238 research outputs found

    Epidemiologic Relationship between Toscana Virus Infection and Leishmania infantum Due to Common Exposure to Phlebotomus perniciosus Sandfly Vector

    Get PDF
    Sand flies are recognised vectors of parasites in the genus Leishmania and a number of arthropod-borne viruses, in particular viruses within the genus Phlebovirus, family Bunyaviridae. In southern France, Toscana phlebovirus (TOSV) is recognized as a prominent cause of summer meningitis. Since Leishmania and TOSV have a common vector (Phlebotomus perniciosus), an epidemiologic link has been assumed for a long time. However, there is no scientific evidence of such a link between human leishmaniosis and phleboviral infections. To identify a possible link, we investigated the presence and distribution of antibodies against these two microorganisms (i) in individuals and (ii) at a spatial level in the city of Marseille (south-eastern France). Five hundred sera were selected randomly in the biobank of the Department of Parasitology of the Public Hospitals of Marseille. All sera were previously tested for IgG against Leishmania by Western Blotting, and TOSV IgG were detected by indirect immunofluorescence. The seropositivity rates were 21.4% for TOSV and 28% for Leishmania. Statistical analysis demonstrated that seropositivity for one pathogen was significantly associated with seropositivity to the other pathogen. This result provided the first robust evidence for the existence of an epidemiological relationship between Leishmania infantum and TOSV. Addresses of tested patients were geolocalized and integrated into Geographical Information System software, in order to test spatial relationship between the two pathogens. Spatial analysis did not allow to identify (i) specific patterns for the spatial distribution of positive serological results for TOSV or Leishmania, and (ii) a spatial relationship between Leishmania and TOSV positive serological results. This may reflect the fact that the sample studied was not powerful enough to demonstrate either a spatial clustering or co-location, i.e. that the actual risk exposure area is smaller than the mean of distance between patients in our study (245 m)

    A Mixed Blessing: Market-Mediated Religious Authority in Neopaganism

    Get PDF
    This research explores how marketplace dynamics affect religious authority in the context of Neopagan religion. Drawing on an interpretivist study of Wiccan practitioners in Italy, we reveal that engagement with the market may cause considerable, ongoing tensions, based on the inherent contradictions that are perceived to exist between spirituality and commercial gain. As a result, market success is a mixed blessing that can increase religious authority and influence, but is just as likely to decrease authority and credibility. Using an extended case study method, we propose a theoretical framework that depicts the links between our informants’ situated experiences and the macro-level factors affecting religious authority as it interacts with market-mediated dynamics at the global level. Overall, our study extends previous work in macromarketing that has looked at religious authority in the marketplace) and how the processes of globalization are affecting religion

    A historical overview of the classification, evolution, and dispersion of Leishmania parasites and sandflies

    Get PDF
    Background The aim of this study is to describe the major evolutionary historical events among Leishmania, sandflies, and the associated animal reservoirs in detail, in accordance with the geographical evolution of the Earth, which has not been previously discussed on a large scale. Methodology and Principal Findings Leishmania and sandfly classification has always been a controversial matter, and the increasing number of species currently described further complicates this issue. Despite several hypotheses on the origin, evolution, and distribution of Leishmania and sandflies in the Old and New World, no consistent agreement exists regarding dissemination of the actors that play roles in leishmaniasis. For this purpose, we present here three centuries of research on sandflies and Leishmania descriptions, as well as a complete description of Leishmania and sandfly fossils and the emergence date of each Leishmania and sandfly group during different geographical periods, from 550 million years ago until now. We discuss critically the different approaches that were used for Leishmana and sandfly classification and their synonymies, proposing an updated classification for each species of Leishmania and sandfly. We update information on the current distribution and dispersion of different species of Leishmania (53), sandflies (more than 800 at genus or subgenus level), and animal reservoirs in each of the following geographical ecozones: Palearctic, Nearctic, Neotropic, Afrotropical, Oriental, Malagasy, and Australian. We propose an updated list of the potential and proven sandfly vectors for each Leishmania species in the Old and New World. Finally, we address a classical question about digenetic Leishmania evolution: which was the first host, a vertebrate or an invertebrate? Conclusions and Significance We propose an updated view of events that have played important roles in the geographical dispersion of sandflies, in relation to both the Leishmania species they transmit and the animal reservoirs of the parasites

    Basic notions of information structure

    Get PDF
    This article takes stock of the basic notions of Information Structure (IS). It first provides a general characterization of IS — following Chafe (1976) — within a communicative model of Common Ground(CG), which distinguishes between CG content and CG management. IS is concerned with those features of language that concern the local CG. Second, this paper defines and discusses the notions of Focus (as indicating alternatives) and its various uses, Givenness (as indicating that a denotation is already present in the CG), and Topic (as specifying what a statement is about). It also proposes a new notion, Delimitation, which comprises contrastive topics and frame setters, and indicates that the current conversational move does not entirely satisfy the local communicative needs. It also points out that rhetorical structuring partly belongs to IS.Peer Reviewe

    H and Cl isotope characteristics of indigenous and late hydrothermal fluids on the differentiated asteroidal parent body of Grave Nunataks 06128

    Get PDF
    The paired achondrites Graves Nunataks (GRA) 06128 and 06129 are samples of an asteroid that underwent partial melting within a few million years after the start of Solar System formation. In order to better constrain the origin and processing of volatiles in the early Solar System, we have investigated the abundance of H, F and Cl and the isotopic composition of H and Cl in phosphates in GRA 06128 using secondary ion mass spectrometry. Indigenous H in GRA 06128, as recorded in magmatic merrillite, is characterised by an average δD of ca. -152 ± 330‰, which is broadly similar to estimates of the H isotope composition of indigenous H in other differentiated asteroidal and planetary bodies such as Mars, the Moon and the angrite and eucrite meteorite parent bodies. The merrillite data thus suggest that early accretion of locally-derived volatiles was widespread for the bodies currently populating the asteroid belt. Apatite formed at the expense of merrillite around 100 million years after the differentiation of the GRA 06128/9 parent body, during hydrothermal alteration, which was probably triggered by an impact event. Apatite in GRA 06128 contains 5.4-5.7 wt.% Cl, 0.6-0.8 wt.% F, and ~20 to 60 ppm H2O, which is similar to the H2O abundance in merrillite from which apatite formed. The apatite δD values range between around +100‰ and +2000‰ and are inversely correlated with apatite H2O contents. The Cl isotope composition of apatite appears to be homogeneous across various grains, with an average δ37 Cl value of 3.2 ± 0.7‰. A possible scenario to account for the apatite chemical and isotopic characteristics involves interaction of GRA 06128/9 with fumarole-like fluids derived from D- and HCl-rich ices delivered to the GRA 06128/9 parent-body by an ice-rich impactor
    corecore