Effects of vitamin C treatment on collar-induced intimal thickening

Vitamin C has efficient antioxidant properties and is involved in important physiological processes such as collagen synthesis. As such, vitamin C deficiency leads to serious complications, including vascular diseases. The aim of this study was to investigate the effects of vitamin C treatment on collar-induced intimal thickening. Rabbits were fed a normocholesterolemic diet and a non-occlusive silicon collar was placed around the left carotid artery for 3, 7, and 14 days. The rabbits were treated with or without vitamin C (150 mg/kg/day). Collar-induced intimal thickening became apparent at day 7. The effect of the collar on intimal thickening was more prominent at day 14. Vitamin C treatment significantly inhibited collar-induced intimal thickening at day 14. The placement of the collar around the carotid artery decreased maximum contractile responses against contractile agents (KCl, phenylephrine, 5-hydroxytryptamine). The effect of the collar on contractile responses was enhanced as days elapsed. Decreased contractile responses of collared carotid arteries normalized at day 14 in the vitamin C treatment group. Vitamin C treatment also restored sensitivity to phenylephrine. The collar also significantly decreased acetylcholine-induced relaxations at day 3 and day 7. Acetylcholine-induced relaxations normalized in collared-arteries in the placebo group at day 14. Vitamin C treatment significantly increased acetylcholine-induced relaxations of both normal and collared carotid arteries at day 14. MMP-9 expression increased in collared arteries at day 3 and day 7 but did not change at day 14. MMP-2 expression increased in collared arteries at day 14. However, vitamin C treatment reduced collar-stimulated expression of MMP-2 at day 14. These findings indicate that vitamin C may have potentially beneficial effects on the early stages of atherosclerosis. Furthermore these results, for the first time, may indicate that vitamin C can also normalize decreased contractile response through perivascular collar placement

Samsun Yöresi Halk Müziği Örneklerinin Müzikal ve Edebi Yönden İncelenmesi

Bu araştırma TRT repertuvarında Samsun iline kayıtlı bulunan halk ezgilerinin müzikal ve edebî yönlerinin incelenmesi amacıyla yapılmış betimsel bir araştırmadır. Çalışmada Karadeniz ve Samsun yöresinin müziği, Samsun ilindeki müzik eğitimi ve müzikle ilişkili kurumlar, ilin tarihi ve coğrafi özellikleri, ilin coğrafi konumunun müzik kültürüne olan etkileri, yörede yaygın olarak kullanılan çalgılar ve halk oyunları hakkında genel bilgiler verilmiştir. TRT sözlü ve sözsüz repertuarında Samsun iline kayıtlı toplam 28 halk ezgisi tespit edilmiş ve bu ezgiler alfabetik sıraya göre incelenmiştir. Bütün ezgiler; makamsal yapı, ses genişlikleri, usul ve edebî özelliklerine göre incelenmiştir. Elde edilen veriler yorumlanmış ve bu verilerden bazıları grafikler ile sunulmuştur.  Sonuçta elde edilen bulgular doğrultusunda önerilerde bulunulmuştur

High dose zoledronic acid increases ischemia-reperfusion damage of the liver

OBJECTIVE: Zoledronic acid (ZA), a nitrogen-containing bisphosphonate, has been reported to exhibit a protective effect against cancers and prevent bone fractures. It also induces apoptosis by increasing proinflammatory cytokines and oxidative stress. Oxidative stress increases significantly during ischemia-reperfusion (IR) injury. The liver is highly sensitive to IR injury. In this study, we aim to investigate whether high-dose ZA treatment affects the liver during IR. MATERIALS AND METHODS: We used twenty-one Sprague-Dawley male rats in our study. and they were subdivided randomly into three groups, each containing seven rats. A single dose of 100 pg/kg ZA was administered via the intraperitoneal route in the ZA group. Forty-eight hours after the ZA administration, infrarenal abdominal aortic cross ligation was performed on the ZA and IR groups. After 2 hours of ischemia, 2 hours of reperfusion was applied. RESULTS: The malondialdehyde (MDA) level of the control group was significantly lower than the IR (p = 0.006) and ZA (p<0.001) groups. However, the superoxide dismutase (SOD), catalase (CAT), and glutathione peroxidase (GPx) values of the control group were significantly higher than the values of the IR group (p<0.05. p<0.001, and p<0.05) and ZA group (p = 0.002, p<0.001, and p<0.001). Caspase-3 activity was significantly higher in the IR group as compared to the control group (p<0.001). The caspase-3 activity in the ZA group, on the other hand, was higher than both the control (p<0.001) and IR groups (p<0.001). CONCLUSIONS: High-dose ZA may exacerbate liver injury during IR by increasing reactive oxygen species production and apoptosis

