Una herramienta de apoyo a la gestión del proceso de desarrollo de software

En muchos centros de cómputo de la región no se aplican modelos de proceso de desarrollo de software. Esto tiene varios orígenes, principalmente la falta de recursos y capacitación en las mejores prácticas de la industria. En general, no está extendido el conocimiento y el uso de metodologías de gestión de riesgos, la mayoría de las cuales no son estructuradas y requieren de gerentes con experiencia, un recurso siempre escaso. El intercambio de información y experiencia se hace difícil y sólo es posible compararnos con organizaciones de otros contextos sociales, tecnológicos, económicos y culturales. Como resultado, las opiniones están basadas más en percepciones personales que en información objetiva. Esta investigación propone proveer una herramienta de bajo costo junto con un modelo de implantación, que aporte valor a toda la comunidad informática, y permita implantar y controlar un proceso de desarrollo de software, ágil y flexible, orientado a grupos de desarrollo pequeños y medianos, que desarrollan utilizando GeneXus[1], con control de calidad y proceso de mejora continua, que permita la planificación de la capacitación continua del equipo, controlar los costos de calidad y brindar automáticamente indicadores de gestión de proyectos, poniendo énfasis en el seguimiento del riesgo del proyecto.Eje: Ingeniería de Software y Bases de Datos (ISBD)Red de Universidades con Carreras en Informática (RedUNCI

Una herramienta de apoyo a la gestión del proceso de desarrollo de software

En muchos centros de cómputo de la región no se aplican modelos de proceso de desarrollo de software. Esto tiene varios orígenes, principalmente la falta de recursos y capacitación en las mejores prácticas de la industria. En general, no está extendido el conocimiento y el uso de metodologías de gestión de riesgos, la mayoría de las cuales no son estructuradas y requieren de gerentes con experiencia, un recurso siempre escaso. El intercambio de información y experiencia se hace difícil y sólo es posible compararnos con organizaciones de otros contextos sociales, tecnológicos, económicos y culturales. Como resultado, las opiniones están basadas más en percepciones personales que en información objetiva. Esta investigación propone proveer una herramienta de bajo costo junto con un modelo de implantación, que aporte valor a toda la comunidad informática, y permita implantar y controlar un proceso de desarrollo de software, ágil y flexible, orientado a grupos de desarrollo pequeños y medianos, que desarrollan utilizando GeneXus[1], con control de calidad y proceso de mejora continua, que permita la planificación de la capacitación continua del equipo, controlar los costos de calidad y brindar automáticamente indicadores de gestión de proyectos, poniendo énfasis en el seguimiento del riesgo del proyecto.Eje: Ingeniería de Software y Bases de Datos (ISBD)Red de Universidades con Carreras en Informática (RedUNCI

Qui meurt après une néphrectomie pour cancer ? Étude des facteurs de risque de décès, des causes de décès et des réunions de morbi-mortalité (étude UroCCR-33)

