467 research outputs found
Text detection and recognition based on a lensless imaging system
Lensless cameras are characterized by several advantages (e.g.,
miniaturization, ease of manufacture, and low cost) as compared with
conventional cameras. However, they have not been extensively employed due to
their poor image clarity and low image resolution, especially for tasks that
have high requirements on image quality and details such as text detection and
text recognition. To address the problem, a framework of deep-learning-based
pipeline structure was built to recognize text with three steps from raw data
captured by employing lensless cameras. This pipeline structure consisted of
the lensless imaging model U-Net, the text detection model connectionist text
proposal network (CTPN), and the text recognition model convolutional recurrent
neural network (CRNN). Compared with the method focusing only on image
reconstruction, UNet in the pipeline was able to supplement the imaging details
by enhancing factors related to character categories in the reconstruction
process, so the textual information can be more effectively detected and
recognized by CTPN and CRNN with fewer artifacts and high-clarity reconstructed
lensless images. By performing experiments on datasets of different
complexities, the applicability to text detection and recognition on lensless
cameras was verified. This study reasonably demonstrates text detection and
recognition tasks in the lensless camera system,and develops a basic method for
novel applications
Competing spin-glass and spin-fluctuation states in NdxPr4-xNi3O8
Neodymium nickelates have attracted research interest due to their strongly
correlated behaviour and remarkable magnetic properties. More importantly,
superconductivity has recently been confirmed in thin-film samples of Sr-doped
NdNiO2, bringing the layered rare earth nickel oxides into the research
spotlight. In this report, we present results on a series of NdNiO2 analogues,
NdxPr4-xNi3O8 (x = 0.1, 0.25, 1, 2, and 4) obtained by topotactic reduction, in
which we observe systematic changes in the magnetic behaviour. As the Nd3+
content increases, the initially large spin-freezing region with magnetic
frustration becomes smaller and gradually shifts to low temperatures, while the
magnetic response gradually increases. The muon-spin spectroscopy measurements
on Nd4Ni3O8 show that this phenomenon is likely due to the enhancement of spin
fluctuations in NdxPr4-xNi3O8, which weakens the spin frustration behaviour for
high Nd3+ contents and at low temperatures. These spin fluctuations can be
caused by both Nd and Ni ions and could be one of the factors determining the
occurrence of possible superconductivity.Comment: 21 pages 10 figure
Competing spin-glass and spin-fluctuation states in NdPrNiO
Neodymium nickelates have attracted research interest due to their strongly correlated behavior and remarkable magnetic properties. More importantly, superconductivity has recently been confirmed in thin-film samples of Sr-doped NdNiO, bringing the layered rare earth nickel oxides into the research spotlight. In this report, we present results on a series of NdNiO analogs, NdPrNiO (x=0.1, 0.25, 1, 2, and 4) obtained by topotactic reduction, in which we observe systematic changes in the magnetic behavior. As the Nd content increases, the initially large spin-freezing region with magnetic frustration becomes smaller and gradually shifts to low temperatures, while the magnetic response gradually increases. The muon-spin spectroscopy measurements on NdNiO show that this phenomenon is likely due to the enhancement of spin fluctuations in NdPrNiO, which weakens the spin frustration behavior for high Nd contents and at low temperatures. These spin fluctuations can be caused by both Nd and Ni ions and could be one of the factors determining the occurrence of possible superconductivity
Adequate vitamin D level associated with reduced risk of sporadic colorectal cancer
