Cold stress stimulates algae to produce value-added compounds

Two cold-tolerant microalgae, Chlorella vulgaris and Scenedesmus sp., were grown at 22 and 5 °C. At the lower temperature, the microalgae showed substantial biochemical and morphological changes. The soluble sugar profile in response to low-temperature cultivation was very different in the two strains. C. vulgaris increased both the sucrose and raffinose family oligosaccharides (RFOs) content at 5 °C while Scenedesmus sp. drastically reduced the sucrose content. Both strains increased the total fatty acid methyl ester (FAME) content when grown at 5 °C. However, the FAME profiles were very different: C. vulgaris mainly increased C18:1 and less so C18:3, while Scenedesmus sp. decreased C18:1 but greatly increased C18:3. The morphology of C. vulgaris changed slightly at the lower temperature, while Scenedesmus sp. showed substantial changes in the size and shape. Low temperature triggered the synthesis of unsaturated fatty acids that are essential for human nutrition

Harald Lindberg – a Finnish botanist

Harald Lindberg was one of the most eminent botanist in Finland during the 1900’s. He studied a wide range of taxa, including subfossils and bryophytes. He investigated subfossils on peatlands in 60 municipalities, many of them now belonging to Russia. Lindberg described 11 new bryophyte taxa, and discovered 12 new species to Finland (including areas of former Finnish territory of today’sRussia). For East Fennoscandia he described 8 new vascular plant species to science, discovered 42 new species and 26 hybrids to country. Apomictic species interested him also, and he described 4 new Alchemilla species, 34 Hieraciumtaxa and 80 Taraxacum species or subspecies. Later he became expertise also onMediterranean species, and described 50 new species and 22 subspecies, especially fromMorocco and Spain. Plantae Finlandiae Exsiccatae was an extensive effort. 2,081 numbers were distributed to 23 museum

Between empowerment and abuse: citizen participation beyond the post-democratic turn

In this special issue on “Democratization beyond the Post-Democratic Turn. Political Participation between Empowerment and Abuse”, we have explored changing understandings of participation in contemporary Western representative democracies through the analytical lens of the concept of the post-democratic-turn. We have investigated technology-based, market-based, and expert-led innovations that claim to enhance democratic participation and to provide policy legitimation. In this concluding article, I revisit the cases made by the individual contributors and analyse how shifting notions of participation alter dominant understandings of democracy. I carve out how new and emerging ideas of participation are based on different understandings of political subjectivity; furthermore, how constantly rising democratic expectations and simultaneously increasing scepticism with regard to democratic processes and institutions point to a growing democratic ambivalence within Western societies. Making use of Dahl’s conceptualization of democracy, in this article, I review changing understandings of participation in light of their contribution to further democratization. The article shows how under post-democratic conditions the simulative performance of autonomy and subjectivity has become central to democratic participation. It emphasizes that what in established perspectives on democratization might appear as an abuse of participation, through the lens of a post-democratic-turn might be perceived as emancipatory and liberating

Assessment of two essential elements of BVDV control on selected Flemish dairy and beef farms

Bovine viral diarrhea virus (BVDV) is one of the most important viruses to cause disease in cattle worldwide. The virus is endemically present in Belgium. Clinical diagnosis of BVDV infection is difficult. Therefore, monitoring through testing is necessary to detect the presence of the virus on farms. As vaccination alone does not suffice for eradication, a combination of measures is required for successful control. Via a questionnaire, the BVDV policy on 241 selected Flemish cattle farms was investigated. This revealed some striking results. For the majority of the herds, the BVDV status was unknown (63%), And only 23% had a monitoring program in place. Furthermore, on seven out of ten (71%) BVDV-vaccinating farms, vaccination against BVDV was implemented as a strategy without knowing the actual BVDV status

Helico-conical optical beams self-heal

An optical beam is said to be self-healing when, distorted by an obstacle, the beam corrects itself upon propagation. In this letter, we show through experiments supported by numerical simulations, that Helico-conical optical beams (HCOBs) self-heal. We observe the strong resilience of these beams with different types of obstructions, and relate this to the characteristics of their transverse energy flow.Comment: 4 pages, 5 figure

Improved risk stratification of patients with atrial fibrillation: an integrated GARFIELD-AF tool for the prediction of mortality, stroke and bleed in patients with and without anticoagulation.

