Compliance with legal minimum wages and overtime pay regulations in China

A matched firm-employee data set is used to examine the extent of compliance with minimum wage and overtime pay regulations in Chinese formal sector firms. Evidence shows that there is broad compliance with legal minimum wages in China; fewer than 3.5% of full-time workers earn less than the legal monthly minimum wage. On the other hand, there is substantial non-compliance with overtime pay regulations; almost 29% of the employees who work overtime are not paid any additional wage for overtime hours, and 70% are paid less than the legally-required 1.5 times the regular wage

Research on Water Absorption and Frost Resistance of Concrete Coated with Different Impregnating Agents for Ballastless Track Structure

In consideration of performance requirement of ballastless track concrete in cold regions of China, 3 types of commercially available impregnating agents were employed to research their effect on water absorption and frozen resistance of concrete, containing silanes, potassium silicate and osmotic curing agent. The results presented that coating silanes was the most effective on the reduction of water absorption among all employed impregnating agents, because of the most significant character change of concrete surface from hydrophilicity to hydrophobicity which could be proved by the contact angle test of concrete. The promotion on frozen resistance of concrete was not as significant as that for water absorption by coating 3 commercially available types of impregnant agents, because of the spalling damage on concrete surface during the freezing-thawing cycles

Understanding impacts of minimum wage policy on labor market in China

PowerPoint presentationPart of the project “Labour Market Regulations in China: Minimum Wage Policy,” this presentation draws conclusions from the study indicating that the process is largely driven by political competition of local governments at city and provincial level, in response to the appeal of the central government for raising wage share in national income. However, there are few studies about effects of minimum wages on skills, prices and profits. Controversial findings of effects on wage and income increase, working hours, and inequality are provided and discussed. Minimum wages are generally set at a low level by regional governments with no strong incentive to implement any, and no enforcement

Role and potential therapeutic value of histone methyltransferases in drug resistance mechanisms in lung cancer

Lung cancer, ranking second globally in both incidence and high mortality among common malignant tumors, presents a significant challenge with frequent occurrences of drug resistance despite the continuous emergence of novel therapeutic agents. This exacerbates disease progression, tumor recurrence, and ultimately leads to poor prognosis. Beyond acquired resistance due to genetic mutations, mounting evidence suggests a critical role of epigenetic mechanisms in this process. Numerous studies have indicated abnormal expression of Histone Methyltransferases (HMTs) in lung cancer, with the abnormal activation of certain HMTs closely linked to drug resistance. HMTs mediate drug tolerance in lung cancer through pathways involving alterations in cellular metabolism, upregulation of cancer stem cell-related genes, promotion of epithelial-mesenchymal transition, and enhanced migratory capabilities. The use of HMT inhibitors also opens new avenues for lung cancer treatment, and targeting HMTs may contribute to reversing drug resistance. This comprehensive review delves into the pivotal roles and molecular mechanisms of HMTs in drug resistance in lung cancer, offering a fresh perspective on therapeutic strategies. By thoroughly examining treatment approaches, it provides new insights into understanding drug resistance in lung cancer, supporting personalized treatment, fostering drug development, and propelling lung cancer therapy into novel territories

Inhibition of IRAK 1/4 alleviates colitis by inhibiting TLR4/ NF-κB pathway and protecting the intestinal barrier

Interleukin-1 receptor-associated kinase 1/4 (IRAK1/4) is the main kinase of the Toll-like receptor (TLR)-mediated pathway, considered a new target for treating inflammatory diseases. Studies showed a significant correlation between TLRs and inflammatory responses in ulcerative colitis (UC). Therefore, in this study, after inducing experimental colitis in mice with 3% dextran sulfate sodium (DSS), different concentrations of IRAK1/4 inhibitors were administered intraperitoneally. Then, the disease activity index was assessed, including the degree of pathological damage, by HE staining. Subsequently, while western blotting detected the TLR4/NF-κB pathway and intestinal barrier protein expression (Zonula-1, Occludin, Claudin-1, JAM-A), real-time polymerase chain reaction (RT-PCR) detected the mRNA expression levels of IRAK1/4 and mucin1/2. Furthermore, the expression levels of Zonula-1 and occludin were detected by immunofluorescence, including the plasma FITC-dextran 4000 concentration, to evaluate intestinal barrier permeability. However, ELISA measured the expression of inflammatory factors to reflect intestinal inflammation in mice. Investigations showed that the IRAK 1/4 inhibitor significantly reduced clinical symptoms and pathological DSS-induced colitis damage in mice and then inhibited the cytoplasmic and nuclear translocation of NF-κB p65, including the phosphorylation of IκBα and reduction in downstream inflammatory factor production. Therefore, we established that the IRAK1/4 inhibitor effectively improves colitis induced by DSS, partly by inhibiting the TLR4/NF-κB pathway, reducing inflammation, and maintaining the integrity of the colonic barrier