PurposeThe effect of vitamin D level pertinent to colorectal cancer incidence, progression, or mortality risk is complicated, and study findings are mixed. Therefore, we evaluated whether serum vitamin D [25-hydroxyvitamin D, 25(OH)D] is associated with the incidence of sporadic colorectal cancer (CRC).MethodsThis study is a retrospective analysis of the relationship between serum 25(OH)D level and the risk of CRC. Age, sex, body mass index, history of polyp, disease conditions (i.e., diabetes), medications, and other eight vitamins were used as confounding factors. A total of 389 participants were enrolled in this study, including comprising 83 CRC patients without a family history and 306 healthy controls, between January 2020 and March 2021 at the Department of Colorectal Surgery and Endoscope Center at the Xinhua Hospital, Shanghai Jiao Tong University School of Medicine. Adjusted smoothing spline plots, subgroup analysis, and multivariate logistic regression analysis were conducted to estimate the relative risk between serum 25(OH)D and sporadic CRC risk.ResultsAfter fully adjusting the confounding factors, it was found that circulating 25(OH)D played a protective role in patients with CRC (OR = 0.76 [0.63, 0.92], p = 0.004) and that an adequate vitamin D level was significantly associated with a reduced CRC risk compared to vitamin D deficiency or sufficiency (OR = 0.31 [0.11, 0.9], p = 0.03). According to this study, statins did not affect the potential protective effects of vitamin D (OR = 1.02 [0.97, 1.08], p = 0.44) and may account for the inverse association between serum 25(OH)D and colorectal cancer.ConclusionAn adequate level of serum 25(OH)D was associated with a reduced CRC risk, especially for the elderly. The finding on the absence of protective effect of vitamin D in the statin use subgroup, suggests it may be one of the substantial contributing confounders, and warrants further investigation
A Novel Selective JAK2 Inhibitor Identified Using Pharmacological Interactions
The JAK2/STAT signaling pathway mediates cytokine receptor signals that are involved in cell growth, survival and homeostasis. JAK2 is a member of the Janus kinase (JAK) family and aberrant JAK2/STAT is involved with various diseases, making the pathway a therapeutic target. The similarity between the ATP binding site of protein kinases has made development of specific inhibitors difficult. Current JAK2 inhibitors are not selective and produce unwanted side effects. It is thought that increasing selectivity of kinase inhibitors may reduce the side effects seen with current treatment options. Thus, there is a great need for a selective JAK inhibitor. In this study, we identified a JAK2 specific inhibitor. We first identified key pharmacological interactions in the JAK2 binding site by analyzing known JAK2 inhibitors. Then, we performed structure-based virtual screening and filtered compounds based on their pharmacological interactions and identified compound NSC13626 as a potential JAK2 inhibitor. Results of enzymatic assays revealed that against a panel of kinases, compound NSC13626 is a JAK2 inhibitor and has high selectivity toward the JAK2 and JAK3 isozymes. Our cellular assays revealed that compound NSC13626 inhibits colorectal cancer cell (CRC) growth by downregulating phosphorylation of STAT3 and arresting the cell cycle in the S phase. Thus, we believe that compound NSC13626 has potential to be further optimized as a selective JAK2 drug
Causal associations of sleep traits with cancer incidence and mortality
To explore the correlation and causality between multidimensional sleep traits and pan-cancer incidence and mortality among patients with cancer. The multivariable Cox regression, linear and nonlinear Mendelian randomization (MR), and survival curve analyses were conducted to assess the impacts of chronotype, sleep duration, and insomnia symptoms on pan-cancer risk (N = 326,417 from United Kingdom Biobank) and mortality (N = 23,956 from United Kingdom Biobank). In the Cox regression, we observed a linear and J-shaped association of sleep duration with pan-cancer incidence and mortality among cancer patients respectively. In addition, there was a positive association of insomnia with pan-cancer incidence (HR, 1.03, 95% CI: 1.00–1.06, p = 0.035), all-cause mortality (HR, 1.17, 95% CI: 1.06–1.30, p = 0.002) and cancer mortality among cancer patients (HR, 1.25, 95% CI: 1.11–1.41, p < 0.001). In the linear MR, there was supporting evidence of positive associations between long sleep duration