OBJECTIVES: To provide an accurate, web-based tool for stratifying patients with atrial fibrillation to facilitate decisions on the potential benefits/risks of anticoagulation, based on mortality, stroke and bleeding risks. DESIGN: The new tool was developed, using stepwise regression, for all and then applied to lower risk patients. C-statistics were compared with CHA2DS2-VASc using 30-fold cross-validation to control for overfitting. External validation was undertaken in an independent dataset, Outcome Registry for Better Informed Treatment of Atrial Fibrillation (ORBIT-AF). PARTICIPANTS: Data from 39 898 patients enrolled in the prospective GARFIELD-AF registry provided the basis for deriving and validating an integrated risk tool to predict stroke risk, mortality and bleeding risk. RESULTS: The discriminatory value of the GARFIELD-AF risk model was superior to CHA2DS2-VASc for patients with or without anticoagulation. C-statistics (95% CI) for all-cause mortality, ischaemic stroke/systemic embolism and haemorrhagic stroke/major bleeding (treated patients) were: 0.77 (0.76 to 0.78), 0.69 (0.67 to 0.71) and 0.66 (0.62 to 0.69), respectively, for the GARFIELD-AF risk models, and 0.66 (0.64-0.67), 0.64 (0.61-0.66) and 0.64 (0.61-0.68), respectively, for CHA2DS2-VASc (or HAS-BLED for bleeding). In very low to low risk patients (CHA2DS2-VASc 0 or 1 (men) and 1 or 2 (women)), the CHA2DS2-VASc and HAS-BLED (for bleeding) scores offered weak discriminatory value for mortality, stroke/systemic embolism and major bleeding. C-statistics for the GARFIELD-AF risk tool were 0.69 (0.64 to 0.75), 0.65 (0.56 to 0.73) and 0.60 (0.47 to 0.73) for each end point, respectively, versus 0.50 (0.45 to 0.55), 0.59 (0.50 to 0.67) and 0.55 (0.53 to 0.56) for CHA2DS2-VASc (or HAS-BLED for bleeding). Upon validation in the ORBIT-AF population, C-statistics showed that the GARFIELD-AF risk tool was effective for predicting 1-year all-cause mortality using the full and simplified model for all-cause mortality: C-statistics 0.75 (0.73 to 0.77) and 0.75 (0.73 to 0.77), respectively, and for predicting for any stroke or systemic embolism over 1 year, C-statistics 0.68 (0.62 to 0.74). CONCLUSIONS: Performance of the GARFIELD-AF risk tool was superior to CHA2DS2-VASc in predicting stroke and mortality and superior to HAS-BLED for bleeding, overall and in lower risk patients. The GARFIELD-AF tool has the potential for incorporation in routine electronic systems, and for the first time, permits simultaneous evaluation of ischaemic stroke, mortality and bleeding risks. CLINICAL TRIAL REGISTRATION: URL: http://www.clinicaltrials.gov. Unique identifier for GARFIELD-AF (NCT01090362) and for ORBIT-AF (NCT01165710)

Democratization beyond the post-democratic turn: towards a research agenda on new conceptions of citizen participation

Following extensive debates about post-democracy and post-politics, scholarly attention has shifted to conceptualizing the ongoing transformation of democracy. In this endeavour, the change in understandings, expectations and functions of political participation is a key parameter. Improving citizen participation is widely regarded as the hallmark of democratization. Yet, a variety of actors are also increasingly ambivalent about democratic institutions and the further expansion of participation. Meanwhile, new forms of participation are gaining in significance – neoliberal activation, the responsibilization of consumers, digital data mining, managed behaviour guided by choice architects – which some believe much improve representation, but which others perceive as a threat to the citizens’ autonomy. This article introduces a special issue focusing on the participation-democratization nexus in well-established democracies in the economically affluent global North. Based on a critical review of popular narratives of post-democracy and post-politics we sketch the notion of the post-democratic turn – which offers a new perspective on emerging forms of participation and in this special issue serves as a conceptual lens for their analysis. We then revisit more traditional conceptualizations of democratic participation which are challenged by the post-democratic turn. The article concludes with an overview of the individual contributions to this special issue

Comparison of bulk milk antibody and youngstock serology screens for determining herd status for Bovine Viral Diarrhoea Virus

BACKGROUND: This paper examines the use of Bulk Milk antibody (BM Ab), Youngstock (YS) serology (Check Tests) and Bulk Milk PCR (BM PCR) for determining the presence or absence of animals persistently infected (PI) with Bovine Viral Diarrhoea Virus (BVDV) within a herd. Data is presented from 26 herds where average herd sizes were 343 and 98 animals for dairy and beef units respectively. Seventeen herds had sufficient data to analyse using Receiver Operating Characteristic (ROC) and probability curves enabling calculation of the sensitivity and specificity of BM Ab and YS Check tests for determining the presence of PI animals within herds in this dataset. RESULTS: Using BM Ab to screen a herd for the presence of PI animals, achieved a herd level sensitivity and specificity of 80.00 % (44.39–97.48 %) and 85.71 % (42.13–99.64 %) respectively (95 % confidence intervals quoted). Sensitivity and specificity of YS Check Tests at a cut off of 3/10 Ab positive YS were 81.82 % (48.22–97.72 %) and 66.67 % (22.28–95.67 %) respectively (95 % confidence interval). These results were achieved by comparing the screening tests to whole herd PI searches that took place 1–19 months after the initial screen with a mean interval of 8 months. Removal of this delay by taking BM samples on the day of a whole herd test and simulating a YS Check Test from the herd test data produced improvements in the reliability of the Check Tests. BM Ab sensitivity and specificity remained unchanged. However, the Check Test sensitivity and specificity improved to 90.9 % (58.72–99.77 %) and 100 % (54.07–100 %) respectively (95 % confidence interval) at a cut of off 2.5/10 Ab positive animals. Our limited BM PCR results identified 5/23 dairy farms with a positive BM PCR result; two contained milking PIs, two had non-milking PIs and another had no PIs identified. CONCLUSIONS: Delaying a PI search following an initial herd screen decreased the diagnostic accuracy and relevance of our results. With careful interpretation, longitudinal surveillance using a combination of the techniques discussed can successfully determine farm status and therefore allow changes in BVDV status to be detected early, thus enabling prompt action in the event of a BVDV incursion

Generalized Bessel beams with two indices

We report on a new class of exact solutions of the scalar Helmholtz equation obtained by carefully engineering the form of the angular spectrum of a Bessel beam. We consider in particular the case in which the angular spectrum of such generalized beams has, in the paraxial zone, the same radial structure as Laguerre-Gaussian beams. We investigate the form of these new beams as well as their peculiar propagation properties