520 research outputs found
The Twin--Jet System in NGC 1052: VLBI-Scrutiny of the Obscuring Torus
NGC 1052 offers the possibility to study the obscuring torus around a
supermassive black hole, predicted by the standard model of active galactic
nuclei, over a wide range of wavelengths from the radio to the X-ray regime. We
present a detailed VLBI study of the parsec-scale structure of the ``twin-jet''
system in NGC 1052 in both total and polarized intensity and at multiple
frequencies. We report the detection of linearly polarized emission from the
base of the eastern jet at 5 GHz. While the radio spectrum in this region might
be still consistent with synchrotron self absorption, the highly inverted
spectrum of the western jet base represents a clear sign of pronounced
free-free absorption in a circumnuclear torus. We observe an abrupt change of
the brightness temperature gradient at a distance of pc to 0.3 pc
from the central engine. This might provide an observational signature of the
edge of the central torus, where the transition from an external
pressure-dominated jet regime to a more or less freely expanding jet takes
place. We determine the absorbing column density towards the western jet core
to be cm in good agreement with the values
derived from various X-ray observations. This suggests that the nuclear X-ray
emission and the jet emission imaged by VLBI originate on the same scales.Comment: 14 pages, 11 figures, needs aa.cls, accepted for publication in
Astronomy & Astrophysics, note that the resolution of figure 2 has been
decreased in comparison to the journal versio
The milliarcsecond-scale jet of PKS 0735+178 during quiescence
We present polarimetric 5 GHz to 43 GHz VLBI observations of the BL Lacertae
object PKS 0735+178, spanning March 1996 to May 2000. Comparison with previous
and later observations suggests that the overall kinematic and structural
properties of the jet are greatly influenced by its activity. Time intervals of
enhanced activity, as reported before 1993 and after 2000 by other studies, are
followed by highly superluminal motion along a rectilinear jet. In contrast the
less active state in which we performed our observations, shows subluminal or
slow superluminal jet features propagating through a twisted jet with two sharp
bends of about 90 deg. within the innermost three-milliarcsecond jet structure.
Proper motion estimates from the data presented here allow us to constrain the
jet viewing angle to values < 9 deg., and the bulk Lorentz factor to be between
2 and 4.Comment: 11 pages, 12 figures. Accepted for publication in A&
Task-oriented reading efficiency: interplay of general cognitive ability, task demands, strategies and reading fluency
The associations among readers’ cognitive skills (general cognitive ability, reading skills, and attentional functioning), task demands (easy versus difficult questions), and process measures (total fixation time on relevant and irrelevant paragraphs) was investigated to explain task-oriented reading accuracy and efficiency (number of scores in a given time unit). Structural equation modeling was applied to a large dataset collected with sixth-grade students, which included samples of dysfluent readers and those with attention difficulties. The results are in line with previous findings regarding the dominant role of general cognitive ability in the accuracy of task-oriented reading. However, efficiency in task-oriented reading was mostly explained by the shorter viewing times of both paragraph types (i.e., relevant and irrelevant), which were modestly explained by general cognitive ability and reading fluency. These findings suggest that high efficiency in task orientation is obtained by relying on a selective reading strategy when reading both irrelevant and relevant paragraphs. The selective reading strategy seems to be specifically learned, and this potentially applies to most students, even those with low cognitive abilities
Performance of HPGe Detectors in High Magnetic Fields
A new generation of high-resolution hypernuclear gamma$-spectroscopy
experiments with high-purity germanium detectors (HPGe) are presently designed
at the FINUDA spectrometer at DAPhiNE, the Frascati phi-factory, and at PANDA,
the antiproton proton hadron spectrometer at the future FAIR facility. Both,
the FINUDA and PANDA spectrometers are built around the target region covering
a large solid angle. To maximise the detection efficiency the HPGe detectors
have to be located near the target, and therefore they have to be operated in
strong magnetic fields B ~ 1 T. The performance of HPGe detectors in such an
environment has not been well investigated so far. In the present work VEGA and
EUROBALL Cluster HPGe detectors were tested in the field provided by the ALADiN
