1,205 research outputs found
Intravenous ibandronate in men with osteoporosis: An open pilot study over 2 years
In the treatment of osteoporosis, the tolerance of oral bisphosphonates is often low. The high potency of ibandronate allows iv bolus injections that can be repeated every 2 to 3 months. However, the best dose and time interval of the treatment with iv ibandronate is still debated. Efficacy of 2-mg ibandronate injected every 3 months was tested in men with osteoporosis over 2 yr, in a prospective, open study. Fourteen men with primary osteoporosis, mean age 57±12 yr (range: 40-73), received 2-mg ibandronate iv every 3 months over 2 yr. All got 1 g/day calcium and 880 UI/day vitamin D for 2 yr. Bone mineral density (BMD) increased after 2 yr by 6.7±1.5% (mean change±SEM) at lumbar spine (p<0.001), by 3.2±08% at trochanter (p<0.001) and by 1.4±1.1% at femoral neck (ns). Serum Ă-crosslaps and osteocalcin decreased significantly by 30-45 and 30%, respectively, during the 2 yr of treatment. Serum calcium increased from the lower to the middle tertile of the normal range during the 2 yr of the study. The observed decrease of bone remodelling and the increase of BMD are of the same magnitude as those described with oral bisphosphonates. The increase of plasma calcium confirms the positive effect of the supplementation with calcium and vitamin D. These results suggest that 3 months are a good interval between two doses of iv ibandronate, when 2 mg are give
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Characterization of the Subsurface of 67P/Churyumov-Gerasimenko's Abydos Site
We investigate the structure of the subsurface of the Abydos site using a cometary nucleus model with parameters adapted to comet 67P/Churyumov-Gerasimenko and the Abydos landing site. We aim to compare the production rates derived from our model with those of the main molecules measured by Ptolemy. This will allow us to retrieve the depths at which the different molecules still exist in solid form
Ionization Quenching Factor Measurement of Helium 4
The ionization quenching factor (IQF) is defined as the fraction of energy released by a recoil in a medium through ionization compared with its total kinetic energy. At low energies, in the range of a few keV, the ionization produced in a medium falls rapidly and systematic measurements are needed. We report measurements carried out at such low energies as a function of the pressure in He4 at 350, 700, 1000 and 1300 mbar. In order to produce a nucleus moving with a controlled energy in the detection volume, we have developed an Electron Cyclotron Resonance Ion Source (ECRIS) coupled to an ionization chamber by a differential pumping. The quenching factor of He4 has been measured for the first time down to 1 keV recoil energies. An important deviation with respect to the phenomenological calculations has been found allowing an estimation of the scintillation produced in He4 as a function of pressure. The variation of the IQF as a function of the percentage of isobutane, used as quencher, is also presented
Normal subgroups in the Cremona group (long version)
Let k be an algebraically closed field. We show that the Cremona group of all
birational transformations of the projective plane P^2 over k is not a simple
group. The strategy makes use of hyperbolic geometry, geometric group theory,
and algebraic geometry to produce elements in the Cremona group that generate
non trivial normal subgroups.Comment: With an appendix by Yves de Cornulier. Numerous but minors
corrections were made, regarding proofs, references and terminology. This
long version contains detailled proofs of several technical lemmas about
hyperbolic space
Globalization, the ambivalence of European integration and the possibilities for a post-disciplinary EU studies
Using the work of Manuel Castells as a starting point, this article explores the ambivalent relationship between globalization and European integration and the variety of ways in which the mainstream political science of the EU has attempted to deal with this issue. The analysis here suggests that various 'mainstreaming' disciplinary norms induce types of work that fail to address fully the somewhat paradoxical and counter-intuitive range of possible relationships between globalization and European integration. The article explores critically four possible analytical ways out of this paradoxâabandonment of the concept of globalization, the development of definition precision in globalization studies, the reorientation of work to focus on globalization as discourse, and inter- and post-disciplinarity. The argument suggests that orthodox discussions of the relationship require a notion of social geography that sits at odds with much of the literature on globalization and while greater dialogue between disciplines is to be welcomed, a series of profound epistemological questions need to be confronted if studies of the interplay between global and social process are to be liberated from their disciplinary chains
Spitzer observations of the asteroid-comet transition object and potential spacecraft target 107P (4015) Wilson-Harrington
Context. Near-Earth asteroid-comet transition object 107P/ (4015)
Wilson-Harrington is a possible target of the joint European Space Agency (ESA)
and Japanese Aerospace Exploration Agency (JAXA) Marco Polo sample return
mission. Physical studies of this object are relevant to this mission, and also
to understanding its asteroidal or cometary nature. Aims. Our aim is to obtain
significant new constraints on the surface thermal properties of this object.
