Consequências da implantação pontual de ferramentas Lean

A manufatura lean vem sendo amplamente discutida e difundida desde os primórdios de sua criação. Entretanto, este enfoque produz alguns efeitos contrários, como o problema das empresas que não adotam a filosofia como um todo utilizando apenas algumas ferramentas isoladas. Este é o tema do artigo, que visa responder a seguinte pergunta: “Qual o impacto da implantação pontual do lean?”. Para isto foi desenvolvido um estudo de caso em uma fábrica pertencente a um grupo multinacional automobilístico. Este estudo teve como principal contribuição a confirmação de que quando são aplicadas apenas ferramentas e técnicas desconexas da filosofia lean, isto gera incoerência entre as ações e desta forma, provoca o aparecimento de não conformidades dentro das atividades da empresa e também gera a descrença das pessoas quanto ao próprio sistema de produção e o lean

Conhecendo os impactos pulmonares ocasionados pelo uso de cigarros eletrônicos

O presente trabalho tem por objetivo a análise dos impactos pulmonares que são ocasionados pelo uso de cigarros eletrônicos. Este trabalho trata-se de uma revisão integrativa, sendo realizada a partir da busca dos seguintes Descritores em Ciências da Saúde (DeCS) na base de dados PubMed: electronic; cigarette; lung; impacts. Dos artigos encontrados, foram selecionados apenas artigos publicados nos anos de 2021 a 2023 até a data de 25/10/2023, sendo escolhidos 18 artigos, em que 10 foram excluídos após a análise de enquadramento ao tema, sendo apenas 8 analisados para a confecção deste estudo. O uso de E-cigarros está relacionado a diversas alterações pulmonares, sendo que em 2019, nos Estados Unidos, foi responsável pelo surto de doença pulmonar associada a cigarros eletrônicos, além disso é capaz de induzir alterações como síndrome respiratória aguda grave, alterações na função e composição do surfactante alterando a hematose, tosse, falta de ar e dentre outras alterações. Com isto, é essencial que se faça um apanhado das principais evidências científicas acerca deste tema para que todas estas problemáticas sejam evidenciadas.&nbsp

Hexapoda Yearbook (Arthropoda: Mandibulata: Pancrustacea) Brazil 2020: the first annual production survey of new Brazilian species

