42 research outputs found
Deep Sequencing of B Cell Receptor Repertoires From COVID-19 Patients Reveals Strong Convergent Immune Signatures.
- Author
- Bashford-Rogers Rachael JM
- Betley Jason
- Caldas Carlos
- Cavlan Olivia
- Deane Charlotte M
- Dias Jorge
- Finch Donna K
- Galson Jacob D
- James Louisa K
- Kilpatrick Gavin J
- Kovaltsuk Aleksandr
- Lee Wing-Yiu Jason
- Leech Alex
- Minter Ralph
- Osbourn Jane
- Pennington Daniel J
- Pfeffer Paul
- Raybould Matthew IJ
- Schaetzle Sebastian
- Seoane Joan
- Thomas Gavin
- Publication venue
- Front Immunol
- Publication date
- 01/01/2020
- Field of study
Deep sequencing of B cell receptor (BCR) heavy chains from a cohort of 31 COVID-19 patients from the UK reveals a stereotypical naive immune response to SARS-CoV-2 which is consistent across patients. Clonal expansion of the B cell population is also observed and may be the result of memory bystander effects. There was a strong convergent sequence signature across patients, and we identified 1,254 clonotypes convergent between at least four of the COVID-19 patients, but not present in healthy controls or individuals following seasonal influenza vaccination. A subset of the convergent clonotypes were homologous to known SARS and SARS-CoV-2 spike protein neutralizing antibodies. Convergence was also demonstrated across wide geographies by comparison of data sets between patients from UK, USA, and China, further validating the disease association and consistency of the stereotypical immune response even at the sequence level. These convergent clonotypes provide a resource to identify potential therapeutic and prophylactic antibodies and demonstrate the potential of BCR profiling as a tool to help understand patient responses
Robust estimation of bacterial cell count from optical density
- Author
- Aarnio Tiu
- Aaron Leow Chung Yong
- Abbas Anser
- Abduraimova Aiganym
- Abraham Doris
- Acar Beliz Leyla
- Acosta Joaquin
- Adler Nina
- Adulyanukosol Natthawut
- Agena Ejouan
- Agena Ethan
- Aggarwal Priya
- Aguirre Adriana Lizeth Rubio
- Ahlgren Christopher
- Ahuja Janvi
- Aizik Dror
- Akbary Mina
- Akinfenwa Akinwumi
- Akingbesote Ngozi D.
- Akova Umut
- Aldo Ferdinan
- Alexopoulos Ioannis
- Allen Lucy
- Alonso Alejandro
- Altarawneh Dina
- Alvarado Andres Benjamin Sanchez
- Ambre Sanika
- Ameziane Annissa
- Amheine Khadija
- Amin Ihya Fakhrurizal
- Amir Sayeda Sakina
- Amstel Chiel van
- An Yongyan
- Anand Nithishwer Mouroug
- Ananthakrishnan Sathvik
- Anderson Karl
- Angel Sagi
- Annem Vidhya
- Anson Chung Tsun Ho
- Anwar Mariam
- Appel Alana
- Araya Lucas
- Armstrong Alexander
- Arora Neha
- Arora Vasu
- Arruda Beck
- Ashwin F Amal Jude
- Astapenka Artur
- Astles Ben
- Astorino Gabe
- Aubry Celine
- Avileli Rebecca
- Azad Mahnaz Sabeta
- Babar Rehmat
- Babu Priyanka
- Badalli Turan
- Badash Lior
- Baichman-Kass Amichai
- Baldwin Geoff S.
- Baltensperger Oliver Andreas
- Bao Guanke
- Bao Minyue
- Baronaite Ugne
- Barrat Leon Michael
- Barrington Seth
- Barshap Alon
- Bartzoka Natalia
- Basu Anubhav
- Basulto Cynthia
- Bath Scott
- Battina Rohith
- Bauersachs Daniel
- Beal Jacob
- Beale Renee
- Beard Eleanor
- Beck Selina
- Becker Evan
- Benavides Samantha Ayde Pena
- Bennis Nicole
- Bete Anna
- Bhatt Darshak
- Bhowmick Shilpa
- Bian Weixin
- Bijman Eline Yafele
- Bindt Felix
- Blas Karla Soto
- Bo Tang
- Boada Yadira
- Boer Meine
- Bohner Ariel
- Borovko Irina
- Bott Amie
- Bouwmeester Susan
- Bowman Kyle
- Boxem Mike
- Boxuan Cheng
- Boyce Kira
- Boyer Jess
- Brasas Valentas
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- Briand William
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- Budhan Stephanie
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- Burckhardt Nele
- Burgland Zachary
- Burns Frank
- Burridge Matt
- Burud Hanna Nedreberg
- Buson Felipe Xavier
- Butterfield Tom
- Byagathvalli Gaurav
- Byatt Gabriel
- Byun Sumin
- Caballero Amalia
- Cai Fu
- Cai Niangui
- Caldwell Sarah
- Camacho Yazmin
- Camille Monteil
- Campbell Robert
- Cao Qinhao
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- Carter Jonah
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- Castillo Nora Esther Torres
- Castillo Sandra
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- Chavez Benjamin
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- Chehade Ibrahim
- Chen Carmen
- Chen Chih-Chiang
- Chen Ching-Wei
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- Chen Junhong
- Chen Junyang
- Chen Junyu
- Chen Pei-Hong
- Chen Ryan
- Chen Weixuan
- Chen Yan
- Chen Yi-Cian
- Chen Yifei
- Chen Zhuoyang
- Cheng Cheng
- Cheng Haolun
- Cheng Hsuan
- Cheng Yu-Hong
- Cheng Yu-Hsuan
- Chenxi Liang
- Cherupalla Arjun
- Chi Jordi
- Chi Shumei
- Chiang Jason
- Chiang Woody
- Ching Lai Tsz
- Ching Lam Kai
- Ching Law Hiu
- Ching Luk Hau
- Chinnathambi Sathivel
- Cho Sungwoo
- Choi Lee Sze
- Choi Youngeun
- Chou Ryan
- Chou Ryan
- Chu Wai Yan
- Chua Yah Tse Sabrina
- Chuang Yi-Chien
- Chulkova Nadezhda
- Chun Cheung Man
- Chun Emily
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- Cifuentes Rodrigo Hernandez
- Clapper Jude
- Clapper Jude
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- Clemente Borja Sanchez
- Clerc Valerian
- Clodomir Christina
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- Craw Darilyn
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- Crone Michael Andrew
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- Czekster Clarissa
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- Daniels Lea
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- Deepak Kumar S.
- Deibel Emilie
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- Dogra Arushi
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- Dong Shangzhi
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- Dusseaux Theodore A.
- Dvorkin Steve
- Edelmayer Marco
- Ehrenworth Amy
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- Eijkens Bruno
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- El Moubayed Yorgo
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- Elikan Max
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- Espinoza Diego
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- Shinde Mousami
- Shkolnikov Irene
- Shola Chemay
- Shuan Cheah Matthew Yun
- Shuan Yun
- Shulun [NO FIRST NAME IN SCOPUS]
- Shuyu Shi
- Sia Nympha Elisa M.
- Siemer Jessica
- Sillner Cassandra
- Silva Bruna Fernandes
- Silva Dewuni De
- Simona Magda Faijes
- Sing Lo Ho
- Singh Priyanka
- Sinha Shubhankar
- Sison Abigail
- Sjolin Jacob
- Smet Ignacio Albert
- Smith Caroline
- Smith Ryan
- Smith Zion
- Snaith Eva
- So Kam Pang
- Solano Margarita Sofia Calixto
- Solvang Vanessa
- Somvanshi Tejas
- Son Tinh
- Song Guowei
- Song Haoyue
- Song Li
- Song Yiran
- Song Yong Rafael
- Soni Abhinav
- Sonnier Matt
- Spatharas Panagiotis
- Srinivasan Keerthana
- Standforth Kyle
- Starkel John
- Stewart Thomas
- Stocks Jon
- Strasser Dominik
- Street Morgan
- Stuhlweissenburg Fynn
- Stukenberg Daniel
- Sudarshan Bhuvana
- Suer Gun
- Sumner Kylie
- Sun Dongchang
- Sun Kai
- Sun Shiyu
- Sun Ting
- Suss Beatrix
- Swart Pim
- Sweet Bailey
- Tairan Li
- Takeyasu Reanna
- Tamayo Diana
- Tan Huishuang
- Tan Li Yang
- Tang Cassie
- Tang Christian
- Tang Erting
- Tang Jiaqi
- Tang Weiyi
- Tang Yu-Cheng
- Tang Yu-Hsin
- Tao Yibing
- Tapia Jennifer
- Tariq Ali
- Taskar Poorva
- Taylor Max
- Telesz Lauren
- ten Dam Marjolijn
- Tharp Darron
- Thokachichu Pranav
- Thomas Sophie
- Thormar Eirikur Andri
- Throsberg Christian
- Tian Hong
- Tian Qinghe
- Tian Ruonan
- Tianyi Chang
- Ting Weiyu
- Tirad Alice
- Toanen Marion
- Tobin David
- Toghani Dorsa
- Torell Agnes
- Toro Bibiana
- Torres Ares
- Totten Stephanie
- Trevizo Cynthia Lizeth Gonzalez
- Trivellin Cecilia
- Trujillo-Rodriguez Lidimarie
- Tsai Leona
- Tsai You-Yang
- Tsang Helen
- Tsitsilonis Ourania E.
- Tsui Jennifer
- Tunaj Brigit
- Turner Matthew
- Turton Kristi
- Tutuianu Anna
- Tuzov Vladislav
- Twisk Simone
- Ucan Kutay
- Uday Adwaith B.
- Ueding Elisa
- Unal Tunc
- Urban Julia
- Uslu Attila
- Vaidya Anjali
- Vaitkus Dovydas
- Vanini Nadine Vaz
- Varaljay Vanessa
- Vardi Omri
- Velasco Maria Antonia Luna
- Velikov Lukas
- Vella Toni
- Venclovas Tomas
- Venkatraghavan Sankalpa
- Verhagen Mick
- Verma Yashna
- Vignoni Alejandro
- Vincent Annette
- Vincent Sara
- Viswanathan Ashwin
- Vitkute Kornelija
- von Schoenberg Sophie
- Voort Gemma van der
- Vornholt Tobias
- Vries Philip Gorter de
- Waard Jazzy de
- Wadhams George
- Wagner Camille
- Wai Leung Chung
- Wan Chan Tsey
- Wan Leon
- Wan Mitchell
- Wang Cheng-Chieh
- Wang Chenxi
- Wang Choi Seong
- Wang Hao
- Wang Huichao
- Wang Kai
- Wang Kelsey
- Wang Kelsey
- Wang Ken
- Wang Li
- Wang Pengying
- Wang Ping
- Wang Qiupeng
- Wang Raven
- Wang Sibo
- Wang Sihan
- Wang Tian
- Wang Wei
- Wang Xiangxuan
- Wang Xin
- Wang Xinyue
- Wang Xuan
- Wang Xueyao
- Wang Yaling
- Wang Yi
- Wang Yifan
- Wang Yuefei
- Wang Yunyi
- Wang Yuyang
- Wang Yuyao
- Wang Zihao
- Wang Ziru
- Wang Ziyu
- Wanji Li
- Warzecha Heribert
- Watson Emily
- Wawrzyniak Dominika
- Weber Elisa
- Wei Zemeng
- Weile Carl
- Wenhao Xu
- Went Sam
- Whalen Kathleen
- Whiteside Jonny
- Whittle Michaella
- Wickiser Ken
- Windo Joe
- Wintermute Edwin
- Withanage Shamal
- Wolfbeisz Chiara
- Wong Angel
- Wong Hei Man
- Wong Joanne
- Woodward Noble
- Workman C. T.
