Renal pericytes: regulators of medullary blood flow

Regulation of medullary blood flow (MBF) is essential in maintaining normal kidney function. Blood flow to the medulla is supplied by the descending vasa recta (DVR), which arise from the efferent arterioles of juxtamedullary glomeruli. DVR are composed of a continuous endothelium, intercalated with smooth muscle-like cells called pericytes. Pericytes have been shown to alter the diameter of isolated and in situ DVR in response to vasoactive stimuli that are transmitted via a network of autocrine and paracrine signalling pathways. Vasoactive stimuli can be released by neighbouring tubular epithelial, endothelial, red blood cells and neuronal cells in response to changes in NaCl transport and oxygen tension. The experimentally described sensitivity of pericytes to these stimuli strongly suggests their leading role in the phenomenon of MBF autoregulation. Because the debate on autoregulation of MBF fervently continues, we discuss the evidence favouring a physiological role for pericytes in the regulation of MBF and describe their potential role in tubulo-vascular cross-talk in this region of the kidney. Our review also considers current methods used to explore pericyte activity and function in the renal medulla

Scalar perturbations in conformal rolling scenario with intermediate stage

Scalar cosmological perturbations with nearly flat power spectrum may originate from perturbations of the phase of a scalar field conformally coupled to gravity and rolling down negative quartic potential. We consider a version of this scenario whose specific property is a long intermediate stage between the end of conformal rolling and horizon exit of the phase perturbations. Such a stage is natural, e.g., in cosmologies with ekpyrosis or genesis. Its existence results in small negative scalar tilt, statistical anisotropy of all even multipoles starting from quardupole of general structure (in contrast to the usually discussed single quadrupole of special type) and non-Gaussianity of a peculiar form.Comment: 35 pages, 1 figure. Journal version. Discussion of the range of relevant momentum scales and bounds on parameters adde

The Caravan Rolls On

Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/68409/2/10.1177_107554707900100103.pd

Indicadores de qualidade do solo em sistemas de cultivo orgânico e convencional no semi-árido Cearense.

A qualidade do solo pode mudar com o passar do tempo, em decorrência de eventos naturais ou ações antrópicas. A adoção de práticas de cultivo orgânico reduz o revolvimento do solo, favorecendo a recuperação de suas propriedades físicas e químicas. Este trabalho teve como objetivo comparar propriedades físicas,químicas e biológicas de solos cultivados com algodão em bases orgânicas e no sistema convencional, assim como identificar as que possam ser utilizadas como indicadores de qualidade do solo. Selecionaram-se seis áreas submetidas ao cultivo orgânico e três ao cultivo convencional para coleta de amostras de solo deformadas e indeformadas, nas camadas de 0–10, 10–20 e 20–30 cm. Técnicas de estatística univariada e multivariada foram utilizadas para análise dos dados. Os resultados mostraram que os indicadores físicos e químicos testados individualmente não foram sensíveis para diferenciar as áreas sob sistema de cultivo orgânico daquelas sob cultivo convencional. No entanto, a aplicação de técnicas de análise multivariada – no caso, componentes principais e a discriminante de Anderson – permitiu a distinção entre algumas áreas cultivadas sob cultivo orgânico comparativamente às convencionais, até mesmo as que estavam em transição.Dos indicadores biológicos, a fauna edáfica mostrou-se mais precisa na avaliação da qualidade do solo, distinguindo de forma satisfatória as áreas sob sistema de cultivo orgânico das que estavam sob sistema convencional

Measuring our Peculiar Velocity by "Pre-deboosting" the CMB

It was recently shown that our peculiar velocity \beta with respect to the CMB induces mixing among multipoles and off-diagonal correlations at all scales which can be used as a measurement of \beta, which is independent of the standard measurement using the CMB temperature dipole. The proposed techniques rely however on a perturbative expansion which breaks down for \ell \gtrsim 1/(\beta) \approx 800. Here we propose a technique which consists of deboosting the CMB temperature in the time-ordered data and show that it extends the validity of the perturbation analysis multipoles up to \ell \sim 10000. We also obtain accurate fitting functions for the mixing between multipoles valid in a full non-linear treatment. Finally we forecast the achievable precision with which these correlations can be measured in a number of current and future CMB missions. We show that Planck could measure the velocity with a precision of around 60 km/s, ACTPol in 4 years around 40 km/s, while proposed future experiments could further shrink this error bar by over a factor of around 2.Comment: 14 pages, 7 figures. Revised projections for ACTPol, SPTPol and ACBAR; included projections for BICEP2; extended conclusions; typos correcte

