Two Perceptions of Change in Judeo-Spanish Rabbinic Literature

In this article, I analyze the brief references to the invention of the telegraph in Yeuda Papo's Judeo-Spanish version of the Pele Yo ´ets and Ben Tsion Rodeti's Sefer Ki Ze Kol ha-Adam, two Judeo-Spanish books of musar from the nineteenth century. These rather unlikely references permit us to study perceptions of present, future, and change held by two Sephardic rabbis from the Ottoman Empire in a period of accelerated technological progress and social transformation. Two different attitudes towards change can be described. While Papo's work announces important transformations in the semantics of understanding time, without stepping outside rabbinic tradition itself, Ben Tsion Rodeti denies the very fact of change and affirms that everything that has to be known already is included once and for all in the rabbinic literary tradition.En este artículo analizo las referencias a la introducción del telégrafo en dos libros de musar del siglo XIX publicados en ladino: el Pele Yo 'éŝ, cuyo versión judeoespañola preparó Yeudá Papo, y el Séfer Ki źe kol haadam, de Ben-Ŝiyón Binyamín Rodeti. Los pasajes nos permiten estudiar cómo entendieron estos dos rabinos sefardíes el tiempo presente y el futuro, así como los cambios en un período de avances técnicos y transformaciones sociales como los que se produjeron en el Imperio Otomano del siglo XIX. Podemos distinguir dos tendencias. Mientras que el libro de Papo anuncia importantes transformaciones semánticas en el entendimiento del tiempo -aunque él mismo nunca sale del margen de la tradición rabínica-, Ben-Ŝiyón Rodeti descarta que haya cambios y afirma que todo ya se ha dicho en la tradición literaria rabínica y que los tiempos actuales no cuestionan ni pueden cuestionar esta tradición

Logistic Organ Dysfunction Score (LODS): A reliable postoperative risk management score also in cardiac surgical patients?

<p>Abstract</p> <p>Background</p> <p>The original Logistic Organ Dysfunction Sore (LODS) excluded cardiac surgery<ul/>patients from its target population, and the suitability of this score in cardiac surgery patients has never been tested. We evaluated the accuracy of the LODS and the usefulness of its daily measurement in cardiac surgery patients. The LODS is not a true logistic scoring system, since it does not use β-coefficients.</p> <p>Methods</p> <p>This prospective study included all consecutive adult patients who were admitted to<ul/>the intensive care unit (ICU) after cardiac surgery between January 2007 and December 2008. The LODS was calculated daily from the first until the seventh postoperative day. Performance was assessed with Hosmer-Lemeshow (HL) goodness-of-fit test (calibration) and receiver operating characteristic (ROC) curves (discrimination) from ICU admission day until day 7. The outcome measure was ICU mortality.</p> <p>Results</p> <p>A total of 2801 patients (29.6% female) with a mean age of 66.4 ± 10.7 years were<ul/>included. The ICU mortality rate was 5.2% (n = 147). The mean stay on the ICU was 4.3 ± 6.8 days. Calibration of the LODS was good with no significant difference between expected and observed mortality rates on any day (p ≥ 0.05). The initial LODS had an area under the ROC curve (AUC) of 0.81. The AUC was best on ICU day 3 with a value of 0.93, and declined to 0.85 on ICU day 7.</p> <p>Conclusions</p> <p>Although the LODS has not previously been validated for cardiac surgery<ul/>patients it showed reasonable accuracy in prediction of ICU mortality in patients after cardiac surgery.</p

Devitalization of Glioblastoma Cancer Cells by Non-invasive Physical Plasma: Modulation of Proliferative Signalling Cascades

Background/Aim: Glioblastoma (GBM) is the most common and most lethal type of cancer of the central nervous system in adults. Despite aggressive treatment, which is based on surgical resection, if possible, followed by radiation and chemotherapy, a high recurrence rate and therapy resistance is observed. Thus, additional innovative therapies are urgently needed to improve the poor median survival of only 15 months. Treatment of solid tumours with non-invasive physical plasma (NIPP) represents such a novel and innovative anticancer procedure. Materials and Methods: In this study, we investigated the effect of NIPP, an ionized argon gas, on the in vitro growth of human GBM cell lines, LN-18 and U-87 MG. Proliferation was measured by live cell count. Subsequently, proliferative factors were analysed at the level of nucleic acids (polymerase chain reaction) and proteins (western blotting). Results: For both GBM lines, a treatment time-dependent decrease in growth was observed compared to controls. Additionally, NIPP treatment resulted in reduced rates of AKT serine/threonine kinase 1 (AKT1) and extracellular-regulated kinase 1/2 ERK1/2 expression, whereas expression of p21, proliferating cell nuclear antigen, and heat-shock proteins 90α and 90β was not affected. In both cell lines, a strong increase in expression of tumour-suppressive microRNA-1 (miR-1) was detected after exposure to NIPP. Conclusion: Our results demonstrated that NIPP is able to efficiently attenuate growth of GBM cells and suggest AKT1, ERK1/2 and miR-1 to be pivotal factors of NIPP-modulated cellular signalling. Translated into the clinical setting, NIPP may represent a promising option for the treatment of GBM

