70. Ocena skuteczności przeciwbólowej radioterapii ostróg piętowych

Założenia i cel pracyOdokostnowy wzrost kości w miejscu przyczepu ścięgien do kości piętowej (ostrogi) często jest powodem uciążliwych bólów. Celem naszej pracy była ocena skuteczności radioterapii, jako metody leczenia tych zespołów bólowych.Materiał i metodykaRetrospektywny materiał obejmował 798 przypadków (181 M, 617 K) bolesnych ostróg kości piętowych napromienianych przy użyciu dawki frakcyjnej 1–3 Gy (średnia 1,5 Gy) do dawki całkowitej zawierającej się w przedziale od 1,5 do 22,5 Gy (średnia 8 Gy). Wiek chorych zawierał się w przedziale od 24 do 85 lat (średnia 56). Podobna liczba zmian była zlokalizowana po lewej i prawej stronie. Średnia wielkość ostrogi wynosiła 0,9 cm, a średnia wielkość napromienianego pola 57 cm2. Średni czas trwania objawów wynosił 32 miesiące. W 155 przypadkach było to powtórne napromienianie. W 768 przypadkach zastosowano promieniowanie X, w 18 wysokoenergetyczne fotony, w 9 elektrony, a w 3 promieniowanie gamma. Średni okres obserwacji wynosił 17,5 miesiąca. Oceniono stopień zmniejszenia bólu po zakończeniu leczenia oraz czas utrzymywania się efektu przeciwbólowego. Obliczono odsetek chorych nie zgłaszających bólu spoczynkowego oraz bólu w trakcie chodzenia podczas ostatniej kontroli.WynikiPo zakończeniu radioterapii całkowite ustąpienie bólu odnotowano w 44%. W pozostałej grupie zmniejszenie bólu o więcej niż 50% w stosunku do stanu z przed leczenia osiągnięto u 42%, o mniej niż 50% u 28%, a w 30% nie odnotowano efektu przeciwbólowego. Średni czas utrzymywania się efektu wyniósł 12 miesięcy. Podczas ostatniej kontroli 45% chorych nie zgłaszało bólów w spoczynku, a 29% podczas chodzenia.WniosekOtrzymane wyniki pozwa1ają na sformułowanie wniosku, że radioterapia jest skuteczną i bezpieczną metodą leczenia bolesnych ostróg kości piętowych oraz może być stosowane w przypadkach nie poddających się leczeniu konwencjonalnemu

Biologic variability of human foreskin fibroblasts in 2D and 3D culture: implications for a wound healing model

<p>Abstract</p> <p>Background</p> <p>The fibroblast-populated 3D collagen matrix is a model of tissue and healing which has been used since the 1980's. It was hypothesized that anchorage disruption of the collagen matrix would produce p53-dependent apoptosis in the embedded fibroblasts, but results of hypothesis testing were variant.</p> <p>Findings</p> <p>The response of p53 to anchorage disruption in 3D culture or to UV irradiation in 2D culture was influenced both by fibroblast strain and culture conditions. It also was determined that data scatter in a collagen matrix contraction assay was related to fibroblast strain and possibly to technical factors, such as cell culture technician and/or number of matrices utilized. Subsequent analysis suggested that phenotypic drift and/or inter-strain genetic variability may have been responsible for the data scatter. In addition, several technical factors were identified that may have contributed to the scatter.</p> <p>Conclusion</p> <p>Experimentation with human foreskin fibroblasts in both 2D and 3D culture can produce variant data. The underlying cause of the data scatter appears to be partially due to the biologic variability of the fibroblast.</p

Faddeev study of heavy baryon spectroscopy

We investigate the structure of heavy baryons containing a charm or a bottom quark. We employ a constituent quark model successful in the description of the baryon-baryon interaction which is consistent with the light baryon spectra. We solve exactly the three-quark problem by means of the Faddeev method in momentum space. Heavy baryon spectrum shows a manifest compromise between perturbative and nonperturbative contributions. The flavor dependence of the one-gluon exchange is analyzed. We assign quantum numbers to some already observed resonances and we predict the first radial and orbital excitations of all states with $J=1/2$ or 3/2. We combine our results with heavy quark symmetry and lowest-order SU(3) symmetry breaking to predict the masses and quantum numbers of six still non-measured ground-state beauty baryons.Comment: 22 pages, 4 figures, 8 tables. Accepted for publication in J. Phys.

