4,240 research outputs found
Observing the sky at extremely high energies with the Cherenkov Telescope Array: Status of the GCT project
The Cherenkov Telescope Array is the main global project of ground-based
gamma-ray astronomy for the coming decades. Performance will be significantly
improved relative to present instruments, allowing a new insight into the
high-energy Universe [1]. The nominal CTA southern array will include a
sub-array of seventy 4 m telescopes spread over a few square kilometers to
study the sky at extremely high energies, with the opening of a new window in
the multi-TeV energy range. The Gamma-ray Cherenkov Telescope (GCT) is one of
the proposed telescope designs for that sub-array. The GCT prototype recorded
its first Cherenkov light on sky in 2015. After an assessment phase in 2016,
new observations have been performed successfully in 2017. The GCT
collaboration plans to install its first telescopes and cameras on the CTA site
in Chile in 2018-2019 and to contribute a number of telescopes to the
subsequent CTA production phase.Comment: 8 pages, 7 figures, ICRC201
Partnering in a Pandemic: a Case Study on Designing Teaching and Learning Tools by Undergraduate and Graduate Medical Students with Academic Support
This case study reflects on the concept of student\u27s-as-partners in a project that took place during the Summer 2020, during the COVID-19 pandemic, involving nine students from two medical schools in Ireland (University College Dublin (UCD) and the Royal College of Surgeons in Ireland (RCSI) and makes a pedagogical case for partnership in learning and teaching in medical education. This virtual partnership project lasted three weeks under the supervision of practitioners from the National Maternity Hospital (NMH). The focus of this paper on one output from the project: designing and developing Multiple Choice Questions (MCQ) bank. This bank of MCQ questions were written by the students, based on national and international guidelines, then peer reviewed by the students before final review by academic staff and then integrated into the online teaching for the next iteration of the Obstetrics and Gynaecology module in September 2020. The reflections on this MCQ development work provides valuable insights on challenges and opportunities for medical students at both undergraduate and graduate level who are planning for collaborative partnerships as a component of their medical education, as well as academic-practitioners in medical education who are initiating student-staff partnership
Low Energy States of : Elements on the Doubly-Magic Nature of Ni
Excited levels were attributed to Ga for the first time
which were fed in the -decay of its mother nucleus Zn produced in
the fission of U using the ISOL technique. We show that the structure
of this nucleus is consistent with that of the less exotic proton-deficient
N=50 isotones within the assumption of strong proton Z=28 and neutron N=50
effective shell effects.Comment: 4 pages, REVTeX 4, 5 figures (eps format
Mesenchymal Stromal Cells Engage Complement and Complement Receptor Bearing Innate Effector Cells to Modulate Immune Responses
Infusion of human third-party mesenchymal stromal cells (MSCs) appears to be a promising therapy for acute graft-versus-host disease (aGvHD). To date, little is known about how MSCs interact with the body's innate immune system after clinical infusion. This study shows, that exposure of MSCs to blood type ABO-matched human blood activates the complement system, which triggers complement-mediated lymphoid and myeloid effector cell activation in blood. We found deposition of complement component C3-derived fragments iC3b and C3dg on MSCs and fluid-phase generation of the chemotactic anaphylatoxins C3a and C5a. MSCs bound low amounts of immunoglobulins and lacked expression of complement regulatory proteins MCP (CD46) and DAF (CD55), but were protected from complement lysis via expression of protectin (CD59). Cell-surface-opsonization and anaphylatoxin-formation triggered complement receptor 3 (CD11b/CD18)-mediated effector cell activation in blood. The complement-activating properties of individual MSCs were furthermore correlated with their potency to inhibit PBMC-proliferation in vitro, and both effector cell activation and the immunosuppressive effect could be blocked either by using complement inhibitor Compstatin or by depletion of CD14/CD11b-high myeloid effector cells from mixed lymphocyte reactions. Our study demonstrates for the first time a major role of the complement system in governing the immunomodulatory activity of MSCs and elucidates how complement activation mediates the interaction with other immune cells