BACKGROUND AND METHODS: Nephrectomy is the treatment for renal cell cancer from T1-4 tumors but remains at risk. To determine the thirty-day mortality rate after nephrectomy for cancer and to identify causes and risk factors of death in order to find clinical applications. From 2014 to 2017, we performed a retrospective multicentric analysis of prospectively collected data study involving the French network for research on kidney cancer (UroCCR). All patients who died after nephrectomy for cancer during the first thirty days were identified. Patients\u27 characteristics, causes of death and morbidity and mortality reviews reports were analyzed for each death. RESULTS AND LIMITATIONS: In total, 2578 patients underwent nephrectomy and 35 deaths occurred. The thirty-day mortality rate was 1.4%. In univariate analysis, symptoms at diagnosis (P=0.006, OR=2.56 IC (1.3-5.03)), c stage superior to cT1 (P<0.0001, OR=6.13 IC (2.8-13.2)), cT stage superior to cT2 (P<0.0001, OR=8.8 IC (4.39-17.8)), nodal invasion (P<0.0001, OR=4.6 IC (1.9-10.7)), distant metastasis (P=0.001, OR=4.01 IC (1.7-8.9)), open surgery (P<0.0001, OR=0.272 IC (0.13-0.54)) and radical nephrectomy (P=0.007, OR=2.737 IC (1.3-5.7)) were risk factors of thirty-day mortality. In a multivariable model, only cT stage superior to T2 (P=0.015, OR=3.55 IC (1.27-10.01)) was a risk factor of thirty-day mortality. The main cause of postoperative death was pulmonary (n=15; 43%). The second cause was postoperative digestive sepsis for 7 patients (20%). Only 2 morbidity and mortality reviews had been done for the 35 deaths. Limitations are related to the thirty-day mortality criteria and descriptive study design. CONCLUSIONS: Symptomatic patients, stage cTNM and type and techniques of surgery are determinants of thirty-day mortality after nephrectomy for cancer. The first cause of postoperative death is pulmonary. Morbidity and mortality reviews should be considered to better understand causes of death and to reduce early mortality after nephrectomy for cancer. LEVEL OF EVIDENCE: 4

Wheat amylase/trypsin inhibitors (ATIs) : occurrence, function and health aspects

Amylase/trypsin inhibitors (ATIs) are widely consumed in cereal-based foods and have been implicated in adverse reactions to wheat exposure, such as respiratory and food allergy, and intestinal responses associated with coeliac disease and non-coeliac wheat sensitivity. ATIs occur in multiple isoforms which differ in the amounts present in different types of wheat (including ancient and modern ones). Measuring ATIs and their isoforms is an analytical challenge as is their isolation for use in studies addressing their potential effects on the human body. ATI isoforms differ in their spectrum of bioactive effects in the human gastrointestinal (GI), which may include enzyme inhibition, inflammation and immune responses and of which much is not known. Similarly, although modifications during food processing (exposure to heat, moisture, salt, acid, fermentation) may affect their structure and activity as shown in vitro, it is important to relate these changes to effects that may present in the GI tract. Finally, much of our knowledge of their potential biological effects is based on studies in vitro and in animal models. Validation by human studies using processed foods as commonly consumed is warranted. We conclude that more detailed understanding of these factors may allow the effects of ATIs on human health to be better understood and when possible, to be ameliorated, for example by innovative food processing. We therefore review in short our current knowledge of these proteins, focusing on features which relate to their biological activity and identifying gaps in our knowledge and research priorities.Peer reviewe

Tight junctions: from simple barriers to multifunctional molecular gates

Epithelia and endothelia separate different tissue compartments and protect multicellular organisms from the outside world. This requires the formation of tight junctions, selective gates that control paracellular diffusion of ions and solutes. Tight junctions also form the border between the apical and basolateral plasma-membrane domains and are linked to the machinery that controls apicobasal polarization. Additionally, signalling networks that guide diverse cell behaviours and functions are connected to tight junctions, transmitting information to and from the cytoskeleton, nucleus and different cell adhesion complexes. Recent advances have broadened our understanding of the molecular architecture and cellular functions of tight junctions

Enregistrement des mouvements d'un versant par les spéléothèmes de la grotte du chemin du Castellaras (Le Tignet, Alpes-Maritimes, France)