New Particles from Belle

I report recent results on hidden charm spectroscopy from Belle. These include: observation of a near-threshold enhancement in the omega-J/psi invariant mass distribution for exclusive B-->K omega J/psi decays; evidence for the decay X(3872)-->pi+pi-pi0 J/psi, where the pi+pi-pi0 invariant mass distribution has a strong peak between 750 MeV and the kinematic limit of 775 MeV, suggesting that the process is dominated by the sub-threshold decay X-->omega J/psi; and the observation of a peak near 3940 MeV in the J/psi recoil mass spectrum for the inclusive continuum process e+e- --> J/psi X. The results are based on a study of a 287 fb-1 sample of e+e- annihilation data collected at center- of-mass energies around the Upsilon(4S) in the Belle detector at the KEKB collider.Comment: 10 pages 12 figures. Invited talk at the 1st meeting of the APS Topical Group on Hadronic Physics, Fermilab, October 24-26, 2004; revised to correct some reference

Upper limits for a narrow resonance in the reaction p + p -> K^+ + (Lambda p)

The reaction pp -> K^+ + (Lambda p) has been measured at T_p = 1.953 GeV and \Theta = 0 deg with a high missing mass resolution in order to study the Lambda p final state interaction. Narrow S = -1 resonances predicted by bag model calculations are not visible in the missing mass spectrum. Small structures observed in a previous experiment are not confirmed. Upper limits for the production cross section of a narrow resonance are deduced for missing masses between 2058 and 2105 MeV/c^2.Comment: 8 pages, 5 figure

Heavy Quark Spectroscopy -- Theory Overview

Some recent discoveries in the spectroscopy of hadrons containing heavy quarks, and some of their theoretical interpretations, are reviewed.Comment: 13 pages, 6 figures. Presented at Second Meeting of APS Topical Group on Hadron Physics, Nashville, TN, 22-24. Proceedings to be published by Journal of Physics (UK), Conference Series. Uses jpconf.cls, jpconf11.clo. Some corrections; references update

Cross section of the pp→K+Σ+npp\to K^+\Sigma^+n reaction close to threshold

We have measured inclusive data on $K^+$-meson production in $pp$ collisions at COSY J\"ulich close to the hyperon production threshold and determined the hyperon-nucleon invariant mass spectra. The spectra were decomposed into three parts: $\Lambda p$, $\Sigma^0p$ and $\Sigma^+n$. The cross section for the $\Sigma^+n$ channel was found to be much smaller than a previous measurement in that excess energy region. The data together with previous results at higher energies are compatible with a phase space dependence.Comment: accepted by Phys. lett. B some typos correcte

High resolution study of the Lambda p final state interaction in the reaction p + p -> K+ + (Lambda p)

The reaction pp -> K+ + (Lambda p) was measured at Tp=1.953 GeV and Theta = 0 deg with a high missing mass resolution in order to study the Lambda p final state interaction. The large final state enhancement near the Lambda p threshold can be described using the standard Jost-function approach. The singlet and triplet scattering lengths and effective ranges are deduced by fitting simultaneously the Lambda p invariant mass spectrum and the total cross section data of the free Lambda p scattering.Comment: submitted to Physics Letters B, 10 pages, 3 figure

Structure–activity relationships of dinucleotides: Potent and selective agonists of P2Y receptors

Dinucleoside polyphosphates act as agonists on purinergic P2Y receptors to mediate a variety of cellular processes. Symmetrical, naturally occurring purine dinucleotides are found in most living cells and their actions are generally known. Unsymmetrical purine dinucleotides and all pyrimidine containing dinucleotides, however, are not as common and therefore their actions are not well understood. To carry out a thorough examination of the activities and specificities of these dinucleotides, a robust method of synthesis was developed to allow manipulation of either nucleoside of the dinucleotide as well as the phosphate chain lengths. Adenosine containing dinucleotides exhibit some level of activity on P2Y1 while uridine containing dinucleotides have some level of agonist response on P2Y2 and P2Y6. The length of the linking phosphate chain determines a different specificity; diphosphates are most accurately mimicked by dinucleoside triphosphates and triphosphates most resemble dinucleoside tetraphosphates. The pharmacological activities and relative metabolic stabilities of these dinucleotides are reported with their potential therapeutic applications being discussed