Etnologia Brasileira: Behind the Scenes

This text reflects on the changing role of anthropologists carrying out research with indigenous peoples in Brazil and on the increasing constraints that they are subjected to, both in terms of the legislation they must comply with and in terms of the way they are envisioned by contemporary indigenous peoples and non-anthropologists. At the time of this writing, sixty-seven people in Brazil who have acted in defense of the rights of indigenous peoples and Maroon descendants (Quilombolas) face bogus criminal charges. Frequently anthropologists are denigrated and accused of using the knowledge acquired during their research for personal enrichment and academic promotion. While the Code of Ethics (Resolution No. 510) of April 7, 2016 passed by the Brazilian Conselho Nacional de Saúde (National Health Council) that now guides conduct in the field purports to recognize the specificity of the social and human sciences, in reality it is an intromission of biomedicine and bioethics into anthropology, sociology, and related sciences. The bureaucratization involved, if followed to the letter, would discourage people from undertaking research. Field researchers must already avoid thorny issues such as polygamy, abortion, and the use and traffic of illegal drugs. Meanwhile, evangelical churches are undeterred in their zeal to convert Amerindians. They interfere in their way of life, often with devastating effects, and, acting in league with the bloc of large agribusiness interests (ruralistas), have become a force with which to be reckoned. The witch hunt against anthropologists has increased since the ousting of President Dilma Rousseff in May 2016, and the demarcation of Indigenous Lands (Terras Indígenas or TI) has ground to a halt. While miners and loggers invade existing Indigenous Lands with impunity, the 2016 Code of Ethics is a straitjacket that fails to come to grips with various legitimate ethical issues that concern anthropologists. In the present article, I draw on my several decades of research and university teaching in Brazil to explore the contradictions at the heart of anthropological work with indigenous peoples. Este texto reflexiona sobre el cambiante rol de los antropólogos que están llevando a cabo investigaciones con pueblos indígenas en Brasil y en las crecientes limitaciones a las que son sometidos, tanto en términos de la legislación que deben acatar, como en términos de la manera en la que están siendo percibidos por los indígenas contemporáneos y los no antropólogos. Al momento de la redacción de este artículo, 67 personas en Brasil que actuaron en defensa de los derechos de los indígenas y descendientes de cimarrones (Quilombolas) enfrentan cargos criminales falsos. Los antropólogos son con frecuencia denigrados y acusados de usar el conocimiento que adquieren durante las investigaciones para el enriquecimiento personal y la publicidad académica. Mientras el Código de Ética (Resolución No. 510) del 7 de abril del año 2016, promulgado por el Conselho Nacional de Saúde (Consejo Nacional de Salud) de Brasil que ahora guía la conducta en el campo, pretende reconocer la especificidad de las ciencias sociales y humanas, es en realidad una intromisión de la biomedicina y la bioética en la antropología, la sociología y sus ciencias afines. La burocratización involucrada, si se sigue al pie de la letra, podría disuadir a las personas de emprender investigaciones. Los investigadores de campo ya tienen que evadir asuntos espinosos como la poligamia, el aborto y el uso y tráfico de drogas ilícitas. Mientras tanto, las iglesias evangélicas siguen inamovibles en su empeño de convertir a los amerindios. Ellas interfieren en su estilo de vida, a menudo con efectos devastadores, y actuando en conjunto con el bloque de intereses de grandes agroindustrias (ruralistas), se han convertido en una fuerza a tener en cuenta. La cacería de brujas en contra de los antropólogos se ha incrementado desde el derrocamiento de la presidente Dilma Rousseff en mayo de 2016 y la demarcación de las Tierras Indígenas (Terras Indígenas o TI) se ha detenido. Mientras los mineros y los leñadores invaden en impunidad Tierras Indígenas existentes, el Código de Ética de 2016 es una camisa de fuerza que falla en impedir varios asuntos éticos legítimos que preocupan a los antropólogos. En el presente artículo me baso en mis varias décadas de investigadora y profesora universitaria en Brasil para explorar las contradicciones en el corazón del trabajo antropológico con los pueblos indígenas

Xicrin: uma coleção etnográfica

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The Gemini Planet Imager Exoplanet Survey: Giant Planet and Brown Dwarf Demographics From 10-100 AU