- Wu Chenhai
- Wu Justin
- Wu Kangjie
- Wu Mengxuan
- Wu Michelle
- Wu Yaxuan
- Wu Yi
- Wu Yuxuan
- Wu Zishi
- Xi Yukun
- Xia Ruoyu
- Xiang Meredith
- Xiang Yuening
- Xiao Ziyang
- Xiaojin Li
- Xiaowen Mao
- Xilei Peng
- Xin Li
- Xin Tian
- Xing Jinming
- Xinguang Chen
- Xinlei Fang
- Xinyu Liu
- Xinyu Liu
- Xinyu Teng
- Xinyue Ma
- Xiong Xin
- Xiong Zhenyu
- Xirui Chen
- Xiu Yao
- Xiujing Hong
- Xu Guiyang
- Xu Hanning
- Xu Hao
- Xu Huandi
- Xu Sheng
- Xu Shirly
- Xu Xia
- Xu Xin
- Xu Yinsong
- Xuan Chen Zi
- Xue Fang
- Xue Han
- Xun Shu
- Yadav Ravineet
- Yadav Yash
- Yadi Liu
- Yan Calvin
- Yan Cathy
- Yan Han
- Yan Hongfa
- Yan Qingyan
- Yan Tsui Shing
- Yan Yeung Wing
- Yan Yining
- Yang Chao
- Yang Chenghao
- Yang Chuyi
- Yang Fan
- Yang Fuqiang
- Yang Hanyeol
- Yang Jake
- Yang Jianzhe
- Yang Jindian
- Yang Jinshu
- Yang Jun
- Yang Leyi
- Yang Ruofan
- Yang Shaobo
- Yang Shuting
- Yang Xilin
- Yang Yuchen
- Yang Zhuoyi
- Yang Zisang
- Yang Zon En
- Yao Andrew
- Yarbrough Hayden
- Yaxi Zhang
- Ye Yusheng
- Yee Chong Yuk
- Yeh Chan-yu
- Yehouessi Tamara
- Yeliseyeva Hanna
- Yesley Phillip
- Yeung Wong Tsz
- Yifan Li
- Yihang Qiu
- Yiming Quan
- Yin Jiacheng
- Yin Lee Ka
- Yin Xianqi
- Yong Nur Liyana Binte Ayub Ow
- Yong Zhangxiang
- Yongjie Lin
- Yoo Hojun
- Yoon Soohyun
- You Jaewon
- Young Cam
- Yu Haimeng
- Yu Jiacheng
- Yu Kai-Chiang
- Yu Liuhong
- Yu Tam Chi
- Yu Wenfei
- Yu Yuen Wai
- Yuan Hetian
- Yuan Long
- Yuan Xing
- Yuan Zhe
- Yuanxu Jiang
- Yucheng Chen
- Yue Qing
- Yueyi Li
- Yuhan Cheng
- Yujie Peng
- Yun Yejie
- Yung Jay
- Yutong Pan
- Zadeh Daniel
- Zamora Alejandro Robles
- Zanoni Paul
- Zanotti Violetta
- Zeng Chenxu
- Zeng Yuanhong
- Zepeng Xu
- Zerva Anastasia
- Zhan Yang
- Zhang Alice
- Zhang Bonan
- Zhang Jianxiang
- Zhang Jige
- Zhang Jinhan
- Zhang Kaida
- Zhang Kecheng
- Zhang Qian
- Zhang Shuyan
- Zhang Tianyi
- Zhang Wanli
- Zhang Xianyin
- Zhang Xinyu
- Zhang Yihao
- Zhang Yuanzhen
- Zhang Yunqian
- Zhang Zixuan
- Zhao Nannan
- Zhao Peng
- Zhao Tianyan
- Zhao Wenxue
- Zhao Yihang
- Zhaoting Li
- Zhecheng Huang
- Zheng Daniel
- Zheng Jiyang
- Zhiwei Song
- Zhong Yanling
- Zhou Hanmi
- Zhou Jiajie
- Zhou Jianan
- Zhou Rui
- Zhou Shuyao
- Zhou Xuanhao
- Zhou Yanjun
- Zhou Yi
- Zhou Yinchi
- Zhou Yineng
- Zhou Yuezhang
- Zhou Yuxin
- Zhou Zhiyu
- Zhu Chushu
- Zhu Ke
- Zhu Xueqian
- Zi Lihan
- Zilinskaite Nemira
- Zimmermann Andreas
- Zimmermann Jennifer
- Zirong Zeng
- Ziwei Zhou
- Ziyi Zhao
- Zorrilla Francisco
- Zou Jiahua
- Zukauskaite Kristina
- Zulueta Patricia
- Zvirblyte Justina
- Publication venue
- Publication date
- 01/01/2020
- Field of study
Optical density (OD) is widely used to estimate the density of cells in liquid culture, but cannot be compared between instruments without a standardized calibration protocol and is challenging to relate to actual cell count. We address this with an interlaboratory study comparing three simple, low-cost, and highly accessible OD calibration protocols across 244 laboratories, applied to eight strains of constitutive GFP-expressing E. coli. Based on our results, we recommend calibrating OD to estimated cell count using serial dilution of silica microspheres, which produces highly precise calibration (95.5% of residuals <1.2-fold), is easily assessed for quality control, also assesses instrument effective linear range, and can be combined with fluorescence calibration to obtain units of Molecules of Equivalent Fluorescein (MEFL) per cell, allowing direct comparison and data fusion with flow cytometry measurements: in our study, fluorescence per cell measurements showed only a 1.07-fold mean difference between plate reader and flow cytometry data
Blood transcriptional biomarkers of acute viral infection for detection of pre-symptomatic SARS-CoV-2 infection: a nested, case-control diagnostic accuracy study
- Author
- Abbass Hakam
- Abiodun Aderonke
- Alfarih Mashael
- Alldis Zoe
- Altmann Daniel M
- Altmann Daniel M
- Amin Oliver E
- Andiapen Mervyn
- Artico Jessica
- Artico Jessica
- Augusto João B
- Baca Georgiana L
- Bailey Sasha NL
- Bell Lucy C
- Bhuva Anish N
- Boulter Alex
- Bowles Ruth
- Boyton Rosemary J
- Boyton Rosemary J
- Bracken Olivia V
- Brooks Tim
- Bullock Natalie
- Butler David K
- Captur Gabriella
- Chain Benjamin M
- Champion Nicola
- Chan Carmen
- Chandran Aneesh
- Chandran Aneesh
- Collier David
- Couto de Sousa Jorge
- Couto-Parada Xose
- Cutino-Moguel Teresa
- Cutino-Moguel Teresa
- Davies Rhodri H
- Di Genova Cecilia
- Dieobi-Anene Keenan
- Diniz Mariana O
- Douglas Brooke
- Ellis Anaya
- Feehan Karen
- Finlay Malcolm
- Fontana Marianna
- Forooghi Nasim
- Gaier Celia
- Gibbons Joseph M
- Gilroy Derek
- Guerra-Assuncao Jose A
- Gupta Rishi K
- Hamblin Matt
- Harker Gabrielle
- Hewson Jacqueline
- Hickling Lauren M
- Hingorani Aroon D
- Howes Lee
- Hughes Alun
- Hughes Gemma
- Hughes Rebecca
- Itua Ivie
- Jardim Victor
- Jensen Melaniepetra
- Jones Jessica
- Jones Meleri
- Joy George
- Joy George
- Kapil Vikas
- Kurdi Hibba
- Kurdi Hibba
- Lambourne Jonathan
- Lambourne Jonathan
- Lee Wing-Yiu Jason
- Lin Kai-Min
- Louth Sarah
- Maini Mala K
- Maini Mala K
- Mandadapu Vineela
- Manisty Charlotte
- Manisty , Charlotte
- McKnight Aine
- McKnight Áine
- Menacho Katia
- Mfuko Celina
- Mitchelmore Oliver
- Moon Christopher
- Moon James C
- Moon , James C
- Munoz Sandoval Diana
- Murray Sam M
- Noursadeghi Mahdad
- Noursadeghi Mahdad
- O'Brien Ben
- Otter Ashley
- Pade Corinna
- Palma Susana
- Parker Ruth
- Patel Kush
- Pawarova Babita
- Petersen Steffen E
- Pieper Franziska P
- Piniera Brian
- Pollara Gabriele
- Pope Daniel
- Prossora Maria
- Rannigan Lisa
- Rapala Alicja
- Reynolds Catherine J
- Richards Amy
- Robathan Matthew
- Rosenheim Joshua
- Rosenheim Joshua
- Sambile Genine
- Schmidt Nathalie M
- Semper Amanda
- Seraphim Andreas
- Simion Mihaela
- Smit Angelique
- Sugimoto Michelle
- Swadling Leo
- Taylor Stephen
- Temperton Nigel J.
- Thomas Stephen
- Thornton George D
- Treibel Thomas A
- Treibel Thomas A
- Tucker Art
- Veerapen Jessry
- Vijayakumar Mohit
- Welch Sophie
- Whelan Matthew
- Wodehouse Theresa
- Wynne Lucinda
- Zahedi Dan
- Publication venue
- 'Elsevier BV'
- Publication date
- 01/07/2021
- Field of study
Background We hypothesised that host-response biomarkers of viral infections might contribute to early identification of individuals infected with SARS-CoV-2, which is critical to breaking the chains of transmission. We aimed to evaluate the diagnostic accuracy of existing candidate whole-blood transcriptomic signatures for viral infection to predict positivity of nasopharyngeal SARS-CoV-2 PCR testing.Methods We did a nested case-control diagnostic accuracy study among a prospective cohort of health-care workers (aged ≥18 years) at St Bartholomew’s Hospital (London, UK) undergoing weekly blood and nasopharyngeal swab sampling for whole-blood RNA sequencing and SARS-CoV-2 PCR testing, when fit to attend work. We identified candidate blood transcriptomic signatures for viral infection through a systematic literature search. We searched MEDLINE for articles published between database inception and Oct 12, 2020, using comprehensive MeSH and keyword terms for “viral infection”, “transcriptome”, “biomarker”, and “blood”. We reconstructed signature scores in blood RNA sequencing data and evaluated their diagnostic accuracy for contemporaneous SARS-CoV-2 infection, compared with the gold standard of SARS-CoV-2 PCR testing, by quantifying the area under the receiver operating characteristic curve (AUROC), sensitivities, and specificities at a standardised Z score of at least 2 based on the distribution of signature scores in test-negative controls. We used pairwise DeLong tests compared with the most discriminating signature to identify the subset of best performing biomarkers. We evaluated associations between signature expression, viral load (using PCR cycle thresholds), and symptom status visually and using Spearman rank correlation. The primary outcome was the AUROC for discriminating between samples from participants who tested negative throughout the study (test-negative controls) and samples from participants with PCR-confirmed SARS-CoV-2 infection (test-positive participants) during their first week of PCR positivity.Findings We identified 20 candidate blood transcriptomic signatures of viral infection from 18 studies and evaluated their accuracy among 169 blood RNA samples from 96 participants over 24 weeks. Participants were recruited between March 23 and March 31, 2020. 114 samples were from 41 participants with SARS-CoV-2 infection, and 55 samples were from 55 test-negative controls. The median age of participants was 36 years (IQR 27–47) and 69 (72%) of 96 were women. Signatures had little overlap of component genes, but were mostly correlated as components of type I interferon responses. A single blood transcript for IFI27 provided the highest accuracy for discriminating between test-negative controls and test-positive individuals at the time of their first positive SARS-CoV-2 PCR result, with AUROC of 0·95 (95% CI 0·91–0·99), sensitivity 0·84 (0·70–0·93), and specificity 0·95 (0·85–0·98) at a predefined threshold (Z score >2). The transcript performed equally well in individuals with and without symptoms. Three other candidate signatures (including two to 48 transcripts) had statistically equivalent discrimination to IFI27 (AUROCs 0·91–0·95).Interpretation Our findings support further urgent evaluation and development of blood IFI27 transcripts as a biomarker for early phase SARS-CoV-2 infection for screening individuals at high risk of infection, such as contacts of index cases, to facilitate early case isolation and early use of antiviral treatments as they emerge
Immune boosting by B.1.1.529 (Omicron) depends on previous SARS-CoV-2 exposure
- Author
- Abbass Hakam
- Abiodun Aderonke
- Alfarih Mashael
- Alldis Zoe
- Altmann Daniel M.
- Altmann Daniel M.
- Amin Oliver E.
- Andiapen Mervyn
- Artico Jessica
- Augusto João B.
- Baca Georgina L.
- Bailey Sasha N. L.
- Bhuva Anish N.
- Boulter Alex
- Bowles Ruth
- Boyton Rosemary J.
- Boyton Rosemary J.
- Bracken Olivia V.
- Brooks Tim
- Brooks Tim
- Bullock Natalie
- Butler David K.
- Butler David K.
- Captur Gabriella
- Carr Olivia
- Chain Benjamin
- Champion Nicola
- Chan Carmen
- Chandran Aneesh
- Coleman Tom
- Couto de Sousa Jorge
- Couto-Parada Xose
- Cross Eleanor
- Cutino-Moguel Teresa
- Davies Rhodri H.
- Di Genova Cecilia
- Dieobi-Anene Keenan
- Diniz Mariana O.
- Douglas Brooke
- D’Arcangelo Silvia
- Ellis Anaya
- Feehan Karen
- Finlay Malcolm
- Fontana Marianna
- Forooghi Nasim
- Forooghi Nasim
- Francis Sasha
- Gibbons Joseph M.
- Gibbons Joseph M.
- Gillespie David
- Gilroy Derek
- Hamblin Matt
- Harker Gabrielle
- Hemingway Georgia
- Hewson Jacqueline
- Heywood Wendy
- Hickling Lauren M.
- Hicks Bethany
- Hingorani Aroon D.
- Howes Lee
- Itua Ivie
- Jardim Victor
- Jensen Melaniepetra
- Jones Jessica
- Jones Meleri
- Joy George
- Joy George
- Kapil Vikas
- Kelly Caoimhe
- Kurdi Hibba
- Lambourne Jonathan
- Lee Wing-Yiu Jason
- Lin Kai-Min
- Lin Kai-Min
- Liu Siyi
- Liu Siyi
- Lloyd Aaron
- Louth Sarah
- Maini Mala K.
- Mandadapu Vineela
- Manisty Charlotte
- Manisty Charlotte
- McKnight Áine
- McKnight Áine
- Menacho Katia
- Mfuko Celina
- Mills Kevin
- Millward Sebastian
- Mitchelmore Oliver
- Moon Christopher
- Moon James
- Moon James C.
- Moon James C.
- Murray Sam M.
- Muñoz Sandoval Diana
- Muñoz Sandoval Diana
- Noursadeghi Mahdad
- Otter Ashley
- Otter Ashley D.
- O’Brien Ben
- Pade Corinna
- Pade Corinna
- Palma Susana
- Parker Ruth
- Patel Kush
- Pawarova Mihaela
- Petersen Steffen E.
- Pieper Franziska P.
- Pieper Franziska P.
- Piniera Brian
- Rannigan Lisa
- Rapala Alicja
- Reynolds Catherine J.
- Reynolds Catherine J.
- Richards Amy
- Robathan Matthew
- Rosenheim Joshua
- Rowe Cathy
- Royds Matthew
- Sackville West Jane
- Sambile Genine
- Schmidt Nathalie M.
- Selman Hannah
- Semper Amanda
- Semper Amanda
- Seraphim Andreas
- Simion Mihaela
- Smit Angelique
- Sugimoto Michelle
- Swadling Leo
- Taylor Stephen
- Temperton Nigel
- Thomas Stephen
- Thornton George D.
- Treibel Thomas A.
- Treibel Thomas A.
