FEEDING DPS READING: A COMPREHENSIVE PROGRAM TO ENHANCE THIRD-GRADE READING PROFICIENCY IN DURHAM PUBLIC SCHOOLS

Early education is associated with long-term health outcomes. The suboptimal third-grade reading proficiency in Durham Public Schools (DPS) warrants immediate public health action. Low reading proficiency in elementary school is associated with a greater likelihood of dropping out of school, fewer career opportunities, and a negative impact on overall health and wellbeing. We recommend Feeding DPS Reading, which is a public health initiative to improve low reading scores in DPS through a nutrition-focused intervention. The program will assist elementary schools in collecting and submitting data for Community Eligibility Provision qualification, which provides free meals to all students regardless of individual eligibility. In parallel, students will participate in a reading program led by Duke University undergraduate education students. The program’s goal is to increase third-grade reading proficiency by providing healthy meals and targeted reading interventions, with the long-term goal of improving the health and wellness of Durham County residents.Master of Public Healt

The relevance of mitochondrial DNA variants fluctuation during reprogramming and neuronal differentiation of human iPSCs

The generation of inducible pluripotent stem cells (iPSCs) is a revolutionary technique allowing production of pluripotent patient-specific cell lines used for disease modeling, drug screening, and cell therapy. Integrity of nuclear DNA (nDNA) is mandatory to allow iPSCs utilization, while quality control of mitochondrial DNA (mtDNA) is rarely included in the iPSCs validation process. In this study, we performed mtDNA deep sequencing during the transition from parental fibroblasts to reprogrammed iPSC and to differentiated neuronal precursor cells (NPCs) obtained from controls and patients affected by mitochondrial disorders. At each step, mtDNA variants, including those potentially pathogenic, fluctuate between emerging and disappearing, and some having functional implications. We strongly recommend including mtDNA analysis as an unavoidable assay to obtain fully certified usable iPSCs and NPCs.Peer reviewe

KSU Men\u27s Ensemble, KSU Community & Alumni Choir and KSU Chamber Singers, Illumination

KSU School of Music presents Illumination with KSU Men\u27s Ensemble, The Kennesaw State University Community and Alumni Choir and KSU Chamber Singers featuring John Rutter\u27s Gloria!https://digitalcommons.kennesaw.edu/musicprograms/1249/thumbnail.jp

Choral Ensembles Spring Concert

Kennesaw State University School of Music presents Choral Ensembles Spring Concert.https://digitalcommons.kennesaw.edu/musicprograms/1405/thumbnail.jp

Student Compostiton Recital

Kennesaw State University School of Music presents Student Composition Recital.https://digitalcommons.kennesaw.edu/musicprograms/1390/thumbnail.jp

Global disparities in surgeons’ workloads, academic engagement and rest periods: the on-calL shIft fOr geNEral SurgeonS (LIONESS) study

: The workload of general surgeons is multifaceted, encompassing not only surgical procedures but also a myriad of other responsibilities. From April to May 2023, we conducted a CHERRIES-compliant internet-based survey analyzing clinical practice, academic engagement, and post-on-call rest. The questionnaire featured six sections with 35 questions. Statistical analysis used Chi-square tests, ANOVA, and logistic regression (SPSS® v. 28). The survey received a total of 1.046 responses (65.4%). Over 78.0% of responders came from Europe, 65.1% came from a general surgery unit; 92.8% of European and 87.5% of North American respondents were involved in research, compared to 71.7% in Africa. Europe led in publishing research studies (6.6 ± 8.6 yearly). Teaching involvement was high in North America (100%) and Africa (91.7%). Surgeons reported an average of 6.7 ± 4.9 on-call shifts per month, with European and North American surgeons experiencing 6.5 ± 4.9 and 7.8 ± 4.1 on-calls monthly, respectively. African surgeons had the highest on-call frequency (8.7 ± 6.1). Post-on-call, only 35.1% of respondents received a day off. Europeans were most likely (40%) to have a day off, while African surgeons were least likely (6.7%). On the adjusted multivariable analysis HDI (Human Development Index) (aOR 1.993) hospital capacity > 400 beds (aOR 2.423), working in a specialty surgery unit (aOR 2.087), and making the on-call in-house (aOR 5.446), significantly predicted the likelihood of having a day off after an on-call shift. Our study revealed critical insights into the disparities in workload, access to research, and professional opportunities for surgeons across different continents, underscored by the HDI

Antibodies against endogenous retroviruses promote lung cancer immunotherapy

B cells are frequently found in the margins of solid tumours as organized follicles in ectopic lymphoid organs called tertiary lymphoid structures (TLS). Although TLS have been found to correlate with improved patient survival and response to immune checkpoint blockade (ICB), the underlying mechanisms of this association remain elusive. Here we investigate lung-resident B cell responses in patients from the TRACERx 421 (Tracking Non-Small-Cell Lung Cancer Evolution Through Therapy) and other lung cancer cohorts, and in a recently established immunogenic mouse model for lung adenocarcinoma. We find that both human and mouse lung adenocarcinomas elicit local germinal centre responses and tumour-binding antibodies, and further identify endogenous retrovirus (ERV) envelope glycoproteins as a dominant anti-tumour antibody target. ERV-targeting B cell responses are amplified by ICB in both humans and mice, and by targeted inhibition of KRAS(G12C) in the mouse model. ERV-reactive antibodies exert anti-tumour activity that extends survival in the mouse model, and ERV expression predicts the outcome of ICB in human lung adenocarcinoma. Finally, we find that effective immunotherapy in the mouse model requires CXCL13-dependent TLS formation. Conversely, therapeutic CXCL13 treatment potentiates anti-tumour immunity and synergizes with ICB. Our findings provide a possible mechanistic basis for the association of TLS with immunotherapy response

