Hemangioma Infantil: A Propósito de um Caso Clínico

The authors present a case report of a newborn, admitted for pre-auricular swelling associated with a bright red skin patch. The ultrasound and magnetic resonance imaging evaluations were compatible with the diagnosis of parotid gland infantile hemangioma. Infantile hemangioma is a common benign vascular tumor, representing the vascular anomaly most frequently found in pediatric age. Its differential diagnosis includes other vascular tumors and vascular malformations. In most cases, expectant observation is recommended, with pharmacological and / or surgical treatment reserved for particular cases.Os autores apresentam o caso clínico de um recém-nascido, admitido por tumefação pré-auricular associada a mancha cutânea com coloração vermelho vivo. As avaliações imagiológicas por ecografia de partes moles e ressonância magnética (RM) foram compatíveis com o diagnóstico de hemangioma infantil parotídeo. O hemangioma infantil é um tumor vascular benigno comum, representando a anomalia vascular mais frequentemente encontrada em idade pediátrica. O seu diagnóstico diferencial engloba outros tumores vasculares e malformações vasculares. Na maioria dos casos é recomendada observação expectante, sendo o tratamento farmacológico e/ou cirúrgico reservado para casos particulares

Understanding the design context for Australian university teachers: implications for the future of learning design

Based on the premise that providing support for university teachers in designing for their teaching will ultimately improve the quality of student learning outcomes, recent interest in the development of support tools and strategies has gained momentum. This article reports on a study that examined the context in which Australian university teachers design in order to understand what role design support tools and strategies could play. In-depth interviews were conducted with 30 academics across 16 Australian universities. The findings suggest that most Australian university teachers have a high degree of flexibility in their design decisions suggesting that opportunities exist for learning design tools and strategies to be adopted

Hypoxia Promotes Danger-mediated Inflammation via Receptor for Advanced Glycation End Products in Cystic Fibrosis

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Immunobiologic and Antiinflammatory Properties of a Bark Extract from Ampelozizyphus amazonicus Ducke

Ampelozizyphus amazonicus is used in the treatment and prevention of malaria. The effect of an aqueous extract from this plant (SART) on the immune response was investigated by measuring immunoglobulin production induced by immunization with the antigen TNP-Ficoll in Plasmodium chabaudi-infected mice. SART treatment increased antigen-specific IgM and IgG levels in TNPFicoll-immunized mice. The B cell response during malarial infection was also modified by SART. There was an increase in total serum IgM and IgG and a decrease in the percentage of splenic plasma cells (CD138+ cells) in P. chabaudi-infected, SART-treated animals. SART (1, 3 or 10 mg/kg, p.o.) and the reference drug dexamethasone (5 mg/kg) were also tested in carrageenan-induced leukocyte migration to the subcutaneous air pouch (SAP). All SART doses significantly reduced leukocyte migration into the SAP. The protein concentration resulting from extravasation into the peritoneum was also significantly reduced. Our data indicate that SART possesses immunomodulatory properties, inducing an in vivo modification of the B lymphocyte response and antiinflammatory properties, which are partly due to a reduction in cell migration and are most likely due to an inhibition of the production of inflammatory mediators. Preliminary HPLC-ESI-MS/MS analysis of SART shows a complex saponin profile with deprotonated molecule [M-H] − ions in the range of m/z 800-1000

Riociguat treatment in patients with chronic thromboembolic pulmonary hypertension: Final safety data from the EXPERT registry

Objective: The soluble guanylate cyclase stimulator riociguat is approved for the treatment of adult patients with pulmonary arterial hypertension (PAH) and inoperable or persistent/recurrent chronic thromboembolic pulmonary hypertension (CTEPH) following Phase

A História da Alimentação: balizas historiográficas

Os M. pretenderam traçar um quadro da História da Alimentação, não como um novo ramo epistemológico da disciplina, mas como um campo em desenvolvimento de práticas e atividades especializadas, incluindo pesquisa, formação, publicações, associações, encontros acadêmicos, etc. Um breve relato das condições em que tal campo se assentou faz-se preceder de um panorama dos estudos de alimentação e temas correia tos, em geral, segundo cinco abardagens Ia biológica, a econômica, a social, a cultural e a filosófica!, assim como da identificação das contribuições mais relevantes da Antropologia, Arqueologia, Sociologia e Geografia. A fim de comentar a multiforme e volumosa bibliografia histórica, foi ela organizada segundo critérios morfológicos. A seguir, alguns tópicos importantes mereceram tratamento à parte: a fome, o alimento e o domínio religioso, as descobertas européias e a difusão mundial de alimentos, gosto e gastronomia. O artigo se encerra com um rápido balanço crítico da historiografia brasileira sobre o tema

