Information Presentation

The goal of the Information Presentation Directed Research Project (DRP) is to address design questions related to the presentation of information to the crew on flight vehicles, surface landers and habitats, and during extra-vehicular activities (EVA). Designers of displays and controls for exploration missions must be prepared to select the text formats, label styles, alarms, electronic procedure designs, and cursor control devices that provide for optimal crew performance on exploration tasks. The major areas of work, or subtasks, within the Information Presentation DRP are: 1) Controls, 2) Displays, 3) Procedures, and 4) EVA Operations

Unintentional injuries in children with disabilities:a systematic review and meta-analysis

Children with disabilities are thought to have an increased risk of unintentional injuries, but quantitative syntheses of findings from previous studies have not been done. We conducted a systematic review and meta-analysis to assess whether pre-existing disability can increase the risk of unintentional injuries among children when they are compared to children without disability. We searched 13 electronic databases to identify original research published between 1 January 1990 and 28 February 2013. We included those studies that reported on unintentional injuries among children with pre-existing disabilities compared with children without disabilities. We conducted quality assessments and then calculated pooled odds ratios of injury using random-effects models. Fifteen eligible studies were included from 24,898 references initially identified, and there was a total sample of 83,286 children with disabilities drawn from the eligible studies. When compared with children without disabilities, the pooled OR of injury was 1.86 (95 % CI 1.65-2.10) in children with disabilities. The pooled ORs of injury were 1.28, 1.75, and 1.86 in the 0-4 years, 5-9 years, and ≥10 years of age subgroups, respectively. Compared with children without disabilities, the pooled OR was 1.75 (95 % CI 1.26-2.43) among those with International Classification of Functioning (ICF) limitations. When disability was defined as physical disabilities, the pooled OR was 2.39 (95 % CI 1.43-4.00), and among those with cognitive disabilities, the pooled OR was 1.77 (95 % CI 1.49-2.11). There was significant heterogeneity in the included studies. Compared with peers without disabilities, children with disabilities are at a significantly higher risk of injury. Teens with disabilities may be an important subgroup for future injury prevention efforts. More data are needed from low- and middle-income countries

Genome-wide association and Mendelian randomisation analysis provide insights into the pathogenesis of heart failure

Heart failure (HF) is a leading cause of morbidity and mortality worldwide. A small proportion of HF cases are attributable to monogenic cardiomyopathies and existing genome-wide association studies (GWAS) have yielded only limited insights, leaving the observed heritability of HF largely unexplained. We report results from a GWAS meta-analysis of HF comprising 47,309 cases and 930,014 controls. Twelve independent variants at 11 genomic loci are associated with HF, all of which demonstrate one or more associations with coronary artery disease (CAD), atrial fibrillation, or reduced left ventricular function, suggesting shared genetic aetiology. Functional analysis of non-CAD-associated loci implicate genes involved in cardiac development (MYOZ1, SYNPO2L), protein homoeostasis (BAG3), and cellular senescence (CDKN1A). Mendelian randomisation analysis supports causal roles for several HF risk factors, and demonstrates CAD-independent effects for atrial fibrillation, body mass index, and hypertension. These findings extend our knowledge of the pathways underlying HF and may inform new therapeutic strategies

Genome-wide association and Mendelian randomisation analysis provide insights into the pathogenesis of heart failure

Abstract: Heart failure (HF) is a leading cause of morbidity and mortality worldwide. A small proportion of HF cases are attributable to monogenic cardiomyopathies and existing genome-wide association studies (GWAS) have yielded only limited insights, leaving the observed heritability of HF largely unexplained. We report results from a GWAS meta-analysis of HF comprising 47,309 cases and 930,014 controls. Twelve independent variants at 11 genomic loci are associated with HF, all of which demonstrate one or more associations with coronary artery disease (CAD), atrial fibrillation, or reduced left ventricular function, suggesting shared genetic aetiology. Functional analysis of non-CAD-associated loci implicate genes involved in cardiac development (MYOZ1, SYNPO2L), protein homoeostasis (BAG3), and cellular senescence (CDKN1A). Mendelian randomisation analysis supports causal roles for several HF risk factors, and demonstrates CAD-independent effects for atrial fibrillation, body mass index, and hypertension. These findings extend our knowledge of the pathways underlying HF and may inform new therapeutic strategies