- Tucker Art
- Varghese Ann
- Veerapen Jessry
- Vijayakumar Mohit
- Warner Tim
- Welch Sophie
- White Hannah
- Wodehouse Theresa
- Wynne Lucinda
- Zahedi Dan
- Publication venue
- 'American Association for the Advancement of Science (AAAS)'
- Publication date
- 14/06/2022
- Field of study
The Omicron, or Pango lineage B.1.1.529, variant of SARS-CoV-2 carries multiple spike mutations with high transmissibility and partial neutralizing antibody (nAb) escape. Vaccinated individuals show protection from severe disease, often attributed to primed cellular immunity. We investigated T and B cell immunity against B.1.1.529 in triple mRNA vaccinated healthcare workers (HCW) with different SARS-CoV-2 infection histories. B and T cell immunity against previous variants of concern was enhanced in triple vaccinated individuals, but magnitude of T and B cell responses against B.1.1.529 spike protein was reduced. Immune imprinting by infection with the earlier B.1.1.7 (Alpha) variant resulted in less durable binding antibody against B.1.1.529. Previously infection-naïve HCW who became infected during the B.1.1.529 wave showed enhanced immunity against earlier variants, but reduced nAb potency and T cell responses against B.1.1.529 itself. Previous Wuhan Hu-1 infection abrogated T cell recognition and any enhanced cross-reactive neutralizing immunity on infection with B.1.1.529
Quantitative, multiplexed, targeted proteomics for ascertaining variant specific SARS-CoV-2 antibody response
- Author
- Abbass Hakam
- Abiodun Aderonke
- Alfarih Mashael
- Alldis Zoe
- Altmann Daniel M.
- Altmann Daniel M.
- Amin Oliver E.
- Andiapen Mervyn
- Artico Jessica
- Augusto João B.
- Baca Georgina L.
- Bailey Sasha N.L.
- Baldwin Tomas
- Bhuva Anish N.
- Boulter Alex
- Bowles Ruth
- Boyton Rosemary J.
- Boyton Rosemary J.
- Bracken Olivia V.
- Brooks Tim
- Brooks Tim
- Bullock Natalie
- Butler David K.
- Captur Gabriella
- Captur Gabriella
- Carr Olivia
- Champion Nicola
- Chan Carmen
- Chandran Aneesh
- Coleman Tom
- Couto de Sousa Jorge
- Couto-Parada Xose
- Cross Eleanor
- Cutino-Moguel Teresa
- Davies Rhodri H.
- Di Genova Cecilia
- Dieobi-Anene Keenan
- Diniz Mariana O.
- Douglas Brooke
- Doykov Ivan
- D’Arcangelo Silvia
- Ellis Anaya
- Feehan Karen
- Finlay Malcolm
- Fontana Marianna
- Fontana Marianna
- Forooghi Nasim
- Francis Sasha
- Gibbons Joseph M.
- Gibbons Joseph M.
- Gillespie David
- Gilmour Kimberly C.
- Gilroy Derek
- Hamblin Matt
- Harker Gabrielle
- Hemingway Georgia
- Hewson Jacqueline
- Heywood Wendy
- Heywood Wendy E.
- Hickling Lauren M.
- Hicks Bethany
- Hingorani Aroon D.
- Howes Lee
- Itua Ivie
- Jardim Victor
- Jensen Melaniepetra
- Jones Jessica
- Jones Meleri
- Joy George
- Kapil Vikas
- Kelly Caoimhe
- Kurdi Hibba
- Lambourne Jonathan
- Lee Wing-Yiu Jason
- Lin Kai-Min
- Liu Siyi
- Lloyd Aaron
- Louth Sarah
- Maini Mala K.
- Maini Mala K.
- Mandadapu Vineela
- Manisty Charlotte
- Manisty Charlotte
- McKnight Áine
- McKnight Áine
- Menacho Katia
- Mfuko Celina
- Mills Kevin
- Mills Kevin
- Millward Sebastian
- Mitchelmore Oliver
- Moon Christopher
- Moon James
- Moon James C.
- Murray Sam M.
- Noursadeghi Mahdad
- Noursadeghi Mahdad
- Otter Ashley
- O’Brien Ben
- Pade Corinna
- Pade Corinna
- Palma Susana
- Parker Ruth
- Patel Kush
- Pawarova Mihaela
- Petersen Steffen E.
- Pieper Franziska P.
- Piniera Brian
- Rannigan Lisa
- Rapala Alicja
- Reynolds Catherine J.
- Reynolds Catherine J.
- Richards Amy
- Robathan Matthew
- Rosenheim Joshua
- Rowe Cathy
- Royds Matthew
- Sambile Genine
- Sandoval Diana Muñoz
- Schmidt Nathalie M.
- Selman Hannah
- Semper Amanda
- Semper Amanda
- Seraphim Andreas
- Simion Mihaela
- Smit Angelique
- Spiewak Justyna
- Sugimoto Michelle
- Swadling Leo
- Taylor Stephen
- Temperton Nigel J.
- Thomas Stephen
- Thornton George D.
- Treibel Thomas
- Treibel Thomas A.
- Tucker Art
- Varghese Ann
- Veerapen Jessry
- Vijayakumar Mohit
- Warner Tim
- Welch Sophie
- West Jane Sackville
- White Hannah
- Wodehouse Theresa
- Wynne Lucinda
- Zahedi Dan
- Publication venue
- 'Elsevier BV'
- Publication date
- 12/08/2022
- Field of study
Determining the protection an individual has to severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) variants of concern (VoCs) is crucial for future immune surveillance, vaccine development, and understanding of the changing immune response. We devised an informative assay to current ELISA-based serology using multiplexed, baited, targeted proteomics for direct detection of multiple proteins in the SARS-CoV-2 anti-spike antibody immunocomplex. Serum from individuals collected after infection or first- and second-dose vaccination demonstrates this approach and shows concordance with existing serology and neutralization. Our assays show altered responses of both immunoglobulins and complement to the Alpha (B.1.1.7), Beta (B.1.351), and Delta (B.1.617.1) VoCs and a reduced response to Omicron (B1.1.1529). We were able to identify individuals who had prior infection, and observed that C1q is closely associated with IgG1 (r > 0.82) and may better reflect neutralization to VoCs. Analyzing additional immunoproteins beyond immunoglobulin (Ig) G, provides important information about our understanding of the response to infection and vaccination
COVID-19 symptoms at hospital admission vary with age and sex: results from the ISARIC prospective multinational observational study
- Author
- Abdukahil Sheryl Ann
- Abdukahil Sheryl,
- Abe Ryuzo
- Abel Laurent
- Abreu Julia Rodriguez
- Abreu Julia,
- Absil Lara
- Acker Andrew
- Adachi Shingo
- Adam Elisabeth
- Adrião Diana
- Ainscough Kate
- Akimoto Takako
- Al Qasim Eman
- Al-Dabbous Tala
- Al-Fares Abdulrahman
- Alalqam Razi
- Alex Beatrice
- Alexandre Kévin
- Alfoudri Huda
- Alidjnou Kazali Enagnon
- Alidjnou Kazali,
- Aliudin Jeffrey
- Allavena Clotilde
- Allou Nathalie
- Alves João
- Alves Rita
- Amaral Maria
- Ammerlaan Heidi
- Ampaw Phoebe
- Andini Roberto
- Andrejak Claire
- Angheben Andrea
- ANGOULVANT François
- Ansart Séverine
- Antonelli Massimo
- Arabi Yaseen
- Aragao Irene
- Arcadipane Antonio
- Arenz Lukas
- Arlet Jean-Benoît
- Arnold-Day Christel
- Arora Lovkesh
- Artaud-Macari Elise
- Asensio Angel
- Assie Jean Baptiste
- Assie Jean,
- Atique Anika
- Auchabie Johann
- Aumaitre Hugues
- Azemar Laurène
- Azoulay Cécile
- Bach Benjamin
- Bachelet Delphine
- Baillie J. Kenneth,
- Bak Erica
- Bakakos Agamemnon
- Banisadr Firouzé
- Barbalho Renata
- Barclay Wendy,
- Barnikel Michaela
- Barrelet Audrey
- Barrigoto Cleide
- Basmaci Romain
- Bassi Gianluigi Li
- Bassi Gianluigi,
- Bedossa Alexandra
- Behilill Sylvie
- Bekken Gry Kloumann
- Bekken Gry,
- Beljantsev Aleksandr
- Bellemare David
- Beltrame Anna
- Beluze Marine
- Benech Nicolas
- Benkerrou Dehbia
- Bennett Suzanne
- Bento Luís
- Berdal Jan-Erik
- Bergeaud Delphine
- Bertolino Lorenzo
- Bessis Simon
- Bevilcaqua Sybille
- Bhavsar Krishna
- Bissuel François
- Biston Patrick
- Bitker Laurent
- Blanco-Schweizer Pablo
- Blot Mathieu
- Boccia Filomena
- Bogaert Debby
- Bompart François
- Booth Gareth
- Borges Diogo
- Borie Raphaël
- Bos Jeannet
- Bosse Hans Martin
- Bosse Hans,
- Botelho-Nevers Elisabeth
- Bouadma Lila
- Bouchaud Olivier
- Bouchez Sabelline
- Bouhmani Dounia
- Bouhour Damien
- Bouiller Kévin
- Bouillet Laurence
- Bouisse Camille
- Boureau Anne-Sophie
- Bouscambert Maude
- Bouziotis Jason
- Boxma Bianca
- Boyer-Besseyre Marielle
- Boylan Maria
- Braga Cynthia
- Brandenburger Timo
- Brazzi Luca
- Breen Dorothy
- Breen Patrick
- Brickell Kathy
- Brozzi Nicolas
- Buchtele Nina
- Buesaquillo Christian
- Bugaeva Polina
- Buisson Marielle
- Burhan Erlina
- Bustos Ingrid,
- Butnaru Denis
- Cabie André
- Cabral Susana
- Caceres Eder
- Callahan Mia
- Calligy Kate
- Calvache Jose Andres
- Calvache Jose,
- Campana Valentine
- Campbell Paul
- Camões João
- Canepa Cecilia
- Cantero Mireia
- Caraux-Paz Pauline
- Cardoso Filipa
- Cardoso Filipe
- Cardoso Sofia
- Carelli Simone
- Carlier Nicolas
- Carney Gayle
- Carpenter Chloe
- Carret Marie-Christine
- Carrier François Martin
- Carrier François,
- Carson Gail
- Casanova Maire-Laure
- Cascão Mariana
- Casimiro José
- Cassandra Bailey
- Castanheira Nidyanara
- Castañeda Silvia
- Castor-Alexandre Guylaine
- Castrillón Henry
- Castro Ivo
- Catarino Ana
- Catherine François-Xavier
- Cavalin Roberta
- Cavalli Giulio Giovanni
- Cavalli Giulio,
- Cavayas Alexandros
- Ceccato Adrian
- Cervantes-Gonzalez Minerva
- Chair Anissa
- Chakveatze Catherine
- Chan Adrienne
- Chand Meera
- Chas Julie
- Chassin Camille
- Chen Anjellica
- Chen Yih-Sharng
- Cheng Matthew Pellan
- Cheng Matthew,
- Cheret Antoine
- Chiarabini Thibault
- Chica Julian
- Chirouze Catherine
- Chiumello Davide
- Cho Hwa Jin
- Cho Hwa,
- Cho Sung Min
- Cho Sung,
- Choez Xavier Sánchez
- Choez Xavier,
- Choileain Orna Ni
- Choileain Orna,
- Cholley Bernard
- Cidade Jose Pedro
- Cidade Jose,
- Citarella Barbara Wanjiru
- Citarella Barbara,
- Ciullo Anna
- Clarke Jennifer
- Clohisey Sara
- Codan Cassidy
- Cody Caitriona
- Coelho Alexandra
- Colin Gwenhaël
- Collins Michael
- Colombo Sebastiano Maria
- Colombo Sebastiano,
- Combs Pamela
- Connelly J.,
- Connor Marie
- Conrad Anne
