Prevalence of intimate partner violence against women in Republic of Benin

The present study was conducted to estimate the prevalence of intimate partner violence against women (IPVAW) of reproductive age in Benin and to assess the factors related to the experience of IPVAW and attitude towards wife beating among women. The study also assessed whether a family history of violence is a risk factor for experiencing IPVAW. The study used the Benin Demographic and Health Survey 2017-18 data for analyses. A national representative sample of 4488 ever married women was selected to respond to a domestic violence and abuse questionnaire. Cross-tabulation and multivariate logistic regression analyses were performed. The prevalence of IPVAW experience in Benin was as follows: emotional violence, 35.4%; physical violence, 18.4%; and sexual violence, 8.2%. Older age, rural residence, the practice of Vodoun religion, living in a household headed by a male member, family history of domestic violence, and attitudes towards wife beating were significantly associated with the prevalence of IPVAW. Thirty-two percent of women supported wife beating. Women residing in urban areas, having higher educational qualification, higher socioeconomic status, and no family history of domestic violence were less likely to support wife beating. Policymakers should place emphasis on evidence-based prevention programs, gender equality, women empowerment, and policy priority for curbing IPVAW

High versus standard doses interferon-alpha in the treatment of naïve chronic hepatitis C patients in Taiwan: a 10-year cohort study

BACKGROUND: Interferon-alpha monotherapy is effective in less than one-third patients with chronic hepatitis C. The dose-effect, tolerability and durability of interferon-alpha treatment and its long-term effect on the prevention of cirrhosis and hepatocellular carcinoma in naïve Taiwanese patients with chronic hepatitis C have not been well investigated. We conducted the present cohort study treated with high and standard interferon-alpha to illustrate the issues. METHODS: We performed a long-term virologic and histological follow-up of 214 chronic hepatitis C patients treated with interferon-alpha, 3 million units (3-MU, n = 80) or 6-MU (n = 134) thrice weekly for 24 weeks, in Taiwan between 1992 and 2001. RESULTS: There was no difference in the incidence of discontinuation between 3-MU and 6-MU groups (4/80, 5.0% versus 10/134. 7.5%). The 6-MU group had similar incidence of adverse events with the 3-MU group, except that 6-MU group had significantly higher incidence of psychological manifestations, mainly presented as irritability. The rates of sustained virological response (SVR) were significantly higher in 6-MU regimen (37.1%) than in 3-MU regimen (23.7%, p < 0.05) in per protocol analysis. Based on multivariate analysis, baseline viral load was strongly associated with SVR, followed by hepatitis C virus genotype, interferon-alpha regimen, and liver fibrosis. A histological improvement in necroinflammatory activity, but not in fibrosis was observed in the follow-up biopsy performed 0.5–5.5 years (mean: 1.9 years, n = 51) after end-of-treatment. Among patients without SVR, there was more activity improvement in 6-MU group. The durability of SVR was 100% (18/18) and 97.8% (45/46) for 3-MU and 6-MU group, respectively, in a mean follow-up period of 6.81 years (5.25–9.18 years). For 163 baseline non-cirrhotic patients, 9 of 84 (10.7%) non-responders and 3 of 79 (3.8%) sustained responders progressed to cirrhosis during a mean follow-up period of 5.52 and 5.74 years, respectively (p = 0.067, Kaplan-Meier survival analysis, log-rank test). For all 200 patients, hepatocellular carcinoma was detected in 12 of 113 (10.6%) non-responders and one of 87 (1.1%) sustained responders during a mean follow-up period of 5.67 and 5.73 years, respectively (p < 0.01, Kaplan-Meier survival analysis, log-rank test). CONCLUSION: We confirm the dose effect of interferon-alpha in chronic hepatitis C. Six-MU regimen had better efficacy than 3-MU regimen in virologic and histological responses. Both regimens had good tolerability and durability in Taiwan. Sustained response could reduce the incidence of cirrhotic change and hepatocarcinogenesis

Targeting DNA Damage Response and Replication Stress in Pancreatic Cancer

Background and aims: Continuing recalcitrance to therapy cements pancreatic cancer (PC) as the most lethal malignancy, which is set to become the second leading cause of cancer death in our society. The study aim was to investigate the association between DNA damage response (DDR), replication stress and novel therapeutic response in PC to develop a biomarker driven therapeutic strategy targeting DDR and replication stress in PC. Methods: We interrogated the transcriptome, genome, proteome and functional characteristics of 61 novel PC patient-derived cell lines to define novel therapeutic strategies targeting DDR and replication stress. Validation was done in patient derived xenografts and human PC organoids. Results: Patient-derived cell lines faithfully recapitulate the epithelial component of pancreatic tumors including previously described molecular subtypes. Biomarkers of DDR deficiency, including a novel signature of homologous recombination deficiency, co-segregates with response to platinum (P &lt; 0.001) and PARP inhibitor therapy (P &lt; 0.001) in vitro and in vivo. We generated a novel signature of replication stress with which predicts response to ATR (P &lt; 0.018) and WEE1 inhibitor (P &lt; 0.029) treatment in both cell lines and human PC organoids. Replication stress was enriched in the squamous subtype of PC (P &lt; 0.001) but not associated with DDR deficiency. Conclusions: Replication stress and DDR deficiency are independent of each other, creating opportunities for therapy in DDR proficient PC, and post-platinum therapy

