802 research outputs found

    The one dimensional Kondo lattice model at partial band filling

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    The Kondo lattice model introduced in 1977 describes a lattice of localized magnetic moments interacting with a sea of conduction electrons. It is one of the most important canonical models in the study of a class of rare earth compounds, called heavy fermion systems, and as such has been studied intensively by a wide variety of techniques for more than a quarter of a century. This review focuses on the one dimensional case at partial band filling, in which the number of conduction electrons is less than the number of localized moments. The theoretical understanding, based on the bosonized solution, of the conventional Kondo lattice model is presented in great detail. This review divides naturally into two parts, the first relating to the description of the formalism, and the second to its application. After an all-inclusive description of the bosonization technique, the bosonized form of the Kondo lattice hamiltonian is constructed in detail. Next the double-exchange ordering, Kondo singlet formation, the RKKY interaction and spin polaron formation are described comprehensively. An in-depth analysis of the phase diagram follows, with special emphasis on the destruction of the ferromagnetic phase by spin-flip disorder scattering, and of recent numerical results. The results are shown to hold for both antiferromagnetic and ferromagnetic Kondo lattice. The general exposition is pedagogic in tone.Comment: Review, 258 pages, 19 figure

    En torno a la oralidad de la prensa en el siglo XVIII: recepción, representación y escritura

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    Este artículo se propone analizar la importancia de la modalidad oral y pública de la lectura para la prensa cultural del Siglo de las Luces español. El primer enfoque será prágmatico: se evocará la importancia de la recepción colectiva en la realidad histórica de la prensa. El segundo enfoque será metaperiodístico: ¿cómo aparece representada esta oralidad de la lectura en los periódicos que tratan de letras, artes, costumbres y que, como tal, interrogan las funciones del periodismo a la vez que lo practican? El tercer enfoque será literario, y se interesará en el impacto de las relaciones estrechas entre prensa y oralidad sobre las opciones de redacción adoptadas

    Enfermement et correspondances chez Patrick White

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    La critique dite post-coloniale a montré que contre le modèle impérial fondé sur les notions de centre et de périphérie se sont élaborées dans les « nouvelles littératures » des tentatives pour conjurer la « dislocation » liée à l’expérience de la migration forcée ou volontaire, combinée à une dénigration culturelle. Dans l’univers excentrique de l’Australie, le problème du rapport identitaire au lieu se pose à la conscience « blanche » de manière particulièrement complexe du fait des origine..

    La prensa literaria y la «pasión de amor» en el teatro español del siglo XVIII

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    The object of this article is to show how eighteenth century Spanish literary press conveys the Neo-classical ideas about the presence of love in theatre and its pernicious consequences. The study of El Pensador and Diario estrangero, as well as other journals, shows that the critics of that time consider the omnipresence of the theme of love on stage to be a threat to Spaniards' moral rectitude. Indeed, they claim that instead of improving the spectators’ morality by purging them of their passions, plays glorify these emotions by showing obscene examples of love overco­ming all obstacles standing on its way. This article thus examines these fierce criticisms along with the various suggestions of amendment put forward in the literary press. Furthermore, we try to understand the reasons why Neo-classical authors chiefly focus on dramatic works by assessing how accessible eighteenth century Spanish theatre is and by analyzing how powerfully its representations affect the audience.El objeto de este artículo es presentar cómo la prensa literaria española del siglo XVIII se hace eco de las ideas neoclásicas sobre la presencia del amor en el teatro y sus efectos perniciosos. El estudio de El Pensador y del Diario estrangero así como de otras publicaciones nos muestra que los críticos de aquella época consideran que el lema amoroso es omnipresente en la escena y que esta omnipresencia representa una amenaza para la buena moralidad de los españoles. Afirman en efecto que en vez de corregir a los espectadores purgándoles de sus pasiones, las obras de teatro exaltan éstas dando a ver ejemplos de amores deshonestos que triunfan de todos los obstáculos que se les oponen. Se examinan por lo tanto en el articulo estas virulentas críticas así como las distintas propuestas de reforma formuladas en la prensa literaria. Además, se intenta entender cuáles son los motivos que hacen que la atención de los neoclásicos se focalice esencialmente sobre las obras dramáticas, analizando para ello la accesibilidad del teatro en la España del siglo XVIII y su fuerza de representación

