8 research outputs found
Combination phentermine and topiramate for weight maintenance: the first Australian experience
OBJECTIVE: To investigate the safety, tolerability and efficacy of combination phentermine and topiramate therapy for maintenance of weight loss. DESIGN, SETTING AND PATIENTS: Retrospective audit of patients attending the Austin Health Weight Control Clinic who were dispensed phentermine-topiramate between 22 January 2010 and 16 July 2012 and after reaching a target weight by following a very low energy diet (VLED). Data collection continued until July 2013. MAIN OUTCOME MEASURES: Number of patients who ceased pharmacotherapy; duration of use of pharmacotherapy; types and numbers of adverse effects; and mean weight and blood pressure measurements at the initial visit, the end of the VLED and the last observation during pharmacotherapy. RESULTS: Data were available for 103 patients who were dispensed phentermine-topiramate; 61 patients ceased combination pharmacotherapy before the end of the data collection period, 41 due to adverse effects (eg, paraesthesia, cognitive changes, dry mouth and depression). The mean duration of use of pharmacotherapy was 10 months. Mean weight decreased by 10% due to the VLED (from 135.5 kg to 122.5 kg) and this loss was maintained. For 30 patients who continued on phentermine-topiramate, the mean duration of pharmacotherapy was 22 months and the mean weight decreased by 6.7 kg between the end of the VLED and the last observation during pharmacotherapy. CONCLUSION: Phentermine-topiramate therapy was not well tolerated; more than half of the patients in our study stopped taking it because of adverse effects, and more than half of the adverse events reported were ascribed to topiramate. However, in those able to continue with pharmacotherapy, the combination was efficacious for both maintenance of weight loss and ongoing weight loss
Desperately seeking…Models to find the right partner and the best use for checkpoint inhibitors
Pilot study of 89Zr-bevacizumab positron emission tomography in patients with advanced non-small cell lung cancer
Overproduction of salicylic acid in plants by bacterial transgenes enhances pathogen resistance
After a hypersensitive response to invading pathogens, plants show elevated accumulation of salicylic
acid (SA), induced expression of plant defense genes, and systemic acquired resistance (SAR) to further
infection by a broad range of pathogens. There is compelling evidence that SA plays a crucial role in triggering
SAR. We have transformed tobacco with two bacterial genes coding for enzymes that convert
chorismate into SA by a two-step process. When the two enzymes were targeted to the chloroplasts, the
transgenic (CSA, constitutive SA biosynthesis) plants showed a 500- to 1,000-fold increased accumulation
of SA and SA glucoside compared to control plants. Defense genes, particularly those encoding
acidic pathogenesis-related (PR) proteins, were constitutively expressed in CSA plants. This expression
did not affect the plant phenotype, but the CSA plants showed a resistance to viral and fungal infection resembling SAR in nontransgenic plants.Ministry of Economic Affairs, the Ministry of
Education, Culture and Science, and the Ministry of Agriculture, Nature
Management and Fishery in the framework of a research program of the
Association of Biotechnology Centres in the Netherlands (ABON)Peer reviewe