Hyperoxemia and excess oxygen use in early acute respiratory distress syndrome : Insights from the LUNG SAFE study

Publisher Copyright: © 2020 The Author(s). Copyright: Copyright 2020 Elsevier B.V., All rights reserved.Background: Concerns exist regarding the prevalence and impact of unnecessary oxygen use in patients with acute respiratory distress syndrome (ARDS). We examined this issue in patients with ARDS enrolled in the Large observational study to UNderstand the Global impact of Severe Acute respiratory FailurE (LUNG SAFE) study. Methods: In this secondary analysis of the LUNG SAFE study, we wished to determine the prevalence and the outcomes associated with hyperoxemia on day 1, sustained hyperoxemia, and excessive oxygen use in patients with early ARDS. Patients who fulfilled criteria of ARDS on day 1 and day 2 of acute hypoxemic respiratory failure were categorized based on the presence of hyperoxemia (PaO2 > 100 mmHg) on day 1, sustained (i.e., present on day 1 and day 2) hyperoxemia, or excessive oxygen use (FIO2 ≥ 0.60 during hyperoxemia). Results: Of 2005 patients that met the inclusion criteria, 131 (6.5%) were hypoxemic (PaO2 < 55 mmHg), 607 (30%) had hyperoxemia on day 1, and 250 (12%) had sustained hyperoxemia. Excess FIO2 use occurred in 400 (66%) out of 607 patients with hyperoxemia. Excess FIO2 use decreased from day 1 to day 2 of ARDS, with most hyperoxemic patients on day 2 receiving relatively low FIO2. Multivariate analyses found no independent relationship between day 1 hyperoxemia, sustained hyperoxemia, or excess FIO2 use and adverse clinical outcomes. Mortality was 42% in patients with excess FIO2 use, compared to 39% in a propensity-matched sample of normoxemic (PaO2 55-100 mmHg) patients (P = 0.47). Conclusions: Hyperoxemia and excess oxygen use are both prevalent in early ARDS but are most often non-sustained. No relationship was found between hyperoxemia or excessive oxygen use and patient outcome in this cohort. Trial registration: LUNG-SAFE is registered with ClinicalTrials.gov, NCT02010073publishersversionPeer reviewe

[[alternative]]The survey of correlated variables of the physical activity , health-related physical fitness in the primary school and the junior high school

[[abstract]]The purpose of this research is to understand the estimated energy expenditure,health-related physical fitness, and correlated variables of the students of theprimary school and the junior high school. The subjects chosen were the 4th, 5th,and 6th grade students of the I-chang Primary school and the 1st , 2nd , and 3rdgrade students of the I-chang Junior High School. Correlated variables of physicalactivity and health related physical fitness were measured by a closed-endedquestionnaire.The Bouchard three-day physical activity record was used to recordsubjects' energy expenditure. Besides, 1600(800)-meter run, sit-ups, BMI,sit-and-reach, and the percentage of body fat were the items used to measurestudents' health-related physical fitness. Among 1221 effective samples, therewere 626 males and 595 females. The statistical techniques, such as frequency,t-test, ONE-WAY ANOVA, multiple regression, ANCOVA, were used for data analysisfrom which the following conclusions were drawn. 1. The energy expenditure of thesubjects was higher on weekends than on weekdays. Males' mean energy expenditure ,mean frequency and absolute energy expenditure of MVPA (moderate to vigorousphysical activities) were significantly higher than females'. 2. There was a tendencyindicating that the average of the absolute energy expenditure was increased withthe grades. The students in the junior high school had significantly higher absoluteenergy expenditure than the students had in the primary school. 3.Both males andfemales, there was a tendency becoming fatter with the growing of their ages,the flexibility and the cardiovascular endurance were not good, the performance ofmuscular strength and muscular endurance were good but there was a tendency thatkeep going down . 4. Role modeling, whether students participated the sport club ,and thepeers' support were the important predicable factors of all relative energy expenditureand the relative energy expenditure of MVPA (moderate to vigorous physical activity)of the students in the primary school. 5.Sex, age , whether students participatedthe sport club ,whether students were the members of the school athletic team ,role modeling , self- efficacy for exercise and peers' support are the predicablefactors of all relative energy expenditure and the relative energy expenditure ofMVPA of the students in the junior high school. 6.Sex, race and age were the importantpredicable factors of each health- related physical fitness items which could explainthe variance from 5.5% to 16.5%. 7.The most correlated variables between the relativeenergy expenditure and health-related physical fitness were the muscular strength andmuscular endurance ,but the relationship was low. As a result, this study providesschools with information on how to increase students' physical activity and developtheir health-related physical fitness.