Insight on the fundamentals of advanced oxidation processes. Role and review of the determination methods of reactive oxygen species

Advanced oxidation processes (AOPs) have known increased application to treat wastewaters containing recalcitrant compounds that are hardly degraded by conventional technologies. AOPs are characterized by the formation of strong oxidants such as hydroxyl radicals, superoxide anions, hydroperoxyl radicals and singlet oxygen, which react with the contaminant, contributing to its degradation. This paper provides an overview of the determination methods of reactive oxygen species, ROS, in the application of AOPs; the methods developed in the available literature for the detection and quantification of ROS are reviewed as a first step in the assessment and detailed description of the mechanisms involved in the oxidation reactions, focusing on the critical analysis of the main strengths and weaknesses presented by the probe molecules employed in the evaluated studies.This research was supported by the Ministry of Economy and Competitiveness (MINECO/SPAIN) and European Regional Development Fund (ERDF) under the project CTQ2011-25262

Investigation on the Injection Pattern of Intermittent Natural Gas Flooding in Ultra-Low Permeability Reservoirs

Natural gas is a viable oil displacement agent in ultra-low-permeability reservoirs due to its good fluidity. It can also cause gas channeling during continuous injection, which limits its oilfield application. In order to relieve gas channeling during natural gas flooding, the injection mode should be changed. The use of intermittent natural gas injection (IGI) after the continuous natural gas injection in an ultra-low-permeability reservoir is proposed, and optimization of the injection parameters is discussed. The results show that IGI can be divided into three stages, the gas injection stage, the well shutting stage and the oil production stage. With the increase in injection time, the oil recovery enhances obviously as a result of IGI because the gas fingering can be controlled at the well shutting stage, and the gas/liquid ratio grows slowly because the gas breakthrough can be reduced at the oil production stage. The oil recovery improves with the increase in cycle time of IGI, while the increase rate reduces evidently after the cycle time reaches 360 min. The oil recovery increment is low if the cycle index exceeds 3 in the ultra-low-permeability reservoir. Thus, the optimal cycle time for each round and the appropriate cycle index of IGI are 360 min and three rounds

LncRNA MIR100HG affects the proliferation and metastasis of lung cancer cells through mediating the microRNA‐5590‐3p/DCBLD2 axis

Abstract Objective The aim of this paper is to investigate the effect of long noncoding RNA (lncRNA) MIR100HG on the proliferation and metastasis of lung cancer cells by mediating the microRNA (miR)−5590‐3p/DCBLD2 axis. Methods RNA levels of MIR100HG, miR‐5590‐3p, and DCBLD2 in lung cancer tissues and cells were detected by quantitative reverse‐transcription polymerase chain reaction, and protein level was assessed by Western blot. Effects of MIR100HG or miR‐5590‐3p on proliferation, migration, and invasion of lung cancer cells were detected by Cell Counting Kit‐8, colony formation, and Transwell assays. Luciferase reporter assay and RNA‐immunoprecipitation assay confirmed the target relationship between miR‐5590‐3p and MIR100HG or DCBLD2. Results MIR100HG and DCBLD2 were highly expressed, while miR‐5590‐3p was lowly expressed in lung cancer tissues and cells. Silencing MIR100HG or upregulating miR‐5590‐3p impeded lung cancer cell proliferation, migration, and invasion. MIR100HG could up‐regulate DCBLD2 by sponging miR‐5590‐3p. Downregulation of miR‐5590‐3p partly overturned the suppressive effect of silencing MIR100HG on lung cancer cell proliferation and metastasis, and overexpression of DCBLD2 also reversed the effect of overexpression of miR‐5590‐3p on lung cancer cell proliferation and metastasis. Conclusion LncRNA MIR100HG promotes lung cancer progression by targeting and negatively regulating DCBLD2 through binding with miR‐5590‐3p

Dependence of Thermal Stability on Molecular Structure of RAFT/MADIX Agents : A Kinetic and Mechanistic Study