This paper provided a list of all new Brazilian Hexapoda species described in 2020. Furthermore, based on the information extracted by this list, we tackled additional questions regarding the taxa, the specialists involved in the species descriptions as well as the journals in which those papers have been published. We recorded a total of 680 new Brazilian species of Hexapoda described in 2020, classified in 245 genera, 112 families and 18 orders. These 680 species were published in a total of 219 articles comprising 423 different authors residing in 27 countries. Only 30% of these authors are women, which demonstrates an inequality regarding sexes. In relation to the number of authors by species, the majority of the new species had two authors and the maximum of authors by species was five. We also found inequalities in the production of described species regarding the regions of Brazil, with Southeast and South leading. The top 10 institutions regarding productions of new species have four in the Southeast, two at South and with one ate North Region being the outlier of this pattern. Out of the total 219 published articles, Zootaxa dominated with 322 described species in 95 articles. The average impact factor was of 1.4 with only seven articles being published in Impact Factors above 3, indicating a hardship on publishing taxonomic articles in high-impact journals.The highlight of this paper is that it is unprecedent, as no annual record of Hexapoda species described was ever made in previous years to Brazil.Fil: Silva Neto, Alberto Moreira. Ministério da Ciência, Tecnologia, Inovações. Instituto Nacional de Pesquisas da Amazônia; BrasilFil: Lopes Falaschi, Rafaela. Universidade Estadual do Ponta Grossa; BrasilFil: Zacca, Thamara. Universidade Federal Do Rio de Janeiro. Museu Nacional; BrasilFil: Hipólito, Juliana. Universidade Federal da Bahia; BrasilFil: Costa Lima Pequeno, Pedro Aurélio. Universidade Federal de Roraima; BrasilFil: Alves Oliveira, João Rafael. Ministério da Ciência, Tecnologia, Inovações. Instituto Nacional de Pesquisas da Amazônia; BrasilFil: Oliveira Dos Santos, Roberto. Ministério da Ciência, Tecnologia, Inovações. Instituto Nacional de Pesquisas da Amazônia; BrasilFil: Heleodoro, Raphael Aquino. Ministério da Ciência, Tecnologia, Inovações. Instituto Nacional de Pesquisas da Amazônia; BrasilFil: Jacobina, Adaiane Catarina Marcondes. Universidade Federal do Paraná; BrasilFil: Somavilla, Alexandre. Ministério da Ciência, Tecnologia, Inovações. Instituto Nacional de Pesquisas da Amazônia; BrasilFil: Camargo, Alexssandro. Ministério da Ciência, Tecnologia, Inovações. Instituto Nacional de Pesquisas da Amazônia; BrasilFil: de Oliveira Lira, Aline. Universidad Federal Rural Pernambuco; BrasilFil: Sampaio, Aline Amanda. Ministério da Ciência, Tecnologia, Inovações. Instituto Nacional de Pesquisas da Amazônia; BrasilFil: da Silva Ferreira, André. Universidad Federal Rural Pernambuco; BrasilFil: Martins, André Luis. Universidade Federal do Paraná; BrasilFil: Figueiredo de Oliveira, Andressa. Universidade Federal do Mato Grosso do Sul; BrasilFil: Gonçalves da Silva Wengrat , Ana Paula. Universidade do Sao Paulo. Escola Superior de Agricultura Luiz de Queiroz; BrasilFil: Batista Rosa, Augusto Henrique. Universidade Estadual de Campinas; BrasilFil: Dias Corrêa, Caio Cezar. Universidade Federal Do Rio de Janeiro. Museu Nacional; BrasilFil: Costa De-Souza, Caroline. Museu Paraense Emilio Goeldi; BrasilFil: Anjos Dos Santos, Danielle. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Patagonia Norte. Centro de Investigación Esquel de Montaña y Estepa Patagónica. Universidad Nacional de la Patagonia "San Juan Bosco". Centro de Investigación Esquel de Montaña y Estepa Patagónica; ArgentinaFil: Pacheco Cordeiro, Danilo. Instituto Nacional Da Mata Atlantica; BrasilFil: Silva Nogueira, David. Ministério da Ciência, Tecnologia, Inovações. Instituto Nacional de Pesquisas da Amazônia; BrasilFil: Almeida Marques, Dayse Willkenia. Ministério da Ciência, Tecnologia, Inovações. Instituto Nacional de Pesquisas da Amazônia; BrasilFil: Nunes Barbosa, Diego. Universidade Federal do Paraná; BrasilFil: Mello Mendes, Diego Matheus. Instituto de Desenvolvimento Sustentável Mamirauá; BrasilFil: Galvão de Pádua, Diego. Ministério da Ciência, Tecnologia, Inovações. Instituto Nacional de Pesquisas da Amazônia; BrasilFil: Silva Vilela, Diogo. Universidade Estadual Paulista Julio de Mesquita Filho; BrasilFil: Gomes Viegas, Eduarda Fernanda. Ministério da Ciência, Tecnologia, Inovações. Instituto Nacional de Pesquisas da Amazônia; BrasilFil: Carneiro dos Santos, Eduardo. Universidade Federal do Paraná; BrasilFil: Rodrigues Fernandes, Daniell Rodrigo. Ministério da Ciência, Tecnologia, Inovações. Instituto Nacional de Pesquisas da Amazônia; Brasi

The Li-8(p, alpha)He-5 reaction at low energies, and Be-9 spectroscopy around the proton threshold

We present a direct measurement of the low-energy Li-8(p, alpha)He-5 cross section, using a radioactive Li-8 beam impinging on a thick target. With four beam energies, we cover the energy range between E-c.m. = 0.2 and 2.1 MeV. An R-matrix analysis of the data is performed and suggests the existence of two broad overlapping resonances (5/2(+) at E-c.m. = 1.69 MeV and 7/2(+) at E-c.m. = 1.76 MeV). At low energies our data are sensitive to the properties of a subthreshold state (E-x = 16.67 MeV) and of two resonances above threshold. These resonances were observed in previous experiments. The R-matrix fit confirms spin assignments, and provides partial widths. We propose a new Li-8(p, alpha)He-5 reaction rate and briefly discuss its influence in nuclear astrophysics. DOI: 10.1103/PhysRevC.86.064321Fundacao de Amparo a Pesquisa do Estado de Sao Paulo (FAPESP) [2003/10099-2, 2004/07379-6, 2008/09341-7]Fundacao de Amparo a Pesquisa do Estado de Sao Paulo (FAPESP)Conselho Nacional de Desenvolvimento Cientifico e Tecnologico (CNPq)Conselho Nacional de Desenvolvimento Cientifico e Tecnologico (CNPq)Comissao de Aperfeicoamento do Ensino Superior (CAPES)Comissao de Aperfeicoamento do Ensino Superior (CAPES

Rationale, study design, and analysis plan of the Alveolar Recruitment for ARDS Trial (ART): Study protocol for a randomized controlled trial