COVID-19 symptoms at hospital admission vary with age and sex: results from the ISARIC prospective multinational observational study

Background: The ISARIC prospective multinational observational study is the largest cohort of hospitalized patients with COVID-19. We present relationships of age, sex, and nationality to presenting symptoms. Methods: International, prospective observational study of 60 109 hospitalized symptomatic patients with laboratory-confirmed COVID-19 recruited from 43 countries between 30 January and 3 August 2020. Logistic regression was performed to evaluate relationships of age and sex to published COVID-19 case definitions and the most commonly reported symptoms. Results: ‘Typical’ symptoms of fever (69%), cough (68%) and shortness of breath (66%) were the most commonly reported. 92% of patients experienced at least one of these. Prevalence of typical symptoms was greatest in 30- to 60-year-olds (respectively 80, 79, 69%; at least one 95%). They were reported less frequently in children (≤ 18 years: 69, 48, 23; 85%), older adults (≥ 70 years: 61, 62, 65; 90%), and women (66, 66, 64; 90%; vs. men 71, 70, 67; 93%, each P < 0.001). The most common atypical presentations under 60 years of age were nausea and vomiting and abdominal pain, and over 60 years was confusion. Regression models showed significant differences in symptoms with sex, age and country. Interpretation: This international collaboration has allowed us to report reliable symptom data from the largest cohort of patients admitted to hospital with COVID-19. Adults over 60 and children admitted to hospital with COVID-19 are less likely to present with typical symptoms. Nausea and vomiting are common atypical presentations under 30 years. Confusion is a frequent atypical presentation of COVID-19 in adults over 60 years. Women are less likely to experience typical symptoms than men

A case study of how using laptops in a primary classroom facilitated Higher Order Thinking

Research about 1:1 laptop school initiatives highlight benefits for learning, however, there is little research about the impact of such initiatives in the primary school context. This case study reports how a 1:1 laptop program facilitated Higher Order Thinking (HOT) in an upper primary classroom in Australia. The class was observed during one unit of work and Bloom\u27s taxonomy of HOT was used as the analysis framework. Results showed that Higher Order Thinking was evident when laptop tasks encouraged students to take an active role in their learning. HOT was facilitated by students being able to make decisions on applications to use to complete tasks and class discussion facilitated by the teacher. Technical problems experienced using laptops also promoted HOT from students. This study suggests that a 1:1 computer initiative can promote HOT but is dependent on the pedagogical practices of the teacher. This small-scale study highlights that the teacher is key when implementing laptops in the classroom and further research is warranted to inform future 1:1 computer initiatives in primary schools

An examination of learning design descriptions in a repository

The past decade has seen a significant expansion of flexible learning in higher education as new communication technologies have broadened the scope and potential for online learning. With this expansion has come the need for pedagogically sound learning experiences and an interest in reusing effective pedagogical designs. The concept of a ‘learning design’ - a formalism for documenting educational practice to facilitate sharing and reuse by teachers, is being researched as one way of supporting dissemination of ‘best practice’. This paper reports an analytical study that sought to advance understanding of what constitutes an effective learning design description based on an analysis of learning designs in an existing repository. The study contended that an effective learning design description comprises a clear description of the pedagogy, a quality rating and advice on potential reuse. Six, from a repository of 32, were identified as effective learning design descriptions

Understanding university teachers\u27 approaches to design

Although there has been significant research into approaches to teaching in higher education, comparatively little is known about university teachers’ approaches to design. This paper presents preliminary findings from a study that is investigating the design processes of Australian university academics across disciplines in the Arts, the Sciences and the Professions. A summary of the design processes of two Australian university teachers in the Sciences is presented. The purpose of this paper is to provide a brief background to the study and discuss the preliminary insights gained from these two individual