Recordings of the slope movements by speleothems (Le Tignet, Alpes-Maritimes, France). The study of speleothems in a sub-cutaneous cave developed between a scree and its bedrock, shows the slope movements. All the speleothem couples (stalactite facing a stalagmite) are displaced. Among the speleothems, a 50 cm long thin stalactite (soda-straw type) has recorded the movements that have affected the slope. Every slope movement is shown in a speleothem axis variation. Radiocarbon datings help define growth speed and make clear the movement history over a 30,000 year period. This analysis confirms the possibility of using speleothem as verticality gauges to define an area stability.RÉSUMÉ : L'étude des concrétions d'une cavité sous cutanée développée entre un éboulis de versant et son substratum a permis de mettre en évidence les mouvements du versant. Tous les couples stalactites / stalagmites sont décalés. Parmi les concrétions une stalactite de type fistuleuse a enregistré au cours de sa croissance les mouvements qui ont affecté l'éboulis. Chaque mouvement se traduit par une variation de l'axe de la concrétion. Les datations au radio-carbone permettent de définir une vitesse de croissance et de préciser l'historique du mouvement depuis 30 000 ans. Cette analyse confirme que les spéléothèmes constituent d'intéressants marqueurs de verticalité et peuvent donc être utilisés pour définir la stabilité d'un secteur.Gilli Eric, Mangan Claude, Delange Patrick, Larre P., Evin Jacques. Enregistrement des mouvements d'un versant par les spéléothèmes de la grotte du chemin du Castellaras (Le Tignet, Alpes-Maritimes, France). In: Karstologia : revue de karstologie et de spéléologie physique, n°26, 2e semestre 1995. pp. 47-50

Nivel e natureza do estoque organico de latossolos sob diferentes sistemas de uso e manejo.

O papel fundamental da materia organica (MO) justifica o crescente interesse pela identificacao de sistemas de uso e manejo que melhorem o estoque organico em solos tropicais. O objetivo destge trabalho foi analisar variacoes quantitativas e qualitativas da MO e caracterizar compartimentos organicos em um Latossolo Vermelho-Escuro argiloso sob vegetacao natural antropizada (CER), pastagem de longa duracao (PAL), pastagem degradada (PAD), e pousio (PAC), comparados com culturas sob preparo convencional (CCL) e plantio direto (PD). Foi encontrada pouca variacao dos estoques organicos na camada superficial, explicada pela antropizacao da vegetacao em CER, pela nao-exportacao dos residuos em PD e CCL e pla pratica de pousio em PAC. Fracionamento granulometrico, considerando os compartimentos residuos vegetais (20-2.000um), organo-siltoso (2-20um) e organo-argiloso (0-2um), mostrou diferencas na qualidade da MO quando comparadas situacoes edafoambientais semelhantes. Mosmo com pequenas variacoes, o compartimento residuos vegetais foi um indicador da evolucao dos estoques organicos,permitindo a caracterizacao da degradacao nas pastagens e do efeito do plantio direto quando comparado ao sistema convencional. PD favoreceu a estocagem de C no compartimento organo-argiloso. Solos estudados diferem de outros solos argilosos tropicais pela mais elevada relacao C/N encontrada nas fracoes 0-20um.Made available in DSpace on 2018-10-16T01:39:30Z (GMT). No. of bitstreams: 1 NIVELENATUREZAok.pdf: 75263 bytes, checksum: 95c76227a538aab150adccaaa4e6c26f (MD5) Previous issue date: 2002-11-22bitstream/item/184345/1/NIVEL-E-NATUREZA-ok.pd

Intérêt de la résection complémentaire (ou « second look ») pour les carcinomes urothéliaux de vessie classés pTa haut grade

International audienc

Signs Of Quality Loss In Rice Seeds At Different Temperatures Through Of Enzymatic Activity And Respiration [indicativos Da Perda De Qualidade De Sementes De Arroz Sob Diferentes Temperaturas Através Da Atividade Enzimática E Respira Tória]

