Regional Trade and Logistics Infrastructure: A Spatial Approach

This paper aims to analyze whether the existing logistics platforms network in Spain affects Spanish transport demand by using a spatial framework. In particular, we use demand for transport to export goods to other Spanish provinces as a proxy for logistics infrastructure demand in Spain. Then, we obtain data for trade flows between provinces (NUTS3) in the year 2007. We also obtain data about the number and area of logistics platforms existing in each Spanish province to proxy for the transportation network structure in Spain. In a first step, we construct weight matrixes considering first-order contiguity and we obtain that spatial dependence is significant in a spatial econometric model of commodity flows (LeSage and Polasek, 2008). Secondly, we incorporate logistics network structure dependence into the model so that the spatial lags measure the impact and significance on trade flows from all origins to all destinations by considering the importance of logistics performance in the neighboring provinces. Finally, we perform the analysis for different economic activities. The results obtained provide evidence about the role of the location of logistics platforms for satisfying existing demand for transport structure in the Spanish provinces..

Is the effect of economic integration on trade margins time sensitive? Sectoral evidence from Latin America

The present paper follows the methodology of Baier et al (2011) and Hummels and Klenow (2005) to determine the effects of different levels of EIAs on the intensive and the extensive margins of trade. The long time period considered will allow us to determine whether different effects on trade margins might arise on the following two sub-periods: 1962-1989 and from 1990 onwards (before and after the proliferation of regional integration agreements and the deepening of the liberalization process in the region). Finally, we focus on those specific sectors in which Latin American countries present a higher relative participation.El presente trabajo estudia los efectos de diferentes niveles de integración económica sobre los márgenes intensivo y extensivo de comercio, siguiendo la metodología de Baier et al (2011) y Hummels y Klenow (2005). La longitud del periodo bajo estudio permite determinar si los efectos sobre los márgenes de comercio han sido diferentes para los sub periodos 1962-1989 y 1990-2009, es decir antes y después de la proliferación de acuerdos de integración regional y la profundización del proceso de liberalización comercial que tuvo lugar en la región. Por último, el trabajo analiza los efectos sobre aquellos sectores donde los países latinoamericanos presentan una mayor participación relativa.http://www.aaep.org.ar/anales/works/works2013/florensa.pdfFil: Florensa, Luis Marcelo. Universidad Nacional de Córdoba. Facultad de Ciencias Económicas. Instituto de Economía y Finanzas; Argentina.Fil: Marquez-Ramos, Laura. Universitat Jaume I. Departamento de Economía; España.Fil: Recalde, María Luisa. Universidad Nacional de Córdoba. Facultad de Ciencias Económicas. Instituto de Economía y Finanzas; Argentina.Economía, Econometrí

Is the effect of the economic integration on trade margins time sensitive? Sectoral evidence from Latin America

The present paper follows the methodology of Baier et al (2011) and Hummels and Klenow (2005) to determine the effects of different levels of EIAs (non-reciprocal PTA, PTA, FTA and customs unions) on the intensive and the extensive margins of trade. It uses a gravity equation for the exports of eleven countries of the Latin American Integration Association (LAIA) to 161 partners over the period 1962-2009. The long time period considered will allow us to determine whether different effects on trade margins might arise on the following two sub-periods: 1962-1989 and from 1989 onwards (before and after the proliferation of regional integration agreements and the deepening of the liberalization process in the region). Finally, we focus on those specific sectors in which Latin American countries present a higher relative participation.http://www.etsg.org/ETSG2013/Papers/201.pdfFil: Florensa, Luis Marcelo. Universidad Nacional de Córdoba. Facultad de Ciencias Económicas. Instituto de Economía y Finanzas; Argentina.Fil: Marquez-Ramos, Laura. Universitat Jaume I. Departamento de Economía; España.Fil: Recalde, María Luisa. Universidad Nacional de Córdoba. Facultad de Ciencias Económicas. Instituto de Economía y Finanzas; Argentina.Economía, Econometrí

Statins: Could an old friend help the fight against COVID-19?

This is the peer reviewed version of the following article: "Statins: Could an old friend help the fight against COVID-19?" . British Journal of Pharmacology (2020): 19 June, which has been published in final form at https://doi.org/10.1111/bph.15166. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Use of Self-Archived Versionshe COVID-19 pandemic caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has overwhelmed healthcare systems requiring the rapid development of treatments, at least, to reduce COVID-19 severity. Drug repurposing offers a fast track. Here, we discuss the potential beneficial effects of statins in COVID-19 patients based on evidence that they may target virus receptors, replication, degradation, and downstream responses in infected cells, addressing both basic research and epidemiological information. Briefly, statins could modulate virus entry, acting on the SARS-CoV-2 receptors, ACE2 and CD147, and/or lipid rafts engagement. Statins, by inducing autophagy activation, could regulate virus replication or degradation, exerting protective effects. The well-known anti-inflammatory properties of statins, by blocking several molecular mechanisms, including NF-κB and NLRP3 inflammasomes, could limit the "cytokine storm" in severe COVID-19 patients which is linked to fatal outcome. Finally, statin moderation of coagulation response activation may also contribute to improving COVID-19 outcomesThis work and data discussed here were supported by grants from the Instituto de Salud Carlos III (ISCIII) and Fondos FEDER European Union (PI17/00119 and Red de Investigación Renal (REDINREN): RD16/0009, to M.R-O, PI17/01495 to J.E, PI18/01133 to AMR, PI19/00815 to A.O); Comunidad de Madrid (“NOVELREN” B2017/BMD3751 to M.R-O, B2017/BMD-3686 CIFRA2-CM to A.O); Spanish Ministry of Economy and Competitiveness MINECO (DTS17/00203, DTS19/00093) to J,E; “Convocatoria Dinamización Europa Investigación 2019” MINECO (EIN2019-103294 to M.R-O and SR-M); ERA-PerMed-JTC2018 (KIDNEY ATTACK AC18/00064 and PERSTIGAN AC18/00071) and DTS18/00032 to A.O; The “Sara Borrell” postdoctoral training program of the ISCIII supported the salary of SR-M (CD19/00021), IMPROVE-PD project (“Identification and Management of Patients at Risk–Outcome and Vascular Events in Peritoneal Dialysis”) funding from the European Union’s Horizon 2020 research and innovation program under the Marie Skłodowska-Curie Grant Agreement No. 812699 to M.R.O

