Determinants of European tourism demand in a demographic ageing society

This study identifies the senior European tourists determinants that explained their decisions to go on holidays. The empirical study was conducted among European tourists by applying a logit model. The model intends to explain the determinants related to the decision to go on holidays since the probability of a senior European tourist taking holidays in a country depends on a mix of motives as previous travel experience and demographic characteristics. Policy and theoretical implications are derived for contributing to the discussion between demographic variables and tourism demand choice patterns.The authors are pleased to acknowledge financial support from FCT – The Portuguese National Funding Agency for Science, Research and Technology - COMPETE, FEDER, Portugal 2020 under the Project UID/HIS/00057/2013 (POCI-01-0145-FEDER-007702) - CIDEHU

Competencias de egreso en Ingeniería y requerimientos del sector metalmecánico del Conurbano bonaerense: determinación de índices de adecuación y de desarrollo en el mediano plazo

El Consejo Federal de Decanos de Ingeniería (CONFEDI) viene sosteniendo que la enseñanza como transferencia de conocimientos perdió espacio en la realidad actual, postura que está en sintonía con la aprobación en el año 2006 del documento que sintetiza las competencias genéricas de egreso del ingeniero argentino. A más de diez años de la aparición de dicho documento nos preguntamos cuál es la adecuación entre sus competencias y los requerimientos del mercado laboral, en particular del sector metalmecánico del conurbano de la provincia de Buenos Aires. El objetivo del trabajo fue establecer, a partir de la percepción de dicho sector empleador, tres niveles de adquisición de competencias: nivel observado (NO), nivel deseado (NMD) y nivel requerido en el futuro ‒en el mediano plazo‒ (NRF), para lo cual se trabajó con las medias para cada una de las capacidades asociadas definidas y a partir de estos resultados obtener dos indicadores que denominamos indicador de adecuación de la competencia (IAC) e indicador de desarrollo de la competencia (IDC). Los resultados alcanzados permiten advertir que si bien en todos los casos existen brechas, no todas las capacidades demandan la misma atención de desarrollo a futuro.Trabajo presentado por el Instituto de Investigaciones en Tecnología y Educación (IIT&E

Análisis de las causas de mortalidad en pacientes con enfermedades articulares inflamatorias crónicas y autoinmunes sistémicas en un hospital terciario entre 2011 y 2020

Los pacientes con enfermedades articulares inflamatorias crónicas y autoinmunes sistémicas tienen una esperanza de vida disminuida con respecto a la población general, con la que comparten la mayoría de las causas de muerte: enfermedad cardiovascular o cáncer. El objetivo es analizar cuáles son las causas de muerte en las diferentes enfermedades reumáticas en nuestra cohorte y, secundariamente, explorar los factores asociados a las mismas.Patients suffering from rheumatic diseases have a significantly decreased life expectancy, even though they share the same causes of death as the general population, such as heart disease or cancer. Our aim is to determine the causes of death in our sample and what factors may have been associated with it.Medicin

Asistencia al embarazo y parto en mujeres víctimas de mutilación genital femenina de Somalia

Titulación::Grado::Grado en EnfermeríaLa mutilación genital femenina, es una tradición que persiste a través del tiempo y que en algunos países representa un grave problema para las mujeres. Produce complicaciones físicas y psíquicas, la gran mayoría de ellas graves. Pero es durante el embarazo y el parto donde más peligra su salud. El objetivo de este proyecto es generar una guía que oriente a los profesionales de la enfermería. En el contexto de proporcionar cuidados durante el embarazo, parto y postparto, en mujeres con mutilación genital femenina tipo 3. El fin, será lograr reducir el número de complicaciones y mortalidad materna en Somalia. Para ello elaboraremos una serie de protocolos, que más tarde evaluaremos mediante una recogida de datos y análisis de resultados a lo largo de las intervenciones.Female genital mutilation is a tradition that persist through time and that in some countries represents a serious problem for women. This cause severe physique and psychological complications in the clear majority. But is during pregnancy where women's health can be more affected. The aim of this project is creating a guideline for nursing professionals. In the context of providing pregnancy, childbirth and postpartum cares in women with type 3 female genital mutilation. The purpose of the study will be to reduce the number of complications and maternal mortality in Somalia. To do this will be draft a series of protocols. Later assess trough a collection of data analysis of results throughout the interventions

Proteínas de unión a DNA metilado y cáncer: familia MBD (Methyl-CpG Binding Domain/)