Genome-wide association and Mendelian randomisation analysis provide insights into the pathogenesis of heart failure

Abstract: Heart failure (HF) is a leading cause of morbidity and mortality worldwide. A small proportion of HF cases are attributable to monogenic cardiomyopathies and existing genome-wide association studies (GWAS) have yielded only limited insights, leaving the observed heritability of HF largely unexplained. We report results from a GWAS meta-analysis of HF comprising 47,309 cases and 930,014 controls. Twelve independent variants at 11 genomic loci are associated with HF, all of which demonstrate one or more associations with coronary artery disease (CAD), atrial fibrillation, or reduced left ventricular function, suggesting shared genetic aetiology. Functional analysis of non-CAD-associated loci implicate genes involved in cardiac development (MYOZ1, SYNPO2L), protein homoeostasis (BAG3), and cellular senescence (CDKN1A). Mendelian randomisation analysis supports causal roles for several HF risk factors, and demonstrates CAD-independent effects for atrial fibrillation, body mass index, and hypertension. These findings extend our knowledge of the pathways underlying HF and may inform new therapeutic strategies

Operator Information Tool to Manage Heat Treat Furnace Parts for A.Finkl & Sons (semester?), IPRO 330: Finkl Operator Info Tool Manage Heat Treat Furnace IPRO 330 Final Report Sp06

To generate an accurate survey of temperature distribution within the furnace. To determine a method of stacking that provides the most uniform temperature distribution. To create an efficient and intuitive tracking system that allows the exact location of each part in the furnace to be recorded and catalogued for future reference. To put this knowledge together to create a software package that can be used to quickly and easily generate a stacking sequence that will result in a proper heat treatment for each piece in the furnace each time. To fulfill all IPRO requirementsSponsorship: A. Finkl & SonsDeliverables for IPRO 330: Operator Information Tool to Manage Heat Treat Furnace Parts for A.Finkl & Sons for the Spring 2006 semeste

Operator Information Tool to Manage Heat Treat Furnace Parts for A.Finkl & Sons (semester?), IPRO 330

To generate an accurate survey of temperature distribution within the furnace. To determine a method of stacking that provides the most uniform temperature distribution. To create an efficient and intuitive tracking system that allows the exact location of each part in the furnace to be recorded and catalogued for future reference. To put this knowledge together to create a software package that can be used to quickly and easily generate a stacking sequence that will result in a proper heat treatment for each piece in the furnace each time. To fulfill all IPRO requirementsSponsorship: A. Finkl & SonsDeliverables for IPRO 330: Operator Information Tool to Manage Heat Treat Furnace Parts for A.Finkl & Sons for the Spring 2006 semeste

Operator Information Tool to Manage Heat Treat Furnace Parts for A.Finkl & Sons (semester?), IPRO 330: Finkl Operator Info Tool Manage Heat Treat Furnace IPRO 330 Abstract Sp06

To generate an accurate survey of temperature distribution within the furnace. To determine a method of stacking that provides the most uniform temperature distribution. To create an efficient and intuitive tracking system that allows the exact location of each part in the furnace to be recorded and catalogued for future reference. To put this knowledge together to create a software package that can be used to quickly and easily generate a stacking sequence that will result in a proper heat treatment for each piece in the furnace each time. To fulfill all IPRO requirementsSponsorship: A. Finkl & SonsDeliverables for IPRO 330: Operator Information Tool to Manage Heat Treat Furnace Parts for A.Finkl & Sons for the Spring 2006 semeste

Operator Information Tool to Manage Heat Treat Furnace Parts for A.Finkl & Sons (semester?), IPRO 330: Finkl Operator Info Tool Manage Heat Treat Furnace IPRO 330 Project Plan Sp06

To generate an accurate survey of temperature distribution within the furnace. To determine a method of stacking that provides the most uniform temperature distribution. To create an efficient and intuitive tracking system that allows the exact location of each part in the furnace to be recorded and catalogued for future reference. To put this knowledge together to create a software package that can be used to quickly and easily generate a stacking sequence that will result in a proper heat treatment for each piece in the furnace each time. To fulfill all IPRO requirementsSponsorship: A. Finkl & SonsDeliverables for IPRO 330: Operator Information Tool to Manage Heat Treat Furnace Parts for A.Finkl & Sons for the Spring 2006 semeste