Study of the N=50 major shell effect close to Ni : First evidence of a weak coupling structure in Ge and three-proton configuration states in Ga
New levels were attributed to Ga and
Ge which were fed by the -decay of their respective
mother nuclei Zn and Ga produced by
fission at the "PARRNe" ISOL set-up installed at the Tandem accelerator of the
Institut de Physique Nucl\'eaire, Orsay. We show that the low energy structure
of Ga and Ge can easily be explained
within the natural hypothesis of a strong energy gap at N=50 and a doubly-magic
character for Ni.Comment: 2 pages, pdf file, To be published in the Proceedings of
"International Symposium on Structure of Exotic Nuclei and Nuclear Forces
(SENUF 06)", March 2006, Tokyo, Japa
Chronic Kidney Disease and Cognitive Function in Older Adults: Findings from the Chronic Renal Insufficiency Cohort Cognitive Study
To investigate cognitive impairment in older, ethnically diverse individuals with a broad range of kidney function, to evaluate a spectrum of cognitive domains, and to determine whether the relationship between chronic kidney disease (CKD) and cognitive function is independent of demographic and clinical factors.Cross-sectional.Chronic Renal Insufficiency Cohort Study.Eight hundred twenty-five adults aged 55 and older with CKD.Estimated glomerular filtration rate (eGFR, mL/min per 1.73âm 2 ) was estimated using the four-variable Modification of Diet in Renal Disease equation. Cognitive scores on six cognitive tests were compared across eGFR strata using linear regression; multivariable logistic regression was used to examine level of CKD and clinically significant cognitive impairment (score â€1 standard deviations from the mean).Mean age of the participants was 64.9, 50.4% were male, and 44.5% were black. After multivariable adjustment, participants with lower eGFR had lower cognitive scores on most cognitive domains ( P <.05). In addition, participants with advanced CKD (eGFR<30) were more likely to have clinically significant cognitive impairment on global cognition (adjusted odds ratio (AOR) 2.0, 95% CI=1.1â3.9), naming (AOR=1.9, 95% CI=1.0â3.3), attention (AOR=2.4, 95% CI=1.3â4.5), executive function (AOR=2.5, 95% CI=1.9â4.4), and delayed memory (AOR=1.5, 95% CI=0.9â2.6) but not on category fluency (AOR=1.1, 95% CI=0.6â2.0) than those with mild to moderate CKD (eGFR 45â59).In older adults with CKD, lower level of kidney function was associated with lower cognitive function on most domains. These results suggest that older patients with advanced CKD should be screened for cognitive impairment.Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/78647/1/j.1532-5415.2009.02670.x.pd
The COSMOS-WIRCam near-infrared imaging survey: I: BzK selected passive and star forming galaxy candidates at z>1.4
(abridged) We present a new near-infrared survey covering the 2 deg sq COSMOS
field. Combining our survey with Subaru B and z images we construct a deep,
wide-field optical-infrared catalogue. At Ks<23 (AB magnitudes) our survey
completeness is greater than 90% and 70% for stars and galaxies respectively
and contains 143,466 galaxies and 13,254 stars. At z~2 our catalogues contain
3931 quiescent and 25,757 star-forming BzK-selected galaxies representing the
largest and most secure sample of these objects to date. Our counts of
quiescent galaxies turns over at Ks~22 an effect which we demonstrate cannot be
due to sample incompleteness. In our survey both the number of faint and bright
quiescent objects exceeds the predictions of a semi-analytic galaxy formation
model, indicating potentially the need for further refinements in the amount of
merging and AGN feedback at z~2 in these models. We measure the angular
correlation function for each sample and find that at small scales the
correlation function for passive BzK galaxies exceeds the clustering of dark
matter. We use 30-band photometric redshifts to derive the spatial correlation
length and the redshift distributions for each object class. At Ks<22 we find
r_0^{\gamma/1.8}=7.0 +/-0.5h^{-1} Mpc for the passive BzK candidates and
4.7+/-0.8h^{-1} Mpc for the star-forming BzK galaxies. Our pBzK galaxies have
an average photometric redshift of z_p~1.4, in approximate agreement with the
limited spectroscopic information currently available. The stacked Ks image
will be made publicly available from IRSA.Comment: Accepted for publication in Astrophysical Journal. 17 pages, 17
figures, minor revisions to match published version available at
http://adsabs.harvard.edu/abs/2010ApJ...708..202
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