Lumbar dynamic stabilization with 2-stage surgery: early results

Background: Screw loosening, which is a major problem in dynamic systems, can be easily overcome with 2-stage surgery. In this article, the clinical and radiological results of patients undergoing dynamic stabilization with a Dynesys device in 2 stages are discussed. Methods: A total of 10 male and 13 female adult patients were included in this single-center retrospective study conducted between 2018 and 2021. The mean age of the patients was 65.6 years. All of the patients had pain complaints that affected their daily lives. Bone density T scores were determined with the dual-energy x-ray absorptiometry method before patients were admitted for surgery. In the first surgery, Dynesys system pedicle screws were inserted. After 6 months of osteointegration, Dynesys system spacers and elastic bandages were placed. Preoperative, early postoperative, and late postoperative visual analog pain scale (VAS) scores and Oswestry Disability Index (ODI) scores were determined and statistically compared. Results: Patients were followed for an average of 30 months. Complications and recurrence were not observed. Neurological deficits were not observed after patients recovered from anesthesia. Significant improvement was observed in the ODI and VAS parameters in the preoperative (ODI: 66.2%, VAS: 7.8), early postoperative (ODI: 20.3%, VAS: 2.4), and late postoperative (ODI: 6.8% and VAS: 1.1) periods. Symptomatic improvement was seen in all patients. No screw breakage or loosening was detected by radiological evaluation in any of the patients during the 2-year follow-up period. Conclusions: In our experience, the insufficiency of the proximal and distal end screws is eliminated when 2 stages of dynamic system stabilizations are completed after osteointegration of the screws

Outcomes of endovascular treatment of thoracic aorta pathologies: 10-year single-center results

PURPOSEThoracic endovascular aortic repair (TEVAR) is a safe and effective treatment method for a variety of thoracic aortic pathologies. We aimed to investigate the mortality and complication outcomes and associated factors of TEVAR treatment in Turkey.METHODSIn this single-centered retrospective study, patients with thoracic aorta pathologies treated with TEVAR at Gazi University School of Medicine, Department of Radiology, between January 2009 and January 2020 were included. Perioperative, early, and late mortality, complications, and technical success were the outcomes.RESULTSThe sample comprised 58 patients with 68 TEVAR interventions. Eleven (16.2%) patients were female, the mean age was 60.1 ± 13.4 years. Emergent TEVAR was required in 20.7% of the patients. The main indications of TEVAR were intact descending aorta aneurysms in 37.9% of the sample, 31.0% Stanford type-B dissection, and 12.1% traumatic transections. The technical success rate of primary and secondary interventions was 98.3% and 100%, respectively. The mortality rate in the first 30 days was 8.6%. Seventeen (29.3%) cases had at least 1 complication related to TEVAR treatment. The most common complication was type-1A endoleak (10.3%). Having acute symptoms, stroke, and acute renal failure were significantly associated with mortality (P=.020, .049, and .009, respectively).CONCLUSIONThis study reported the outcomes of TEVAR treatment from a tertiary medical center in Turkey over a decade. Patients presenting with acute symptoms and who developed stroke and acute renal failure after the procedure should be carefully followed up as these factors were found to be associated with mortality

Obsessive- compulsive disorder in the parkinson disease

Purpose: Obsessive disorder assessment using Leyton Obsessional Inventory was done in patients with idiopathic Parkinson's Disease. Materials and Methods: Fifty patients diagnosed with Parkinson's disease according to United Kingdom Parkinson's Disease Society Brain Bank (UK-PDSBB) criteria and 37 healty individuals were included in the study.All subjects were assesed by the same psychiatrist using the Leyton obsessional inventory. Results: The Leyton obssesional scores were higher in the Parkinson's disease group than in the control group (p<0,001). In addition, correlation was found between the severity of disease and degree of obsession (p:0,771). Conclusion: Parkinson's disease is a neurodejenerative disorder with predominant motor symptoms but with progression , nonmotor symptoms also emerge. The patient's qualty of life may be much affected by these nonmotor symptoms. Diagnosis and treatment of the pyschiatric symptoms in Parkinson's disease may help improve life quality

Kamu Yöneticilerinin Siyasal Ve Yönetsel Ahlaki Davraniş Tipleri

Çalışmada siyasal-yönetsel ahlak ve siyasal-yönetsel yozlaşma kavramları incelenmiştir. Siyasi ve yönetsel yozlaşamaya sebep olan ahlaki tavırları açıklayabilmek için bireyin ahlak gelişimini anlatan teoriler üzerinde durulmuştur. Günümüz Türkiye’sindeki siyasi ve yönetsel yozlaşmalar sadece bugüne ait olmayıp geçmişten günümüze miras olarak gelmişlerdir. Bu durumun nedeni de ülkenin geçirmiş olduğu siyasi kültürel ve ekonomik değişimler olarak açıklanabilir

Evaluating the acquired learning outcomes of secondary school students living abroad through baglama (saz) training (Example of Bishkek/Kyrgyzstan)