The thermal decomposition of different classes of RAFT/MADIX agents, namely dithioesters, trithiocarbonates, xanthates, and dithiocarbamates, were investigated through heating in solution. It was found that the decomposition behavior is complicated interplay of the effects of stabilizing Z-group and leaving R-group. The mechanism of the decomposition is mainly through three pathways, i.e., ?-elimination, α-elimination, and homolysis of dithiocarbamate (particularly for universal RAFT agent). The most important pathway is the ?-elimination of thiocarbonylthio compounds possessing ?-hydrogen, leading to the formation unsaturated species. For the leaving group containing solely α-hydrogen, such as benzyl, α-elimination takes place, resulting in the formation of (E)-stilbene through a carbene intermediate. Homolysis occurs specifically in the case of a universal RAFT agent, in which a thiocarbonyl radical and an alkylthio radical are generated, finally forming thiolactone through a radical process. The stabilities of the RAFT/MADIX agents are investigated by measuring the apparent kinetics and activation energy of the thermal decomposition reactions. Both Z-group and R-group influence the stability of the agents through electronic and steric effects. Lone pair electron donating heteroatoms of Z-group show a remarkable stabilizing effect while electron withdrawing substituents, either in Z- or R-group, tends to destabilize the agent. In addition, bulkier or more ?-hydrogens result in faster decomposition rate or lower decomposition temperature. Thus, the stability of the RAFT/MAIDX agents decreases in the order where R is (with identical Z = phenyl) ?CH2Ph (5) > ?PS (PS-RAFT 15) > ?C(Me)HPh (2) > ?C(Me)2C(═O)OC2H5 (7) > ?C(Me)2Ph(1) > ?PMMA (PMMA-RAFT 16) > ?C(Me)2CN (6). For those possessing identical leaving group such as 1-phenylethyl, the stability decreases in the order of O-ethyl (11) > ?N(CH2CH3)2 (13) > ?SCH(CH3)Ph (8) > ?Ph (2) > ?CH2Ph (4) > ?PhNO2 (3). These results consort with the chain transfer acitivities measured by the CSIRO group and agree well with the ab initio theoretical results by Coote. In addition, the difference between thermal stabilities of the universal RAFT agents at neutral and protonated states has also been demonstrated. The thermal decomposition of different classes of RAFT/MADIX agents, namely dithioesters, trithiocarbonates, xanthates, and dithiocarbamates, were investigated through heating in solution. It was found that the decomposition behavior is complicated interplay of the effects of stabilizing Z-group and leaving R-group. The mechanism of the decomposition is mainly through three pathways, i.e., ?-elimination, α-elimination, and homolysis of dithiocarbamate (particularly for universal RAFT agent). The most important pathway is the ?-elimination of thiocarbonylthio compounds possessing ?-hydrogen, leading to the formation unsaturated species. For the leaving group containing solely α-hydrogen, such as benzyl, α-elimination takes place, resulting in the formation of (E)-stilbene through a carbene intermediate. Homolysis occurs specifically in the case of a universal RAFT agent, in which a thiocarbonyl radical and an alkylthio radical are generated, finally forming thiolactone through a radical process. The stabilities of the RAFT/MADIX agents are investigated by measuring the apparent kinetics and activation energy of the thermal decomposition reactions. Both Z-group and R-group influence the stability of the agents through electronic and steric effects. Lone pair electron donating heteroatoms of Z-group show a remarkable stabilizing effect while electron withdrawing substituents, either in Z- or R-group, tends to destabilize the agent. In addition, bulkier or more ?-hydrogens result in faster decomposition rate or lower decomposition temperature. Thus, the stability of the RAFT/MAIDX agents decreases in the order where R is (with identical Z = phenyl) ?CH2Ph (5) > ?PS (PS-RAFT 15) > ?C(Me)HPh (2) > ?C(Me)2C(═O)OC2H5 (7) > ?C(Me)2Ph(1) > ?PMMA (PMMA-RAFT 16) > ?C(Me)2CN (6). For those possessing identical leaving group such as 1-phenylethyl, the stability decreases in the order of O-ethyl (11) > ?N(CH2CH3)2 (13) > ?SCH(CH3)Ph (8) > ?Ph (2) > ?CH2Ph (4) > ?PhNO2 (3). These results consort with the chain transfer acitivities measured by the CSIRO group and agree well with the ab initio theoretical results by Coote. In addition, the difference between thermal stabilities of the universal RAFT agents at neutral and protonated states has also been demonstrated