324 research outputs found
Magnetization reversal in amorphous Fe/Dy multilayers: a Monte Carlo study
The Monte Carlo method in the canonical ensemble is used to investigate
magnetization reversal in amorphous transition metal - rare earth multilayers.
Our study is based on a model containing diluted clusters which exhibit an
effective uniaxial anisotropy in competition with random magnetic anisotropy in
the matrix. We simulate hysteresis loops for an abrupt profile and a diffuse
one obtained from atom probe tomography analyses. Our results evidence that the
atom probe tomography profile favors perpendicular magnetic anisotropy in
agreement with magnetic measurements. Moreover, the hysteresis loops calculated
at several temperatures qualitatively agree with the experimental ones
Magnetoelectric properties of the multiferroic CuCrO studied by means of ab initio calculations and Monte Carlo simulations
Motivated by the discovery of multiferroicity in the geometrically frustrated
triangular antiferromagnet CuCrO below its N\'eel temperature , we
investigate its magnetic and ferroelectric properties using ab initio
calculations and Monte Carlo simulations. Exchange interactions up to the third
nearest neighbors in the plane, inter-layer interaction and single ion
anisotropy constants in CuCrO are estimated by series of density functional
theory calculations. In particular, our results evidence a hard axis along the
[110] direction due to the lattice distortion that takes place along this
direction below . Our Monte Carlo simulations indicate that the system
possesses a N\'eel temperature K very close to the ones reported
experimentally ( K). Also we show that the ground state is a
proper-screw magnetic configuration with an incommensurate propagation vector
pointing along the [110] direction. Moreover, our work reports the emergence of
spin helicity below which leads to ferroelectricity in the extended
inverse Dzyaloshinskii-Moriya model. We confirm the electric control of spin
helicity by simulating - hysteresis loops at various temperatures.Comment: 6 pages, 8 figure
Magnetic properties of Fe/Dy multilayers: a Monte Carlo investigation
We investigate the magnetic properties of a Heisenberg ferrimagnetic
multilayer by using Monte Carlo simulations. The aim of this work is to study
the local structural anisotropy model which is a possible origin of the
perpendicular magnetic anisotropy in transition metal/rare earth amorphous
multilayers. We have considered a face centered cubic lattice where each site
is occupied by a classical Heisenberg spin. We have introduced in our model of
amorphous multilayers a small fraction of crystallized Fe-Dy nanoclusters with
a mean anisotropy axis along the deposition direction. We show that a
competition in the energy terms takes place between the mean uniaxial
anisotropy of the Dy atoms in the nanoclusters and the random anisotropy of the
Dy atoms in the matrix.Comment: accepte pour publication - Proceeding of the Joint European Magnetic
Symposia (JEMS 06) - Journal of Magnetism and Magnetic Material
3D quantitative imaging of unprocessed live tissue reveals epithelial defense against bacterial adhesion and subsequent traversal requires MyD88.
While a plethora of in vivo models exist for studying infectious disease and its resolution, few enable factors involved in the maintenance of health to be studied in situ. This is due in part to a paucity of tools for studying subtleties of bacterial-host interactions at a cellular level within live organs or tissues, requiring investigators to rely on overt outcomes (e.g. pathology) in their research. Here, a suite of imaging technologies were combined to enable 3D and temporal subcellular localization and quantification of bacterial distribution within the murine cornea without the need for tissue processing or dissection. These methods were then used to demonstrate the importance of MyD88, a central adaptor protein for Toll-Like Receptor (TLR) mediated signaling, in protecting a multilayered epithelium against both adhesion and traversal by the opportunistic bacterial pathogen Pseudomonas aeruginosa ex vivo and in vivo
Protection against Staphylococcus aureus colonization and infection by B-and T-cell-mediated mechanisms