- Contreras Sofía
- Cooke Graham,
- Copland Mary
- Cordel Hugues
- Corley Amanda
- Cormican Sarah
- Cornelis Sabine
- Corpuz Arianne Joy
- Corpuz Arianne,
- Corvaisier Grégory
- Couffignal Camille
- Couffin-Cadiergues Sandrine
- Courtois Roxane
- Croonen Sabine
- Crowl Gloria
- Crump Jonathan
- Cruz Claudina
- Csete Marc
- Cucino Alberto
- Cullen Caroline
- Cummings Matthew
- Curley Gerard
- Curlier Elodie
- Curto Elena Gallego
- Curto Elena,
- Custodio Paula
- Cárcel Sheila
- Da Silva Filipe Ana
- Da Silveira Charlene
- Dabaliz Al-Awwab
- Dagens Andrew,
- Dalton Heidi
- Dalton Jo
- Daneman Nick
- Dankwa Emmanuelle,
- Dantas Jorge
- De Araújo Mariz Carolline
- De Brito Carlos Alexandre Antunes
- De Brito Carlos,
- De Castro Nathalie
- De Mendoza Diego
- De Oliveira França Rafael Freitas
- De Oliveira França Rafael,
- De Rosa Rosanna
- De Silva Thushan
- De Vries Peter
- Dean David
- Debray Marie-Pierre
- Dechert William
- Deconninck Lauren
- Decours Romain
- Delacroix Isabelle
- Delavigne Karen
- Deligiannis Ionna
- Dell’amore Andrea
- Delobel Pierre
- Demonchy Elisa
- Denis Emmanuelle
- Deplanque Dominique
- Depuydt Pieter
- Desai Mehul
- Descamps Diane
- Desvallée Mathilde
- Devouge Eglantine Ferrand
- Devouge Eglantine,
- Dewayanti Santi Rahayu
- Dewayanti Santi,
- Diallo Alpha
- Diamantis Sylvain
- Dias André
- Diaz Juan Jose Diaz
- Diaz Juan,
- DIAZ Rodrigo
- Didier Kévin
- Diehl Jean-Luc
- Dieperink Wim
- Dimet Jérôme
- Dinot Vincent
- Diouf Alphonsine
- Dishon Yael
- Djossou Félix
- Docherty Annemarie,
- Dominguez Carmen Infante
- Dominguez Carmen,
- Dong Andy
- Donnelly Christl,
- Donnelly Maria
- Donohue Chloe
- Dorival Céline
- Douglas James Joshua
- Douglas James,
- Douma Renee
- Dournon Nathalie
- Downer Triona
- Downing Mark
- Drake Tom
- Dubee Vincent
- DUBOS François
- Ducancelle Alexandra
- Dudman Susanne
- Dunning Jake
- Duranti Silvia
- Durham Lucian
- Dussol Bertrand
- Duval Xavier
- Dyrhol-Riise Anne Margarita
- Dyrhol-Riise Anne,
- D’aragon Frédérick
- D’Orleans Charles Crepy
- D’orleans Charles,
- D’Ortenzio Eric
- Eid Charbel Maroun
- Eid Charbel,
- Eira Carla
- Elapavaluru Subbarao
- Elharrar Brigitte
- Elkheir Natalie
- Ellerbroek Jacobien
- Ellis Rachael
- Eloy Philippine
- Elshazly Tarek
- Enderle Isabelle
- Engelmann Ilka
- Enouf Vincent
- Epaulard Olivier
- Esperatti Mariano
- Esperou Hélène
- Esposito-Farese Marina
- Estevão João
- Etienne Manuel
- Ettalhaoui Nadia
- Everding Anna Greti
- Everding Anna,
- Evers Mirjam
- Fabre Isabelle
- Faheem Amna
- Fahy Arabella
- Fairfield Cameron,
- Faria Pedro
- Farshait Nataly
- Fatoni Arie Zainul
- Fatoni Arie,
- Faure Karine
- Fayed Mohamed
- Feely Niamh
- Fernandes Jorge
- Fernandes Marília
- Fernandes Susana
- Ferraz Mário
- Ferreira Benigno
- Ferrer-Roca Ricard
- Ferrão Joana
- Figueiredo-Mello Claudia
- Flateau Clara
- Fletcher Tom
- Florio Letizia Lucia
- Florio Letizia,
- Foley Claire
- Fomin Victor
- Fonseca Claudio Duarte
- Fonseca Claudio,
- Fonseca Tatiana
- Fontela Patricia
- Forsyth Simon
- Foti Giuseppe
- Fourn Erwan
- Fowler Rob
- Franch-Llasat Diego
- Fraser Christophe
- Fraser John
- Freire Marcela Vieira
- Freire Marcela,
- Friedrich Caren
- Fry Stéphane
- Fuentes Nora
- Fukuda Masahiro
- Gaborieau Valérie
- Gachet Benoît
- Gaci Rostane
- Gagliardi Massimo
- Gagnard Jean-Charles
- Gagneux-Brunon Amandine
- Gaião Sérgio
- Gallagher Phil
- Gamble Carrol
- Garan Arthur
- Garcia Rebekha
- Garcia-Gallo Esteban
- GarcÍa Ruth Noemí Jorge
- García Ruth,
- Garot Denis
- Garrait Valérie
- Gault Nathalie
- Gavin Aisling
- Gaymard Alexandre
- Gebauer Johannes
- Germano Nuno
- Ghosn Jade
- Giani Marco
- Giaquinto Carlo
- Gibson Jess
- Gigante Tristan
- Gilg Morgane
- Giordano Guillermo
- Girvan Michelle
- Gissot Valérie
- Giwangkancana Gezy
- Glikman Daniel
- Glybochko Petr
- Gnall Eric
- Goco Geraldine
- Goehringer François
- Goepel Siri
- Goffard Jean-Christophe
- Golob Jonathan
- Gorenne Isabelle
- Goujard Cécile
- Goulenok Tiphaine
- Grable Margarite
- Grandin Edward Wilson
- Grandin Edward,
- Granier Pascal
- Grasselli Giacomo
- Green Christopher,
- Greenhalf William
- Greffe Segolène
- Grieco Domenico Luca
- Grieco Domenico,
- Griffee Matthew
- Griffiths Fiona
- Grigoras Ioana
- Groenendijk Albert
- Gruner Heidi
- Gu Yusing
- Guedj Jérémie
- Guellec Dewi
- Guerguerian Anne-Marie
- Guerreiro Daniela
- Guery Romain
- Guillaumot Anne
- Guilleminault Laurent
- Guimard Thomas
- Gómez-Junyent Joan
- Haber Daniel
- Hakak Sheeba
- Hall Matthew
- Halpin Sophie
- Hamer Ansley
- Hamidfar Rebecca
- Hammond Terese
- Hardwick Hayley
- Harley Kristen
- Harrison Ewen,
- Harrison Janet
- Hays Leanne
- Heerman Jan
- Heggelund Lars
- Hendry Ross
- Hennessy Martina
- Henriquez-Trujillo Aquiles
- Hentzien Maxime
- Hernandez-Montfort Jaime
- Herreros Jose Miguel Cisneros
- Herreros Jose,
- Hidayah Astarini
- Higgins Dawn
- Higgins Eibhilin
- Hinton Samuel
- Hipólito-Reis Ana
- Hiraiwa Hiroaki
- Hiscox Julian,
- Ho Antonia Ying Wai
- Ho Antonia,
- Hoctin Alexandre
- Hoffmann Isabelle
- Hoiting Oscar
- Holt Rebecca
- Holten Aleksander Rygh
- Holten Aleksander,
- Holter Jan Cato
- Holter Jan,
- Horby Peter
- Horcajada Juan Pablo
- Horcajada Juan,
- Hoshino Koji
- Hoshino Kota
- Hough Catherine,
- Hssain Ali Ait
- Hssain Ali,
- Hsu Jimmy Ming-Yang
- Hulot Jean-Sébastien
- Humaid Felwa Bin
- Humaid Felwa,
- Ijaz Samreen
- Illes Hajnal-Gabriela
- Inácio Hugo
- Iosifidis Elias
- Irvine Lacey
- Isgett Sarah
- Isidoro Tiago
- Isnard Margaux
- Itai Junji
- Ivulich Daniel
- Jaafoura Salma
- Jabot Julien
- Jackson Clare
- Jamieson Nina
- Jaureguiberry Stéphane
- Javidfar Jeffrey
- Jean-Benoît Zabbe
- Jego Florence
- Jenum Synne
- Jimenez Juan Fernado Masa
- Jimenez Juan,
- Johal Simreen Kaur
- Johal Simreen,
- Joseph Cédric
- Joseph Mark
- Jouvet Philippe
- Jung Hanna
- Kafif Ouifiya
- Kaguelidou Florentia
- Kali Sabina
- Kalomoiri Smaragdi
- Kandamby Darshana Hewa
- Kandamby Darshana,
- Kandel Chris
- Kant Ravi
- Kartsonaki Christiana
- Kasugai Daisuke
- Katz Kevin
- Keating Sean
- Kelly Andrea
- Kelly Sadie
- Kennedy Lisa
- Kennon Kalynn
- Kerroumi Younes
- Kestelyn Evelyne
- Khalid Imrana
- Khalil Antoine
- Khan Coralie
- Khan Irfan
- Kho Michelle,
- Khoo Saye
- Kida Yuri
- Kiiza Peter
- Kildal Anders Benjamin
- Kildal Anders,
- Kimmoun Antoine
- Kindgen-Milles Detlef
- Kitamura Nobuya
- Klenerman Paul
- Knight Stephen
- Kobbe Robin
- Korten Volkan
- Kosgei Caroline
- Krawczyk Karolina
- KUMAR Deepali
- Kurtzman Ethan
- Kutsogiannis Demetrios
- Kyriakoulis Konstantinos
- LACHATRE Marie
- Lacoste Marie
- Laffey John,
- Lagrange Marie
- Laine Fabrice
- Lambert Marc
- Lamontagne François
- Langelot-Richard Marie
- Lantang Eka Yudha
- Lantang Eka,
- Lanza Marina
- Laouénan Cédric
- Laribi Samira
- Lariviere Delphine
- Launay Odile
- Lavie-Badie Yoan
- Law Andrew
- Le Bihan Clément
- Le Bris Cyril
- Le Coustumier Eve
- Le Falher Georges
- Le Gac Sylvie
- Le Hingrat Quentin
- Le Maréchal Marion
- Le Mestre Soizic
- Le Moing Vincent
- Le Nagard Hervé
- Le Turnier Paul
- Le Van Tan
- Le Minh
- Leal Ema
- Lee James
- Lee Su Hwan
- Lee Su,
- Lee Todd
- Leeming Gary
- Lefebvre Bénédicte
- Lefebvre Laurent
- Lefevre Benjamin
- Lellouche François
- Lemaignen Adrien
- Lemee Véronique
- Lemmink Gretchen
- Leone Michela
- Lepiller Quentin
- Lescure François-Xavier
- Lesens Olivier
- Lesouhaitier Mathieu
- Levy Bruno
- Levy Yves
- Levy-Marchal Claire
- León Rafael
- Liang Janet
- Lim Wei Shen
- Lim Wei,
- Lina Bruno
- Lind Andreas
- Lingas Guillaume
- Lion-Daolio Sylvie
- Liu Keibun
- Loforte Antonio
- Lolong Navy
- Lopes Diogo
- Lopez-Colon Dalia
- Lordemann Anja Grosse
- Lordemann Anja,
- Loubet Paul
- Lucet Jean Christophe
- Lucet Jean,
- Luna Carlos,
- Lungu Olguta
- Luong Liem
- Luton Dominique
- Lyons Ruth
- L’Her Erwan
- Maasikas Olavi
- Macdonald Sarah
- Machado Moïse
- Macheda Gabrielle
- Madhok Jai
- Mahieu Rafael
- Mahy Sophie
- Maier Lars Siegfrid
- Maier Lars,
- Maillet Mylène
- Maitre Thomas
- Malaque Ana
- Maldonado Hugo Miranda
- Maldonado Hugo,
- Malfertheiner Maximilian
- Malik Nadia
- Maltez Fernando
- Malvy Denis
- MAMBERT Marina
- Manda Victoria
- Mandei Jose,
- Mangoni Emanuele Durante
- Mangoni Emanuele,
- Manning Edmund
- Manuel Aldric
- Marino Flávio
- Marques Ana
- Marquis Catherine
- Marsh Brian
- Marsh Laura
- Marshall John
- Martelli Celina Turchi
- Martelli Celina,
- Martin Dori-Ann
- Martin Emily
- Martin-Blondel Guillaume
- Martin-Loeches Ignacio
- Martin-Quiros Alejandro
- Martinot Martin
- Martins Ana
- Martins João
- Martucci Gennaro
- Marwali Eva Miranda
- Marwali Eva,
- Maslove David
- Mason Sabina
- Matan Moshe
- Mathieu Daniel
- Mattei Mathieu
- Matulevics Romans
- Maulin Laurence
- Mc Evoy Natalie
- Mccarthy Aine
- Mccloskey Colin
- Mcconnochie Rachael
- Mcdermott Sherry
- McDonald Sarah
- Mcelwee Samuel
- Mcevoy Natalie
- McGeer Allison
- Mcguinness Niki
- Mclean Kenneth,
- Mcnicholas Bairbre
- Meaney Edel
- Mear-Passard Cécile
- Mechlin Maggie
- Mele Ferruccio
- Menon Kusum
- Mentré France
- Mentzer Alexander,
- Mercier Noémie
- Merckx Antoine
- Mergler Blake
- Merson Laura
- Mesquita António
- Meybeck Agnès
- Meynert Alison,
- Meyssonnier Vanina
