Liquefaction Susceptibility: Proposed New York City Building Code Revision

A simplified procedure is presented for evaluating liquefaction susceptibility of cohesionless saturated soils based on available technology. In 2001, a Committee of engineers working in the New York City (NYC) area was formed under the direction of the first Author, to review the liquefaction aspects of the 1995 New York City Building Code. The purpose was to gain consensus on a possible revision and augmentation of the exisiting regulations as part of the ongoing Code review by the Structural Engineers Association of New York (SEAoNY). This article summarizes the recommendations of the Committee, as compiled in 2002. The following topics are reviewed: (a) history of the current code; (b) seismicity and design motions in NYC; (c) updated screening criteria for liquefaction susceptibility. With reference to the topic in (c), recommendations are developed for Code language pertaining to: (1) method of analysis; (2) site classification schemes; (3) design considerations for bearing capacity and displacements of foundations in liquefied soil; (4) maximum depth of liquefaction; (5) field methods to evaluate soil resistance; (6) parameters to be considered in analyses; (7) treatment of sloped strata. Analytical results for typical NYC profiles subjected to 500-year rock motions are presented. Based on the these results, the Committee proposed a revised liquefaction screening diagram

UV Properties of Galactic Globular Clusters with GALEX I. The Color-Magnitude Diagrams

We present GALEX data for 44 Galactic globular clusters obtained during 3 GALEX observing cycles between 2004 and 2008. This is the largest homogeneous data set on the UV photometric properties of Galactic globular clusters ever collected. The sample selection and photometric analysis are discussed, and color-magnitude diagrams are presented. The blue and intermediate-blue horizontal branch is the dominant feature of the UV color-magnitude diagrams of old Galactic globular clusters. Our sample is large enough to display the remarkable variety of horizontal branch shapes found in old stellar populations. Other stellar types that are obviously detected are blue stragglers and post core-He burning stars. The main features of UV color-magnitude diagrams of Galactic globular clusters are briefly discussed. We establish the locus of post-core He burning stars in the UV color-magnitude diagram and present a catalog of candidate AGB-manqu \'e, post early-AGB, and post-AGB stars within our cluster sample.Comment: Accepted for publication by The Astronomical Journal. 46 pages, including 21 Figures and 3 tables. All data will be made publicly available by the time the article is published. In the meantime, please contact the authors for data requests. Revised version fixed error with figure numbers and caption

A Survey of MgII Absorption at 2 < z < 6 with Magellan / FIRE: I: Sample and Evolution of the MgII Frequency

We present initial results from the first systematic survey for MgII quasar absorption lines at z > 2.5. Using infrared spectra of 46 high-redshift quasars, we discovered 111 MgII systems over a path covering 1.9 < z < 6.3. Five systems have z > 5, with a maximum of z = 5.33 - the most distant MgII system now known. The comoving MgII line density for weaker systems (Wr < 1.0A) is statistically consistent with no evolution from z = 0.4 to z = 5.5, while that for stronger systems increases three-fold until z \sim 3 before declining again towards higher redshifts. The equivalent width distribution, which fits an exponential, reflects this evolution by flattening as z approaches 3 before steepening again. The rise and fall of the strong absorbers suggests a connection to the star formation rate density, as though they trace galactic outflows or other byproducts of star formation. The weaker systems' lack of evolution does not fit within this interpretation, but may be reproduced by extrapolating low redshift scaling relations between host galaxy luminosity and absorbing halo radius to earlier epochs. For the weak systems, luminosity-scaled models match the evolution better than similar models based on MgII occupation of evolving CDM halo masses, which greatly underpredict dN/dz at early times unless the absorption efficiency of small haloes is significantly larger in the early universe. Taken together, these observations suggest that the general structure of MgII-bearing haloes was put into place early in the process of galaxy assembly. Except for a transient appearance of stronger systems near the peak epoch of cosmic star formation, the basic properties of MgII absorbers have evolved fairly little even as the (presumably) associated galaxy population grew substantially in stellar mass and half light radius.Comment: Submitted to ApJ. 22 pages, 21 figure

