46.8 (11.1), 78.5% female; 5271 control, Mean age (±SD) = 46.7 (11.2), 79.4% female). After a 6-month intervention, 64.2% of the intervention arm reported influenza vaccination, vers us 61.1% in the control arm (diff = 3.1, RR = 1.05, 95% CI [1.02, 1.08], p = 0.0013, number needed to treat = 33 to obtain 1 additional vaccination). Completion of one or more intervention messages was associated with up to an 8% increase in vaccination rate (OR 1.27, 95% CI [1.17, 1.38], p < 0.0001). The intervention improved influenza vaccination rates in PWD, suggesting that leveraging new technology to deliver knowledge and information can improve influenza vaccination rates in high-risk populations to reduce public health burden of influenza. Rapid cycle innovation could maximize the effects of these digital interventions in the future with other populations and vaccines