© 2018 Zhang et al. Staphylococcus aureus is a major cause of morbidity and mortality worldwide. S. aureus colonizes 20 to 80% of humans at any one time and causes a variety of illnesses. Strains that are resistant to common antibiotics further complicate management. S. aureus vaccine development has been unsuccessful so far, largely due to the incomplete understanding of the mechanisms of protection against this pathogen. Here, we studied the role of different aspects of adaptive immunity induced by an S. aureus vaccine in protection against S. aureus bacteremia, dermonecrosis, skin abscess, and gastrointestinal (GI) colonization. We show that, depending on the challenge model, the contributions of vaccine-induced S. aureus-specific antibody and Th1 and Th17 responses to protection are different: antibodies play a major role in reducing mortality during S. aureus bacteremia, whereas Th1 or Th17 responses are essential for prevention of S. aureus skin abscesses and the clearance of bacteria from the GI tract. Both antibody-and T-cell-mediated mechanisms contribute to prevention of S. aureus dermonecrosis. Engagement of all three immune pathways results in the most robust protection under each pathological condition. Therefore, our results suggest that eliciting multipronged humoral and cellular responses to S. aureus antigens may be critical to achieve effective and comprehensive immune defense against this pathogen. IMPORTANCE S. aureus is a leading cause of healthcare-and community-associated bacterial infections. S. aureus causes various illnesses, including bacteremia, meningitis, endocarditis, pneumonia, osteomyelitis, sepsis, and skin and soft tissue infections. S. aureus colonizes between 20 and 80% of humans; carriers are at increased risk for infection and transmission to others. The spread of multidrug-resistant strains limits antibiotic treatment options. Vaccine development against S. aureus has been unsuccessful to date, likely due to an inadequate understanding about the mechanisms of immune defense against this pathogen. The significance of our work is in illustrating the necessity of generating multipronged B-cell, Th1-, and Th17-mediated responses to S. aureus antigens in conferring enhanced and broad protection against S. aureus invasive infection, skin and soft tissue infection, and mucosal colonization. Our work thus, provides important insights for future vaccine development against this pathogen
Monte Carlo investigation of the magnetic anisotropy in Fe/Dy multilayers
By Monte Carlo simulations in the canonical ensemble, we have studied the
magnetic anisotropy in Fe/Dy amorphous multilayers. This work has been
motivated by experimental results which show a clear correlation between the
magnetic perpendicular anisotropy and the substrate temperature during
elaboration of the samples. Our aim is to relate macroscopic magnetic
properties of the multilayers to their structure, more precisely their
concentration profile. Our model is based on concentration dependent exchange
interactions and spin values, on random magnetic anisotropy and on the
existence of locally ordered clusters that leads to a perpendicular
magnetisation. Our results evidence that a compensation point occurs in the
case of an abrupt concentration profile. Moreover, an increase of the
noncollinearity of the atomic moments has been evidenced when the Dy anisotropy
constant value grows. We have also shown the existence of inhomogeneous
magnetisation profiles along the samples which are related to the concentration
profiles
Magnetisation switching in a ferromagnetic Heisenberg nanoparticle with uniaxial anisotropy: A Monte Carlo investigation
We investigate the thermal activated magnetisation reversal in a single
ferromagnetic nanoparticle with uniaxial anisotropy using Monte Carlo
simulations. The aim of this work is to reproduce the reversal magnetisation by
uniform rotation at very low temperature in the high energy barrier hypothesis,
that is to realize the N\'eel-Brown model. For this purpose we have considered
a simple cubic nanoparticle where each site is occupied by a classical
Heisenberg spin. The Hamiltonian is the sum of an exchange interaction term, a
single-ion anisotropy term and a Zeeman interaction term. Our numerical data of
the thermal variation of the switching field are compared to an approximated
expression and previous experimental results on Co nanoparticles
Ability of Lactobacillus fermentum to overcome host α-galactosidase deficiency, as evidenced by reduction of hydrogen excretion in rats consuming soya α-galacto-oligosaccharides