Environmental and social life cycle assessment of growing media for urban rooftop farming

Acord transformatiu CRUE-CSICUnidad de excelencia María de Maeztu CEX2019-000940-MPurpose: New environmental strategies are emerging for cities to become more self-sufficient, such as hydroponic crop production. The implementation of such systems requires materials that usually originate in countries with low labour costs and other legal regulations. To what extent could these strategies be shifting problems across the globe? To answer this question, we performed a comprehensive environmental and social assessment of the various extended soilless systems used to grow vegetables on urban roofs. Methods: Three different growing media constituents were chosen for this study: perlite, peat and coir; which are produced in three countries, Turkey, Germany and the Philippines, respectively, and are imported to Spain. By using a life cycle assessment, we evaluated the environmental performances of the production and transport of these growing media. Additionally, we performed a social life cycle assessment at different levels. First, we used the Social Hotspots Database to analyse the constituents in aggregated sectors. Second, we performed a social assessment at the country and sector levels, and finally, we evaluated primary company data for the social assessment of the constituents through questionnaires given to businesses. Results and discussion: The coir-based growing medium exerted the lowest environmental burden in 5 out of 8 impact categories because it is a by-product from coconut trees. In contrast, perlite obtained the highest environmental impacts, with impacts 44 to 99.9% higher than those of peat and coir, except in the land use. Perlite is a material extracted from open-pit mines that requires high energy consumption and a long road trip. Regarding the social assessment, peat demonstrated the best performance on all the social assessment levels. In contrast, coir showed the worst scores in the Social Hotspots Database and for the impact categories of community infrastructure and human rights, whereas perlite displayed the lowest performance in health and safety. Nevertheless, coir and perlite evidenced much better scores than peat in the impact subcategory of the contribution to economic development. Conclusions: This study contributes to a first comparison of three imported growing media constituents for urban rooftop farming from environmental and social perspectives to choose the most suitable option. Peat appears to be the best alternative from a social perspective. However, from an environmental standpoint, peat represents a growing medium whose availability is aiming to disappear in Germany to preserve peatlands. Therefore, we identify a new market niche for the development of local growing media for future rooftop farming in cities

The \u3csup\u3e18\u3c/sup\u3eO-Signal Transfer from Water Vapour to Leaf Water and Assimilates Varies Among Plant Species and Growth Forms

The 18O signature of atmospheric water vapour (δ18OV) is known to be transferred via leaf water to assimilates. It remains, however, unclear how the 18O‐signal transfer differs among plant species and growth forms. We performed a 9‐hr greenhouse fog experiment (relative humidity ≥ 98%) with 18O‐depleted water vapour (−106.7‰) on 140 plant species of eight different growth forms during daytime. We quantified the 18O‐signal transfer by calculating the mean residence time of O in leaf water (MRTLW) and sugars (MRTSugars) and related it to leaf traits and physiological drivers. MRTLW increased with leaf succulence and thickness, varying between 1.4 and 10.8 hr. MRTSugars was shorter in C3 and C4 plants than in crassulacean acid metabolism (CAM) plants and highly variable among species and growth forms; MRTSugars was shortest for grasses and aquatic plants, intermediate for broadleaf trees, shrubs, and herbs, and longest for conifers, epiphytes, and succulents. Sucrose was more sensitive to δ18OV variations than other assimilates. Our comprehensive study shows that plant species and growth forms vary strongly in their sensitivity to δ18OV variations, which is important for the interpretation of δ18O values in plant organic material and compounds and thus for the reconstruction of climatic conditions and plant functional responses

Updating the Dual C and O Isotope—Gas-exchange Model: A Concept to Understand Plant Responses to the Environment and Its Implications for Tree Rings