Early Radio and X-Ray Observations of the Youngest Nearby Type Ia Supernova PTF 11kly (SN 2011fe)

On 2011 August 24 (UT) the Palomar Transient Factory (PTF) discovered PTF11kly (SN 2011fe), the youngest and most nearby Type Ia supernova (SN Ia) in decades. We followed this event up in the radio (centimeter and millimeter bands) and X-ray bands, starting about a day after the estimated explosion time.We present our analysis of the radio and X-ray observations, yielding the tightest constraints yet placed on the pre-explosion mass-loss rate from the progenitor system of this supernova. We find a robust limit of Ṁ ≾ 10^(−8)(w/100 km s^(−1))M_☉ yr^(−1) from sensitive X-ray non-detections, as well as a similar limit from radio data, which depends, however, on assumptions about microphysical parameters. We discuss our results in the context of single-degenerate models for SNe Ia and find that our observations modestly disfavor symbiotic progenitor models involving a red giant donor, but cannot constrain systems accreting from main-sequence or sub-giant stars, including the popular supersoft channel. In view of the proximity of PTF11kly and the sensitivity of our prompt observations, we would have to wait for a long time (a decade or longer) in order to more meaningfully probe the circumstellar matter of SNe Ia

Increased Foxo3a nuclear translocation and activity is an early neuronal response to βγ-secretase mediated processing of the Amyloid-β-Protein Precursor Protein: Utility of an AβPP-GAL4 reporter assay

Sequential cleavage of the amyloid-β protein precursor (AβPP) by BACE1 (β-secretase) followed by the γ-secretase complex, is strongly implicated in Alzheimer’s Disease (AD) but the initial cellular responses to these cleavage events are not fully defined. β-secretase-mediated AβPP processing yields an extracellular domain (sAβPPβ) and a C-terminal fragment of APP of 99 amino acids (C99). Subsequent cleavage by γ-secretase produces amyloid-β (Aβ) and an APP intracellular domain (AICD). A cellular screen based on the generation of AICD from an AβPP-Gal4 fusion protein was adapted by introducing familial AD (FAD) mutations into the AβPP sequence and linking the assay to Gal4-UAS driven luciferase and GFP expression, to identify responses immediately downstream of AβPP processing in neurons with a focus on the transcription factor Foxo3a which has been implicated in neurodegeneration. The K670N/M671L, E682K, E693G, V717I FAD mutations and the A673T protective mutation, were introduced into the AβPP sequence by site directed mutagenesis. When expressed in mouse cortical neurons AβPP-Gal4-UAS driven luciferase and GFP expression was substantially reduced by γ-secretase inhibitors, lowered by β-secretase inhibitors and enhanced by α-secretase inhibitors suggesting that AICD is a product of the β-secretase pathway. AβPP-Gal4-UAS driven GFP expression was exploited to identify individual neurons undergoing amyloidogenic AβPP processing, revealing increased nuclear localization of Foxo3a and enhanced Foxo3a-mediated transcription downstream of AICD production. Foxo3a translocation was not driven by AICD directly but correlated with reduced Akt phosphorylation. Collectively this suggests that βγ-secretase-mediated AβPP processing couples to Foxo3a which could be an early neuronal signaling response in AD

Pharmacodynamics of the Orotomides against Aspergillus fumigatus: New Opportunities for Treatment of Multidrug-Resistant Fungal Disease.

