Scalable Dashboard for Identifying Split Failures and Heuristic for Reallocating Split Times

The three fundamental parameters of a traffic signal system are split, cycle, and offset. This paper describes the use of high-resolution data (a) to identify time periods during which split parameters may be insufficient and (b) to help practitioners identify opportunities for reallocating split time. A case study of seven corridors with 47 intersections is presented. A drill-down approach was developed to identify movements that could be improved by a reallocation of split times. A heuristic that can reallocate up to 5 seconds of underutilized green time on a competing phase was applied to those corridors. For the selected phase identified in this study, the adjustment reduced split failures by an average of 40% while also decreasing yellow occupancy an average of 40% and red light violations an average of 66%. The paper concludes by recommending that central systems implement drill-down dashboards. Such tools would enable easy identification and systemwide monitoring of split failures and would provide opportunities to reallocate slack time

Sentinel Case of Candida auris in the Western United States Following Prolonged Occult Colonization in a Returned Traveler from India.

Candida auris is an emerging multidrug-resistant yeast with high mortality. We report the sentinel C. auris case on the United States West Coast in a patient who relocated from India. We identified close phylogenetic relatedness to the South Asia clade and ERG11 Y132F and FKS1 S639Y mutations potentially explaining antifungal resistance

Deprojection technique for galaxy cluster considering point spread function

We present a new method for the analysis of Abell 1835 observed by XMM-Newton. The method is a combination of the Direct Demodulation technique and deprojection. We eliminate the effects of the point spread function (PSF) with the Direct Demodulation technique. We then use a traditional depro-jection technique to study the properties of Abell 1835. Compared to that of deprojection method only, the central electron density derived from this method increases by 30%, while the temperature profile is similar.Comment: accepted for publication in Sciences in China -- G, the Black Hole special issu

Detector-Free Optimization of Traffic Signal Offsets with Connected Vehicle Data

It has recently been shown that signal offset optimization is feasible using vehicle trajectory data at low levels of market penetration. This study performs offset optimization on two corridors using this type ofdata. Six weeks oftrajectory splines were processed for two corridors including 25 signalized intersections, in order to create vehicle arrival profiles, using a proposed procedure called virtual detection. After processing and filtering the data, penetration rates between 0.09-0.80% were observed, varying by approach. The arrival profiles were statistically compared against those measured with physical detectors, with the majority of the approaches showing statistically significant goodness-of-fit at a 90% confidence level. Finally, the virtual detection arrival profiles were used to optimize offsets, and compared against a solution derived from physical detector arrival profiles. The results demonstrate that virtual detection can produce good quality offsets with current market penetration rates of probe data. The study also includes a sensitivity analysis to the sample period, which shows that two weeks of data may be sufficient for data collection at current penetration rates

Real-Time Probe Data Dashboard for Monitoring Detour Route during I-65 N Road Closure

On August 7, 2015, a 37 mile stretch of I-65 N from MM 141 to 178 was closed due to a structural evaluation of a bridge. Traffic was detoured onto US-52, SR-26, and US-231 before returning to the highway. In order to monitor delay and congestion on the detour route, a real-time dashboard was implemented in the style of the interstate Traffic Ticker. Throughout the detour, this website was used to monitor congestion in real time and measure the impact of mitigation actions. The improvement in travel can be seen from the addition of temporary signals, retiming of the US-231 corridor, and conversion of US-231 and SR-18 to a two-way stop

Therapeutic potential of delivering arsenic trioxide into HPV-infected cervical cancer cells using liposomal nanotechnology

Arsenic trioxide (ATO) has been used successfully to treat acute promyelocytic leukaemia, and since this discovery, it has also been researched as a possible treatment for other haematological and solid cancers. Even though many positive results have been found in the laboratory, wider clinical use of ATO has been compromised by its toxicity at higher concentrations. The aim of this study was to explore an improved method for delivering ATO using liposomal nanotechnology to evaluate whether this could reduce drug toxicity and improve the efficacy of ATO in treating human papillomavirus (HPV)-associated cancers. HeLa, C33a, and human keratinocytes were exposed to 5 μm of ATO in both free and liposomal forms for 48 h. The stability of the prepared samples was tested using inductively coupled plasma optical emission spectrometer (ICP-OES) to measure the intracellular arsenic concentrations after treatment. Fluorescent double immunocytochemical staining was carried out to evaluate the protein expression levels of HPV-E6 oncogene and caspase-3. Cell apoptosis was analysed by flow cytometry. Results showed that liposomal ATO was more effective than free ATO in reducing protein levels of HPV-E6 and inducing cell apoptosis in HeLa cells. Moreover, lower toxicity was observed when liposomal-delivered ATO was used. This could be explained by lower intracellular concentrations of arsenic. The slowly accumulated intracellular ATO through liposomal delivery might act as a reservoir which releases ATO gradually to maintain its anti-HPV effects. To conclude, liposome-delivered ATO could protect cells from the direct toxic effects induced by higher concentrations of intracellular ATO. Different pathways may be involved in this process, depending on local architecture of the tissues and HPV status