<p>Abstract</p> <p>Background</p> <p>Soya and its derivatives represent nutritionally high quality food products whose major drawback is their high content of α-galacto-oligosaccharides. These are not digested in the small intestine due to the natural absence of tissular α-galactosidase in mammals. The passage of these carbohydrates to the large intestine makes them available for fermentation by gas-producing bacteria leading to intestinal flatulence. The aim of the work reported here was to assess the ability of α-galactosidase-producing lactobacilli to improve the digestibility of α-galacto-oligosaccharides <it>in situ</it>.</p> <p>Results</p> <p>Gnotobiotic rats were orally fed with soy milk and placed in respiratory chambers designed to monitor fermentative gas excretion. The validity of the animal model was first checked using gnotobiotic rats monoassociated with a <it>Clostridium butyricum </it>hydrogen (H<sub>2</sub>)-producing strain. Ingestion of native soy milk by these rats caused significant H<sub>2 </sub>emission while ingestion of α-galacto-oligosaccharide-free soy milk did not, thus validating the experimental system. When native soy milk was fermented using the α-galactosidase-producing <it>Lactobacillus fermentum </it>CRL722 strain, the resulting product failed to induce H<sub>2 </sub>emission in rats thus validating the bacterial model. When <it>L. fermentum </it>CRL722 was coadministered with native soy milk, a significant reduction (50 %, <it>P </it>= 0.019) in H<sub>2 </sub>emission was observed, showing that α-galactosidase from <it>L. fermentum </it>CRL722 remained active <it>in situ</it>, in the gastrointestinal tract of rats monoassociated with <it>C. butyricum</it>. In human-microbiota associated rats, <it>L. fermentum </it>CRL722 also induced a significant reduction of H<sub>2 </sub>emission (70 %, <it>P </it>= 0.004).</p> <p>Conclusion</p> <p>These results strongly suggest that <it>L. fermentum </it>α-galactosidase is able to partially alleviate α-galactosidase deficiency in rats. This offers interesting perspectives in various applications in which lactic acid bacteria could be used as a vector for delivery of digestive enzymes in man and animals.</p
О способах организации учебной деятельности студентов неязыковых вузов по дисциплине "Иностранный язык"
In magnetic alloys, the effect of finite temperature magnetic excitations on phase stability below the Curie temperature is poorly investigated, although many systems undergo phase transitions in this temperature range. We consider random Ni-rich Fe-Ni alloys, which undergo chemical order-disorder transition approximately 100 K below their Curie temperature, to demonstrate from ab initio calculations that deviations of the global magnetic state from ideal ferromagnetic order due to temperature induced magnetization reduction have a crucial effect on the chemical transition temperature. We propose a scheme where the magnetic state is described by partially disordered local magnetic moments, which in combination with Heisenberg Monte Carlo simulations of the magnetization allows us to reproduce the transition temperature in good agreement with experimental data.Original Publication: Marcus Ekholm, H Zapolsky, A V Ruban, I Vernyhora, D Ledue and Igor Abrikosov, Influence of the Magnetic State on the Chemical Order-Disorder Transition Temperature in Fe-Ni Permalloy, 2010, PHYSICAL REVIEW LETTERS, (105), 16, 167208. http://dx.doi.org/10.1103/PhysRevLett.105.167208 Copyright: American Physical Society http://www.aps.org
A critical role for astrocytes in hypercapnic vasodilation in brain
Cerebral blood flow (CBF) is controlled by arterial blood pressure, arterial CO2, arterial O2, and brain activity and is largely constant in the awake state. Although small changes in arterial CO2 are particularly potent to change CBF (1 mmHg variation in arterial CO2 changes CBF by 3-4%), the coupling mechanism is incompletely understood. We tested the hypothesis that astrocytic prostaglandin E2 (PgE2) plays a key role for cerebrovascular CO2 reactivity and that preserved synthesis of glutathione is essential for the full development of this response.
We combined two-photon imaging microscopy in brain slices with in vivo work in rats and C57Bl/6J mice to examine the hemodynamic responses to CO2 and somatosensory stimulation before and after inhibition of astrocytic glutathione and PgE2 synthesis. We demonstrate that hypercapnia (increased CO2) evokes an increase in astrocyte [Ca2+]i and stimulates COX-1 activity. The enzyme downstream of COX-1 that synthesizes PgE2 (microsomal prostaglandin E synthase-1) depends critically for its vasodilator activity on the level of glutathione in the brain. We show that when glutathione levels are reduced, astrocyte calcium-evoked release of PgE2 is decreased and vasodilation triggered by astrocyte [Ca2+]i in vitro and by hypercapnia in vivo is inhibited.
Astrocyte synthetic pathways, dependent on glutathione, are involved in cerebrovascular reactivity to CO2. Reductions in glutathione levels in ageing, stroke or schizophrenia could lead to dysfunctional regulation of CBF and subsequent neuronal damage
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