- Meziane Amina
- Mezidi Medhi
- Michelanglei Céline
- Mihnovitš Vladislav
- Mohammed Nassima Si
- Mohammed Nassima,
- Moin Asma
- Molina David
- Molinos Elena
- Mone Mary
- Monteiro Agostinho
- Montes Claudia
- Montrucchio Giorgia
- Moore Sarah
- Moore Shona,
- Morales-Cely Lina
- Morlaes Louis Gerbaud
- Morlaes Louis,
- Moro Lucia
- Motos Ana
- Mouquet Hugo
- Moyet Julien
- Mullaert Jimmy
- Munblit Daniel
- Murphy Derek
- Murris Marlène
- Myrodia Dimitra Melia
- Myrodia Dimitra,
- Müller Fredrik
- Müller Karl Erik
- Müller Karl,
- Neant Nadège
- Neb Holger
- Nekliudov Nikita,
- Neto Raul
- Neumann Emily
- Neves Bernardo
- Ng Pauline Yeung
- Ng Pauline,
- Ng Wing Yiu
- Ng Wing,
- Nichol Alistair
- Nonas Stephanie
- Noret Marion
- Norman Lisa
- Notari Alessandra
- Noursadeghi Mahdad
- Nowicka Karolina
- Nseir Saad
- Nunez Jose,
- Nuñez Maria Angelica Rivera
- Nuñez Maria,
- Nyamankolly Elsa
- N’Guyen Yohan
- Occhipinti Giovanna
- Ogston Tawnya
- Ogura Takayuki
- Oh Tak-Hyuk
- Ohshimo Shinichiro
- Oinam Budha Charan Singh
- Oinam Budha,
- Oliveira Ana Pinho
- Oliveira Ana,
- Oliveira João
- Olliaro Piero
- Ong David,
- Oosthuyzen Wilna
- Openshaw Peter,
- Orozco-Chamorro Claudia Milena
- Orozco-Chamorro Claudia,
- Orquera Andrés
- Osatnik Javier
- Ouamara Nadia
- Ouissa Rachida
- Owyang Clark
- Oziol Eric
- O’donnell Max
- O’hearn Katie
- O’neil Conar
- Pagadoy Maïder
- Pages Justine
- Palacios Mario
- Palmarini Massimo
- Panarello Giovanna
- Panda Prasan Kumar
- Panda Prasan,
- Panigada Mauro
- Pansu Nathalie
- Papadopoulos Aurélie
- Parra Briseida
- Pasquier Jérémie
- Patauner Fabian
- Patrão Luís
- Paul Christelle
- Paul Mical
- Paulos Jorge
- Paxton William,
- Payen Jean-François
- Pearse India
- Peek Giles,
- Peelman Florent
- Peiffer-Smadja Nathan
- Peigne Vincent
- Pejkovska Mare
- Peltan Ithan,
- Pereira Rui
- Perez Daniel
- Perpoint Thomas
- Perrot Clara Mouton
- Perrot Clara,
- Pesenti Antonio
- Petroušová Lenka
- Petrov-Sanchez Ventzislava
- Peytavin Gilles
- Pharand Scott
- Piagnerelli Michael
- Picard Walter
- Picone Olivier
- Piel-Julian Marie
- Pierobon Carola
- Pimentel Carlos
- Piroth Lionel
- Pius Riinu
- Piva Simone
- Plantier Laurent
- Plotkin Daniel
- Poissy Julien
- Pokorska-Spiewak Maria
- Poli Sergio
- Pollakis Georgios
- Popielska Jolanta
- Postma Douwe,
- Povoa Pedro
- Powis Jeff
- Prapa Sofia
- Prebensen Christian
- Preiser Jean-Charles
- Prestre Vincent
- Price Nicholas
- Prinssen Anton
- Pritchard Mark,
- Proença Lúcia
- Purcell Gregory
- Puéchal Oriane
- Póvoas Diana
- Quesada Luisa
- Quist-Paulsen Else
- Quraishi Mohammed
- Rabaud Christian
- Rafiq Marie
- Ragazzo Gabrielle
- Rainieri Fernando
- Ramakrishnan Nagarajan
- Ramanathan Kollengode
- Rammaert Blandine
- Rapp Christophe
- Rasmin Menaldi
- Rau Cornelius
- Rebaudet Stanislas
- Redl Sarah
- Reeve Brenda
- Rego Caroline Martins
- Rego Caroline,
- Reid Liadain
- Reis Renato
- Remppis Jonathan
- Remy Martine
- Renk Hanna
- Resende Liliana
- Resseguier Anne-Sophie
- Revest Matthieu
- Rewa Oleksa
- Reyes Luis Felipe
- Reyes Luis,
- Ribeiro Ana Freitas
- Ribeiro Ana,
- Richardson David
- Richardson Denise
- Richier Laurent
- Riera Jordi
- Rincon Diego Fernando Bautista
- Rincon Diego,
- Rios Ana Lúcia
- Rios Ana,
- Rishu Asgar
- Rispal Patrick
- Risso Karine
- Rizer Nicholas
- Roberto André
- Roberts Stephanie
- Robertson David,
- Robineau Olivier
- Roche-Campo Ferran
- Rodari Paola
- Rodeia Simão
- Roilides Emmanuel
- Rojek Amanda
- Romaru Juliette
- Roncon-Albuquerque Roberto
- Roriz Mélanie
- Rosa-Calatrava Manuel
- Rose Michael
- Rosenberger Dorothea
- Rossanese Andrea
- Rossignol Bénédicte
- Rossignol Patrick
- Roy Carine
- Roze Benoît
- Russell Clark,
- Ryckaert Steffi
- Rätsep Indrek
- Rössler Bernhard
- Saba Isabela
- Sadat Musharaf
- Saidani Nadia
- Salazar Leonardo
- Sales Gabriele
- Sallaberry Stéphane
- Salvator Hélène
- Sanchez Juan Macias
- Sanchez Juan,
- Sanchez Olivier
- Sanchez-Miralles Angel
- Sancho-Shimizu Vanessa
- Sandhu Gyan
- Sandulescu Oana
- Sanharawi Mohammed El
- Sanharawi Mohammed,
- Sant Ceila Maria
- Sant Ceila,
- Santos Marlene
- Santos Marta Leal
- Santos Marta,
- Santos-Olmo Rosario Maria Torres
- Santos-Olmo Rosario,
- Sarfo-Mensah Shirley
- Sarton Benjamine
- Saviciute Egle
- Savvidou Parthena
- Scarsbrook Joshua
- Schermer Tjard
- Scherpereel Arnaud
- Schneider Marion
- Schroll Stephan
- Schwameis Michael
- Scott Janet,
- Scott-Brown James
- Sedillot Nicholas
- Seitz Tamara
- Semaille Caroline
- Semple Malcolm,
- Senneville Eric
- Sequeira Filipa
- Sequeira Tânia
- Shadowitz Ellen
- Shamsah Mohammad
- Sharma Pratima
- Shaw Catherine,
- Shaw Victoria
- Shiban Nisreen
- Shime Nobuaki
- Shimizu Hiroaki
- Shimizu Keiki
- Shrapnel Sally
- Shum Hoi Ping
- Shum Hoi,
- Sigfrid Louise
- Silva Catarina
- Silva Maria Joao
- Silva Maria,
- Sin Wai Ching
- Sin Wai,
- Skogen Vegard
- Smith Sue
- Smood Benjamin
- Smyth Michelle
- Snacken Morgane
- So Dominic
- Solis Monserrat
- Solomon Joshua
- Solomon Tom
- Somers Emily
- Sommet Agnès
- Song Myung Jin
- Song Myung,
- Song Rima
- Song Tae
- Sonntagbauer Michael
- Sotomayor Ruth Jimbo
- Sotomayor Ruth,
- Soum Edouard
- Sousa Marta
- Souza-Dantas Vicente
- Sperry Alexandra
- Sriskandan Shiranee
- Staudinger Thomas
- Stecher Stephanie-Susanne
- Stienstra Ymkje
- Stiksrud Birgitte
- Streinu-Cercel Adrian
- Streinu-Cercel Anca
- Strudwick Samantha
- Stuart Ami
- Stuart David
- Suen Jacky,
- Sultana Asfia
- Summers Charlotte
- Svistunov Magdalena Surovcová Andrey A.
- Svistunov Magdalena,
- Syrigos Konstantinos
- Sztajnbok Jaques
- Szuldrzynski Konstanty
- Tabrizi Shirin
- Tagherset Lysa
- Talarek Ewa
- Taleb Sara
- Talsma Jelmer
- Tamlihat Younes Ait
- Tamlihat Younes,
- Tanaka Hiroyuki
- Tanaka Taku
- Taniguchi Hayato
- Tardivon Coralie
- Tattevin Pierre
- Taufik M. Azhari,
- Tedder Richard,
- Teixeira João
- Tellier Marie-Capucine
- Terpstra Pleun
- Terrier Olivier
- Terzi Nicolas
- Tessier-Grenier Hubert
- Thibault V.
- Thiberville Simon-Djamel
- Thill Benoît
- Thompson A.,
- Thompson Shaun
- Thomson David
- Thomson Emma,
- Thuy Duong Bich
- Thuy Duong,
- Thwaites Ryan,
- Timashev Peter,
- Timsit Jean-François
- Toki Maria
- Tonby Kristian
- Torres Antoni
- Torres Margarida
- Trieu Huynh Trung
- Trieu Huynh,
- Trioux Théo
- Tromeur Cécile
- Trontzas Ioannis
- Troost Jonathan
- Trouillon Tiffany
- Tual Christelle
- Tubiana Sarah
- Tuite Helen
- Turtle Lance,
- Tutillo Diego Rolando Morocho
- Tutillo Diego,
- Twardowski Pawel
- Téoulé François
- Uchiyama Makoto
- Ullrich Roman
- Uribe Alberto
- Usman Asad
- Uva Maria Sousa
- Uva Maria,
- Val-Flores Luís
- Van De Velde Stijn
- Van Den Berge Marcel
- Van Der Feltz Machteld
- Van Der Vekens Nicky
- Van Der Voort Peter
- Van Der Werf Sylvie
- Van Dyk Marlice
- Van Gulik Laura
- Van Hattem Jarne
- Van Lelyveld Steven
- Van Netten Carolien
- Van Vinh Chau Nguyen
- Vanel Noémie
- Vanoverschelde Henk
- Vasconcelos Malte Kohns
- Vasconcelos Malte,
- Vauchy Charline
- Vecham Pavan Kumar
- Vecham Pavan,
- Veislinger Aurélie
- Velazco Jorge
- Ventura Sara
- Verbon Annelies
- Vidal José Ernesto
- Vidal José,
- Vieira César
- Vijayaraghavan Bharath Kumar Tirupakuzhi
- Vijayaraghavan Bharath,
- Villanueva Joy Ann
- Villanueva Joy,
- Villar Judit
- Villeneuve Pierre-Marc
- Villoldo Andrea
- Visseaux Benoit
- Visser Hannah
- Vuorinen Aapeli
- Vuotto Fanny
- Wang Chih-Hsien
- Wei Jia
- Weil Katharina
- Wesselius Sanne
- Wham Murray
- Whelan Bryan
- White Nicole
- Wiedemann Aurélie
- Wille Keith
- Wils Evert-Jan
- Xynogalas Ioannis
- Yacoub Sophie
- Yamazaki Masaki
- Yazdanpanah Yazdan
- Yelnik Cécile
- Yerkovich Stephanie
- Yokoyama Toshiki
- Yonis Hodane
- Young Paul
- Yuliarto Saptadi
- Zabbe Marion
- Zacharowski Kai
- Zahran Maram
- Zambon Maria
- Zanella Alberto
- Zawadka Konrad
- Zayyad Hiba
- Zoufaly Alexander
- Zucman David
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/01/2021
- Field of study
Background:
The ISARIC prospective multinational observational study is the largest cohort of hospitalized patients with COVID-19. We present relationships of age, sex, and nationality to presenting symptoms.
Methods:
International, prospective observational study of 60 109 hospitalized symptomatic patients with laboratory-confirmed COVID-19 recruited from 43 countries between 30 January and 3 August 2020. Logistic regression was performed to evaluate relationships of age and sex to published COVID-19 case definitions and the most commonly reported symptoms.
Results:
‘Typical’ symptoms of fever (69%), cough (68%) and shortness of breath (66%) were the most commonly reported. 92% of patients experienced at least one of these. Prevalence of typical symptoms was greatest in 30- to 60-year-olds (respectively 80, 79, 69%; at least one 95%). They were reported less frequently in children (≤ 18 years: 69, 48, 23; 85%), older adults (≥ 70 years: 61, 62, 65; 90%), and women (66, 66, 64; 90%; vs. men 71, 70, 67; 93%, each P < 0.001). The most common atypical presentations under 60 years of age were nausea and vomiting and abdominal pain, and over 60 years was confusion. Regression models showed significant differences in symptoms with sex, age and country.