Tesis Doctoral inédita leída en la Universidad Autónoma de Madrid, Facultad de Ciencias, Departamento de Biología Molecular. Fecha de lectura: 03-12-200

La resiliencia y el apoyo social como factores de protección del maltrato en personas con demencia: un estudio en cuidadores familiares

[ES] La literatura se tiene centrado más en identificar factores de riesgo asociados al maltrato a las personas mayores con demencia y poco sobre las variables de protección psicosocial de las experiencias de maltrato. Este estudio tiene como objetivo principal investigar un conjunto de factores del cuidador y el propio enfermo que pueden estar relacionados con el maltrato a personas mayores con demencia. Fueron evaluados un total de 326 cuidadores, principales y familiares, residentes en la comunidad de Castilla y León. Todos los participantes completaron un protocolo estandarizado que evaluó las características sociodemográficas, variables relacionadas con el enfermo y el cuidado, además de la sobrecarga percibida, resiliencia y apoyo social. El maltrato fue evaluado a través de la Caregiver Abuse Screen (CASE). Los resultados muestran que la intensidad del deterioro cognitivo y las alteraciones de conducta del anciano, un mayor número de horas de cuidado, una peor relación previa con el cuidador y la sobrecarga percibida se relacionan positivamente con el maltrato. No obstante, la resiliencia y el apoyo social mostraron una relación negativa con la puntuación en la CASE. Así, la resiliencia y el apoyo social tienen un efecto de protección sobre el maltrato, incluso tras controlar el efecto de diferentes covariables. Sin embargo, la resiliencia fue la única que se mantuvo significativa tras incluir el efecto de la sobrecarga. En conclusión, este trabajo confirma el papel de la sobrecarga en la aparición del maltrato, mientras que la resiliencia y el apoyo social son factores relacionados con la prevención. Estas variables deben ser consideradas en las guías de acción para la prevención del maltrato del anciano con demencia.[EN] Scientific literature has identified different risk factors associated to abuse in patients with dementia, but little is known about the psychosocial protective variables of abuse. The main objective of this study is to investigate a set of factors from the caregiver and the patient that can be related to abuse of patients with dementia. A total of 326 primary and family caregivers were evaluated, residents of the Castilla and León community. All participants filled out a standardized protocol, which assessed the sociodemographic characteristics, variables related to the patient and care, as well as the perceived burden, resilience and social support. Abuse was evaluated using the Caregiver Abuse Screen (CASE). Results show that the severity of cognitive impairment and behavior disorders of the patients, a greater number of caregiving hours, a worse previous relationship with the caregiver, and perceived burden are positively related with abuse. Nevertheless, resilience and social support showed a negative relationship with CASE scores, suggesting a protective effect on abuse, even after controlling the effect of a number of covariates. Indeed, resilience was the only variable that remained significant after including the effect of burden. In conclusion, this paper states the role of burden in abuse of patients with dementia, while resilience and social support are abuse protective factors. These variables should be considered in future guidelines for the prevention of abuse against patients with dementia

DIREITO SISTÊMICO E MERCOSUL

A Constelação Familiar é uma abordagem utilizada em toda América do Sul como forma de tratamento de conflitos nos mais diversos âmbitos.  A par disso, e considerando os conflitos que impedem o bom desenvolvimento do MERCOSUL, que entre as formas de solução de controvérsia prioriza a negociação direta entre as partes, busca-se analisar a possibilidade de aplicação do Direito sistêmico no âmbito do Mercado Comum do Sul. Para tanto, utiliza-se de pesquisa documental e bibliográfica por meio do método dedutivo, concluindo-se pela compatibilidade do Direito sistêmico como meio de tratamento de conflitos no âmbito internacional, em especial, no MERCOSUL

Carriage of Neisseria Meningitidis in Low and Middle Income Countries of the Americas and Asia: A Review of the Literature.