Background: Acute respiratory distress syndrome (ARDS) is associated with high in-hospital mortality. Alveolar recruitment followed by ventilation at optimal titrated PEEP may reduce ventilator-induced lung injury and improve oxygenation in patients with ARDS, but the effects on mortality and other clinical outcomes remain unknown. This article reports the rationale, study design, and analysis plan of the Alveolar Recruitment for ARDS Trial (ART). Methods/Design: ART is a pragmatic, multicenter, randomized (concealed), controlled trial, which aims to determine if maximum stepwise alveolar recruitment associated with PEEP titration is able to increase 28-day survival in patients with ARDS compared to conventional treatment (ARDSNet strategy). We will enroll adult patients with ARDS of less than 72 h duration. The intervention group will receive an alveolar recruitment maneuver, with stepwise increases of PEEP achieving 45 cmH(2)O and peak pressure of 60 cmH2O, followed by ventilation with optimal PEEP titrated according to the static compliance of the respiratory system. In the control group, mechanical ventilation will follow a conventional protocol (ARDSNet). In both groups, we will use controlled volume mode with low tidal volumes (4 to 6 mL/kg of predicted body weight) and targeting plateau pressure <= 30 cmH2O. The primary outcome is 28-day survival, and the secondary outcomes are: length of ICU stay; length of hospital stay; pneumothorax requiring chest tube during first 7 days; barotrauma during first 7 days; mechanical ventilation-free days from days 1 to 28; ICU, in-hospital, and 6-month survival. ART is an event-guided trial planned to last until 520 events (deaths within 28 days) are observed. These events allow detection of a hazard ratio of 0.75, with 90% power and two-tailed type I error of 5%. All analysis will follow the intention-to-treat principle. Discussion: If the ART strategy with maximum recruitment and PEEP titration improves 28-day survival, this will represent a notable advance to the care of ARDS patients. Conversely, if the ART strategy is similar or inferior to the current evidence-based strategy (ARDSNet), this should also change current practice as many institutions routinely employ recruitment maneuvers and set PEEP levels according to some titration method.Hospital do Coracao (HCor) as part of the Program 'Hospitais de Excelencia a Servico do SUS (PROADI-SUS)'Brazilian Ministry of Healt

Reducing the environmental impact of surgery on a global scale: systematic review and co-prioritization with healthcare workers in 132 countries

Abstract Background Healthcare cannot achieve net-zero carbon without addressing operating theatres. The aim of this study was to prioritize feasible interventions to reduce the environmental impact of operating theatres. Methods This study adopted a four-phase Delphi consensus co-prioritization methodology. In phase 1, a systematic review of published interventions and global consultation of perioperative healthcare professionals were used to longlist interventions. In phase 2, iterative thematic analysis consolidated comparable interventions into a shortlist. In phase 3, the shortlist was co-prioritized based on patient and clinician views on acceptability, feasibility, and safety. In phase 4, ranked lists of interventions were presented by their relevance to high-income countries and low–middle-income countries. Results In phase 1, 43 interventions were identified, which had low uptake in practice according to 3042 professionals globally. In phase 2, a shortlist of 15 intervention domains was generated. In phase 3, interventions were deemed acceptable for more than 90 per cent of patients except for reducing general anaesthesia (84 per cent) and re-sterilization of ‘single-use’ consumables (86 per cent). In phase 4, the top three shortlisted interventions for high-income countries were: introducing recycling; reducing use of anaesthetic gases; and appropriate clinical waste processing. In phase 4, the top three shortlisted interventions for low–middle-income countries were: introducing reusable surgical devices; reducing use of consumables; and reducing the use of general anaesthesia. Conclusion This is a step toward environmentally sustainable operating environments with actionable interventions applicable to both high– and low–middle–income countries

Study of electromagnetic transverse energy in Pb-Pb collisions at √SNN = 2.76 TeV with ALICE

A física de altas energias, mais especificamente o estudo de colisões entre de íons pesados relativísticos tem como objetivo o estudo do comportamento de quarks e glúons em condições extremas de temperatura, pressão e densidade. Tais condições levam à formação de um novo estado da matéria chamado Plasma de Quarks e Glúons (QGP, do inglês Quark-Gluon Plasma). Medidas de observáveis globais tem sido usadas como uma importante ferramenta para a caracterização desse novo estado. Entre esses observáveis, a energia transversal por unidade de rapidez (dET/dy) das partículas emitidas em uma colisão entre íons pesados pode ser usada como evidência da formação do QGP. Este trabalho propõe um procedimento para obtenção da energia transversal eletromagnética, que é um importante componente da energia transversal total, em colisões Pb-Pb no experimento ALICE no LHC. O estudo foi feito através de simulações de Monte Carlo e validou o procedimento proposto com uma diferença sistemática em função da centralidade em torno de 2%.High energy physics with heavy ion collisions studies quarks and gluons under extreme conditions of temperature, pressure and density. Such conditions lead to the formation of a new state of matter called the Quark-Gluon Plasma (QGP). The measurement of global observables have been used as an important tool for the characterization of this new state. Among these observables, the transverse energy per unit of rapidity (dET/dy) from particles emitted in a heavy ion collision can be used as evidence of QGP formation. The work proposes a procedure to obtain the transverse electromagnetic energy, an important component of total transverse energy, in Pb-Pb collisions measured by the LHC-ALICE experiment. The study was done using Monte Carlo simulations, and validated the proposed procedure with a systematic difference as function of the centrality around 2%