An updated radiocarbon-based ice margin chronology for the last deglaciation of the North American Ice Sheet Complex

The North American Ice Sheet Complex (NAISC; consisting of the Laurentide, Cordilleran and Innuitian ice sheets) was the largest ice mass to repeatedly grow and decay in the Northern Hemisphere during the Quaternary. Understanding its pattern of retreat following the Last Glacial Maximum is critical for studying many facets of the Late Quaternary, including ice sheet behaviour, the evolution of Holocene landscapes, sea level, atmospheric circulation, and the peopling of the Americas. Currently, the most up-to-date and authoritative margin chronology for the entire ice sheet complex is featured in two publications (Geological Survey of Canada Open File 1574 [Dyke et al., 2003]; ‘Quaternary Glaciations – Extent and Chronology, Part II’ [Dyke, 2004]). These often-cited datasets track ice margin recession in 36 time slices spanning 18 ka to 1 ka (all ages in uncalibrated radiocarbon years) using a combination of geomorphology, stratigraphy and radiocarbon dating. However, by virtue of being over 15 years old, the ice margin chronology requires updating to reflect new work and important revisions. This paper updates the aforementioned 36 ice margin maps to reflect new data from regional studies. We also update the original radiocarbon dataset from the 2003/2004 papers with 1541 new ages to reflect work up to and including 2018. A major revision is made to the 18 ka ice margin, where Banks and Eglinton islands (once considered to be glacial refugia) are now shown to be fully glaciated. Our updated 18 ka ice sheet increased in areal extent from 17.81 to 18.37 million km2, which is an increase of 3.1% in spatial coverage of the NAISC at that time. Elsewhere, we also summarize, region-by-region, significant changes to the deglaciation sequence. This paper integrates new information provided by regional experts and radiocarbon data into the deglaciation sequence while maintaining consistency with the original ice margin positions of Dyke et al. (2003) and Dyke (2004) where new information is lacking; this is a pragmatic solution to satisfy the needs of a Quaternary research community that requires up-to-date knowledge of the pattern of ice margin recession of what was once the world’s largest ice mass. The 36 updated isochrones are available in PDF and shapefile format, together with a spreadsheet of the expanded radiocarbon dataset (n = 5195 ages) and estimates of uncertainty for each interval

Should science educators deal with the science/religion issue?

I begin by examining the natures of science and religion before looking at the ways in which they relate to one another. I then look at a number of case studies that centre on the relationships between science and religion, including attempts to find mechanisms for divine action in quantum theory and chaos theory, creationism, genetic engineering and the writings of Richard Dawkins. Finally, I consider some of the pedagogical issues that would need to be considered if the science/religion issue is to be addressed in the classroom. I conclude that there are increasing arguments in favour of science educators teaching about the science/religion issue. The principal reason for this is to help students better to learn science. However, such teaching makes greater demands on science educators than has generally been the case. Certain of these demands are identified and some specific suggestions are made as to how a science educator might deal with the science/religion issue. © 2008 Taylor & Francis

Statistical mechanics of two-dimensional vortices and stellar systems

The formation of large-scale vortices is an intriguing phenomenon in two-dimensional turbulence. Such organization is observed in large-scale oceanic or atmospheric flows, and can be reproduced in laboratory experiments and numerical simulations. A general explanation of this organization was first proposed by Onsager (1949) by considering the statistical mechanics for a set of point vortices in two-dimensional hydrodynamics. Similarly, the structure and the organization of stellar systems (globular clusters, elliptical galaxies,...) in astrophysics can be understood by developing a statistical mechanics for a system of particles in gravitational interaction as initiated by Chandrasekhar (1942). These statistical mechanics turn out to be relatively similar and present the same difficulties due to the unshielded long-range nature of the interaction. This analogy concerns not only the equilibrium states, i.e. the formation of large-scale structures, but also the relaxation towards equilibrium and the statistics of fluctuations. We will discuss these analogies in detail and also point out the specificities of each system.Comment: Chapter of the forthcoming "Lecture Notes in Physics" volume: ``Dynamics and Thermodynamics of Systems with Long Range Interactions'', T. Dauxois, S. Ruffo, E. Arimondo, M. Wilkens Eds., Lecture Notes in Physics Vol. 602, Springer (2002

Use of SMS texts for facilitating access to online alcohol interventions: a feasibility study

A41 Use of SMS texts for facilitating access to online alcohol interventions: a feasibility study In: Addiction Science & Clinical Practice 2017, 12(Suppl 1): A4

GOALS-JWST: tracing AGN feedback on the star-forming interstellar medium in NGC 7469

Galaxie