We present a statistical analysis of the first 300 stars observed by the Gemini Planet Imager Exoplanet Survey (GPIES). This subsample includes six detected planets and three brown dwarfs; from these detections and our contrast curves we infer the underlying distributions of substellar companions with respect to their mass, semi-major axis, and host stellar mass. We uncover a strong correlation between planet occurrence rate and host star mass, with stars M $>$ 1.5 $M_\odot$ more likely to host planets with masses between 2-13 M$_{\rm Jup}$ and semi-major axes of 3-100 au at 99.92% confidence. We fit a double power-law model in planet mass (m) and semi-major axis (a) for planet populations around high-mass stars (M $>$ 1.5M$_\odot$) of the form $\frac{d^2 N}{dm da} \propto m^\alpha a^\beta$, finding $\alpha$ = -2.4 $\pm$ 0.8 and $\beta$ = -2.0 $\pm$ 0.5, and an integrated occurrence rate of $9^{+5}_{-4}$% between 5-13 M$_{\rm Jup}$ and 10-100 au. A significantly lower occurrence rate is obtained for brown dwarfs around all stars, with 0.8$^{+0.8}_{-0.5}$% of stars hosting a brown dwarf companion between 13-80 M$_{\rm Jup}$ and 10-100 au. Brown dwarfs also appear to be distributed differently in mass and semi-major axis compared to giant planets; whereas giant planets follow a bottom-heavy mass distribution and favor smaller semi-major axes, brown dwarfs exhibit just the opposite behaviors. Comparing to studies of short-period giant planets from the RV method, our results are consistent with a peak in occurrence of giant planets between ~1-10 au. We discuss how these trends, including the preference of giant planets for high-mass host stars, point to formation of giant planets by core/pebble accretion, and formation of brown dwarfs by gravitational instability.Comment: 52 pages, 18 figures. AJ in pres

Multi-ancestry meta-analysis of tobacco use disorder prioritizes novel candidate risk genes and reveals associations with numerous health outcomes

Tobacco use disorder (TUD) is the most prevalent substance use disorder in the world. Genetic factors influence smoking behaviors, and although strides have been made using genome-wide association studies (GWAS) to identify risk variants, the majority of variants identified have been for nicotine consumption, rather than TUD. We leveraged five biobanks to perform a multi-ancestral meta-analysis of TUD (derived via electronic health records, EHR) in 898,680 individuals (739,895 European, 114,420 African American, 44,365 Latin American). We identified 88 independent risk loci; integration with functional genomic tools uncovered 461 potential risk genes, primarily expressed in the brain. TUD was genetically correlated with smoking and psychiatric traits from traditionally ascertained cohorts, externalizing behaviors in children, and hundreds of medical outcomes, including HIV infection, heart disease, and pain. This work furthers our biological understanding of TUD and establishes EHR as a source of phenotypic information for studying the genetics of TUD

The Gemini Planet Imager Exoplanet Survey: Giant Planet and Brown Dwarf Demographics from 10 To 100 Au

We present a statistical analysis of the first 300 stars observed by the Gemini Planet Imager Exoplanet Survey. This subsample includes six detected planets and three brown dwarfs; from these detections and our contrast curves we infer the underlying distributions of substellar companions with respect to their mass, semimajor axis, and host stellar mass. We uncover a strong correlation between planet occurrence rate and host star mass, with stars M ∗ \u3e1.5 M o more likely to host planets with masses between 2 and 13M Jup and semimajor axes of 3-100 au at 99.92% confidence. We fit a double power-law model in planet mass (m) and semimajor axis (a) for planet populations around high-mass stars (M ∗ \u3e1.5 M o) of the form , finding α = -2.4 +0.8 and β = -2.0 +0.5, and an integrated occurrence rate of % between 5-13M Jup and 10-100 au. A significantly lower occurrence rate is obtained for brown dwarfs around all stars, with % of stars hosting a brown dwarf companion between 13-80M Jup and 10-100 au. Brown dwarfs also appear to be distributed differently in mass and semimajor axis compared to giant planets; whereas giant planets follow a bottom-heavy mass distribution and favor smaller semimajor axes, brown dwarfs exhibit just the opposite behaviors. Comparing to studies of short-period giant planets from the radial velocity method, our results are consistent with a peak in occurrence of giant planets between ∼1 and 10 au. We discuss how these trends, including the preference of giant planets for high-mass host stars, point to formation of giant planets by core/pebble accretion, and formation of brown dwarfs by gravitational instability

The Gemini Planet Imager Exoplanet Survey : giant planet and brown dwarf demographics from 10 to 100 au

We present a statistical analysis of the first 300 stars observed by the Gemini Planet Imager Exoplanet Survey. This subsample includes six detected planets and three brown dwarfs; from these detections and our contrast curves we infer the underlying distributions of substellar companions with respect to their mass, semimajor axis, and host stellar mass. We uncover a strong correlation between planet occurrence rate and host star mass, with stars M* > 1.5 M⊙ more likely to host planets with masses between 2 and 13MJup and semimajor axes of 3–100 au at 99.92% confidence. We fit a double power-law model in planet mass (m) and semimajor axis (a) for planet populations around high-mass stars (M* > 1.5 M⊙) of the form d2N/(dm da) ∝ mα aβ, finding α = −2.4 ± 0.8 and β = −2.0 ± 0.5, and an integrated occurrence rate of 9+5-4% between 5–13MJup and 10–100 au. A significantly lower occurrence rate is obtained for brown dwarfs around all stars, with 0.8+0.8-0.5% of stars hosting a brown dwarf companion between 13–80MJup and 10–100 au. Brown dwarfs also appear to be distributed differently in mass and semimajor axis compared to giant planets; whereas giant planets follow a bottom-heavy mass distribution and favor smaller semimajor axes, brown dwarfs exhibit just the opposite behaviors. Comparing to studies of short-period giant planets from the radial velocity method, our results are consistent with a peak in occurrence of giant planets between ∼1 and 10 au. We discuss how these trends, including the preference of giant planets for high-mass host stars, point to formation of giant planets by core/pebble accretion, and formation of brown dwarfs by gravitational instability.Peer reviewe

