The use of air induction nozzles for herbicide application to sugar beet.

End of Project ReportTrials were carried out over a three-year period in Oak Park to compare airinduction with conventional nozzles for weed control in sugar beet. Two makes of low-drift nozzle (Bubble Jet and DriftBETA) were compared with conventional fans. All nozzles were used at a pressure of 3 bar. Two sizes (015 and 03) of each type of nozzle were used, to allow volumes of 110 and 220 litres per hectare to be applied. These nozzles were used to apply two-spray programmes to sugar-beet crops. In four of the weed control trials, tank mixes of products with some residual action (Progress, Goltix, Venzar and Debut) were used. In the other two trials, a contact-only spray (Betanal E) was used. The aim was to see how the nozzles behaved with contact-only sprays as well as those with more complex modes of action. Spray drift was also measured with the size 03 nozzles. Spray drift reductions from 37% to 64% were measured when the air-induction nozzles were compared with conventional fans. In general, the tank mix programme gave better weed control than the contact-only treatments. Within programmes, differences between the application methods were significant in two trials. In both of these, the conventional nozzles gave the best results. Looking at the mean results of the tank-mix trials, two trends were suggested: higher water volumes gave slightly better weed control, and the effect of the coarser sprays was slight. With the contact-only sprays, the decline in performance with the coarser sprays was more emphatic, and the lower volumes appeared to give slightly better control. It is concluded that in calm conditions conventional fan or cone nozzles should continue to be used, but that air-induction nozzles are a valuable fall-back when it is necessary to spray in a moderate breeze. In these situations, and with the normal tank-mix programmes, small nozzle sizes applying very low volumes should be avoided. Makes of air-induction nozzle which give very coarse spray should also be avoided

Evaluation of a home monitoring application for follow up after lung transplantation—a pilot study

Home spirometry after lung transplantation is common practice, to monitor graft function. However, there is little experience with online home monitoring applications with direct data transfer to the hospital. We evaluated the feasibility and patient experiences with a new online home monitoring application, integrated with a Bluetooth-enabled spirometer and real-time data transfer. Consecutive lung transplant recipients were asked to evaluate this home monitoring application for three months in a pilot study. Home spirometry measurements were compared with in-hospital lung function tests (the forced expiratory volume in 1 s (FEV1) and forced vital capacity (FVC)) at the end of the study. Ten patients participated. The home and hospital spirometry measurements showed a high correlation, for both the FEV1 (r = 0.99, p < 0.01) and FVC (r = 0.99, p < 0.01). The adherence and patient satisfaction were high, and the patients preferred the home monitoring application over the current home spirometer, with a difference of 1.4 ± 1.5 points on a scale from 0 to 10 (p = 0.02). Online home monitoring with direct data transfer is feasible and reliable after lung transplantation and results in high patient satisfaction. Whether the implementation of online home monitoring enables the earlier detection of lung function decline and improves patient and graft outcomes will be the subject of future research

The COSINE-100 liquid scintillator veto system

This paper describes the liquid scintillator veto system for the COSINE-100 dark matter experiment and its performance. The COSINE-100 detector consists of eight NaI(Tl) crystals immersed in 2200 L of linear alkylbenzene-based liquid scintillator. The liquid scintillator tags between 65 and 75% of the internal 40K background in the 2–6 keV energy region. We also describe the background model for the liquid scintillator, which is primarily used to assess its energy calibration and threshold

Randomized controlled field trial to assess the immunogenicity and safety of rift valley fever clone 13 vaccine in livestock

BACKGROUND:Although livestock vaccination is effective in preventing Rift Valley fever (RVF) epidemics, there are concerns about safety and effectiveness of the only commercially available RVF Smithburn vaccine. We conducted a randomized controlled field trial to evaluate the immunogenicity and safety of the new RVF Clone 13 vaccine, recently registered in South Africa. METHODS:In a blinded randomized controlled field trial, 404 animals (85 cattle, 168 sheep, and 151 goats) in three farms in Kenya were divided into three groups. Group A included males and non-pregnant females that were randomized and assigned to two groups; one vaccinated with RVF Clone 13 and the other given placebo. Groups B included animals in 1st half of pregnancy, and group C animals in 2nd half of pregnancy, which were also randomized and either vaccinated and given placebo. Animals were monitored for one year and virus antibodies titers assessed on days 14, 28, 56, 183 and 365. RESULTS:In vaccinated goats (N = 72), 72% developed anti-RVF virus IgM antibodies and 97% neutralizing IgG antibodies. In vaccinated sheep (N = 77), 84% developed IgM and 91% neutralizing IgG antibodies. Vaccinated cattle (N = 42) did not develop IgM antibodies but 67% developed neutralizing IgG antibodies. At day 14 post-vaccination, the odds of being seropositive for IgG in the vaccine group was 3.6 (95% CI, 1.5 - 9.2) in cattle, 90.0 (95% CI, 25.1 - 579.2) in goats, and 40.0 (95% CI, 16.5 - 110.5) in sheep. Abortion was observed in one vaccinated goat but histopathologic analysis did not indicate RVF virus infection. There was no evidence of teratogenicity in vaccinated or placebo animals. CONCLUSIONS:The results suggest RVF Clone 13 vaccine is safe to use and has high (>90%) immunogenicity in sheep and goats but moderate (> 65%) immunogenicity in cattle

