Anomalías g-2 y los Modelos Mínimos para el Z'

En este trabajo se presenta parte del formalismo de la electrodinámica cuántica QED (por sus siglas en inglés). En particular se obtiene la ecuación de Dirac para campos de espı́n 1/2 y las reglas de Feynman para la QED. Ası́ mismo se estudió con gran detalle las propiedades de covariancia de esta teorı́a. Como una aplicación de este formalismo se muestra el cálculo explı́cito del momento magnético anómalo del electrón a nivel de un loop, y se presenta una discusión acerca de las correcciones cuánticas que se requieren en el modelo estándar para calcular de forma adecuada el momento magnético anómalo del muón g − 2. Finalmente se usó este formalismo para obtener una solución de la anomalı́a experimental en g − 2 usando modelos de extensión. En este caso se encontró una solución para las cargas del Z 0 permitidas por las ecuaciones de anomalı́as y las ligaduras provenientes de los términos de Yukawa. El Z 0 que se consideró tiene un contenido mı́nimo de fermiones en el sentido que nuestro modelo sólo contiene los fermiones del modelo estándar y adicionalmente 3 neutrinos derechos y un leptón exótico cargado. Se consideraron las restricciones experimentales reportadas por experimentos en colisionadores obteniendo ası́ el espacio de parámetros permitidos para g−2 con un nivel de confianza de 1σ, la región permitida por producción de tridente de neutrinos m Z 0 g Z 0 > 0,75 TeV, asumiendo que la masa de la partı́cula exótica tiene un valor de 80 GeV

Eutanasia en la clínica de pequeños animales : una visión ética contrastada : análisis y consideraciones éticas y legales en la eutanasia de pequeños animales /

Treball presentat a l'assignatura de Deontologia i Veterinària Legal (21223

Estudio de la obra David y Goliat del Museo San Telmo para su posible atribucion

En el presente Trabajo de Fin de Grado se estudia “David y Goliat” perteneciente a los fondos del Museo San Telmo de San Sebastián para su posible autentificación la obra. Se parte de una mención en un catálogo rea- lizado en 1969 por el historiador Alfonso Pérez Sánchez en el que habla de un desaparecido “David vencedor de Goliat” del artista español Diego Polo (1610-1655). El lienzo objeto de estudio posee la misma iconografía y características mencionadas en dicho catálogo, por lo que su autoría podría adjudicarse al mencionado artista. El objetivo principal de este trabajo consiste en identificar una serie de pruebas que ayuden a verifi- car o descartar que el artista al que se le atribuye la autoría de la obra es el responsable de su realización

Using absorption models for insulin and carbohydrates and deep leaning to improve glucose level predictions

This article belongs to the Special Issue Sensors, Systems, and AI for Healthcare.Diabetes is a chronic disease caused by the inability of the pancreas to produce insulin or problems in the body to use it efficiently. It is one of the fastest growing health challenges affecting more than 400 million people worldwide, according to the World Health Organization. Intensive research is being carried out on artificial intelligence methods to help people with diabetes to optimize the way in which they use insulin, carbohydrate intakes, or physical activity. By predicting upcoming levels of blood glucose concentrations, preventive actions can be taken. Previous research studies using machine learning methods for blood glucose level predictions have mainly focused on the machine learning model used. Little attention has been given to the pre-processing of insulin and carbohydrate signals in order to mimic the human absorption processes. In this manuscript, a recurrent neural network (RNN) based model for predicting upcoming blood glucose levels in people with type 1 diabetes is combined with several carbohydrate and insulin absorption curves in order to optimize the prediction results. The proposed method is applied to data from real patients suffering type 1 diabetes mellitus (T1DM). The achieved results are encouraging, obtaining accuracy levels around 0.510 mmol/L (9.2 mg/dl) in the best scenario.This work was supported in part by the project "ANALISIS EN TIEMPO REAL DE SEN-SORES SOCIALES Y ESTIMACION DE RECURSOS PARA TRANSPORTE MULTIMODAL BASADA EN APRENDIZAJE PROFUNDO" MaGIST-RALES, funded by the Spanish Agencia Estatal de Investi-gación (AEI, doi 10.13039/501100011033) under grant PID2019-105221RB-C44/AEI/10.13039/501100011033

Differential in vitro and in vivo effect of barley cysteine and serine protease inhibitors on phytopathogenic microorganisms