Multiple Recurrent De Novo CNVs, Including Duplications of the 7q11.23 Williams Syndrome Region, Are Strongly Associated with Autism

SummaryWe have undertaken a genome-wide analysis of rare copy-number variation (CNV) in 1124 autism spectrum disorder (ASD) families, each comprised of a single proband, unaffected parents, and, in most kindreds, an unaffected sibling. We find significant association of ASD with de novo duplications of 7q11.23, where the reciprocal deletion causes Williams-Beuren syndrome, characterized by a highly social personality. We identify rare recurrent de novo CNVs at five additional regions, including 16p13.2 (encompassing genes USP7 and C16orf72) and Cadherin 13, and implement a rigorous approach to evaluating the statistical significance of these observations. Overall, large de novo CNVs, particularly those encompassing multiple genes, confer substantial risks (OR = 5.6; CI = 2.6–12.0, p = 2.4 × 10-7). We estimate there are 130–234 ASD-related CNV regions in the human genome and present compelling evidence, based on cumulative data, for association of rare de novo events at 7q11.23, 15q11.2-13.1, 16p11.2, and Neurexin 1

EMSL Geochemistry, Biogeochemistry and Subsurface Science-Science Theme Advisory Panel Meeting

This report covers the topics of discussion and the recommendations of the panel members. On December 8 and 9, 2010, the Geochemistry, Biogeochemistry, and Subsurface Science (GBSS) Science Theme Advisory Panel (STAP) convened for a more in-depth exploration of the five Science Theme focus areas developed at a similar meeting held in 2009. The goal for the fiscal year (FY) 2011 meeting was to identify potential topical areas for science campaigns, necessary experimental development needs, and scientific members for potential research teams. After a review of the current science in each of the five focus areas, the 2010 STAP discussions successfully led to the identification of one well focused campaign idea in pore-scale modeling and five longer-term potential research campaign ideas that would likely require additional workshops to identify specific research thrusts. These five campaign areas can be grouped into two categories: (1) the application of advanced high-resolution, high mass accuracy experimental techniques to elucidate the interplay between geochemistry and microbial communities in terrestrial ecosystems and (2) coupled computation/experimental investigations of the electron transfer reactions either between mineral surfaces and outer membranes of microbial cells or between the outer and inner membranes of microbial cells

Vaccine breakthrough hypoxemic COVID-19 pneumonia in patients with auto-Abs neutralizing type I IFNs

Life-threatening `breakthrough' cases of critical COVID-19 are attributed to poor or waning antibody response to the SARS- CoV-2 vaccine in individuals already at risk. Pre-existing autoantibodies (auto-Abs) neutralizing type I IFNs underlie at least 15% of critical COVID-19 pneumonia cases in unvaccinated individuals; however, their contribution to hypoxemic breakthrough cases in vaccinated people remains unknown. Here, we studied a cohort of 48 individuals ( age 20-86 years) who received 2 doses of an mRNA vaccine and developed a breakthrough infection with hypoxemic COVID-19 pneumonia 2 weeks to 4 months later. Antibody levels to the vaccine, neutralization of the virus, and auto- Abs to type I IFNs were measured in the plasma. Forty-two individuals had no known deficiency of B cell immunity and a normal antibody response to the vaccine. Among them, ten (24%) had auto-Abs neutralizing type I IFNs (aged 43-86 years). Eight of these ten patients had auto-Abs neutralizing both IFN-a2 and IFN-., while two neutralized IFN-omega only. No patient neutralized IFN-ss. Seven neutralized 10 ng/mL of type I IFNs, and three 100 pg/mL only. Seven patients neutralized SARS-CoV-2 D614G and the Delta variant (B.1.617.2) efficiently, while one patient neutralized Delta slightly less efficiently. Two of the three patients neutralizing only 100 pg/mL of type I IFNs neutralized both D61G and Delta less efficiently. Despite two mRNA vaccine inoculations and the presence of circulating antibodies capable of neutralizing SARS-CoV-2, auto-Abs neutralizing type I IFNs may underlie a significant proportion of hypoxemic COVID-19 pneumonia cases, highlighting the importance of this particularly vulnerable population