159 research outputs found

    Simultaneously sorting overlapping quantum states of light

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    The efficient manipulation, sorting, and measurement of optical modes and single-photon states is fundamental to classical and quantum science. Here, we realise simultaneous and efficient sorting of non-orthogonal, overlapping states of light, encoded in the transverse spatial degree of freedom. We use a specifically designed multi-plane light converter (MPLC) to sort states encoded in dimensions ranging from d=3d = 3 to d=7d = 7. Through the use of an auxiliary output mode, the MPLC simultaneously performs the unitary operation required for unambiguous discrimination and the basis change for the outcomes to be spatially separated. Our results lay the groundwork for optimal image identification and classification via optical networks, with potential applications ranging from self-driving cars to quantum communication systems

    Carotid Atheroma Rupture Observed In Vivo and FSI-Predicted Stress Distribution Based on Pre-rupture Imaging

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    Atherosclerosis at the carotid bifurcation is a major risk factor for stroke. As mechanical forces may impact lesion stability, finite element studies have been conducted on models of diseased vessels to elucidate the effects of lesion characteristics on the stresses within plaque materials. It is hoped that patient-specific biomechanical analyses may serve clinically to assess the rupture potential for any particular lesion, allowing better stratification of patients into the most appropriate treatments. Due to a sparsity of in vivo plaque rupture data, the relationship between various mechanical descriptors such as stresses or strains and rupture vulnerability is incompletely known, and the patient-specific utility of biomechanical analyses is unclear. In this article, we present a comparison between carotid atheroma rupture observed in vivo and the plaque stress distribution from fluid–structure interaction analysis based on pre-rupture medical imaging. The effects of image resolution are explored and the calculated stress fields are shown to vary by as much as 50% with sub-pixel geometric uncertainty. Within these bounds, we find a region of pronounced elevation in stress within the fibrous plaque layer of the lesion with a location and extent corresponding to that of the observed site of plaque rupture

    The Gallery 2009

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    This is a digital copy of the print content produced by the Gallery 2009 team. It consists of four books. Book 1 contains Introduction, Reel Art, and Gallery Members. Book 2 contains 3D Artwork: Ceramics, Metal Work, and Sculpture. Book 3 contains Graphic Design, Illustration, and Painting. Book 4 contains Photography and Printmaking. The final product also included a Viewfinder with accompanying reels, and time-based media such as animation. This content is not included. Files for individual books may be viewed on the detailed metadata page by clicking on the title.https://rdw.rowan.edu/the_gallery/1011/thumbnail.jp

    S100A8 & S100A9: alarmin mediated inflammation in tendinopathy

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    Alarmins S100A8 and S100A9 are endogenous molecules released in response to environmental triggers and cellular damage. They are constitutively expressed in immune cells such as monocytes and neutrophils and their expression is upregulated under inflammatory conditions. The molecular mechanisms that regulate inflammatory pathways in tendinopathy are largely unknown therefore identifying early immune effectors is essential to understanding the pathology. Based on our previous investigations highlighting tendinopathy as an alarmin mediated pathology we sought evidence of S100A8 & A9 expression in a human model of tendinopathy and thereafter, to explore mechanisms whereby S100 proteins may regulate release of inflammatory mediators and matrix synthesis in human tenocytes. Immunohistochemistry and quantitative RT-PCR showed S100A8 & A9 expression was significantly upregulated in tendinopathic tissue compared with control. Furthermore, treating primary human tenocytes with exogenous S100A8 & A9 significantly increased protein release of IL-6, IL-8, CCL2, CCL20 and CXCL10; however, no alterations in genes associated with matrix remodelling were observed at a transcript level. We propose S100A8 & A9 participate in early pathology by modulating the stromal microenvironment and influencing the inflammatory profile observed in tendinopathy. S100A8 and S100A9 may participate in a positive feedback mechanism involving enhanced leukocyte recruitment and release of pro-inflammatory cytokines from tenocytes that perpetuates the inflammatory response within the tendon in the early stages of disease

    Observing the Evolution of the Universe

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    How did the universe evolve? The fine angular scale (l>1000) temperature and polarization anisotropies in the CMB are a Rosetta stone for understanding the evolution of the universe. Through detailed measurements one may address everything from the physics of the birth of the universe to the history of star formation and the process by which galaxies formed. One may in addition track the evolution of the dark energy and discover the net neutrino mass. We are at the dawn of a new era in which hundreds of square degrees of sky can be mapped with arcminute resolution and sensitivities measured in microKelvin. Acquiring these data requires the use of special purpose telescopes such as the Atacama Cosmology Telescope (ACT), located in Chile, and the South Pole Telescope (SPT). These new telescopes are outfitted with a new generation of custom mm-wave kilo-pixel arrays. Additional instruments are in the planning stages.Comment: Science White Paper submitted to the US Astro2010 Decadal Survey. Full list of 177 author available at http://cmbpol.uchicago.ed

    Basin analysis using seismic interpretation as tools to examine the extent of a basin ore 'play'

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    Stratiform and stratabound base metal ores typically form in sedimentary basins during the overall rifting process with mineralising fluids transported along the growing normal faults. Understanding the detailed structural evolution, i.e. the timing, the growth and the extent of the faults, and the distribution and thickness of the syn-faulting sedimentary packages, is critical for focusing exploration efforts. In this paper, we describe how seismic interpretation and basin analysis techniques can help to do this. We assess the potential for Pb-Zn mineralisation within the Northumberland Trough, northern England, in the context of the wider Early Carboniferous basin evolution and the associated base metal ores. Through structural interpretation of seismic reflection data, we consider the detailed evolution of the fault geometries and sedimentation in time and space, to show the extent and distribution of the Early Carboniferous faulting and growth packages at depth in the study area. We conclude that basin evolution and structural framework in northern England is very similar to that associated with the significant Pb-Zn mineralisation in Ireland. We suggest a refined model for the Carboniferous evolution of this part of the basin. The study demonstrates how the techniques of basin analysis can be a used in ore exploration to establish whether the basic structural and sedimentary framework exists to enable mineralisation. In addition to assessing the general potential of base metal mineralisation, a more precise identification of potentially suitable areas for further investigation can be made. The seismic data and basin analysis approach used in this paper and exemplified through the Northumberland case should be directly applicable to any basin ore 'play' associated with rifting and/or sedimentation. The added, significant advantage of this method is the ability to assess the 3D fault geometries, including fault linkage and growth in space and time, and the associated sedimentation - an unachievable outcome if relying solely on other geophysical and geological data traditionally used in regional ore exploration
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