Protease inhibitors from plants have been involved in defence mechanisms against pests and pathogens. Phytocystatins and trypsin/α-amylase inhibitors are two of the best characterized protease inhibitor families in plants. In barley, thirteen cystatins (HvCPI-1 to 13) and the BTI-CMe trypsin inhibitor have been previously studied. Their capacity to inhibit pest digestive proteases, and the negative in vivo effect caused by plants expressing these inhibitors on pests support the defence function of these proteins. Barley cystatins are also able to inhibit in vitro fungal growth. However, the antifungal effect of these inhibitors in vivo had not been previously tested. Moreover, their in vitro and in vivo effect on plant pathogenous bacteria is still unknown. In order to obtain new insights on this feature, in vitro assays were made against different bacterial and fungal pathogens of plants using the trypsin inhibitor BTI-CMe and the thirteen barley cystatins. Most barley cystatins and the BTI-CMe inhibitor were able to inhibit mycelial growth but no bacterial growth. Transgenic Arabidopsis plants independently expressing the BTI-CMe inhibitor and the cystatin HvCPI-6 were tested against the same bacterial and fungal pathogens. Neither the HvCPI-6 expressing transgenic plants nor the BTI-CMe ones were more resistant to plant pathogen fungi and bacteria than control Arabidopsis plants. The differences observed between the in vitro and in planta assays against phytopathogenic fungi are discusse

Association among salivary alpha-amylase activity and executive functioning in healthy children

Salivary alpha-amylase (sAA) is employed in basic research as a surrogate and non-invasive marker of the activity of Autonomous Nervous System (ANS) and Adrenomedullar System (AMS). In particular, sAA has showed a statistically sig- nificant association with levels of peripheral noradrenaline under acute psychoso- cial stress conditions in young and healthy participants. In this study, our aim was directed to describe the relation among sAA and cognitive performance in differ- ent executive tasks in a sample composed by 69 healthy children (45 boys). The tasks employed to assess executive functioning belong to the ENFEN battery (which measures different aspects of executive functions through four subtests: Phonologic and Semantic Fluency, Trail Making Test, Towers, and Interference). Saliva samples were obtained at baseline (10 minutes before the start of neuro- psychological assessment), just one minute before and just one minute after the end of the last subtest of ENFEN. Our statistical analyses showed a direct and sig- nificant association among sAA and scores in Phonologic Fluency, Trail Making, Towers and Interference subtests of ENFEN after controlling the effect of BMI. These results show a positive lineal association among sAA and executive behav- ior in healthy children. We discuss these findings in relation with those studies what have suggested a main role of the noradrenergic central action mediated via Locus Coeruleus-Noradrenaline System (LC-NA System) in the regulation of executive behavior.Universidad de Málaga. Campus de Excelencia Internacional Andalucía Tech

Limitations of a commercial assay as diagnostic test of autoimmune encephalitis

Detection of neuronal surface antibodies (NSAb) is important for the diagnosis of autoimmune encephalitis (AE). Although most clinical laboratories use a commercial diagnostic kit (Euroimmun, Lübeck, Germany) based on indirect immunofluorescence on transfected cells (IIFA), clinical experience suggests diagnostic limitations. Here, we assessed the performance of the commercial IIFA in serum and CSF samples of patients with suspected AE previously examined by rat brain immunohistochemistry (Cohort A). Of 6213 samples, 404 (6.5%) showed brain immunostaining suggestive of NSAb: 163 (40%) were positive by commercial IIFA and 241 (60%) were negative. When these 241 samples were re-assessed with in-house IIFA, 42 (18%) were positive: 21 (9%) had NSAb against antigens not included in the commercial IIFA and the other 21 (9%) had NSAb against antigens included in the commercial kit (false negative results). False negative results occurred more frequently with CSF (29% vs 10% in serum) and predominantly affected GABABR (39%), LGI1 (17%) and AMPAR (11%) antibodies. Results were reproduced in a separate cohort (B) of 54 AE patients with LGI1, GABABR or AMPAR antibodies in CSF which were missed in 30% by commercial IIFA. Patients with discordant GABABR antibody results (positive in-house but negative commercial IIFA) were less likely to develop full-blown clinical syndrome; no significant clinical differences were noted for the other antibodies. Overall, NSAb testing by commercial IIFA led to false negative results in a substantial number of patients, mainly those affected by anti-LG1, GABABR or AMPAR encephalitis. If these disorders are suspected and commercial IIFA is negative, more comprehensive antibody studies are recommende

Manifold analysis of the P-wave changes induced by pulmonary vein isolation during cryoballoon procedure

Background/Aim: In atrial fibrillation (AF) ablation procedures, it is desirable to know whether a proper disconnection of the pulmonary veins (PVs) was achieved. We hypothesize that information about their isolation could be provided by analyzing changes in P-wave after ablation. Thus, we present a method to detect PV disconnection using P-wave signal analysis. Methods: Conventional P-wave feature extraction was compared to an automatic feature extraction procedure based on creating low-dimensional latent spaces for cardiac signals with the Uniform Manifold Approximation and Projection (UMAP) method. A database of patients (19 controls and 16 AF individuals who underwent a PV ablation procedure) was collected. Standard 12-lead ECG was recorded, and P-waves were segmented and averaged to extract conventional features (duration, amplitude, and area) and their manifold representations provided by UMAP on a 3-dimensional latent space. A virtual patient was used to validate these results further and study the spatial distribution of the extracted characteristics over the whole torso surface. Results: Both methods showed differences between P-wave before and after ablation. Conventional methods were more prone to noise, P-wave delineation errors, and inter-patient variability. P-wave differences were observed in the standard leads recordings. However, higher differences appeared in the torso region over the precordial leads. Recordings near the left scapula also yielded noticeable differences. Conclusions: P-wave analysis based on UMAP parameters detects PV disconnection after ablation in AF patients and is more robust than heuristic parameterization. Moreover, additional leads different from the standard 12-lead ECG should be used to detect PV isolation and possible future reconnections better