Funder: Pfizer IncINTRODUCTION: Meningococcal colonization, or carriage, can progress to invasive meningococcal disease, a serious public health concern, with rapid progression of disease and severe consequences if left untreated. Information on meningococcal carriage and epidemiology in low/middle income American and Asian countries remains sparse. These data are crucial to ensure that appropriate preventive strategies such as vaccination can be implemented in these regions. The goal of this study was to summarize the Neisseria meningitidis carriage literature in low and middle income countries of the Americas and Asia. METHODS: Target countries were categorized as low and middle income according to the International Monetary Fund classification of low income/developing economies and middle income/emerging market economies, respectively. A PubMed search identified English-language publications that examined carriage in these countries. Studies reporting the epidemiology of N. meningitidis carriage or assessing risk factors for carriage were included. RESULTS: Fourteen studies from the Americas [Brazil (n = 7), Chile (n = 3), and Colombia, Cuba, Mexico, and Paraguay (n = 1 each)] and nine from Asia [China (n = 2), India (n = 3), and Malaysia, Nepal, Philippines, and Thailand (n = 1 each)] were identified; an additional Cuban study from the authors' files was also included. Studies were not identified in many target countries, and substantial diversity was observed among study methodologies, populations, and time periods, thereby limiting comparison between studies. The carriage rate in the Americas ranged from 1.6% to 9.9% and from 1.4% to 14.2% in Asia. Consistent risk factors for carriage were not identified. CONCLUSIONS: There is a lack of comprehensive and contemporary information on meningococcal carriage in low and medium income countries of the Americas and Asia. Future carriage studies should incorporate larger representative populations, a wider age range, and additional countries to improve our understanding of meningococcal epidemiology and disease control

Carriage of Neisseria Meningitidis in Low and Middle Income Countries of the Americas and Asia: A Review of the Literature.

Funder: Pfizer IncINTRODUCTION: Meningococcal colonization, or carriage, can progress to invasive meningococcal disease, a serious public health concern, with rapid progression of disease and severe consequences if left untreated. Information on meningococcal carriage and epidemiology in low/middle income American and Asian countries remains sparse. These data are crucial to ensure that appropriate preventive strategies such as vaccination can be implemented in these regions. The goal of this study was to summarize the Neisseria meningitidis carriage literature in low and middle income countries of the Americas and Asia. METHODS: Target countries were categorized as low and middle income according to the International Monetary Fund classification of low income/developing economies and middle income/emerging market economies, respectively. A PubMed search identified English-language publications that examined carriage in these countries. Studies reporting the epidemiology of N. meningitidis carriage or assessing risk factors for carriage were included. RESULTS: Fourteen studies from the Americas [Brazil (n = 7), Chile (n = 3), and Colombia, Cuba, Mexico, and Paraguay (n = 1 each)] and nine from Asia [China (n = 2), India (n = 3), and Malaysia, Nepal, Philippines, and Thailand (n = 1 each)] were identified; an additional Cuban study from the authors' files was also included. Studies were not identified in many target countries, and substantial diversity was observed among study methodologies, populations, and time periods, thereby limiting comparison between studies. The carriage rate in the Americas ranged from 1.6% to 9.9% and from 1.4% to 14.2% in Asia. Consistent risk factors for carriage were not identified. CONCLUSIONS: There is a lack of comprehensive and contemporary information on meningococcal carriage in low and medium income countries of the Americas and Asia. Future carriage studies should incorporate larger representative populations, a wider age range, and additional countries to improve our understanding of meningococcal epidemiology and disease control

Mecp2-null mice provide new neuronal targets for Rett syndrome

BACKGROUND: Rett syndrome (RTT) is a complex neurological disorder that is one of the most frequent causes of mental retardation in women. A great landmark in research in this field was the discovery of a relationship between the disease and the presence of mutations in the gene that codes for the methyl-CpG binding protein 2 (MeCP2). Currently, MeCP2 is thought to act as a transcriptional repressor that couples DNA methylation and transcriptional silencing. The present study aimed to identify new target genes regulated by Mecp2 in a mouse model of RTT. METHODOLOGY/PRINCIPAL FINDINGS: We have compared the gene expression profiles of wild type (WT) and Mecp2-null (KO) mice in three regions of the brain (cortex, midbrain, and cerebellum) by using cDNA microarrays. The results obtained were confirmed by quantitative real-time PCR. Subsequent chromatin immunoprecipitation assays revealed seven direct target genes of Mecp2 bound in vivo (Fkbp5, Mobp, Plagl1, Ddc, Mllt2h, Eya2, and S100a9), and three overexpressed genes due to an indirect effect of a lack of Mecp2 (Irak1, Prodh and Dlk1). The regions bound by Mecp2 were always methylated, suggesting the involvement of the methyl-CpG binding domain of the protein in the mechanism of interaction. CONCLUSIONS: We identified new genes that are overexpressed in Mecp2-KO mice and are excellent candidate genes for involvement in various features of the neurological disease. Our results demonstrate new targets of MeCP2 and provide us with a better understanding of the underlying mechanisms of RTT