The Science Performance of JWST as Characterized in Commissioning

This paper characterizes the actual science performance of the James Webb Space Telescope (JWST), as determined from the six month commissioning period. We summarize the performance of the spacecraft, telescope, science instruments, and ground system, with an emphasis on differences from pre-launch expectations. Commissioning has made clear that JWST is fully capable of achieving the discoveries for which it was built. Moreover, almost across the board, the science performance of JWST is better than expected; in most cases, JWST will go deeper faster than expected. The telescope and instrument suite have demonstrated the sensitivity, stability, image quality, and spectral range that are necessary to transform our understanding of the cosmos through observations spanning from near-earth asteroids to the most distant galaxies.Comment: 5th version as accepted to PASP; 31 pages, 18 figures; https://iopscience.iop.org/article/10.1088/1538-3873/acb29

Impact of COVID-19 on cardiovascular testing in the United States versus the rest of the world

Objectives: This study sought to quantify and compare the decline in volumes of cardiovascular procedures between the United States and non-US institutions during the early phase of the coronavirus disease-2019 (COVID-19) pandemic. Background: The COVID-19 pandemic has disrupted the care of many non-COVID-19 illnesses. Reductions in diagnostic cardiovascular testing around the world have led to concerns over the implications of reduced testing for cardiovascular disease (CVD) morbidity and mortality. Methods: Data were submitted to the INCAPS-COVID (International Atomic Energy Agency Non-Invasive Cardiology Protocols Study of COVID-19), a multinational registry comprising 909 institutions in 108 countries (including 155 facilities in 40 U.S. states), assessing the impact of the COVID-19 pandemic on volumes of diagnostic cardiovascular procedures. Data were obtained for April 2020 and compared with volumes of baseline procedures from March 2019. We compared laboratory characteristics, practices, and procedure volumes between U.S. and non-U.S. facilities and between U.S. geographic regions and identified factors associated with volume reduction in the United States. Results: Reductions in the volumes of procedures in the United States were similar to those in non-U.S. facilities (68% vs. 63%, respectively; p = 0.237), although U.S. facilities reported greater reductions in invasive coronary angiography (69% vs. 53%, respectively; p < 0.001). Significantly more U.S. facilities reported increased use of telehealth and patient screening measures than non-U.S. facilities, such as temperature checks, symptom screenings, and COVID-19 testing. Reductions in volumes of procedures differed between U.S. regions, with larger declines observed in the Northeast (76%) and Midwest (74%) than in the South (62%) and West (44%). Prevalence of COVID-19, staff redeployments, outpatient centers, and urban centers were associated with greater reductions in volume in U.S. facilities in a multivariable analysis. Conclusions: We observed marked reductions in U.S. cardiovascular testing in the early phase of the pandemic and significant variability between U.S. regions. The association between reductions of volumes and COVID-19 prevalence in the United States highlighted the need for proactive efforts to maintain access to cardiovascular testing in areas most affected by outbreaks of COVID-19 infection

Search for new particles in events with energetic jets and large missing transverse momentum in proton-proton collisions at root s=13 TeV

A search is presented for new particles produced at the LHC in proton-proton collisions at root s = 13 TeV, using events with energetic jets and large missing transverse momentum. The analysis is based on a data sample corresponding to an integrated luminosity of 101 fb(-1), collected in 2017-2018 with the CMS detector. Machine learning techniques are used to define separate categories for events with narrow jets from initial-state radiation and events with large-radius jets consistent with a hadronic decay of a W or Z boson. A statistical combination is made with an earlier search based on a data sample of 36 fb(-1), collected in 2016. No significant excess of events is observed with respect to the standard model background expectation determined from control samples in data. The results are interpreted in terms of limits on the branching fraction of an invisible decay of the Higgs boson, as well as constraints on simplified models of dark matter, on first-generation scalar leptoquarks decaying to quarks and neutrinos, and on models with large extra dimensions. Several of the new limits, specifically for spin-1 dark matter mediators, pseudoscalar mediators, colored mediators, and leptoquarks, are the most restrictive to date.Peer reviewe