Reducing the environmental impact of surgery on a global scale: systematic review and co-prioritization with healthcare workers in 132 countries

Abstract Background Healthcare cannot achieve net-zero carbon without addressing operating theatres. The aim of this study was to prioritize feasible interventions to reduce the environmental impact of operating theatres. Methods This study adopted a four-phase Delphi consensus co-prioritization methodology. In phase 1, a systematic review of published interventions and global consultation of perioperative healthcare professionals were used to longlist interventions. In phase 2, iterative thematic analysis consolidated comparable interventions into a shortlist. In phase 3, the shortlist was co-prioritized based on patient and clinician views on acceptability, feasibility, and safety. In phase 4, ranked lists of interventions were presented by their relevance to high-income countries and low–middle-income countries. Results In phase 1, 43 interventions were identified, which had low uptake in practice according to 3042 professionals globally. In phase 2, a shortlist of 15 intervention domains was generated. In phase 3, interventions were deemed acceptable for more than 90 per cent of patients except for reducing general anaesthesia (84 per cent) and re-sterilization of ‘single-use’ consumables (86 per cent). In phase 4, the top three shortlisted interventions for high-income countries were: introducing recycling; reducing use of anaesthetic gases; and appropriate clinical waste processing. In phase 4, the top three shortlisted interventions for low–middle-income countries were: introducing reusable surgical devices; reducing use of consumables; and reducing the use of general anaesthesia. Conclusion This is a step toward environmentally sustainable operating environments with actionable interventions applicable to both high– and low–middle–income countries

Implications of Adolescents\u27 Perceptions and Values for Planning and Design

Adults are responsible for selecting and creating the environments where their children and youth live, but it is not clear if these places contain the qualities that young people value. In this study, high school students from three communities were surveyed regarding their perceptions of where they live to determine whether indicators identified by previous research as qualities that youth value are present in those communities and perceived to be important. Although the results suggest the indicators are important to the adolescents, their communities lack a majority of them and this has contributed to low satisfaction ratings. Recommendations for better integrating adolescents into public participation processes are discussed along with implications for planning and design

Etude des variations climatiques de la zone Indo-Pacifique (rôle des basses latitudes dans la variabilité millénaire du climat)

Les régions inter-tropicales sont caractérisées par de fortes températures de surface océaniques et de fortes précipitations. Elles constituent une des sources principales de chaleur et d'humidité vers l'atmosphère et jouent, par conséquent, un rôle important dans la régulation thermique du climat terrestre. Ainsi, les modifications de l'hydrologie des basses latitudes peuvent avoir des répercussions majeures sur notre climat. Les enregistrements isotopiques ( delta-18-O et delta-13-C) et géochimiques (rapport Mg/Ca) de foraminifères marins nous ont permis de reconstruire les variations de température et de salinité inter-tropicales durant les événements climatiques abrupts du dernier cycle climatique. L'étude détaillée des derniers 24000 ans a montré que les températures de surface des basses latitudes variaient en phase avec les températures de l'air en Antarctique, révélant un couplage important avec l'hémisphère Sud. Toutefois, les salinités des eaux de surface ont évolué linéairement avec les températures de l'air enregistrées au Groenland lors des changements millénaires du climat (Heinrich Events, Bolling Allerod, Younger Dryas). Ces résultats mettent en évidence des relations étroites entre l'augmentation de l'évaporation aux tropiques et la croissance et décroissance des calottes de glace de l'hémisphère Nord. La simultanéité de ces variations démontre l'existence d'un lien atmosphérique fort entre ces régions. De plus, l'analyse des eaux intermédiaires et profondes a montré que l'augmentation des salinités de surface en domaine tropical a pu contribuer au démarrage de la déglaciation en augmentant la convection d'eau profonde des eaux antarctiques circumpolaires, entraînant ainsi une initiation de la circulation océanique thermohaline à partir de l'hémisphère Sud.The inter-tropical regions, characterized by high sea surface temperatures and heavy precipitations, are a major source of heat and moisture to the atmosphere and therefore plays an important role in regulating the earth climate. Hence, hydrological variations of the low latitudes would have significant consequences on climate. Marine foraminifera isotopic (delta-18-O et delta-13-C) and geochemical (Mg/Ca ratio) records have drawn the evolution of inter-tropical sea surface temperature and salinity during the past abrupt climatic changes of the last climatic cycle. The detailed study of the last 24 000 years has shown that the low latitude sea surface temperature variations are synchronous with the high latitude southern hemispheric changes, revealing a narrow correlation with the southern hemisphere. Although sea surface salinity evolution is linked to the Greenland temperature record during millennial climatic changes (Heinrich Events, Bolling Allerod, Younger Dryas). These results demonstrate that changes in tropical evaporation is narrowly associated with ice sheet growth and decay of the northern high latitude. The synchronicity of these variations reveals the occurrence of a tight atmospheric link between these regions. Moreover, intermediate and deep water studies have also exhibited that tropical sea surface salinity increase would have strengthened the deglaciation by increasing deep water convection in the Antarctic circumpolar waters, resulting in a southern initiation of the thermohaline circulation.ORSAY-PARIS 11-BU Sciences (914712101) / SudocSudocFranceF