Interpretation:
This international collaboration has allowed us to report reliable symptom data from the largest cohort of patients admitted to hospital with COVID-19. Adults over 60 and children admitted to hospital with COVID-19 are less likely to present with typical symptoms. Nausea and vomiting are common atypical presentations under 30 years. Confusion is a frequent atypical presentation of COVID-19 in adults over 60 years. Women are less likely to experience typical symptoms than men
Retrospective evaluation of whole exome and genome mutation calls in 746 cancer samples
- Author
- A Gordon Robertson
- Abdullah Kahraman
- Abel Gonzalez-Perez
- Adam A Margolin
- Adam Abeshouse
- Adam Grundhoff
- Adam J Struck
- Adam J Struck
- Adam J Wright
- Adam Lambert
- Adam P Butler
- Adam P Butler
- Adel El-Naggar
- Adnan M Nagrial
- Adrian Ally
- Adrian Baez-Ortega
- Adrian Thorogood
- Adriana Salcedo
- Adrienne M Flanagan
- Ake Borg
- Akihiro Fujimoto
- Akihiro Suzuki
- Akinyemi I Ojesina
- Alain Viari
- Alan J Robertson
- Alan P Hoyle
- Alan Thompson
- Alasdair Stenhouse
- Alastair M Thompson
- Aldo Scarpa
- Alessandro Pastore
- Alex Buchanan
- Alex Buchanan
- Alexander Claviez
- Alexander J Lazar
- Alexander Martinez-Fundichely
- Alfonso Muñoz
- Alfonso Valencia
- Aliaksei Z Holik
- Alice Meng
- Alicia L Bruzos
- Allison Creason
- Allison P Heath
- Alvin Wei Tian Ng
- Alvis Brazma
- Amaro Taylor-Weiner
- Amber L Johns
- Amie Radenbaugh
- Amit G Deshwar
- Ana Dueso-Barroso
- Ana Mijalkovic Mijalkovic-Lazic
- Ana Milovanovic
- Ana Milovanovic
- Andre Kahles
- Andrea Haake
- Andrea Holbrook
- Andrea L Richardson
- Andrea Mafficini
- Andrea Ruzzenente
- Andreas Behren
- Andreas Rosenwald
- Andreia V Pinho
- Andrew Berchuck
- Andrew D Cherniack
- Andrew J Dunford
- Andrew J Mungall
- Andrew J Spillane
- Andrew Menzies
- Andrew Menzies
- Andrew P Barbour
- Andrew Tutt
- Andrew V Biankin
- Andrey Korshunov
- Andrés Lanzós
- Andy Cafferkey
- Andy G Lynch
- Angela Chou
- Angela N Brooks
- Angela Tam
- Angelica Ochoa
- Angelika N Christ
- Angelo P Dei Tos
- Anieta M Sieuwerts
- Anil K Sood
- Anita Langerød
- Anja Füllgrabe
- Anke K Bergmann
- Ann-Marie Patch
- Anna deFazio
- Anna Ehinger
- Anna Fitzgerald
- Anne Hamilton
- Anne Vincent-Salomon
- Anne Y Warren
- Anne-Lise Børresen-Dale
- Annegien Broeks
- Anthony DiBiase
- Anthony J Gill
- Anthony Ng
- Anthony R Green
- Antonia L Pritchard
- Antonio Pea
- Antonios Koures
- Aparna Prasad
- Apurva M Hegde
- Aquila Fatima
- Arcadi Navarro
- Arie B Brinkman
- Arif O Harmanci
- Arindam Maitra
- Armando Lopez-Guillermo
- Arndt Borkhardt
- Arnoud Boot
- Asger Hobolth
- Ashley Williams
- Ashton A Connor
- Atul J Butte
- Aurélien Chateigner
- Austin J Hepperla
- Axel Aretz
- Aya Sasaki-Oku
- Ayellet V Segre
- B F Francis Ouellette
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- Barbara Hutter
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- Bernardo Rodriguez-Martin
- Bernhard Radlwimmer
- Bernice H Wong
- Beth Karlan
- Bin Tean Teh
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- Cindy Bell
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- Dale W Garsed
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- Daniel Rosebrock
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- Darell Bigner
- Dariush Etemadmoghadam
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- Electron Kebebew
- Elena Piñeiro-Yáñez
- Elena Provenzano
- Elias Campo
- Elisabet Barrera
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- Elizabeth A Musgrove
- Elizabeth L Appelbaum
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- Elli Papaemmanuil
- Ellrott Kyle
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- G Steven Bova
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- Giada Bonizzato
- Giampaolo Tortora
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- Gunnar Rätsch
- Gurnit Atwal
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- Heather Thorne
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- Helen Davies
- Helena Kilpinen
- Helene Kretzmer
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- Hideki Ohdan
- Hidenori Ojima
- Hidewaki Nakagawa
- Hikmat Al-Ahmadie
- Hilda A Pickett
- Hirofumi Rokutan
- Hirokazu Taniguchi
- Hiroki Yamaue
- Hiroko Tanaka
- Hiromi Nakamura
- Hiroshi Aikata
- Hiroto Katoh
- Hiroyuki Aburatani
- Hitoshi Katai
- Hitoshi Nakagama
- Hojabr Kakavand
- Holger Sültmann
- Holmfridur Hilmarsdottir
- Hong Su
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- Hongtu Zhu
- Hongwei Zhang
- Hongxin Zhang
- Hsiao-Wei Chen
- Huanming Yang
- Hugh Barr
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- Janae V Simons
- Jane E Brock
- Janet S Graham
- Janet S Rader
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- Jaswinder S Samra
- Javier Bartolome
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- Johan Staaf
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- Jonathan Göke
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- Jongsun Jung
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- Julia Markowski
- Julia Richter
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- Julie Livingstone
- Julie M Wilson
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- Jung Kyoon Choi
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- Keiran M Raine
- Keiran M Raine
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- Myron Peto
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- Natalie Saini
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- Nicholas Petrelli
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- Nicola Waddell
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- Nikolajs Zeps
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- Nilanjan Chatterjee
- Nilgun Donmez
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- Nina Thiessen
- Nischalan Pillay
- Nishant Agrawal
- Nobuyoshi Hiraoka
- Nodirjon Fayzullaev
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- Xiuqing Zhang
- Xiuqing Zheng
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- Xuan Le
- Xuanping Zhang
- Xuemei Luo
- Xueqing Zou
- Yan Shi
- Yan Zhang
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- Yann Joly
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- Yassen Assenov
- Yasser Riazalhosseini
- Yasuhito Arai
- Yasushi Rino
- Yasushi Totoki
- Yeng Ang
- Yi Huang
- Yi Huang
- Yifei Men
- Yiling Lu
- Yilong Li
- Yingyan Yu
- Yiwen Chen
- Yogesh Kumar
- Yogesh Kumar
- Yoke-Eng Chiew
- Yong Hou
- Yong Zhou
- Yong-Jie Lu
- Yongzhan Nie
- Yosef E Maruvka
- Yosef E Maruvka
- Yoshiiku Kawakami
- Young Seok Ju
- Youngchoon Woo
- Youngil Koh
- Youngwook Kim
- Youyong Lu
- Yu Fan
- Yu Fan
- Yu Fan
- Yu-Jia Shiah
- Yuan Ji
- Yuan Yuan
- Yuichi Shiraishi
- Yulia Newton
- Yulia Rubanova
- Yumeng Wang
- Yupeng Cun
- Yussanne Ma
- Zachary Heins
- Zechen Chong
- Zechen Chong
- Zemin Zhang
- Zhaohong Chen
- Zhenggang Wu
- Zhenggang Wu
- Zhining Wang
- Zhongming Zhao
- Ziao Lin
- Zsofia Kote-Jarai
- Ólafur Andri Stefánsson
- Øystein Garred
- Publication venue
- Nature Communications
- Publication date
- 01/01/2020
- Field of study
Funder: NCI U24CA211006Abstract: The Cancer Genome Atlas (TCGA) and International Cancer Genome Consortium (ICGC) curated consensus somatic mutation calls using whole exome sequencing (WES) and whole genome sequencing (WGS), respectively. Here, as part of the ICGC/TCGA Pan-Cancer Analysis of Whole Genomes (PCAWG) Consortium, which aggregated whole genome sequencing data from 2,658 cancers across 38 tumour types, we compare WES and WGS side-by-side from 746 TCGA samples, finding that ~80% of mutations overlap in covered exonic regions. We estimate that low variant allele fraction (VAF < 15%) and clonal heterogeneity contribute up to 68% of private WGS mutations and 71% of private WES mutations. We observe that ~30% of private WGS mutations trace to mutations identified by a single variant caller in WES consensus efforts. WGS captures both ~50% more variation in exonic regions and un-observed mutations in loci with variable GC-content. Together, our analysis highlights technological divergences between two reproducible somatic variant detection efforts
Discutindo a educação ambiental no cotidiano escolar: desenvolvimento de projetos na escola formação inicial e continuada de professores
- Author
- Abbaneo Duccio
- Abbiendi Giovanni
- Abbrescia Marcello
- Abdullin Salavat
- Acosta Darin
- Acosta Jhon Gabriel
- Adam Nadia
- Adam Wolfgang
- Adams Mark Raymond
- Adams Todd
- Adiguzel Aytul
- Adler Volker
- Adzic Petar
- Afanasiev Serguei
- Agostino Lorenzo
- Agram Jean-Laurent
- Aguilar-Benitez Manuel
- Aguilo Ernest
- Ahmad Muhammad
- Ahmed Ijaz
- Ahuja Sudha
- Akchurin Nural
- Akgun Bora
- Akgun Ugur
- Akin Ilina Vasileva
- Alagoz Enver
- Albajar Carmen
- Albayrak Elif Asli
- Albergo Sebastiano
- Albrow Michael
- Alcaraz Maestre Juan
- Aldaya Martin Maria
- Alexander James
- Aliev Takhmasib
- Almeida Nuno
- Alver Burak
- Alverson George
- Alves Gilvan
- Amapane Nicola
- Amsler Claude
- Anagnostou Georgios
- Anastassov Anton
- Anderson Jacob
- Anderson Michael
- Andrea Jeremy
- Andreev Valeri
- Andreev Vladimir
- Andreev Yuri
- Andrews Warren
- Anghel Ioana Maria
- Antonelli Louis
- Antunovic Zeljko
- Apanasevich Leonard
- Apollinari Giorgio
- Appelt Eric
- Apresyan Artur
- Aranyi Attila
- Arce Pedro
- Arcidiacono Roberta
- Arenton Michael Wayne
- Arfaei Hessamaddin
- Argiro Stefano
- Arisaka Katsushi
- Arneodo Michele
- Asaadi Jonathan
- Asghar Muhammad Irfan
- Askew Andrew
- Assran Yasser
- Ata Metin
- Atac Muzaffer
- Atramentov Oleksiy
- Attikis Alexandros
- Auffray Etiennette
- Autermann Christian Tobias
- Auzinger Georg
- Avery Paul
- Avetisyan Aram
- Azarkin Maksim
- Azhgirey Igor
- Aziz Tariq
- Azzi Patrizia
- Azzolini Virginia
- Azzurri Paolo
- Baarmand Marc M.
- Babb John
- Bacchetta Nicola
- Bachtis Michail
- Baden Drew
- Baesso Paolo
- Baffioni Stephanie
- Bagliesi Giuseppe
- Bai Yuting
- Baillon Paul
- Bainbridge Robert
- Bakhshiansohi Hamed
- Bakirci Mustafa Numan
- Bakken Jon Alan
- Balazs Michael
- Ball Austin
- Ball Gordon
- Ballin Jamie
- Ban Yong
- Banerjee Sudeshna
- Banerjee Sunanda
- Bansal Sunil
- Banzuzi Kukka
- Barbagli Giuseppe
- Barberis Emanuela
- Barbone Lucia
- Bardak Cemile
- Barfuss Anne-fleur
- Bargassa Pedrame
- Barge Derek
- Baringer Philip
- Barker Anthony
- Barnes Virgil E.
- Barnett Bruce Arnold
- Barney David
- Barone Luciano
- Barrett Matthew
- Bartalini Paolo
- Barth Christian
- Basegmez Suzan
- Basso Lorenzo
- Battilana Carlo
- Baty Clement
- Bauer Gerry
- Bauer Julia
- Bauerdick Lothar A. T.
- Baumgartel Darin
- Baur Ulrich
- Bazterra Victor Eduardo
- Bean Alice
- Beauceron Stephanie
- Beaudette Florian
- Beaupere Nicolas
- Bedjidian Marc
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- Behrens Ulf
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- Beliy Nikita
- Bell Alan James
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- Bencze Gyorgy
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- Beni Noemi
- Benucci Leonardo
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- Benvenuti Alberto
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- Bobrovskyi Sergei
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- Bodek Arie
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- Bolla Gino
- Bolognesi Sara
- Bolton Tim
- Bona Marcella
- Bonacorsi Daniele
- Bonato Alessio
- Bondu Olivier
- Bontenackels Michael
- Boos Edouard
- Borcherding Frederick
- Bornheim Adolf
- Borras Kerstin
- Borrello Laura
- Bortignon Pierluigi
- Bortoletto Daniela
- Bose Suvadeep
- Bose Tulika
- Bostock Francis
- Botta Cristina
- Boudoul Gaelle
- Boulahouache Chaouki
- Boumediene Djamel
- Bourilkov Dimitri
- Boutemeur Madjid
- Boutle Sarah
- Braibant-Giacomelli Sylvie
- Branca Antonio
- Branson James G.
- Breedon Richard
- Breuker Horst
- Brew Christopher
- Brigliadori Luca
- Brigljevic Vuko
- Broccolo Giuseppe
- Brochero Cifuentes Javier Andres
- Brom Jean-Marie
- Brona Grzegorz
- Brooke James John
- Broutin Clementine
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- Brownson Eric
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- Bylsma Ben
- Cabrera Andrés
- Cabrillo Iban Jose
- Caebergs Thierry
- Cakir Altan
- Calabria Cesare
- Calderon De La Barca Sanchez Manuel
- Calderon Alicia
- Cali Ivan Amos
- Callner Jeremy
- Calvo Enrique
- Camanzi Barbara
- Caminada Lea
- Campagnari Claudio
- Campbell Alan
- Camporesi Tiziano
- Capiluppi Paolo
- Caponeri Benedetta
- Cappello Gigi
- Cardaci Marco
- Carlin Roberto
- Carlsmith Duncan
- Carrera Jarrin Edgar
- Carrillo Montoya Camilo Andres
- Carrillo Moreno Salvador
- Carroll Ryan
- Cartiglia Nicolo
- Carvalho Wagner
- Casimiro Linares Edgar
- Cassel David
- Castaldi Rino
- Castello Roberto
- Castilla-Valdez Heriberto
- Castro Andrea
- Castro Elena
- Caudron Julien
- Cavallari Francesca
- Cavallo Francesca Romana
- Cavallo Nicola
- Cavanaugh Richard
- Ceard Ludivine
- Cepeda Maria
- Cerati Giuseppe Benedetto
- Cerci Salim
- Cerizza Giordano
- Cerminara Gianluca
- Ceron Cristobal
- Cerrada Marcos
- Chabert Eric Christian
- Chadwick Matthew
- Chakaberia Irakli
- Chamizo Llatas Maria
- Chan Matthew
- Chandra Avdhesh
- Chang Paoti
- Chang Sunghyun
- Chang You-Hao
- Chang Yu-Wei
- Chang Yuan-Hann
- Chanon Nicolas
- Chao Yuan
- Charaf Otman
- Charlot Claude
- Chasco Matthew
- Chasserat Julien
- Chatrchyan Serguei
- Chatterjee Avishek
- Chauhan Sushil
- Checchia Paolo
- Chen Guo-Ming
- Chen He-Sheng
- Chen Jie
- Chen Kai-Feng
- Chen Kuan-Hsin
- Chen Mingshui
- Chen Yi
- Chen Zhiling
- Cheng Teh Lee
- Chertok Maxwell
- Chetluru Vasundhara
- Cheung Harry
- Chierici Roberto
- Chiochia Vincenzo
- Chiorboli Massimiliano
- Chlebana Frank
- Choi Minkyoo
- Choi Suyong
- Choi Young Kyu
- Choi Young-Il
- Chou John Paul
- Choudhary Brajesh C.
- Choudhury Rajani Kant
- Choudhury Somnath
- Christiansen Tim
- Chuang Shan-Huei
- Chung Jin Hyuk
- Chung Yeon Sei
- Chwalek Thorsten
- Ciesielski Robert
- Cihangir Selcuk
- Cimmino Anna
- Cirino Guy
- Cittolin Sergio
- Ciulli Vitaliano
- Civinini Carlo
- Claes Daniel R.
- Clare Robert
- Clarida Warren
- Clement Emyr
- Clerbaux Barbara
- Cline David
- CMS Collaboration
- Coarasa Perez Jose Antonio
- Cockerill David J. A.
- Codispoti Giuseppe
- Colafranceschi Stefano
- Colaleo Anna
- Cole Joanne
- Colino Nicanor
- Collard Caroline
- Colling David
- Contardo Didier
- Conte Eric
- Conway John
- Cooper Seth
- Cooper William
- Cortina Gil Eduardo
- Cossutti Fabio
- Costa Marco
- Costa Salvatore
- Costantini Silvia
- Coughlan John A.
