Optical propagation through a homogeneous turbulent shear flow

Effects of organized turbulent structures on the propagation of an optical beam in a homogeneous shear flow were studied. A passive-scalar field in a computed turbulent shear flow is used to represent index-of-refraction fluctuations, and phase errors induced in a coherent optical beam by turbulent fluctuations are computed. The organized vortical structures produce a scalar distribution with elongated regions of intense fluctuations which have an inclination with respect to the mean flow similar to that of the characteristic hairpin eddies. It is found that r.m.s. phase error is minimized by propagating approximately normal to the inclined vortical structures. Two-point correlations of vorticity and scalar fluctuation suggest that the regions of intense scalar fluctuation are produced primarily by the hairpin eddies

Biomaterials for the Treatment of Myocardial Infarction

For nearly a decade, researchers have investigated the possibility of cell transplantation for cardiac repair. More recently, the emerging fields of tissue engineering and biomaterials have begun to provide potential treatments. Tissue engineering approaches are designed to repair lost or damaged tissue through the use of growth factors, cellular transplantation, and biomaterial scaffolds. There are currently 3 biomaterial approaches for the treatment of myocardial infarction (MI). The first involves polymeric left ventricular restraints in the prevention of heart failure. The second utilizes in vitro engineered cardiac tissue, which is subsequently implanted in vivo. The final approach entails injecting cells and/or a scaffold into the myocardium to create in situ engineered cardiac tissue. This review gives an overview of the current progress in the growing field of biomaterials for the treatment of MI

Kaluza-Klein Excitations of W and Z at the LHC?

Deviations from standard electroweak physics arise in the framework of a Randall-Sundrum model, with matter and gauge fields in the bulk and the Higgs field localized on the TeV brane. We focus in particular on modifications associated with the weak mixing angle. Comparison with the electroweak precision data yields a rather stringent lower bound of about 10 TeV on the masses of the lowest Kaluza-Klein excitation of the W and Z bosons. With some optimistic assumptions the bound could be lowered to about 7 TeV.Comment: 11 pages, 5 figures, comments and references adde

B\Bbar mixing with the bulk fields in the Randall-Sundrum model

We calculate the B\Bbar mixing in the Randall-Sundrum bulk model. In this model, all the Standard Model fields except the Higgs can reside in the bulk. Two suggestive models of "mixed" and "relaxed" scenarios are considered. We find that the enhancement of the loop function is 0.51% for the "relaxed" and 1.07% for the "mixed" scenario when the first 4th KK modes are included, for a bulk fermion mass parameter $\nu=-0.3$.Comment: REVTEX, 20 pages, 3 figure

An engineered cardiac reporter cell line identifies human embryonic stem cell-derived myocardial precursors.

Unlike some organs, the heart is unable to repair itself after injury. Human embryonic stem cells (hESCs) grow and divide indefinitely while maintaining the potential to develop into many tissues of the body. As such, they provide an unprecedented opportunity to treat human diseases characterized by tissue loss. We have identified early myocardial precursors derived from hESCs (hMPs) using an α-myosin heavy chain (αMHC)-GFP reporter line. We have demonstrated by immunocytochemistry and quantitative real-time PCR (qPCR) that reporter activation is restricted to hESC-derived cardiomyocytes (CMs) differentiated in vitro, and that hMPs give rise exclusively to muscle in an in vivo teratoma formation assay. We also demonstrate that the reporter does not interfere with hESC genomic stability. Importantly, we show that hMPs give rise to atrial, ventricular and specialized conduction CM subtypes by qPCR and microelectrode array analysis. Expression profiling of hMPs over the course of differentiation implicate Wnt and transforming growth factor-β signaling pathways in CM development. The identification of hMPs using this αMHC-GFP reporter line will provide important insight into the pathways regulating human myocardial development, and may provide a novel therapeutic reagent for the treatment of cardiac disease

Probe Brane Dynamics and the Cosmological Constant

Recently a brane world perspective on the cosmological constant and the hierarchy problems was presented. Here, we elaborate on some aspects of that particular scenario and discuss the stability of the stationary brane solution and the dynamics of a probe brane. Even though the brane is unstable under a small perturbation from its stationary position, such instability is harmless when the 4-D cosmological constant is very small, as is the case of our universe. One may also introduce radion stabilizing potentials in a more realistic scenario.Comment: 13 pages, 1 figure, REVTE

Impedance-based arc fault determination device (IADD) and method

Embodiments according to the present invention provide an Impedance-based Arc-Fault Determination Device (IADD) and method that, when attached to an electrical node on the power system and through observations on voltage, current and phase shift with a step load change, determine the effective Thevenin equivalent circuit or Norton equivalent circuit at the point of test. The device and method determine the expected bolted fault current at the test location of interest, which enables calculation of incident energy and the assignment of a flash-hazard risk category

Relation between repolarization and refractoriness in the human ventricle: Cycle length dependence and effect of procainamide

The cycle length dependence of the action potential duration and the effective refractory period of the right ventricular endocardium were investigated in 24 patients undergoing electrophysiologic studies for suspected ventricular tachycardia. The action potential duration at 90% repolarization and the effective refractory period at twice diastolic threshold strength were measured at the same catheter site at steady state cycle lengths of 350 to 600 ms. Both measurements decreased linearly with decreasing cycle length, maintaining a parallel relation. When the relation between action potential duration and effective refractory period was expressed as the effective refractory period-action potential duration difference, nearly constant values (range −12 to −15 ms) were obtained at all cycle lengths.To determine whether sodium channel blocking drugs influence the effective refractory period-action potential duration relation in humans, measurements of these two variables were obtained in 15 patients before and during the infusion of procainamide. Procainamide prolonged the action potential duration at each cycle length by a near constant amount over baseline values (p < 0.001). Procainamide also increased the effective refractory period at each cycle length but with a greater incremental increase at the shorter cycle lengths. The rate-dependent increase in the effective refractory period-action potential duration difference became significant at cycle lengths ≤400 ms; at these high rates, the effective refractory period-action potential duration difference became positive (1.6 ms, p < 0.01 compared with baseline).Thus, in the human ventricle, the action potential duration and the effective refractory period have a close relation that remains fixed over a wide range of cycle lengths. The cycle length-dependent increase in the effective refractory period relative to action potential duration induced by procainamide is consistent with use dependency of sodium channel blocking drugs observed in vitro and may be a useful marker for measuring antiarrhythmic drug activity in vivo

Predictive monitoring for early detection of subacute potentially catastrophic illnesses in critical care

We wish to save lives of patients admitted to ICUs. Their mortality is high enough based simply on the severity of the original injury or illness, but is further raised by events during their stay. We target those events that are subacute but potentially catastrophic, such as infection. Sepsis, for example, is a bacterial infection of the bloodstream, that is common in ICU patients and has a \u3e 25% risk of death. Logically, early detection and treatment with antibiotics should improve outcomes. Our fundamental precepts are (1) some potentially catastrophic medical and surgical illnesses have subclinical phases during which early diagnosis and treatment might have life-saving effects, (2) these phases are characterized by changes in the normal highly complex but highly adaptive regulation and interaction of the nervous system and other organs such as the heart and lungs, (3) teams of clinicians and quantitative scientists can work together to identify clinically important abnormalities of monitoring data, to develop algorithms that match the clinicians\u27 eye in detecting abnormalities, and to undertake the clinical trials to test their impact on outcomes