magnet at GSI. No significant degradation of the energy resolution was found,
and a change in the rise time distribution of the pulses from preamplifiers was
observed. A correlation between rise time and pulse height was observed and is
used to correct the measured energy, recovering the energy resolution almost
completely. Moreover, no problems in the electronics due to the magnetic field
were observed.Comment: submitted to Nucl. Instrum. Meth. Phys. Res. A, LaTeX, 19 pages, 9
figure
Associations of physical activity, sedentary time, and cardiorespiratory fitness with heart rate variability in 6- to 9-year-old children: the PANIC study
Abstract: Purpose: To study the associations of physical activity (PA), sedentary time (ST), and cardiorespiratory fitness (CRF) with heart rate variability (HRV) in children. Methods: The participants were a population sample of 377 children aged 6–9 years (49% boys). ST, light PA (LPA), moderate PA (MPA), vigorous PA (VPA), and moderate-to-vigorous PA (MVPA), and PA energy expenditure (PAEE) were assessed using a combined heart rate and movement sensor, maximal power output per kilograms of lean body mass as a measure of CRF by maximal cycle ergometer exercise test, and HRV variables (SDNN, RMSSD, LF, and HF) using 5 min resting electrocardiography. Data were analysed by linear regression adjusted for years from peak height velocity. Results: In boys, ST was inversely associated (β = − 0.185 to − 0.146, p ≤ 0.049) and MVPA, VPA, PAEE, and CRF were directly associated (β = 0.147 to 0.320, p ≤ 0.048) with HRV variables. CRF was directly associated with all HRV variables and PAEE was directly associated with RMSSD after mutual adjustment for ST, PAEE, and CRF (β = 0.169 to 0.270, p ≤ 0.046). In girls, ST was inversely associated (β = − 0.382 to − 0.294, p < 0.001) and LPA, MPA, VPA, MVPA, and PAEE were directly associated with HRV variables (β = 0.144 to 0.348, p ≤ 0.049). After mutual adjustment for ST, PAEE, and CRF, only the inverse associations of ST with HRV variables remained statistically significant. Conclusions: Higher ST and lower PA and CRF were associated with poorer cardiac autonomic nervous system function in children. Lower CRF in boys and higher ST in girls were the strongest correlates of poorer cardiac autonomic function
The structure of the magnetic field in the massive star-forming region W75N
A debated topic in star formation theory is the role of magnetic fields
during the protostellar phase of high-mass stars. It is still unclear how
magnetic fields influence the formation and dynamics of massive disks and
outflows. Most current information on magnetic fields close to high-mass
protostars comes from polarized maser emissions, which allows us to investigate
the magnetic field on small scales by using very long-baseline interferometry.
The massive star-forming region W75N contains three radio continuum sources
(VLA1, VLA2, and VLA3), at three different evolutionary stages, and associated
masers, while a large-scale molecular bipolar outflow is also present. Very
recently, polarization observations of the 6.7 GHz methanol masers at
milliarsecond resolution have been able to probe the strength and structure of
the magnetic field over more than 2000 AU around VLA1. The magnetic field is
parallel to the outflow, suggesting that VLA1 is its powering source. The
observations of water masers at 22 GHz can give more information about the gas
dynamics and the magnetic fields around VLA1 and VLA2. The NRAO Very Long
Baseline Array was used to measure the linear polarization and the
Zeeman-splitting of the 22 GHz water masers in the star-forming region W75N. We
detected 124 water masers, 36 around VLA1 and 88 around VLA2 of W75N, which
indicate two different physical environments around the two sources, where VLA1
is in a more evolved state. The linear polarization of the masers confirms the
tightly ordered magnetic field around VLA1, which is aligned with the
large-scale molecular outflow, and also reveals an ordered magnetic field
around VLA2, which is not parallel to the outflow. [abridged]Comment: 11 pages, 5 figures, 2 Tables, accepted by Astronomy & Astrophysic
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Understanding developmental language disorder -The Helsinki longitudinal SLI study (HelSLI) : A study protocol