- Cousins Robert
- Covarelli Roberto
- Cox Bradley
- Cox Peter Timothy
- Creanza Donato
- Cremaldi Lucien Marcus
- Cripps Nicholas
- Cuevas Javier
- Cuffiani Marco
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- Curé Benoît
- Cushman Priscilla
- Cussans David
- Cutajar Michael
- Cutts David
- Cwiok Mikolaj
- Czellar Sandor
- D'Agnolo Raffaele Tito
- D'Alessandro Raffaello
- D'Alfonso Mariarosaria
- D'Enterria David
- D'Hondt Jorgen
- Da Cunha Marinho Franciole
- Dahmes Bryan
- Dahms Torsten
- Dallavalle Gaetano-Marco
- Damgov Jordan
- Dammann Dirk
- Danielson Thomas
- Darmenov Nikolay
- Das Souvik
- Daskalakis Georgios
- Dasu Sridhara
- Daubie Evelyne
- David Tinoco Mendes Andre
- Davids Martina
- Davies Gavin
- De Almeida Dias Flavia
- de Barbaro Pawel
- De Benedetti Abraham
- De Boer Wim
- De Cosa Annapaola
- De Favereau De Jeneret Jerome
- De Filippis Nicola
- De Gruttola Michele
- De Guio Federico
- De Jesus Damiao Dilson
- De La Cruz Begona
- De La Cruz-Burelo Eduard
- De Lentdecker Gilles
- De Mattia Marco
- De Moraes Gregores Eduardo
- De Oliveira Martins Carley
- De Palma Mauro
- De Roeck Albert
- de Trocóniz Jorge F.
- De Visscher Simon
- De Wolf Eddi A.
- Deisher Amanda
- Deiters Konrad
- Dejardin Marc
- Del Re Daniele
- Delaere Christophe
- Delgado Peris Antonio
- Deliomeroglu Mehmet
- Dell'Orso Roberto
- Della Negra Michel
- Della Ricca Giuseppe
- Demaria Natale
- Demina Regina
- Demir Durmus
- Demortier Luc
- Denegri Daniel
- Deniz Muhammed
- Depasse Pierre
- Dermenev Alexander
- Dero Vincent
- Devroede Olivier
- Dhingra Nitish
- Di Giovanni Gian Piero
- Di Guida Salvatore
- Di Marco Emanuele
- Di Matteo Leonardo
- Diamond Brendan
- Diemoz Marcella
- Dierlamm Alexander
- Dietz-Laursonn Erik
- Diez Pardos Carmen
- Dimitrov Anton
- Dimitrov Lubomir
- Dinardo Mauro Emanuele
- Dirkes Guido
- Dissertori Günther
- Dittmar Michael
- Djordjevic Milos
- Dobrzynski Ludwik
- Dobur Didar
- Doesburg Robert
- Dolen James
- Dominguez Aaron
- Dominik Wojciech
- Domínguez Vázquez Daniel
- Dorigo Tommaso
- Dorney Brian
- Doroba Krzysztof
- Dosselli Umberto
- Dozen Candan
- Draeger Jula
- Dragicevic Marko
- Dragoiu Cosmin
- Drell Brian Robert
- Dremin Igor
- Drouhin Frédéric
- Drozdetskiy Alexey
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- Duda Markus
- Dudero Phillip Russell
- Dudko Lev
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- Duris Joseph
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- Eads Michael
- Eartly David P.
- Eckerlin Guenter
- Ecklund Karl Matthew
- Eckstein Doris
- Edelhoff Matthias
- Edelmaier Christopher
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- Finger jr. Michael
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- Heath Greg P.
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- Hobson Peter R.
- Hoch Michael
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- Kunde Gerd J.
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- Ratti Sergio P.
- Raupach Frank Arthur
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- Razis Panos A.
- Rebane Liis
- Rebassoo Finn
- Redaelli Nicola
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- Reeder Don
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- Reid Ivan
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- Reyes-Santos Marco A.
- Rhee Han-Bum
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- Richman Jeffrey
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- Ro Sang-Ryul
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- Shepherd-Themistocleous Claire H.
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- Skhirtladze Nikoloz
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- Slaunwhite Jason
- Smirnov Igor
- Smirnov Vitaly
- Smith James
- Smith John
- Smith Kenneth
- Smith Vincent J.
- Smith Wesley H.
- Smoron Agata
- Snigirev Alexander
- Snoek Hella
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- Snow Gregory R.
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- Sobol Andrei
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- Sonnenschein Lars
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- Spalding William J.
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- Villasenor-Cendejas Luis Manuel
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- Vitulo Paolo
- Viviani Claudio
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- Vogel Helmut
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- Wagner Stephen Robert
- Wagner-Kuhr Jeannine
- Wakefield Stuart
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- Walsh Sinead
- Waltenberger Wolfgang
- Walzel Gerhard
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- Wang Jian
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- Wang Zheng
- Ward Simon
- Wardle Nicholas
- Wardrope David
- Wasserbaech Steven
- Wayne Mitchell
- Weber Hendrik
- Weber Martin
- Weber Matthias
- Wehrli Lukas
- Weiler Thomas
- Weinberg Marc
- Weinberger Michael
- Wendland Lauri
- Weng Joanna
- Weng Yao
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- Werner Jeremy Scott
- Wetzel James
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- Whitmore Juliana
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- Wickramage Nadeesha
- Widl Edmund
- Wigmans Richard
- Wilken Rachel
- Wilkinson Richard
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- Willmott Carlos
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- Winn Dave
- Winstrom Lucas
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- Wittmer Bruno
- Womersley William John
- Won Steven
- Wood Darien
- Wood Jeffrey Scott
- Worm Steven
- Wright Douglas
- Wrochna Grzegorz
- Wu Jing-Han
- Wu Weimin
- Wulz Claudia-Elisabeth
- Wyslouch Bolek
- Würthwein Frank
- Xiao Hong
- Xie Si
- Xu Ming
- Yagil Avraham
- Yan Ming
- Yang Fan
- Yang Mingming
- Yang Yong
- Yang Zong-Chang
- Yazgan Efe
- Yelton John
- Yetkin Taylan
- Yi Kai
- Yildirim Eda
- Yilmaz Yetkin
- Yiu Chun Hin
- Yohay Rachel
- Yoo Hwi Dong
- Yoo Jaehyeok
- Yoon Sungho
- York Andrew
- Yu Intae
- Yu Shin-Shan
- Yumiceva Francisco
- Yun Jae Chul
- Zabel James
- Zabi Alexandre
- Zablocki Jakub
- Zaganidis Nicolas
- Zakaria Mohammed
- Zalewski Piotr
- Zanetti Marco
- Zang Jingjing
- Zang Shi-Lei
- Zarubin Anatoli
- Zatserklyaniy Andriy
- Zeinali Maryam
- Zeise Manuel
- Zeuner Wolfram Dietrich
- Zeyrek Mehmet
- Zhang Jinzhong
- Zhang Linlin
- Zhang Zhen
- Zheng Yu
- Zhokin Alexander
- Zhu Bo
- Zhu Ren-Yuan
- Zhukov Valery
- Zhukova Victoria
- Ziebarth Eva Barbara
- Ziegler Jill
- Zielinski Marek
- Zito Giuseppe
- Zorbilmez Caglar
- Zotto Pierluigi
- Zou Wei
- Zumerle Gianni
- Zuranski Andrzej
- Zöller Marc Henning
- Publication venue
- Publication date
- 01/01/2011
- Field of study
A presente pesquisa buscou discutir como a Educação Ambiental (EA) vem sendo trabalhada, no Ensino Fundamental e como os docentes desta escola compreendem e vem inserindo a EA no cotidiano escolar., em uma escola estadual do município de Tangará da Serra/MT, Brasil. Para tanto, realizou-se entrevistas com os professores que fazem parte de um projeto interdisciplinar de EA na escola pesquisada. Verificou-se que o projeto da escola não vem conseguindo alcançar os objetivos propostos por: desconhecimento do mesmo, pelos professores; formação deficiente dos professores, não entendimento da EA como processo de ensino-aprendizagem, falta de recursos didáticos, planejamento inadequado das atividades. A partir dessa constatação, procurou-se debater a impossibilidade de tratar do tema fora do trabalho interdisciplinar, bem como, e principalmente, a importância de um estudo mais aprofundado de EA, vinculando teoria e prática, tanto na formação docente, como em projetos escolares, a fim de fugir do tradicional vínculo “EA e ecologia, lixo e horta”.Facultad de Humanidades y Ciencias de la Educació
Healthcare Workers Bioresource: Study outline and baseline characteristics of a prospective healthcare worker cohort to study immune protection and pathogenesis in COVID-19
- Author
- Abbass Hakam
- Alfarih Mashael
- Alldis Zoe
- Andiapen Mervyn
- Artico Jessica
- Augusto João B.
- Baca Georgina L.
- Bhuva Anish N.
- Boulter Alex
- Bowles Ruth
- Bracken Olivia V.
- Brooks Tim
- Bullock Natalie
- Burton Maudrian
- Captur Gabriella
- Champion Nicola
- Chan Carmen
- Couto De Sousa Jorge
- Couto-Parada Xose
- Cutino-Moguel Teresa
- Davies Rhodri H.
- Dieobi-Anene Keenan
- Feehan Karen
- Figtree Gemma
- Figtree Melanie C.
- Finlay Malcolm
- Fontana Marianna
- Forooghi Nasim
- Gibbons Joseph M.
- Griffiths Peter
- Hamblin Matt
- Hickling Lauren M.
- Hingorani Aroon D.
- Howes Lee
- Itua Ivie
- Jardim Victor
- Jason Lee Wing-Yiu
- Jensen Melanie
- Jones Jessica
- Jones Meleri
- Joy George
- Kapil Vikas
- Mandadapu Vineela
- Manisty Charlotte
- Mcknight Áine
- Menacho Katia
- Mfuko Celina
- Mitchelmore Oliver
- Montgomery Hugh
- Moon James C.
- Noursadeghi Mahdad
- Ntusi Ntobeko
- O’Brien Ben
- Pade Corinna
- Palma Susana
- Parker Ruth
- Patel Kush
- Petersen Steffen E.
- Piniera Brian
- Raine Rosalind
- Rapala Alicja
- Richards Amy
- Robathan Mathew
- Sambile Genine
- Semper Amanda
- Seraphim Andreas
- Sugimoto Michelle
- Thornton George D.
- Treibel Thomas A.
- Tucker Art
- Veerapen Jessry
- Vijayakumar Mohit
- Welch Sophie
- Wodehouse Theresa
- Wynne Lucinda
- Zahedi Dan
- Publication venue
- 'F1000 Research Ltd'
- Publication date
- 01/01/2020
- Field of study
Background: Most biomedical research has focused on sampling COVID-19 patients presenting to hospital with advanced disease, with less focus on the asymptomatic or paucisymptomatic. We established a bioresource with serial sampling of health care workers (HCWs) designed to obtain samples before and during mainly mild disease, with follow-up sampling to evaluate the quality and duration of immune memory.Methods: We conducted a prospective observational study on HCWs from three hospital sites in London, initially at a single centre (recruited just prior to first peak community transmission in London), but then extended to multiple sites 3 weeks later (recruitment still ongoing, target n=1,000). Asymptomatic participants attending work complete a health questionnaire, and provide a nasal swab (for SARS-CoV-2 RNA by RT-PCR tests) and blood samples (mononuclear cells, serum, plasma, RNA and DNA are biobanked) at 16 weekly study visits, and at 6 and 12 months.Results: Preliminary baseline results for the first 731 HCWs (400 single-centre, 331 multicentre extension) are presented. Mean age was 38±11 years; 67% are female, 31% nurses, 20% doctors, and 19% work in intensive care units. COVID-19-associated risk factors were: 37% black, Asian or minority ethnicities; 18% smokers; 13% obesity; 11% asthma; 7% hypertension and 2% diabetes mellitus. At baseline, 41% reported symptoms in the preceding 2 weeks. Preliminary test results from the initial cohort (n=400) are available: PCR at baseline for SARS-CoV-2 was positive in 28 of 396 (7.1%, 95% CI 4.9-10.0%) and 15 of 385 (3.9%, 2.4-6.3%) had circulating IgG antibodies.Conclusions: This COVID-19 bioresource established just before the peak of infections in the UK will provide longitudinal assessments of incident infection and immune responses in HCWs through the natural time course of disease and convalescence. The samples and data from this bioresource are available to academic collaborators by application https://covid-consortium.com/application-for-samples/
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Sex differences in oncogenic mutational processes
- Author
- Aaltonen Lauri A.
- Abascal Federico
- Abeshouse Adam
- Aburatani Hiroyuki
- Adams David J.
- Agrawal Nishant
- Ahn Keun Soo
- Ahn Sung-Min
- Aikata Hiroshi
- Akbani Rehan
- Akdemir Kadir C.
- Al-Ahmadie Hikmat
- Al-Sedairy Sultan T.
- Al-Shahrour Fatima
- Alawi Malik
- Albert Monique
- Aldape Kenneth
- Alexandrov Ludmil B.
- Ally Adrian
- Alsop Kathryn
- Alvarez Eva G.
- Amary Fernanda
- Amin Samirkumar B.
- Aminou Brice
- Ammerpohl Ole
- Anderson Matthew J.
- Ang Yeng
- Antonello Davide
- Anur Pavana
- Aparicio Samuel
- Appelbaum Elizabeth L.
- Arai Yasuhito
- Aretz Axel
- Arihiro Koji
- Ariizumi Shun-ichi
- Armenia Joshua
- Arnau Gisela Mir
- Arnould Laurent
- Asa Sylvia
- Assenov Yassen
- Atwal Gurnit
- Aukema Sietse
- Auman J. Todd
- Aure Miriam R.
- Awadalla Philip
- Aymerich Marta
- Bader Gary D.
- Baez-Ortega Adrian
- Bailey Matthew H.
- Bailey Peter J.
- Balasundaram Miruna
- Balu Saianand
- Bandopadhayay Pratiti
- Banks Rosamonde E.
- Barbi Stefano
- Barbour Andrew P.