and pan-cancer incidence (OR, 1.41, 95% CI: 1.08–1.84, p = 0.012), and there was a positive association between long sleep duration and all-cause mortality in cancer patients (OR, 5.56, 95% CI: 3.15–9.82, p = 3.42E-09). Meanwhile, a strong association between insomnia and all-cause mortality in cancer patients (OR, 1.41, 95% CI: 1.27–1.56, p = 4.96E-11) was observed in the linear MR. These results suggest that long sleep duration and insomnia play important roles in pan-cancer risk and mortality among cancer patients. In addition to short sleep duration and insomnia, our findings highlight the effect of long sleep duration in cancer prevention and prognosis
Reduced primary cilia length and altered Arl13b expression are associated with deregulated chondrocyte Hedgehog signaling in alkaptonuria
This work was supported by the Medical Research Council (MR/L002876/1), the Royal
College of Surgeons of England, Fondazione Telethon Italy (GGP10058), and Associazione Italiana Malati di Alcaptonuria (AimAKU, ORPHA263402
HDAC1 regulates pluripotency and lineage specific transcriptional networks in embryonic and trophoblast stem cells
Epigenetic regulation of gene expression is important in maintaining self-renewal of embryonic stem (ES) and trophoblast stem (TS) cells. Histone deacetylases (HDACs) negatively control histone acetylation by removing covalent acetylation marks from histone tails. Because histone acetylation is a known mark for active transcription, HDACs presumably associate with inactive genes. Here, we used genome-wide chromatin immunoprecipitation to investigate targets of HDAC1 in ES and TS cells. Through evaluation of genes associated with acetylated histone H3 marks, and global expression analysis of Hdac1 knockout ES and trichostatin A-treated ES and TS cells, we found that HDAC1 occupies mainly active genes, including important regulators of ES and TS cells self-renewal. We also observed occupancy of methyl-CpG binding domain protein 3 (MBD3), a subunit of the nucleosome remodeling and histone deacetylation (NuRD) complex, at a subset of HDAC1-occupied sequences in ES cells, including the pluripotency regulators Oct4, Nanog and Kfl4. By mapping HDAC1 targets on a global scale, our results describe further insight into epigenetic mechanisms of ES and TS cells self-renewal
Forecasting the impact of diabetes mellitus on tuberculosis disease incidence and mortality in India.
Background: In context of the rapidly expanding diabetes mellitus (DM) epidemic in India and slowly declining tuberculosis (TB) incidence, we aimed to estimate the past, current, and future impact of DM on TB epidemiology. Methods: An age-structured TB-DM dynamical mathematical model was developed and analyzed to assess the DM-on-TB impact. The model was calibrated using a literature review and meta-analyses. The DM-on-TB impact was analyzed using population attributable fraction metrics. Sensitivity analyses were conducted by accommodating less conservative effect sizes for the TB-DM interactions, by factoring the age-dependence of the TB-DM association, and by assuming different TB disease incidence rate trajectories. Results: In 1990, 11.4% (95% uncertainty interval (UI) = 6.3%-14.4%) of new TB disease incident cases were attributed to DM. This proportion increased to 21.9% (95% UI = 12.1%-26.4%) in 2017, and 33.3% (95% UI = 19.0%-44.1%) in 2050. Similarly, in 1990, 14.5% (95% UI = 9.5%-18.2%) of TB-related deaths were attributed to DM. This proportion increased to 28.9% (95% UI = 18.9%-34.1%) in 2017, and 42.8% (95% UI = 28.7%-53.1%) in 2050. The largest impacts originated from the effects of DM on TB disease progression and infectiousness. Sensitivity analyses suggested that the impact could be even greater. Conclusions: The burgeoning DM epidemic is predicted to become a leading driver of TB disease incidence and mortality over the coming decades. By 2050, at least one-third of TB incidence and almost half of TB mortality in India will be attributed to DM. This is likely generalizable to other Asian Pacific countries with similar TB-DM burdens. Targeting the impact of the increasing DM burden on TB control is critical to achieving the goal of TB elimination by 2050
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