Background: Developmental language disorder (DLD, also called specific language impairment, SLI) is a common developmental disorder comprising the largest disability group in pre-school-aged children. Approximately 7% of the population is expected to have developmental language difficulties. However, the specific etiological factors leading to DLD are not yet known and even the typical linguistic features appear to vary by language. We present here a project that investigates DLD at multiple levels of analysis and aims to make the reliable prediction and early identification of the difficulties possible. Following the multiple deficit model of developmental disorders, we investigate the DLD phenomenon at the etiological, neural, cognitive, behavioral, and psychosocial levels, in a longitudinal study of preschool children. Methods: In January 2013, we launched the Helsinki Longitudinal SLI study (HelSLI) at the Helsinki University Hospital ( http://tiny.cc/HelSLI ). We will study 227 children aged 3-6 years with suspected DLD and their 160 typically developing peers. Five subprojects will determine how the child's psychological characteristics and environment correlate with DLD and how the child's well-being relates to DLD, the characteristics of DLD in monolingual versus bilingual children, nonlinguistic cognitive correlates of DLD, electrophysiological underpinnings of DLD, and the role of genetic risk factors. Methods include saliva samples, EEG, computerized cognitive tasks, neuropsychological and speech and language assessments, video-observations, and questionnaires. Discussion: The project aims to increase our understanding of the multiple interactive risk and protective factors that affect the developing heterogeneous cognitive and behavioral profile of DLD, including factors affecting literacy development. This accumulated knowledge will form a heuristic basis for the development of new interventions targeting linguistic and non-linguistic aspects of DLD. © 2018 The Author(s).Non peer reviewe
Uptake of 68gallium in atherosclerotic plaques in LDLR-/- ApoB100/100 mice
Background: Atherosclerosis is a chronic inflammatory disease of artery wall characterized by infiltration of monocytes into subendothelial space and their differentiation into macrophages. Since rupture-prone plaques commonly contain high amounts of activated macrophages, imaging of the macrophage content may provide a useful tool for the evaluation of plaque vulnerability. The purpose of this study was to explore the uptake of 68gallium (68Ga) in atherosclerotic plaques in mice.Methods: Uptake of ionic 68Ga was investigated in atherosclerotic LDLR-/-ApoB100/100 and C57BL/6N control mice at 3 h after injection. The ex vivo biodistribution of the 68Ga was assessed and autoradiography of aortic cryosections was defined. In vivo imaging of 68Ga was performed using a small animal positron emission tomography PET/CT scanner.Results: Our results revealed that the uptake of 68Ga-radioactivity was higher in atherosclerotic plaques than in healthy vessel wall (ratio 1.8 +/- 0.2, p = 0.0002) and adventitia (ratio 1.3 +/- 0.2, p = 0.0011). The autoradiography signal co-localized with macrophages prominently as demonstrated by Mac-3 staining. In both mice strains, the highest level of radioactivity was found in the blood.Conclusions: We observed a moderate but significantly elevated 68Ga-radioactivity uptake in the aortic plaques of atherosclerotic mice, especially at the sites rich in macrophages. While the uptake of 68Ga was promising in this animal model, the slow blood clearance may limit the usability of 68Ga as a PET tracer for clinical imaging of atherosclerotic plaques.</p
Tyrosine Sulfation of Native Mouse Psgl-1 Is Required for Optimal Leukocyte Rolling on P-Selectin In Vivo
We recently demonstrated that tyrosine sulfation is an important contributor to monocyte recruitment and retention in a mouse model of atherosclerosis. P-selectin glycoprotein ligand-1 (Psgl-1) is tyrosine-sulfated in mouse monocyte/macrophages and its interaction with P-selectin is important in monocyte recruitment in atherosclerosis. However, whether tyrosine sulfation is required for the P-selectin binding function of mouse Psgl-1 is unknown. Here we test the function of native Psgl-1 expressed in leukocytes lacking endogenous tyrosylprotein sulfotransferase (TPST) activity.Psgl-1 function was assessed by examining P-selectin dependent leukocyte rolling in post-capillary venules of C57BL6 mice transplanted with hematopoietic progenitors from wild type (WT → B6) or Tpst1;Tpst2 double knockout mice (Tpst DKO → B6) which lack TPST activity. We observed that rolling flux fractions were lower and leukocyte rolling velocities were higher in Tpst DKO → B6 venules compared to WT → B6 venules. Similar results were observed on immobilized P-selectin in vitro. Finally, Tpst DKO leukocytes bound less P-selectin than wild type leukocytes despite equivalent surface expression of Psgl-1.These findings provide direct and convincing evidence that tyrosine sulfation is required for optimal function of mouse Psgl-1 in vivo and suggests that tyrosine sulfation of Psgl-1 contributes to the development of atherosclerosis
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