- Barenboim Jonathan
- Barnholtz-Sloan Jill
- Barr Hugh
- Barrera Elisabet
- Bartlett John
- Bartolome Javier
- Bassi Claudio
- Bathe Oliver F.
- Baumhoer Daniel
- Bavi Prashant
- Baylin Stephen B.
- Bazant Wojciech
- Beardsmore Duncan
- Beck Timothy A.
- Behjati Sam
- Behren Andreas
- Bell Cindy
- Beltran Sergi
- Benz Christopher
- Berchuck Andrew
- Bergmann Anke K.
- Bergstrom Erik N.
- Berman Benjamin P.
- Berney Daniel M.
- Bernhart Stephan H.
- Beroukhim Rameen
- Berrios Mario
- Bersani Samantha
- Bertl Johanna
- Betancourt Miguel
- Bhandari Vinayak
- Bhosle Shriram G.
- Biankin Andrew V.
- Bieg Matthias
- Bigner Darell
- Binder Hans
- Birney Ewan
- Birrer Michael
- Biswas Nidhan K.
- Bjerkehagen Bodil
- Bodenheimer Tom
- Boice Lori
- Bonizzato Giada
- Boot Arnoud
- Bootwalla Moiz S.
- Borg Ake
- Borkhardt Arndt
- Boroevich Keith A.
- Borozan Ivan
- Borst Christoph
- Bosenberg Marcus
- Bosio Mattia
- Boultwood Jacqueline
- Bourque Guillaume
- Boutros Paul C.
- Bova G. Steven
- Bowen David T.
- Bowlby Reanne
- Bowtell David D. L.
- Boyault Sandrine
- Boyce Rich
- Boyd Jeffrey
- Brazma Alvis
- Brennan Paul
- Brewer Daniel S.
- Brinkman Arie B.
- Bristow Robert G.
- Broaddus Russell R.
- Brock Jane E.
- Brock Malcolm
- Broeks Annegien
- Brooks Angela N.
- Brooks Denise
- Brors Benedikt
- Brunak Søren
- Bruxner Timothy J. C.
- Bruzos Alicia L.
- Buchanan Alex
- Buchhalter Ivo
- Buchholz Christiane
- Bullman Susan
- Burke Hazel
- Burkhardt Birgit
- Burns Kathleen H.
- Busanovich John
- Bustamante Carlos D.
- Butler Adam P.
- Butte Atul J.
- Byrne Niall J.
- Børresen-Dale Anne-Lise
- Caesar-Johnson Samantha J.
- Cafferkey Andy
- Cahill Declan
- Calabrese Claudia
- Caldas Carlos
- Calvo Fabien
- Camacho Niedzica
- Campbell Peter J.
- Campo Elias
- Cantù Cinzia
- Cao Shaolong
- Carey Thomas E.
- Carlevaro-Fita Joana
- Carlsen Rebecca
- Cataldo Ivana
- Cazzola Mario
- Cebon Jonathan
- Cerfolio Robert
- Chadwick Dianne E.
- Chakravarty Dimple
- Chalmers Don
- Chan Calvin Wing Yiu
- Chan Kin
- Chan-Seng-Yue Michelle
- Chandan Vishal S.
- Chang David K.
- Chanock Stephen J.
- Chantrill Lorraine A.
- Chateigner Aurélien
- Chatterjee Nilanjan
- Chayama Kazuaki
- Chen Hsiao-Wei
- Chen Jieming
- Chen Ken
- Chen Yiwen
- Chen Zhaohong
- Cherniack Andrew D.
- Chien Jeremy
- Chiew Yoke-Eng
- Chin Suet-Feung
- Cho Juok
- Cho Sunghoon
- Choi Jung Kyoon
- Choi Wan
- Chomienne Christine
- Chong Zechen
- Choo Su Pin
- Chou Angela
- Christ Angelika N.
- Christie Elizabeth L.
- Chuah Eric
- Cibulskis Carrie
- Cibulskis Kristian
- Cingarlini Sara
- Clapham Peter
- Claviez Alexander
- Cleary Sean
- Cloonan Nicole
- Cmero Marek
- Collins Colin C.
- Connor Ashton A.
- Cooke Susanna L.
- Cooper Colin S.
- Cope Leslie
- Corbo Vincenzo
- Cordes Matthew G.
- Cordner Stephen M.
- Cortés-Ciriano Isidro
- Covington Kyle
- Cowin Prue A.
- Craft Brian
- Craft David
- Creighton Chad J.
- Cun Yupeng
- Curley Erin
- Cutcutache Ioana
- Czajka Karolina
- Czerniak Bogdan
- Dagg Rebecca A.
- Danilova Ludmila
- Davi Maria Vittoria
- Davidson Natalie R.
- Davies Helen
- Davis Ian J.
- Davis-Dusenbery Brandi N.
- Dawson Kevin J.
- De Bono Johann S.
- De La Vega Francisco M.
- De Paoli-Iseppi Ricardo
- deFazio Anna
- Defreitas Timothy
- Dei Tos Angelo P.
- Delaneau Olivier
- Demchok John A.
- Demeulemeester Jonas
- Demidov German M.
- Demircioğlu Deniz
- Dennis Nening M.
- Denroche Robert E.
- Dentro Stefan C.
- Desai Nikita
- Deshpande Vikram
- Deshwar Amit G.
- Desmedt Christine
- Deu-Pons Jordi
- Dhalla Noreen
- Dhani Neesha C.
- Dhingra Priyanka
- Dhir Rajiv
- Diamanti Klev
- DiBiase Anthony
- Ding Li
- Ding Shuai
- Dinh Huy Q.
- Dirix Luc
- Doddapaneni HarshaVardhan
- Donmez Nilgun
- Dow Michelle T.
- Drapkin Ronny
- Drechsel Oliver
- Drews Ruben M.
- Dudderidge Tim
- Dueso-Barroso Ana
- Dunford Andrew J.
- Dunn Michael
- Dursi Lewis Jonathan
- Duthie Fraser R.
- Dutton-Regester Ken
- Eagles Jenna
- Easton Douglas F.
- Edmonds Stuart
- Edwards Paul A.
- Edwards Sandra E.
- Eeles Rosalind A.
- Ehinger Anna
- Eils Juergen
- Eils Roland
- El-Naggar Adel
- Eldridge Matthew
- Ellrott Kyle
- Erkek Serap
- Escaramis Georgia
- Espiritu Shadrielle M. G.
- Estivill Xavier
- Etemadmoghadam Dariush
- Eyfjord Jorunn E.
- Faltas Bishoy M.
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- Niu Beifang
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- Ojima Hidenori
- Okusaka Takuji
- Omberg Larsson
- Ong Chovon Kiat
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- Ott German
- Ouellette B. F. Francis
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- O’Donnell Peter
- O’Donovan Maria
- O’Meara Sarah
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- O’Neill J. Robert
- Paczkowska Marta
- Paiella Salvatore
- Pairojkul Chawalit
- Pajic Marina
- Pan-Hammarström Qiang
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- Radovic Petar
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- Raghavan K. Vijay
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- Ramakrishnan Kamna
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- Rathmell W. Kimryn
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- Reifenberger Guido
- Reimand Jüri
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- Rodriguez-Martin Bernardo
- Rodríguez-González F. Germán
- Roehrl Michael H. A.
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- Romieu Gilles
- Rooman Ilse
- Roques Tom
- Rosebrock Daniel
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- Rosenwald Andreas
- Rowe Edward W.
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- Rubanova Yulia
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- Sadeghi Sara
- Sahinalp S. Cenk
- Saini Natalie
- Saito-Adachi Mihoko
- Saksena Gordon
- Salcedo Adriana
- Salgado Roberto
- Salichos Leonidas
- Sallari Richard
- Saller Charles
- Salvia Roberto
- Sam Michelle
- Samra Jaswinder S.
- Sanchez-Vega Francisco
- Sander Chris
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- Sarrafi Iman
- Sasaki-Oku Aya
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- Scarlett Christopher J.
- Scarpa Aldo
- Scelo Ghislaine
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- Schlomm Thorsten
- Schmidt Heather K.
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- Schreiber Stefan
- Schultz Nikolaus
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- Seethala Raja
- Segre Ayellet V.
- Selander Iris
- Semple Colin A.
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- Serra Stefano
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- Shimizu Kiyo
- Shin Seung Jun
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- Shmaya Tal
- Shmulevich Ilya
- Shorser Solomon I.
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- Shriver Craig
- Shuai Shimin
- Sidiropoulos Nikos
- Siebert Reiner
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- Stegle Oliver
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- Su Hong
- Su Xiaoping
- Sun Ren X.
- Sungalee Stephanie
- Susak Hana
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- Sweep Fred
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- Sültmann Holger
- Tam Angela
- Tamborero David
- Tan Benita Kiat Tee
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- Tarabichi Maxime
- Tarnuzzer Roy
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- Tatsuno Kenji
- Tavaré Simon
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- Taylor-Weiner Amaro
- Teague Jon W.
- Teh Bin Tean
- Tembe Varsha
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- Thai Kevin
- Thayer Sarah P.
- Thiessen Nina
- Thomas Gilles
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- Thorogood Adrian
- Tiao Grace
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- Tirabosco Roberto
- Tojo Marta
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- Torrents David
- Tortora Giampaolo
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- Totoki Yasushi
- Townend David
- Traficante Nadia
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- Visakorpi Tapio
- Voet Douglas
- von Kalle Christof
- von Mering Christian
- Vyas Paresh
- Vázquez-García Ignacio
- Waddell Nick M.
- Waddell Nicola
- Wadelius Claes
- Wadi Lina
- Wagener Rabea
- Wala Jeremiah A.
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- Wang Jiayin
- Wang Linghua
- Wang Qi
- Wang Wenyi
- Wang Yumeng
- Wang Zhining
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- Warnatz Hans-Jörg
- Warrell Jonathan
- Warren Anne Y.
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- Weinberger Paul
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- Weischenfeldt Joachim
- Weisenberger Daniel J.
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- Wendl Michael C.
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- Whalley Justin P.
- Wheeler David A.
- Whitaker Hayley C.
- Wigle Dennis
- Wilkerson Matthew D.
- Williams Ashley
- Wilmott James S.
- Wilson Gavin W.
- Wilson Julie M.
- Wilson Richard K.
- Winterhoff Boris
- Wintersinger Jeffrey A.
- Wiznerowicz Maciej
- Wolf Stephan
- Wong Bernice H.
- Wong Tina
- Wong Winghing
- Woo Youngchoon
- Wood Scott
- Wouters Bradly G.
- Wright Adam J.
- Wright Derek W.
- Wright Mark H.
- Wu Chin-Lee
- Wu Dai-Ying
- Wu Guanming
- Wu Jianmin
- Wu Kui
- Wu Yang
- Wu Zhenggang
- Xi Liu
- Xia Tian
- Xiang Qian
- Xiao Xiao
- Xing Rui
- Xiong Heng
- Xu Qinying
- Xu Yanxun
- Xue Hong
- Yachida Shinichi
- Yakneen Sergei
- Yamaguchi Rui
- Yamaguchi Takafumi N.
- Yamamoto Masakazu
- Yamamoto Shogo
- Yamaue Hiroki
- Yang Fan
- Yang Huanming
- Yang Jean Y.
- Yang Liming
- Yang Lixing
- Yang Shanlin
- Yang Tsun-Po
- Yang Yang
- Yao Xiaotong
- Yaspo Marie-Laure
- Yates Lucy
- Yau Christina
- Ye Chen
- Ye Kai
- Yellapantula Venkata D.
- Yoon Christopher J.
- Yoon Sung-Soo
- Yousif Fouad
- Yu Jun
- Yu Kaixian
- Yu Willie
- Yu Yingyan
- Yuan Ke
- Yuan Yuan
- Yuen Denis
- Yugawa Takashi
- Yung Christina K.
- Zaikova Olga
- Zamora Jorge
- Zapatka Marc
- Zenklusen Jean C.
- Zenz Thorsten
- Zeps Nikolajs
- Zhang Cheng-Zhong
- Zhang Fan
- Zhang Hailei
- Zhang Hongwei
- Zhang Hongxin
- Zhang Jiashan
- Zhang Jing
- Zhang Junjun
- Zhang Xiuqing
- Zhang Xuanping
- Zhang Yan
- Zhang Zemin
- Zhao Zhongming
- Zheng Liangtao
- Zheng Xiuqing
- Zhou Wanding
- Zhou Yong
- Zhu Bin
- Zhu Hongtu
- Zhu Jingchun
- Zhu Shida
- Zou Lihua
- Zou Xueqing
- Publication venue
- Nature Communications
- Publication date
- 28/08/2020
- Field of study
Funder: Canadian Network for Research and Innovation in Machining Technology, Natural Sciences and Engineering Research Council of Canada (NSERC Canadian Network for Research and Innovation in Machining Technology); doi: https://doi.org/10.13039/501100002790Funder: Genome Canada (Génome Canada); doi: https://doi.org/10.13039/100008762Funder: Canada Foundation for Innovation (Fondation canadienne pour l'innovation); doi: https://doi.org/10.13039/501100000196Funder: Terry Fox Research Institute (Institut de Recherche Terry Fox); doi: https://doi.org/10.13039/501100004376Abstract: Sex differences have been observed in multiple facets of cancer epidemiology, treatment and biology, and in most cancers outside the sex organs. Efforts to link these clinical differences to specific molecular features have focused on somatic mutations within the coding regions of the genome. Here we report a pan-cancer analysis of sex differences in whole genomes of 1983 tumours of 28 subtypes as part of the ICGC/TCGA Pan-Cancer Analysis of Whole Genomes (PCAWG) Consortium. We both confirm the results of exome studies, and also uncover previously undescribed sex differences. These include sex-biases in coding and non-coding cancer drivers, mutation prevalence and strikingly, in mutational signatures related to underlying mutational processes. These results underline the pervasiveness of molecular sex differences and strengthen the call for increased consideration of sex in molecular cancer research