Measurement of the cosmic muon annual and diurnal flux variation with the COSINE-100 detector

We report measurements of annual and diurnal modulations of the cosmic-ray muon rate in the Yangyang underground laboratory (Y2L) using 952 days of COSINE-100 data acquired between September 2016 and July 2019. A correlation of the muon rate with the atmospheric temperature is observed and its amplitude on the muon rate is determined. The effective atmospheric temperature and muon rate variations are positively correlated with a measured effective temperature coefficient of αT = 0.80 ± 0.11. This result is consistent with a model of meson production in the atmosphere. We also searched for a diurnal modulation in the underground muon rate by comparing one-hour intervals. No significant diurnal modulation of the muon rate was observed

Radiopurity assessment of the energy readout for the NEXT double beta decay experiment

[EN] The "Neutrino Experiment with a Xenon Time-Projection Chamber" (NEXT) experiment intends to investigate the neutrinoless double beta decay of 136Xe, and therefore requires a severe suppression of potential backgrounds. An extensive material screening and selection process was undertaken to quantify the radioactivity of the materials used in the experiment. Separate energy and tracking readout planes using different sensors allow us to combine the measurement of the topological signature of the event for background discrimination with the energy resolution optimization. The design of radiopure readout planes, in direct contact with the gas detector medium, was especially challenging since the required components typically have activities too large for experiments demanding ultra-low background conditions. After studying the tracking plane, here the radiopurity control of the energy plane is presented, mainly based on gamma-ray spectroscopy using ultra-low background germanium detectors at the Laboratorio Subterráneo de Canfranc (Spain). All the available units of the selected model of photomultiplier have been screened together with most of the components for the bases, enclosures and windows. According to these results for the activity of the relevant radioisotopes, the selected components of the energy plane would give a contribution to the overall background level in the region of interest of at most 2.4 × 10¿4 counts per keV, kg and year, satisfying the sensitivity requirements of the NEXT experiment.Special thanks are due to LSC directorate and staff for their strong support for performing the measurements at the LSC Radiopurity Service. We are really grateful to Grzegorz Zuzel for the radon emanation measurements. The NEXT Collaboration acknowledges support from the following agencies and institutions: the European Research Council (ERC) under the Advanced Grant 339787-NEXT; the Ministerio de Economia y Competitividad of Spain under grants FIS2014-53371-C04 and the Severo Ochoa Program SEV-2014-0398; the GVA of Spain under grant PROMETEO/2016/120; the Portuguese FCT and FEDER through the program COMPETE, project PTDC/FIS/103860/2008; the U.S. Department of Energy under contracts number DE-AC02-07CH11359 (Fermi National Accelerator Laboratory) and DE-FG02-13ER42020 (Texas A & and the University of Texas at Arlington.Cebrian, S.; Perez, J.; Bandac, I.; Labarga, L.; Álvarez-Puerta, V.; Azevedo, CDR.; Benlloch-Rodriguez, JM.... (2017). Radiopurity assessment of the energy readout for the NEXT double beta decay experiment. Journal of Instrumentation. 12. https://doi.org/10.1088/1748-0221/12/08/T08003S12Avignone, F. T., Elliott, S. R., & Engel, J. (2008). Double beta decay, Majorana neutrinos, and neutrino mass. Reviews of Modern Physics, 80(2), 481-516. doi:10.1103/revmodphys.80.481Martín-Albo, J., Muñoz Vidal, J., Ferrario, P., Nebot-Guinot, M., Gómez-Cadenas, J. J., … Cárcel, S. (2016). Sensitivity of NEXT-100 to neutrinoless double beta decay. Journal of High Energy Physics, 2016(5). doi:10.1007/jhep05(2016)159Renner, J., Farbin, A., Vidal, J. M., Benlloch-Rodríguez, J. M., Botas, A., Ferrario, P., … Borges, F. I. G. (2017). Background rejection in NEXT using deep neural networks. Journal of Instrumentation, 12(01), T01004-T01004. doi:10.1088/1748-0221/12/01/t01004Dafni, T., Álvarez, V., Bandac, I., Bettini, A., Borges, F. I. G. M., Camargo, M., … Conde, C. A. N. (2016). Results of the material screening program of the NEXT experiment. Nuclear and Particle Physics Proceedings, 273-275, 2666-2668. doi:10.1016/j.nuclphysbps.2015.10.024Cebrián, S., Pérez, J., Bandac, I., Labarga, L., Álvarez, V., Barrado, A. I., … Cárcel, S. (2015). Radiopurity assessment of the tracking readout for the NEXT double beta decay experiment. Journal of Instrumentation, 10(05), P05006-P05006. doi:10.1088/1748-0221/10/05/p05006Wang, X., Chen, X., Fu, C., Ji, X., Liu, X., Mao, Y., … Zhang, T. (2016). Material screening with HPGe counting station for PandaX experiment. Journal of Instrumentation, 11(12), T12002-T12002. doi:10.1088/1748-0221/11/12/t12002Barrow, P., Baudis, L., Cichon, D., Danisch, M., Franco, D., Kaether, F., … Wulf, J. (2017). Qualification tests of the R11410-21 photomultiplier tubes for the XENON1T detector. Journal of Instrumentation, 12(01), P01024-P01024. doi:10.1088/1748-0221/12/01/p01024Busto, J., Gonin, Y., Hubert, F., Hubert, P., & Vuilleumier, J.-M. (2002). Radioactivity measurements of a large number of adhesives. Nuclear Instruments and Methods in Physics Research Section A: Accelerators, Spectrometers, Detectors and Associated Equipment, 492(1-2), 35-42. doi:10.1016/s0168-9002(02)01280-9Nisi, S., Di Vacri, A., Di Vacri, M. L., Stramenga, A., & Laubenstein, M. (2009). Comparison of inductively coupled mass spectrometry and ultra low-level gamma-ray spectroscopy for ultra low background material selection. Applied Radiation and Isotopes, 67(5), 828-832. doi:10.1016/j.apradiso.2009.01.02