F901318 is an antifungal agent with a novel mechanism of action and potent activity against Aspergillus spp. An understanding of the pharmacodynamics (PD) of F901318 is required for selection of effective regimens for study in phase II and III clinical trials. Neutropenic murine and rabbit models of invasive pulmonary aspergillosis were used. The primary PD endpoint was serum galactomannan. The relationships between drug exposure and the impacts of dose fractionation on galactomannan, survival, and histopathology were determined. The results were benchmarked against a clinically relevant exposure of posaconazole. In the murine model, administration of a total daily dose of 24 mg/kg of body weight produced consistently better responses with increasingly fractionated regimens. The ratio of the minimum total plasma concentration/MIC (Cmin/MIC) was the PD index that best linked drug exposure with observed effect. An average Cmin (mg/liter) and Cmin/MIC of 0.3 and 9.1, respectively, resulted in antifungal effects equivalent to the effect of posaconazole at the upper boundary of its expected human exposures. This pattern was confirmed in a rabbit model, where Cmin and Cmin/MIC targets of 0.1 and 3.3, respectively, produced effects previously reported for expected human exposures of isavuconazole. These targets were independent of triazole susceptibility. The pattern of maximal effect evident with these drug exposure targets was also apparent when survival and histopathological clearance were used as study endpoints. F901318 exhibits time-dependent antifungal activity. The PD targets can now be used to select regimens for phase II and III clinical trials.IMPORTANCE Invasive fungal infections are common and often lethal. There are relatively few antifungal agents licensed for clinical use. Antifungal drug toxicity and the emergence of drug resistance make the treatment of these infections very challenging. F901318 is the first in a new class of antifungal agents called the orotomides. This class has a novel mechanism of action that involves the inhibition of the fungal enzyme dihydroorotate dehydrogenase. F901318 is being developed for clinical use. A deep understanding of the relationship between dosages, drug concentrations in the body, and the antifungal effect is fundamental to the identification of the regimens to administer to patients with invasive fungal infections. This study provides the necessary information to ensure that the right dose of F901318 is used the first time. Such an approach considerably reduces the risks in drug development programs and ensures that patients with few therapeutic options can receive potentially life-saving antifungal therapy at the earliest opportunity

Exploring the Optical Transient Sky with the Palomar Transient Factory

The Palomar Transient Factory (PTF) is a wide-field experiment designed to investigate the optical transient and variable sky on time scales from minutes to years. PTF uses the CFH12k mosaic camera, with a field of view of 7.9 deg^2 and a plate scale of 1 asec/pixel, mounted on the the Palomar Observatory 48-inch Samuel Oschin Telescope. The PTF operation strategy is devised to probe the existing gaps in the transient phase space and to search for theoretically predicted, but not yet detected, phenomena, such as fallback supernovae, macronovae, .Ia supernovae and the orphan afterglows of gamma-ray bursts. PTF will also discover many new members of known source classes, from cataclysmic variables in their various avatars to supernovae and active galactic nuclei, and will provide important insights into understanding galactic dynamics (through RR Lyrae stars) and the Solar system (asteroids and near-Earth objects). The lessons that can be learned from PTF will be essential for the preparation of future large synoptic sky surveys like the Large Synoptic Survey Telescope. In this paper we present the scientific motivation for PTF and describe in detail the goals and expectations for this experiment.Comment: 15 pages, 6 figures, submitted to PAS

SDSS-IV MaNGA: the different quenching histories of fast and slow rotators

Do the theorised different formation mechanisms of fast and slow rotators produce an observable difference in their star formation histories? To study this we identify quenching slow rotators in the MaNGA sample by selecting those which lie below the star forming sequence and identify a sample of quenching fast rotators which were matched in stellar mass. This results in a total sample of 194 kinematically classified galaxies, which is agnostic to visual morphology. We use u − r and NUV − u colours from SDSS and GALEX and an existing inference package, STARPY, to conduct a first look at the onset time and exponentially declining rate of quenching of these galaxies. An Anderson-Darling test on the distribution of the inferred quenching rates across the two kinematic populations reveals they are statistically distinguishable (3.2σ). We find that fast rotators quench at a much wider range of rates than slow rotators, consistent with a wide variety of physical processes such as secular evolution, minor mergers, gas accretion and environmentally driven mechanisms. Quenching is more likely to occur at rapid rates (τ≲1 Gyr) for slow rotators, in agreement with theories suggesting slow rotators are formed in dynamically fast processes, such as major mergers. Interestingly, we also find that a subset of the fast rotators quench at these same rapid rates as the bulk of the slow rotator sample. We therefore discuss how the total gas mass of a merger, rather than the merger mass ratio, may decide a galaxy’s ultimate kinematic fate