The combined study of carbon (C) and oxygen (O) isotopes in plant organic matter has emerged as a powerful tool for understanding plant functional responses to environmental change. The approach relies on established relationships between leaf gas exchange and isotopic fractionation to derive a series of model scenarios that can be used to infer changes in photosynthetic assimilation and stomatal conductance driven by changes in environmental parameters (CO2, water availability, air humidity, temperature, nutrients). We review the mechanistic basis for a conceptual model, in light of recently published research, and discuss where isotopic observations do not match our current understanding of plant physiological response to the environment. We demonstrate that (1) the model was applied successfully in many, but not all studies; (2) although originally conceived for leaf isotopes, the model has been applied extensively to tree-ring isotopes in the context of tree physiology and dendrochronology. Where isotopic observations deviate from physiologically plausible conclusions, this mismatch between gas exchange and isotope response provides valuable insights into underlying physiological processes. Overall, we found that isotope responses can be grouped into situations of increasing resource limitation versus higher resource availability. The dual-isotope model helps to interpret plant responses to a multitude of environmental factors

Alleviating the new user problem in collaborative filtering by exploiting personality information

The final publication is available at Springer via http://dx.doi.org/10.1007/s11257-016-9172-zThe new user problem in recommender systems is still challenging, and there is not yet a unique solution that can be applied in any domain or situation. In this paper we analyze viable solutions to the new user problem in collaborative filtering (CF) that are based on the exploitation of user personality information: (a) personality-based CF, which directly improves the recommendation prediction model by incorporating user personality information, (b) personality-based active learning, which utilizes personality information for identifying additional useful preference data in the target recommendation domain to be elicited from the user, and (c) personality-based cross-domain recommendation, which exploits personality information to better use user preference data from auxiliary domains which can be used to compensate the lack of user preference data in the target domain. We benchmark the effectiveness of these methods on large datasets that span several domains, namely movies, music and books. Our results show that personality-aware methods achieve performance improvements that range from 6 to 94 % for users completely new to the system, while increasing the novelty of the recommended items by 3-40 % with respect to the non-personalized popularity baseline. We also discuss the limitations of our approach and the situations in which the proposed methods can be better applied, hence providing guidelines for researchers and practitioners in the field.This work was supported by the Spanish Ministry of Economy and Competitiveness (TIN2013-47090-C3). We thank Michal Kosinski and David Stillwell for their attention regarding the dataset

Management of Suspected Cases of Feline Immunodeficiency Virus Infection in Eurasian Lynx (Lynx lynx) During an International Translocation Program.

The Eurasian lynx (Lynx lynx) population in Switzerland serves as a source for reintroductions in neighboring countries. In 2016-2017, three lynx from the same geographical area were found seropositive for feline immunodeficiency virus (FIV) in the framework of an international translocation program. This novel finding raised questions about the virus origin and pathogenicity to lynx, the emerging character of the infection, and the interpretation of serological results in other lynx caught for translocation. Archived serum samples from 84 lynx captured in 2001-2016 were retrospectively tested for FIV antibodies by Western blot. All archived samples were FIV-negative. The three seropositive lynx were monitored in quarantine enclosures prior to euthanasia and necropsy. They showed disease signs, pathological findings, and occurrence of co-infections reminding of those described in FIV-infected domestic cats. All attempts to isolate and characterize the virus failed but serological data and spatiotemporal proximity of the cases suggested emergence of a lentivirus with antigenic and pathogenic similarities to FIV in the Swiss lynx population. A decision scheme was developed to minimize potential health risks posed by FIV infection, both in the recipient and source lynx populations, considering conservation goals, animal welfare, and the limited action range resulting from local human conflicts. Development and implementation of a cautious decision scheme was particularly challenging because FIV pathogenic potential in lynx was unclear, negative FIV serological results obtained within the first weeks after infection are unpredictable, and neither euthanasia nor repatriation of multiple lynx was acceptable options. The proposed scheme distinguished between three scenarios: release at the capture site, translocation, or euthanasia. Until April 2021, none of the 40 lynx newly captured in Switzerland tested FIV-seropositive. Altogether, seropositivity to FIV was documented in none of 124 lynx tested at their first capture, but three of them seroconverted in 2016-2017. Diagnosis of FIV infection in the three seropositive lynx remains uncertain, but clinical observations and pathological findings confirmed that euthanasia was appropriate. Our experiences underline the necessity to include FIV in pathogen screenings of free-ranging European wild felids, the importance of lynx health monitoring, and the usefulness of health protocols in wildlife translocation