Astronomical Distance Determination in the Space Age: Secondary Distance Indicators

The formal division of the distance indicators into primary and secondary leads to difficulties in description of methods which can actually be used in two ways: with, and without the support of the other methods for scaling. Thus instead of concentrating on the scaling requirement we concentrate on all methods of distance determination to extragalactic sources which are designated, at least formally, to use for individual sources. Among those, the Supernovae Ia is clearly the leader due to its enormous success in determination of the expansion rate of the Universe. However, new methods are rapidly developing, and there is also a progress in more traditional methods. We give a general overview of the methods but we mostly concentrate on the most recent developments in each field, and future expectations. © 2018, The Author(s)

Projected WIMP sensitivity of the LUX-ZEPLIN dark matter experiment

LUX-ZEPLIN (LZ) is a next-generation dark matter direct detection experiment that will operate 4850 feet underground at the Sanford Underground Research Facility (SURF) in Lead, South Dakota, USA. Using a two-phase xenon detector with an active mass of 7 tonnes, LZ will search primarily for low-energy interactions with weakly interacting massive particles (WIMPs), which are hypothesized to make up the dark matter in our galactic halo. In this paper, the projected WIMP sensitivity of LZ is presented based on the latest background estimates and simulations of the detector. For a 1000 live day run using a 5.6-tonne fiducial mass, LZ is projected to exclude at 90% confidence level spin-independent WIMP-nucleon cross sections above 1.4 × 10-48cm2 for a 40 GeV/c2 mass WIMP. Additionally, a 5σ discovery potential is projected, reaching cross sections below the exclusion limits of recent experiments. For spin-dependent WIMP-neutron(-proton) scattering, a sensitivity of 2.3 × 10−43 cm2 (7.1 × 10−42 cm2) for a 40 GeV/c2 mass WIMP is expected. With underground installation well underway, LZ is on track for commissioning at SURF in 2020

Space Telescope and Optical Reverberation Mapping Project. VII. Understanding the Ultraviolet Anomaly in NGC 5548 with X-Ray Spectroscopy

During the Space Telescope and Optical Reverberation Mapping Project observations of NGC 5548, the continuum and emission-line variability became decorrelated during the second half of the six-month-long observing campaign. Here we present Swift and Chandra X-ray spectra of NGC 5548 obtained as part of the campaign. The Swift spectra show that excess flux (relative to a power-law continuum) in the soft X-ray band appears before the start of the anomalous emission-line behavior, peaks during the period of the anomaly, and then declines. This is a model-independent result suggesting that the soft excess is related to the anomaly. We divide the Swift data into on- and off-anomaly spectra to characterize the soft excess via spectral fitting. The cause of the spectral differences is likely due to a change in the intrinsic spectrum rather than to variable obscuration or partial covering. The Chandra spectra have lower signal-to-noise ratios, but are consistent with the Swift data. Our preferred model of the soft excess is emission from an optically thick, warm Comptonizing corona, the effective optical depth of which increases during the anomaly. This model simultaneously explains all three observations: the UV emission-line flux decrease, the soft-excess increase, and the emission-line anomaly

Effects of sleep deprivation on neural functioning: an integrative review

Sleep deprivation has a broad variety of effects on human performance and neural functioning that manifest themselves at different levels of description. On a macroscopic level, sleep deprivation mainly affects executive functions, especially in novel tasks. Macroscopic and mesoscopic effects of sleep deprivation on brain activity include reduced cortical responsiveness to incoming stimuli, reflecting reduced attention. On a microscopic level, sleep deprivation is associated with increased levels of adenosine, a neuromodulator that has a general inhibitory effect on neural activity. The inhibition of cholinergic nuclei appears particularly relevant, as the associated decrease in cortical acetylcholine seems to cause effects of sleep deprivation on macroscopic brain activity. In general, however, the relationships between the neural effects of sleep deprivation across observation scales are poorly understood and uncovering these relationships should be a primary target in future research