DIGITALLY ENABLED COMMUNITY EMPOWERMENT

Ph.DDOCTOR OF PHILOSOPH

ICT-Enabled Community Empowerment in Crisis Response: Social Media in Thailand Flooding 2011

In this paper, we examine the emerging use of ICT in social phenomena such as natural disasters. Researchers have acknowledged that a community possesses the capacity to manage the challenges in crisis response on its own. However, extant IS studies focus predominantly on IS use from the crisis response agency’s perspective, which undermines communities’ role. By adopting an empowerment perspective, we focus on understanding how social media empowers communities during crisis response. As such, we present a qualitative case study of the 2011 Thailand flooding. Using an interpretive approach, we show how social media can empower the community from three dimensions of empowerment process (structural, psychological, and resource empowerment) to achieve collective participation, shared identification, and collaborative control in the community. We make two contributions: 1) we explore an emerging social consequence of ICT by illustrating the roles of social media in empowering communities when responding to crises, and 2) we address the literature gap in empowerment by elucidating the actualization process of empowerment that social media as a mediating structure enables

Depression and quality of life among Macau residents in the 2022 COVID-19 pandemic wave from the perspective of network analysis

BackgroundIn the summer of 2022, Macau experienced a surge of COVID-19 infections (the 618 COVID-19 wave), which had serious effects on mental health and quality of life (QoL). However, there is scant research on mental health problems and QoL among Macau residents during the 618 COVID-19 wave. This study examined the network structure of depressive symptoms (hereafter depression), and the interconnection between different depressive symptoms and QoL among Macau residents during this period.MethodA cross-sectional study was conducted between 26th July and 9th September 2022. Depressive symptoms were measured with the 9-item Patient Health Questionnaire (PHQ-9), while the global QoL was measured with the two items of the World Health Organization Quality of Life-brief version (WHOQOL-BREF). Correlates of depression were explored using univariate and multivariate analyses. The association between depression and QoL was investigated using analysis of covariance (ANCOVA). Network analysis was used to evaluate the structure of depression. The centrality index “Expected Influence” (EI) was used to identify the most central symptoms and the flow function was used to identify depressive symptoms that had a direct bearing on QoL.ResultsA total 1,008 participants were included in this study. The overall prevalence of depression was 62.5% (n = 630; 95% CI = 60.00–65.00%). Having depression was significantly associated with younger age (OR = 0.970; p < 0.001), anxiety (OR = 1.515; p < 0.001), fatigue (OR = 1.338; p < 0.001), and economic loss (OR = 1.933; p = 0.026). Participants with depression had lower QoL F (1, 1,008) =5.538, p = 0.019). The most central symptoms included PHQ2 (“Sad Mood”) (EI: 1.044), PHQ4 (“Fatigue”) (EI: 1.016), and PHQ6 (“Guilt”) (EI: 0.975) in the depression network model, while PHQ4 (“Fatigue”), PHQ9 (“Suicide”), and PHQ6 (“Guilt”) had strong negative associations with QoL.ConclusionDepression was common among Macao residents during the 618 COVID-19 wave. Given the negative impact of depression on QoL, interventions targeting central symptoms identified in the network model (e.g., cognitive behavioral therapy) should be developed and implemented for Macau residents with depression

Diverse Applications of Nanomedicine

The design and use of materials in the nanoscale size range for addressing medical and health-related issues continues to receive increasing interest. Research in nanomedicine spans a multitude of areas, including drug delivery, vaccine development, antibacterial, diagnosis and imaging tools, wearable devices, implants, high-throughput screening platforms, etc. using biological, nonbiological, biomimetic, or hybrid materials. Many of these developments are starting to be translated into viable clinical products. Here, we provide an overview of recent developments in nanomedicine and highlight the current challenges and upcoming opportunities for the field and translation to the clinic. \ua9 2017 American Chemical Society

Prevalence, associated factors and outcomes of pressure injuries in adult intensive care unit patients: the DecubICUs study

Funder: European Society of Intensive Care Medicine; doi: http://dx.doi.org/10.13039/501100013347Funder: Flemish Society for Critical Care NursesAbstract: Purpose: Intensive care unit (ICU) patients are particularly susceptible to developing pressure injuries. Epidemiologic data is however unavailable. We aimed to provide an international picture of the extent of pressure injuries and factors associated with ICU-acquired pressure injuries in adult ICU patients. Methods: International 1-day point-prevalence study; follow-up for outcome assessment until hospital discharge (maximum 12 weeks). Factors associated with ICU-acquired pressure injury and hospital mortality were assessed by generalised linear mixed-effects regression analysis. Results: Data from 13,254 patients in 1117 ICUs (90 countries) revealed 6747 pressure injuries; 3997 (59.2%) were ICU-acquired. Overall prevalence was 26.6% (95% confidence interval [CI] 25.9–27.3). ICU-acquired prevalence was 16.2% (95% CI 15.6–16.8). Sacrum (37%) and heels (19.5%) were most affected. Factors independently associated with ICU-acquired pressure injuries were older age, male sex, being underweight, emergency surgery, higher Simplified Acute Physiology Score II, Braden score 3 days, comorbidities (chronic obstructive pulmonary disease, immunodeficiency), organ support (renal replacement, mechanical ventilation on ICU admission), and being in a low or lower-middle income-economy. Gradually increasing associations with mortality were identified for increasing severity of pressure injury: stage I (odds ratio [OR] 1.5; 95% CI 1.2–1.8), stage II (OR 1.6; 95% CI 1.4–1.9), and stage III or worse (OR 2.8; 95% CI 2.3–3.3). Conclusion: Pressure injuries are common in adult ICU patients. ICU-acquired pressure injuries are associated with mainly intrinsic factors and mortality. Optimal care standards, increased awareness, appropriate resource allocation, and further research into optimal prevention are pivotal to tackle this important patient safety threat