Doktora TeziBu araştırmada Kırgızistan/Bişkek örneği üzerinden yurtdışında yaşayan ortaokul çağındaki Türk öğrencilerin bağlama/saz eğitimi yoluyla elde edebileceği çeşitli kazanımların tespit edilebilmesi amaçlanmıştır. Çalışma nitel bir araştırmadır. Araştırma yöntemi temelde "Durum Çalışması" (Case Study) ana başlığı altında "Programın Etkilerine Dayalı Durum Çalışması" (Program Effects Case Studies) ve "Kritik Olay Durum Çalışmaları" (Critical Instance Case Studies) alt başlıkları üzerinden gerçekleştirilmiştir. Çalışmanın evreni yurt dışında yaşayan Türk ve Türk kökenli öğrenciler örneklemi ise Kırgızistan/Bişkek'te yaşayan Türk ve Türk kökenli ortaokul öğrencileridir. Çalışmada veri toplama araçları olarak öğrencilerin demografik bilgilerini ölçmek amaçlı kişisel bilgi formu, öğrencilerin bilişsel-akademik kazanımlarındaki değişiklikleri karşılaştırmak için eğitim öncesi/sonrası karne notlarının karşılaştırılması ve derslere katılım oranlarında değişiklik olup olmadığıyla ilgili öğretmenleri ile görüşme yapılması. Kişisel kazanımların belirlenmesi için eğitim öncesi/sonrası durumları hakkında sosyal çevreleri ile anket soruları yoluyla görüşmeler yapılması. Çalışma sonunda, öğrencilerle edindikleri kazanımlarının ne oranda farkında oldukları ile ilgili görüşmeler yapılması olarak ifade edilebilir. Anket ve görüşmeler sonrasında elde edilen nitel verilerin çözümlenmesinde, öğrencilerin belirlenen ana başlıklardaki kazanımlarının eğitimden önceki ve sonraki durumları arasındaki fark, karşılaştırma analizi yöntemi ile belirlenerek elde edilen bulgular yorumlanmıştır. Araştırmanın sonucunda yurtdışında yaşayan ortaokul çağındaki Türk öğrenciler için özel olarak oluşturulup yürütülen bağlama/saz eğitimi yoluyla, bu öğrencilerin kültürel kimlik oluşumu ve gelişimi, bilişsel/akademik gelişimleri ve kişisel gelişimleri hususlarında olumlu yönde kazanımlar elde ettikleri görülmüştür.In this study, in the light of the example of Kyrgyzstan, it was aimed to determine the various learning outcomes that Turkish secondary school students living abroad can acquire through the baglama/saz training. This study is a qualitative research. The research was basically carried out via the Program Effects Case Studies and Critical Instance Case Studies methods under the main title of Case Study. The universe of the study is the Turkish and Turkish origin students living abroad and the sample is Turkish and Turkish origin secondary school students living in Kyrgyzstan/Bishkek. In the study, personal information form was used to obtain the demographic information of the students and the pre- and post-education scores were compared to compare the changes in students' cognitive-academic achievements. In addition, interviews were carried out with the teachers about the students' attendance. In order to determine individual learning outcomes, interviews were conducted with the students' social environment about the pre/post-education situations by using questionnaire questions. At the end of the study, interviews were conducted with the students in order to determine to what extent the students were aware of the learning outcomes they achieved. In the analysis of the qualitative data obtained after the questionnaires and interviews, the difference between the pre- and post-education status of the students' achieved learning outcomes were determined by comparison analysis method and the findings were interpreted. As a result of the study, it was seen that these students achieved positive learning outcomes in terms of cultural identity formation and development, cognitive /academic development and personal development through the baglama/saz training which was specially developed and conducted for Turkish students living abroad

Examination of Samsun province Turkish folk music tunes according to their musical and linguistical genres

Yüksek Lisans Tezi. Yök Tez No:407573Özet: Bu araştırma TRT repertuvarındaki Samsun türkülerinin müzikal ve edebi yönlerinin incelenmesi amacıyla yapılmıştır. TRT repertuvarında yer almayan ancak düğünlerde ve müzikli toplantılarda yaygın olarak çalınıp söylenen Samsun türkülerinin bir kısmına da bu araştırmada yer verilmiştir. Samsun ile ilgili genel bilgilerin yanı sıra, Türk halk müziğinde kullanılan usuller, makam dizilerinin isimlendirilmeleri ile ilgili görüşler ve Halk edebiyatının genel özellikleri hakkında da bilgiler verilmiştir. TRT repertuvarındaki Samsun türküleri alfabetik sıraya göre incelenmiştir. Samsun' a ait 47 türkünün makam dizileri, usulleri ve edebi özelliklerine göre gruplandırılması yapılmış ve elde edilen veriler grafikler halinde sunulup yorumlanmıştır. Sonuçta elde edilen bulgular ışığında önerilerde bulunulmuştur. Abstract: The aim of this resarch is to define the folk songs, maqam, usul and linguistical kind of Samsun province in TRT repertoıre. Some of Samsun folk songs that are not founded in TRT repertoıre but they used in this area are studied in this project. In this research, after giving general information about Samsun province, The methods used in Turkish folk music, authorities were given information about the full range of opinions and general characteristics of folk literature. Samsun province folk songs were examined according to alphabetic order. Get reasons, with studies of different city's. As a results 47 folk songs were classfield according to their maqam, usul and linguistically order and the optained data is presented end explained in graphics. The sugguestions were addressed in the lights of the results