TYC 2675-663-1: A newly discovered W UMa system in an active state

The recently discovered eclipsing binary system TYC 2675-663-1 is a X-ray source, and shows properties in the optical that are similar to the W UMa systems, but are somewhat unusual compared to what is seen in other contact binary systems. The goal of this work is to characterize its properties and investigate its nature by means of detailed photometric and spectroscopic observations. We have performed extensive V-band photometric measurements with the INTEGRAL satellite along with ground-based multi-band photometric observations, as well as high-resolution spectroscopic monitoring from which we have measured the radial velocities of the components. These data have been analysed to determine the stellar properties, including the absolute masses and radii. Additional low-resolution spectroscopy was obtained to investigate spectral features. From the measured eclipse timings we determine an orbital period for the binary of P=0.4223576+-0.0000009 days. The light-curve and spectroscopic analyses reveal the observations to be well represented by a model of an overcontact system composed of main-sequence F5 and G7 stars (temperature difference of nearly 1000 K), with the possible presence of a third star. Low-resolution optical spectroscopy reveals a complex H alpha emission, and other features that are not yet understood. The unusually large mass ratio of q=0.81+-0.05 places it in the rare "H" (high mass ratio) subclass of the W UMa systems, which are presumably on their way to coalescence.Comment: 12 pages in double column format. Accepted for publication in Astronomy and Astrophysic

Ultraviolet Spectroscopy of Asteroid (4) Vesta

We report a comprehensive review of the UV-visible spectrum and rotational lightcurve of Vesta combining new observations by Hubble Space Telescope and Swift Gamma-ray Burst Observatory with archival International Ultraviolet Explorer observations. The geometric albedos of Vesta from 220 nm to 953 nm are derived by carefully comparing these observations from various instruments at different times and observing geometries. Vesta has a rotationally averaged geometric albedo of 0.09 at 250 nm, 0.14 at 300 nm, 0.26 at 373 nm, 0.38 at 673 nm, and 0.30 at 950 nm. The linear spectral slope as measured between 240 and 320 nm in the ultraviolet displays a sharp minimum near a sub-Earth longitude of 20^{\circ}, and maximum in the eastern hemisphere. This is consistent with the longitudinal distribution of the spectral slope in the visible wavelength. The photometric uncertainty in the ultraviolet is ~20%, and in the visible wavelengths it is better than 10%. The amplitude of Vesta's rotational lightcurves is ~10% throughout the range of wavelengths we observed, but is smaller at 950 nm (~6%) near the 1-\mum band center. Contrary to earlier reports, we found no evidence for any difference between the phasing of the ultraviolet and visible/near-infrared lightcurves with respect to sub-Earth longitude. Vesta's average spectrum between 220 and 950 nm can well be described by measured reflectance spectra of fine particle howardite-like materials of basaltic achondrite meteorites. Combining this with the in-phase behavior of the ultraviolet, visible, and near-infrared lightcurves, and the spectral slopes with respect to the rotational phase, we conclude that there is no global ultraviolet/visible reversal on Vesta. Consequently, this implies a lack of global space weathering on Vesta, as previously inferred from visible-near-infrared data.Comment: 44 pages, 5 figures, 1 tabl

Measuring Coverage in MNCH:A Validation Study Linking Population Survey Derived Coverage to Maternal, Newborn, and Child Health Care Records in Rural China

Accurate data on coverage of key maternal, newborn, and child health (MNCH) interventions are crucial for monitoring progress toward the Millennium Development Goals 4 and 5. Coverage estimates are primarily obtained from routine population surveys through self-reporting, the validity of which is not well understood. We aimed to examine the validity of the coverage of selected MNCH interventions in Gongcheng County, China.We conducted a validation study by comparing women's self-reported coverage of MNCH interventions relating to antenatal and postnatal care, mode of delivery, and child vaccinations in a community survey with their paper- and electronic-based health care records, treating the health care records as the reference standard. Of 936 women recruited, 914 (97.6%) completed the survey. Results show that self-reported coverage of these interventions had moderate to high sensitivity (0.57 [95% confidence interval (CI): 0.50-0.63] to 0.99 [95% CI: 0.98-1.00]) and low to high specificity (0 to 0.83 [95% CI: 0.80-0.86]). Despite varying overall validity, with the area under the receiver operating characteristic curve (AUC) ranging between 0.49 [95% CI: 0.39-0.57] and 0.90 [95% CI: 0.88-0.92], bias in the coverage estimates at the population level was small to moderate, with the test to actual positive (TAP) ratio ranging between 0.8 and 1.5 for 24 of the 28 indicators examined. Our ability to accurately estimate validity was affected by several caveats associated with the reference standard. Caution should be exercised when generalizing the results to other settings.The overall validity of self-reported coverage was moderate across selected MNCH indicators. However, at the population level, self-reported coverage appears to have small to moderate degree of bias. Accuracy of the coverage was particularly high for indicators with high recorded coverage or low recorded coverage but high specificity. The study provides insights into the accuracy of self-reports based on a population survey in low- and middle-income countries. Similar studies applying an improved reference standard are warranted in the future