Correction to: Prevalence, associated factors and outcomes of pressure injuries in adult intensive care unit patients: the DecubICUs study

The original version of this article unfortunately contained a mistake

Prevalence, associated factors and outcomes of pressure injuries in adult intensive care unit patients: the DecubICUs study

Funder: European Society of Intensive Care Medicine; doi: http://dx.doi.org/10.13039/501100013347Funder: Flemish Society for Critical Care NursesAbstract: Purpose: Intensive care unit (ICU) patients are particularly susceptible to developing pressure injuries. Epidemiologic data is however unavailable. We aimed to provide an international picture of the extent of pressure injuries and factors associated with ICU-acquired pressure injuries in adult ICU patients. Methods: International 1-day point-prevalence study; follow-up for outcome assessment until hospital discharge (maximum 12 weeks). Factors associated with ICU-acquired pressure injury and hospital mortality were assessed by generalised linear mixed-effects regression analysis. Results: Data from 13,254 patients in 1117 ICUs (90 countries) revealed 6747 pressure injuries; 3997 (59.2%) were ICU-acquired. Overall prevalence was 26.6% (95% confidence interval [CI] 25.9–27.3). ICU-acquired prevalence was 16.2% (95% CI 15.6–16.8). Sacrum (37%) and heels (19.5%) were most affected. Factors independently associated with ICU-acquired pressure injuries were older age, male sex, being underweight, emergency surgery, higher Simplified Acute Physiology Score II, Braden score 3 days, comorbidities (chronic obstructive pulmonary disease, immunodeficiency), organ support (renal replacement, mechanical ventilation on ICU admission), and being in a low or lower-middle income-economy. Gradually increasing associations with mortality were identified for increasing severity of pressure injury: stage I (odds ratio [OR] 1.5; 95% CI 1.2–1.8), stage II (OR 1.6; 95% CI 1.4–1.9), and stage III or worse (OR 2.8; 95% CI 2.3–3.3). Conclusion: Pressure injuries are common in adult ICU patients. ICU-acquired pressure injuries are associated with mainly intrinsic factors and mortality. Optimal care standards, increased awareness, appropriate resource allocation, and further research into optimal prevention are pivotal to tackle this important patient safety threat

An inducible and reversible genetics platform for novel drug target discovery

Understanding gene function provides insights into biological processes and disease pathologies. Such knowledge can be applied to benefit human health and medicine. With this in mind, I have established a genetic platform in mouse to study gene function. The platform consists of two transgenic mouse strains that were generated inhouse, through the use of CRISPR/Cas9 gene editing technology: (1) a strain that ubiquitously expresses the reverse tetracycline trans-silencer (rTetR-KRAB) in all tissues and (2) a strain where the tetracycline response element (TRE) has been inserted in close proximity to the target gene’s promoter. With appropriate double transgenic mouse strains, rTetR-KRAB binds to TRE in the presence of doxycycline and represses the target gene. Repression is dose-dependent and reversible. To demonstrate the feasibility of the platform, I have chosen to target Tcf7l2 which is a transcription factor that acts downstream of Wnt signalling. The Wnt signalling pathway has been implicated in colorectal cancer, but there are contradictory views on whether Tcf7l2 acts as an oncogene or tumour suppressor gene in this context. Preliminary data obtained using small intestine organoids derived from double transgenic mouse, show the importance of Tcf7l2 for intestinal homeostasis and ApcMin-associated adenoma maintenance. To expound this, I will utilise the Tcf7l2 transgenic strain to investigate if physiological rebalance of this gene has therapeutic effects in colon cancer. This platform can also be generally useful to study the physiological or pathological role of other target genes.Doctor of Philosoph

The emergence of self-organizing e-commerce ecosystems in remote villages of China: a tale of digital empowerment for rural development

The emergence of Alibaba’s Taobao (e-commerce) Villages in remote China has challenged the assumption that rural, underserved communities must always be the recipients of aid to stimulate ICT-enabled development. Based on an in-depth case study of two remote villages in China, this research note shows how ICT (e-commerce) can empower a marginalized community, giving rise to a rural e-commerce ecosystem that can aid self-development. We propose the concept of digital empowerment to explicate our findings in the exploration of community-driven development: first, we identify the critical actors of a rural e-commerce ecosystem and how ICT is used by them; second, we illustrate how the same ICT can be used for different affordances by the actors in the evolution of a rural e-commerce ecosystem. The paper also presents unintended consequences of rural e-commerce development. We conclude with suggestions on how to make ICT useful for rural development, and in doing this challenge some of the prevailing theoretical arguments about this process