Association among salivary alpha-amylase activity and working memory functioning in healthy children

Salivary Alpha-Amylase (sAA) shows a statistically significant association with levels of peripheral noradrenaline under acute psychosocial stress conditions in young and healthy participants. In this study, our aim was directed to examine the relation among sAA and cognitive performance in various executive tasks in an experimental sample composed by 69 healthy children although we only could obtain the complete set of data for 44 boys and girls for this battery. The cogni- tive tasks employed were: Digits, Letters & Numbers, Arithmetic and Visual Span subtests of WISC-V (this full set of subtests is employed to the assessment of verbal and visual working memory). Saliva samples were obtained at baseline (10 minutes before the start of neuropsychological assessment), one minute before the start, after the end of the verbal tasks, and one minute after the end of the visual span task. Our statistical analyses showed a significant association among sAA levels and some of the parameters employed to describe the perfor- mance of each participant in the subscales of Digits and Letters & Numbers after controlling the effect of BMI. Scores in Letters & Numbers and visual span were associated with levels of salivary flow rate. These results are coherent with the findings of a previous pilot study conducted in our laboratory and are interpreted in relation with those results which have suggested a main role of the Locus Coeruleus-Noradrenaline System (LC-NA System) in the regulation of the level of arousal and executive behaviors.Universidad de Málaga. Campus de Excelencia Internacional Andalucía Tech

A completely-phased diploid genome assembly for ‘Malbec’ cultivar (Vitis vinifera L.)

Poster. Publicado en: BAG Journal of Basic and Applied Genetics, 32 (1 suppl), 2021Most grapevine cultivars originated from the outcrossing of two genetically diverse parents, and are clonally propagated to preserve phenotypes of productive interest. Hence, cultivars are first filial generations (F1) with highly heterozygous diploid genomes, that turn challenging to assemble. ‘Malbec’ is the main cultivar for the Argentine wine industry and it originated in France, from the outcrossing of ‘Magdeleine Noir des Charentes’ and ‘Prunelard’ cultivars. Based on that mother-father-offspring relationship, here we followed the algorithm implemented in the software CanuTrio to produce a phased assembly of ‘Malbec’ genome. For this aim, parental cultivars’ Illumina short-reads were used to sort ‘Malbec’ PacBio long-reads into its haploid complements, to be assembled separately. Postassembly, bioinformatic procedures were employed to reduce the number of duplicated regions and perform sequence error corrections (using ‘Malbec’ Illumina short-reads). We obtained two highly complete and contiguous haploid assemblies for ‘Malbec’, Haplotype-Prunelard (482.4 Mb size; contig N50=7.7 Mb) and Haplotype-Magdeleine (479.4 Mb size; contig N50=6.6 Mb), with 96.1 and 95.8% of BUSCO genes, respectively. We tested for the composition of both haplophases with the tool Merqury, and observed 15% of both assemblies affected by structural variations, along with 3.2 million SNPs and 0.6 million InDels. Our results indicate that this is a valid approach to assemble highly heterozygous and complex diploid genomes in a completely-phased way.EEA MendozaFil: Calderón, Luciano. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mendoza. Instituto de Biología Agrícola de Mendoza; Argentina. Universidad Nacional de Cuyo. Facultad de Ciencias Agrarias. Instituto de Biología Agrícola de Mendoza; ArgentinaFil: Carbonell-Bejerano, P. Max Planck Institute for Developmental Biology; AlemaniaFil: Mauri, Nuria. Instituto de Ciencias de la Vid y del Vino (CSIC, UR, Gobierno de La Rioja). Finca La Grajera; ArgentinaFil: Muñoz, C. Universidad Nacional de Cuyo. Facultad de Ciencias Agrarias; ArgentinaFil: Bree, Laura. Vivero Mercier; ArgentinaFil: Sola, Cristóbal. Vivero Mercier; ArgentinaFil: Bergamin, Daniel. Vivero Mercier; ArgentinaFil: Gomez Talquenca, Gonzalo. Instituto Nacional de Tecnología Agropecuaria (INTA). Estación Experimental Agropecuaria Mendoza; ArgentinaFil: Martínez Zapater, José Miguel. Instituto de Ciencias de la Vid y del Vino (CSIC, UR, Gobierno de La Rioja). Finca La Grajera; ArgentinaFil: Weigel, D. Max Planck Institute for Developmental Biology; AlemaniaFil: Lijavetzky, Diego. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mendoza. Instituto de Biología Agrícola de Mendoza; Argentina. Universidad Nacional de Cuyo. Facultad de Ciencias Agrarias. Instituto de Biología Agrícola de Mendoza; Argentin