Katsaus: Maahanmuuttajien mielenterveyspalvelujen käyttö, erot kantaväestöihin ja erojen taustatekijät

Peer reviewe

Membrane-Type-3 Matrix Metalloproteinase (MT3-MMP) Functions as a Matrix Composition-Dependent Effector of Melanoma Cell Invasion

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Lymphatic endothelium stimulates melanoma metastasis and invasion via MMP14-dependent Notch3 and b1-integrin activation

Lymphatic invasion and lymph node metastasis correlate with poor clinical outcome in melanoma. However, the mechanisms of lymphatic dissemination in distant metastasis remain incompletely understood. We show here that exposure of expansively growing human WM852 melanoma cells, but not singly invasive Bowes cells, to lymphatic endothelial cells (LEC) in 3D co-culture facilitates melanoma distant organ metastasis in mice. To dissect the underlying molecular mechanisms, we established LEC co-cultures with different melanoma cells originating from primary tumors or metastases. Notably, the expansively growing metastatic melanoma cells adopted an invasively sprouting phenotype in 3D matrix that was dependent on MMP14, Notch3 and β1-integrin. Unexpectedly, MMP14 was necessary for LEC-induced Notch3 induction and coincident β1-integrin activation. Moreover, MMP14 and Notch3 were required for LEC-mediated metastasis of zebrafish xenografts. This study uncovers a unique mechanism whereby LEC contact promotes melanoma metastasis by inducing a reversible switch from 3D growth to invasively sprouting cell phenotype

Tying the Extended Family Knot: Grandparents’ Influence on Educational Achievement

In present-day western societies grandparents and grandchildren have longer years of shared lifetime than ever before. We investigate whether children with more grandparent resources have a higher probability of achieving the general secondary degree compared with children with fewer resources, or whether shared lifetime with grandparents increases the probability of achieving the general secondary degree. We use high-quality Finnish Census Panel data and apply sibling random and fixed-effects models that also control for all unobserved factors shared by siblings. Grandparents’ education and socioeconomic status have only a limited ability to explain a grandchild’s educational achievement. However, the sibling fixed-effects models reveal that every shared year between grandparents and grandchildren increases a grandchild’s likelihood of completing general secondary education by 1 percentage point, on average. The effect of shared lifetime is conditional on grandparental type, family resources, and the size of the extended family. Maternal grandmothers have a positive effect on grandchildren’s education in low-income families. Paternal grandmothers provide a link to the resources available through the extended family network, independent of their own resources. The same effects were not observed for grandfathers.</p

Optical projection tomography as a tool for 3D imaging of hydrogels

An Optical Projection Tomography (OPT) system was developed and optimized to image 3D tissue engineered products based in hydrogels. We develop pre-reconstruction algorithms to get the best result from the reconstruction procedure, which include correction of the illumination and determination of sample center of rotation (CoR). Existing methods for CoR determination based on the detection of the maximum variance of reconstructed slices failed, so we develop a new CoR search method based in the detection of the variance sharpest local maximum. We show the capabilities of the system to give quantitative information of different types of hydrogels that may be useful in its characterization.The authors thank to Tekes, Finnish Cultural Foundation, CIMO, Jane and Aatos Erkko Foundation and EXTREMA COST Action MP1207 for supporting this work

SUNSTORM 1/X-ray Flux Monitor for CubeSats (XFM-CS) : Instrument characterization and first results

SUNSTORM 1 CubeSat was launched to Sun-synchronous low Earth orbit on August 17 2021. The primary purpose of the mission is an in-orbit demonstration of X-ray Flux Monitor (XFM) instrument. XFM is an innovative solar X-ray spectrometer for measuring and characterizing solar flares, which are known to be linked to a variety of space weather phenomena. XFM represents a next generation of solar X-ray flux monitors. It is based on silicon drift detector technology, which provides several notable performance improvements over its predecessors, which are based on Si PIN detectors. Transversal electric field and lower output capacitance allow operation at much faster pulse processing shaping times, allowing the system to achieve about 10 times higher throughput without saturation while also making it less sensitive to the increase of leakage current due to high temperature and/or radiation damage. Thus, XFM instruments can cover a very wide dynamic range of solar X-ray emission from the most quiescent conditions to the strongest X-class solar flares, while maintaining good spectral resolution (Peer reviewe

Incidence and prevalence of mental disorders among immigrants and native Finns: a register-based study

Migrants appear to have a higher risk of mental disorders, but findings vary across country settings and migrant groups. We aimed to assess incidence and prevalence of mental disorders among immigrants and Finnish-born controls in a register-based cohort study.A register-based cohort study of 184.806 immigrants and 185.184 Finnish-born controls (1.412.117 person-years) was conducted. Information on mental disorders according to ICD-10 was retrieved from the Hospital Discharge Register, which covers all public health care use.The incidence of any mental disorder was lower among male (adjusted HR 0.82, 95% CI 0.77-0.87) and female (aHR 0.76, 95% CI 0.72-0.81) immigrants, being lowest among Asian and highest among North African and Middle Eastern immigrants. The incidence of bipolar, depressive and alcohol use disorders was lower among immigrants. Incidence of psychotic disorders was lower among female and not higher among male immigrants, compared with native Finns. Incidence of PTSD was higher among male immigrants (aHR 4.88, 95% CI 3.38-7.05).The risk of mental disorders varies significantly across migrant groups and disorders and is generally lower among immigrants than native Finns

FOXP3+ T cells in uterine sarcomas are associated with favorable prognosis, low extracellular matrix expression and reduced YAP activation.

Uterine sarcomas are rare but deadly malignancies without effective treatment. Immunotherapy is a promising new approach to treat these tumors but has shown heterogeneous effects in sarcoma patients. With the goal of identifying key factors for improved patient treatment, we characterized the tumor immune landscape in 58 uterine sarcoma cases with full clinicopathological annotation. Immune cell characterization revealed the overall prevalence of FOXP3+ cells and pro-tumor M2-like macrophages. Hierarchical clustering of patients showed four tumor type-independent immune signatures, where infiltration of FOXP3+ cells and M1-like macrophages associated with favorable prognosis. High CD8+/FOXP3+ ratio in UUS and ESS correlated with poor survival, upregulation of immunosuppressive markers, extracellular matrix (ECM)-related genes and proteins, and YAP activation. This study shows that uterine sarcomas present distinct immune signatures with prognostic value, independent of tumor type, and suggests that targeting the ECM could be beneficial for future treatments

Ideal tau tagging with the multivariate data-analysis toolkit TMVA

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