The modifications caused in the respiration, metabolic enzyme activity and physiological quality of rice seeds under different temperatures was analyzed, and the relationship between these parameters used as an indication of the deterioration process of seeds. Seeds were exposed during 24h and submitted to tests for germination, first count germination, index the germination speed, length and dry weight of shoot and roots, electrical conductivity, and respiratory and enzymatic activity. The experiment was completely randomized with four replicates and the averages compared by Tukey test (p≤0.05) with subsequent regression analysis. Rice seeds showed a decrease En este trabajo se analizan las modificaciones en la respiración, la actividad de las enzimas del metabolismo respiratorio y la calidad fisiológica de las semillas de arroz bajo diferentes temperaturas, así como el uso de la relación entre estos parámetros como indicativo del proceso de deterioro de la semillas. Las semillas fueron expuestas durante 24h a temperaturas de 15, 25, 30 y 35°C, y determinaron: germinación, primer conteo de germinación, índice de velocidad de germinación, longitud y peso seco de brotes y raíces, conductividad eléctrica, actividad respiratoria y enzimática. El diseño experimental fue completamente al azar con cuatro repeticiones y las medias se compararon mediante la prueba de Tukey (p≤0,05), con posterior análisis de regresión polinómica. Las semillas de arroz in germination and vigor in temperatures above 25°C. The activity of malate dehydrogenase enzyme increased in the plants whose seeds were exposed to 15 and 35°C (ranging from 32.55 to 39.04μmol NAD+/g/ MF/min, respectively), while the enzyme glucose-6-hosphate dehydrogenase increased with no significant differences when seeds were subjected to 15, 30 and 35°C (0.58, 0.71 and 0.74μmol NADPH/g MF/min, respectively). It can be concluded that the evaluated biochemical tests can be used to identify the deteriorating process of rice seeds and that temperatures above 25°C can deteriorate the quality of rice seeds var. Pelota.3815459Brasil, Regras para Análise de Sementes. SNAD/CLAV (2009) Ministério da Agricultura e Reforma Agrária, p. 398. , Brasília, BrasilCarvalho, D.B., Rinde, C., Qualidade fisiológica de sementes de guanxuma em influência do envelhecimento acelerado e da luz (2009) Acta Sci. Agron., 31, pp. 489-494Carvalho, L.F., Sediyama, C.S., Reis, M.S., Dias, D.C.F.S., Moreira, M.A., Influência da temperatura de embebição da semente de soja no teste de condutividade elétrica para avaliação da qualidade f isiológica (2009) Rev. Brás. Sem, 41, pp. 9-17Corte, V.B., Borges, E.E.L., Leite, H.G., Pereira, B.L.C., Gonçalves, J.F.C., Estudo enzimático da deterioração de sementes de Melanoxylon braúna submetidas ao envelhecimento natural e acelerado (2010) Rev. Brás. 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BrasilMaguire, J.D., Speed of germination-aid in selection aid evolution for seedling emergence and vigor (1962) Crop Sci, 2, pp. 176-177Matheus, M.T., Lopes, J.C., Temperaturas cardinais para a germinação de sementes de Erythrina variegata L. (2009) Rev. Brás. Sem, 31, pp. 115-122McCue, P., Zheng, Z., Pinkham, J.L., Shetty, K., A model for enhanced pea seedling vigour following low pH and salicylic acid treatments (2000) Process Biochem, 35, pp. 603-613Mendes, C.R., Moraes, D.M., Mgs, L., Lopes, N.F., Respiratory activity for the differentiation of vigor on soybean seeds lots (2009) Rev. Brás. Sem, 31, pp. 171-176Ochoa, S., Malic deshydrogenase from pig heart (1955) Methods in Enzymology, pp. 735-739. , Colowinck SP, Kaplan NO (Eds.) Academic Press. Nova Iorque, EEUUPatané, C., Cavallaro, V., Avola, G., Dagosta, G., Seed respiration of sorghum [Sorghum bicolor (L.) Moench] during germination as affected by temperature and osmoconditioning (2006) Seed Sci. 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Agríc, 57, pp. 263-270Steiner, F., Pinto Júnior, A.S., Zoz, T., Guimarães, V.F., Dranski, J.A.L., Rheinheimer, A.R., Germinação de sementes de rabanete sob temperaturas adversas (2009) Rev. Brás. Sem. Ciênc. Agr, 4, pp. 430-434Van Heerden, P.D.R., De Villiers, M.F., Van Staden, J., Kruger, G.H.J., Dark chilling increases glucose-6-hosphate dehydrogenase activity in soybean leaves (2003) Physiol. Plant, 119, pp. 221-23