Effect of hydrocooling on postharvest storage of sorrel (Rumex acetosa L.)

The objective of this work was to determine the effect of the binomial time/temperature of hydrocooling (10 and 20 min at 0 °C, 10 °C, and 20 °C) on the shelf life of sorrel, a non-conventional vegetable. The experimental design was entirely randomized in a 2 × 3 × 6 factorial scheme with three repetitions. The vegetables were stored at 10±1 °C and 99% relative humidity for 10 days. The effects of time and temperature of hydrocooling on physical and chemical characteristics were observed. The degradation of bioactive compounds was higher in the control samples and samples hydrocooled at 0 °C, resulting in lower antioxidant capacity at 10 days. Hydrocooling at 20 °C for 10 min maintained the color of the vegetables until the tenth day, with a chlorophyll content of 34.54 mg.100 g−1, related to the reduction of the respiration rate and weight loss. Hydrocooled sorrel for 20 min at the same temperature showed a vitamin C content of 63.71 mg.100 g−1 and total phenolics of 249.57 mg of EAG.100 g−1 of fresh matter, by the Fast Blue method. Thus, 20 °C for 10 or 20 min was the most efficient parameter for preserving sorrel samples

Cyclobenzaprine Raises ROS Levels in Leishmania infantum and Reduces Parasite Burden in Infected Mice

Submitted by Sandra Infurna ([email protected]) on 2017-05-04T11:55:40Z No. of bitstreams: 1 edesio_cunhajr_etal_IOC_2017.pdf: 1518221 bytes, checksum: 6be150919adf4e381a7886f6406acc7b (MD5)Approved for entry into archive by Sandra Infurna ([email protected]) on 2017-05-04T12:14:58Z (GMT) No. of bitstreams: 1 edesio_cunhajr_etal_IOC_2017.pdf: 1518221 bytes, checksum: 6be150919adf4e381a7886f6406acc7b (MD5)Made available in DSpace on 2017-05-04T12:14:58Z (GMT). No. of bitstreams: 1 edesio_cunhajr_etal_IOC_2017.pdf: 1518221 bytes, checksum: 6be150919adf4e381a7886f6406acc7b (MD5) Previous issue date: 2017Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Bioquímica de Tripanosomatídeos. Rio de Janeiro, RJ. Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Bioquímica de Tripanosomatídeos. Rio de Janeiro, RJ. Brasil.Universidade de São Paulo. Instituto de Medicina Tropical. São Paulo, SP, Brasil / Instituto Adolfo Lutz. Centro de Parasitologia e Micologia. São Paulo, SP, Brasil.Instituto Adolfo Lutz. Centro de Parasitologia e Micologia. São Paulo, SP, Brasil.Universidade de São Paulo. Instituto de Medicina Tropical. São Paulo, SP, Brasil.Centro de Investigaciones BioloÂgicas (CSIC). Unidad Asociada Interacciones, Metabolismo y Bioanálisis CSIC-CEU. Madrid, Spain.Universidad CEU San Pablo. Faculty of Pharmacy. Center for Metabolomics and Bioanalysis (CEMBIO. Madrid, Spain.Centro de Investigaciones BioloÂgicas (CSIC). Unidad Asociada Interacciones, Metabolismo y Bioanálisis CSIC-CEU. Madrid, Spain.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Bioquímica de Tripanosomatídeos. Rio de Janeiro, RJ. Brasil.Instituto Adolfo Lutz. Centro de Parasitologia e Micologia. São Paulo, SP, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Bioquímica de Tripanosomatídeos. Rio de Janeiro, RJ. Brasil.The leishmanicidal action of tricyclic antidepressants has been studied and evidences have pointed that their action is linked to inhibition of trypanothione reductase, a key enzyme in the redox metabolism of pathogenic trypanosomes. Cyclobenzaprine (CBP) is a tricyclic structurally related to the antidepressant amitriptyline, differing only by the presence of a double bond in the central ring. This paper describes the effect of CBP in experimental visceral leishmaniasis, its inhibitory effect in trypanothione reductase and the potential immunomodulatory activity