An Integrated Study of the Morphological and Gross-Elemental Consequences of Methyl Mercury Intoxication in Rats, with Particular Attention on the Cerebellum

Methylmercury accumulates in the kidney and liver of rats, but fairly selectively damages the cerebellum, resulting in the clinical symptoms of neurological ataxia after prolonged exposures. Within the cerebellum, morphological examination indicated that the small granule cells beneath the Purkinje layer are especially susceptible to the toxin, showing signs of pyknosis during the phase of locomotory disability, whilst the large Purkinje cells are relatively resistant to cytotoxic injury. Flame photometric and electron probe X-ray microanalysis (EPXMA) of digested samples of the major organs failed to detect any significant changes in the Na, K, Ca, Mg, S and P concentrations of the organs, including the cerebellum, at intervals after methylmercury administration by either gastric gavage or via the drinking water. It was suggested that if the lesion within the cerebellum is restricted, as the morphological evidence suggests, to a small cohort of functionally important granule cells, then it may be difficult to detect elemental changes within this subpopulation against the compositionally unaltered majority of cerebellar cells and their extracellular spaces. To identify and compositionally characterize the injured cells requires electron probe X-ray microanalysis of frozen sections, or fractured bulk samples. The deep-seated nature of the \u27target cells\u27 within the cerebellum presents formidable cryopreparative problems

Guided Conversations: Findings and Social Impact

This is the final version.European Regional Development Fund (ERDF

Economies of space and the school geography curriculum

This paper is about the images of economic space that are found in school curricula. It suggests the importance for educators of evaluating these representations in terms of the messages they contain about how social processes operate. The paper uses school geography texts in Britain since the 1970s to illustrate the different ways in which economic space has been represented to students, before exploring some alternative resources that could be used to provide a wider range of representations of economic space. The paper highlights the continued importance of understanding the politics of school knowledge

Indoor environment sensor systems for healthier homes: a feasibility study in social housing

This is the final version. Available on open access from Routledge via the DOI in this recordThis study examines the feasibility of using an indoor environment sensor system to improve property management and health in social housing. Over a 6-year period, sensors were installed and maintained in 280 homes to monitor temperature, humidity, and air quality, with the sensor data provided to residents and the Housing Association (HA) through co-designed dashboards. Employing a mixed method sequential research design, feasibility was evaluated using the RE-AIM model. From the residents’ perspective, monitoring the indoor environment was acceptable, but adoption rates of the dashboard were low and there was minimal evidence of its effectiveness in prompting changes in behavior. From the HA perspective, the system proved effective in identifying high-risk homes, prompting the HA to reach out to vulnerable residents, and provide more timely support and maintenance. The system also facilitated long-term monitoring, planning, and helped the HA achieve its social objectives and legislative responsibilities. Despite initial technical challenges, HA staff expressed a desire to continue using the system, integrate it with existing infrastructure, and expand its deployment to more homes. However, scaling the intervention would require careful planning. In conclusion, sensor systems are a feasible intervention that holds promise in helping to address health risks in underserved communities.European Regional Development Fund (ERDF)Engineering and Physical Sciences Research Council (EPSRC

Commentary 2: The devil is in the detail – lies, damned lies and accounting for the value of banking [part of Book review symposium: Locating banks, tracking money]

Not applicabl

‘The price is different depending on whether you want a receipt or not’: examining the purchasing of goods and services from the informal economy in South-East Europe

Research on the informal economy has largely focussed on supply-side issues, addressing questions like what motivates individuals to work in the informal economy and how can governments tackle this phenomenon. To date, much less attention has been given to demand-side aspects, examining issues around who purchases goods and services from the informal economy, why, and to what extent there are variations according to demographic, socio-economic and geographic dimensions. This paper addresses this imbalance by examining the purchasing of goods and services from the informal economy in South-East Europe. Firstly, this paper identifies the prevalence of such informal purchasing in South-East Europe as well as who undertakes such purchasing. Next, it examines the relative significance of cost factors, social factors and failures in the formal economy, in motivating such purchasing. Finally, it explores variability in the significance of these motivators based on individual-level factors, within and across three South-East European countries

Trust in financial services: Retrospect and prospect

Fostering and maintaining high levels of trust in the financial services sector is seen as crucial because of the characteristics of many financial service and in order to promote consumer engagement in the sector. In this article, we report evidence from a body of work and other commentary to provide an insight into trends in consumer trust in the sector as a whole, in comparison with other organisations and how different types of financial services provider have performed relative to each other. We show that the financial services sector as a whole is trusted more than some comparator institutions, and that aggregate levels of trust in the sector have fluctuated a relatively small amount subsequent to the financial crisis. However, important differences between provider types are apparent and these differences have become more profound in the recent past. We provide suggestions as to how trust in the sector may be improved and provider an analysis of current initiatives to improve trust levels in the sector in general and in banking in particular

The potential of trading activity income to fund third sector organisations operating in deprived areas

In the United Kingdom, as in other countries, Third Sector Organisations (TSOs) have been drawn towards income sources associated with trading activities (Teasdale, 2010), but many remain reliant on grant funding to support such activities (Chell, 2007). Using a multivariate analysis approach and data from the National Survey of Charities and Social Enterprises (NSCSE), it is found that trading activities are used relatively commonly in deprived areas. These organisations are also more likely to attempt to access public sector funds. This suggests policy-makers need to consider the impact of funding cuts on TSOs in the most deprived areas as TSOs are unlikely achieve their objectives without continuing support

Reproducing the City of London’s institutional landscape: the role of education and the learning of situated practices by early career elites

In this paper we argue that postgraduate education forms an important, but hitherto neglected, element in the distinctive institutional landscape of the City of London. In particular, and drawing on research into early-career financial and legal elites in the City, we show how postgraduate education tailored to the demands of employers within London plays an important role in indoctrinating early-career elites into situated, Cityspecific, working practices and, in so doing, helps to sustain the City’s cultures and norms of financial practice. Specifying the role of postgraduate education in reproducing these situated City practices is significant because, although geographical variegation in working practices between international financial centres has been widely reported, less attention has been paid to how such institutionally embedded differences are created and sustained. By identifying education as one mechanism of creation and sustenance, our analysis enhances understanding of how the institutional landscapes that underlie financial centres might be maintained or, when necessary, challenged; challenge being significant in relation to attempts to reform practices and cultures in international financial centres in the wake of the 2007–08 crisis