    Liver Resection after Downstaging Hepatocellular Carcinoma with Sorafenib

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    Background. Sorafenib is a molecular-targeted therapy used in palliative treatment of advanced hepatocellular carcinoma in Child A patients. Aims. To address the question of sorafenib as neoadjuvant treatment. Methods. We describe the cases of 2 patients who had surgery after sorafenib. Results. The patients had a large hepatocellular carcinoma in the right liver with venous neoplastic thrombi (1 in the right portal branch, 1 in the right hepatic vein). After 9 months of sorafenib, reassessment showed that tumours had decreased in size with a necrotic component. A right hepatectomy with thrombectomy was performed, and histopathology showed 35% to 60% necrosis. One patient had a recurrence after 6 months and had another liver resection; they are both recurrence-free since then. Conclusion. Sorafenib can downstage hepatocellular carcinoma and thus could represent a bridge to surgery. It may be possible to select patients in good general condition with partial regression of the tumour with sorafenib for a treatment in a curative intent

    Assessing sinus aerosol deposition: benefits of SPECT-CT imaging

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    International audiencePurpose: Aerosol inhalation therapy is one of the methods to treat rhinosinusitis. However the topical drug delivery to the posterior nose and paranasal sinuses shows only limited efficiency. A precise sinusal targeting remains a main challenge for aerosol treatment of sinus disorders. This paper proposes a comparative study of the nasal deposition patterns of micron and submicron particles using planar gamma-scintigraphy imaging vs. a new 3-dimensional (3D) imaging approach based on SPECT-CT measurements. Methods: Radiolabelled nebulizations have been performed on a plastinated model of human nasal cast coupled with a respiratory pump. First, the benefits provided by SPECT-CT imaging were compared with 2D gamma-scintigraphy and radioactive quantification of maxillary sinus lavage as reference for the sonic 2.8 μm aerosol sinusal deposition. Then, the impact on nasal deposition of various airborne particle sizes was assessed. Results: The 2D methodology overestimates aerosol deposition in the maxillary sinuses by a factor 9 whereas the 3D methodology is in agreement with the maxillary sinus lavage reference methodology. Then with the SPECT-CT approach we highlighted that the higher particle size was mainly deposited in the central nasal cavity contrary to the submicron aerosol particles (33.8 ± 0.6% of total deposition for the 2.8 μm particles vs. 1 ± 0.3% for the 230 nm particles). Conclusion: Benefits of SPECT/CT for the assessment of radiolabelled aerosol deposition in rhinology are clearly demonstrated. This 3D methodology should be preferentially used for scintigraphic imaging of sinusal deposition in Human

    Impact of acoustic airflow nebulization on intrasinus drug deposition of a human plastinated nasal cast: New insights into the mechanisms involved

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    International audienceThe impact of 100 Hz (Hertz) acoustic frequency airflow on sinus drug deposition of aerosols was investigated using a human plastinated nasal cast. The influence of drug concentration and endonasal anatomical features on the sinus deposition enhanced by the 100 Hz acoustic airflow was also examined. Plastinated models were anatomically, geometrically and aerodynamically validated (endoscopy, CT scans, acoustic rhinometry and rhinomanometry). Using the gentamicin as a marker, 286 experiments of aerosol deposition were performed. Changes of airborne particles metrology produced under different nebulization conditions (100 Hz acoustic airflow and gentamicin concentration) were also examined. Aerodynamic and geometric investigations highlighted a global behaviour of plastinated models in perfect accordance with a nasal decongested healthy subject. The results of intrasinus drug deposition clearly demonstrated that the aerosols can penetrate into the maxillary sinuses. The 100 Hz acoustic airflow led to increase the deposition of drug into the maxillary sinuses by a factor 2-3 depending on the nebulization conditions. A differential intrasinus deposition of active substance depending on maxillary ostium anatomical features and drug concentration was emphasized. The existence of a specific transport mechanism of penetration of nebulized particles delivered with acoustic airflow was proposed
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