Methods. We present mid-infrared photometry in two filters (16 and 22 microns)
obtained with NASA's Spitzer Space Telescope on February 12, 2007, and results
from the application of the Near Earth Asteroid Thermal Model (NEATM).We
obtained high S/N in two mid-IR bands allowing accurate measurements of its
thermal emission. Results. We obtain a well constrained beaming parameter (eta
= 1.39 +/- 0.26) and obtain a diameter and geometric albedo of D = 3.46 +/-
0.32 km, and pV = 0.059 +/- 0.011. We also obtain similar results when we apply
this best-fitting thermal model to single-band mid-IR photometry reported by
Campins et al. (1995), Kraemer et al. (2005) and Reach et al. (2007).
Conclusions. The albedo of 4015 Wilson-Harrington is low, consistent with those
of comet nuclei and primitive C-, P-, D-type asteorids. We establish a rough
lower limit for the thermal inertia of W-H of 60 Jm^-2s^(-0.5)K^-1 when it is
at r=1AU, which is slightly over the limit of 30 Jm^-2s^(-0.5)K-1 derived by
Groussin et al. (2009) for the thermal inertia of the nucleus of comet
22P/Kopff.Comment: 4 pages, 1 figure and 3 tables. Paper accepted for publicatio
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Multimedia delivery in the future internet
The term âNetworked Mediaâ implies that all kinds of media including text, image, 3D graphics, audio
and video are produced, distributed, shared, managed and consumed on-line through various networks,
like the Internet, Fiber, WiFi, WiMAX, GPRS, 3G and so on, in a convergent manner [1]. This white
paper is the contribution of the Media Delivery Platform (MDP) cluster and aims to cover the Networked
challenges of the Networked Media in the transition to the Future of the Internet.
Internet has evolved and changed the way we work and live. End users of the Internet have been confronted
with a bewildering range of media, services and applications and of technological innovations concerning
media formats, wireless networks, terminal types and capabilities. And there is little evidence that the pace
of this innovation is slowing. Today, over one billion of users access the Internet on regular basis, more
than 100 million users have downloaded at least one (multi)media file and over 47 millions of them do so
regularly, searching in more than 160 Exabytes1 of content. In the near future these numbers are expected
to exponentially rise. It is expected that the Internet content will be increased by at least a factor of 6, rising
to more than 990 Exabytes before 2012, fuelled mainly by the users themselves. Moreover, it is envisaged
that in a near- to mid-term future, the Internet will provide the means to share and distribute (new)
multimedia content and services with superior quality and striking flexibility, in a trusted and personalized
way, improving citizensâ quality of life, working conditions, edutainment and safety.
In this evolving environment, new transport protocols, new multimedia encoding schemes, cross-layer inthe
network adaptation, machine-to-machine communication (including RFIDs), rich 3D content as well as
community networks and the use of peer-to-peer (P2P) overlays are expected to generate new models of
interaction and cooperation, and be able to support enhanced perceived quality-of-experience (PQoE) and
innovative applications âon the moveâ, like virtual collaboration environments, personalised services/
media, virtual sport groups, on-line gaming, edutainment. In this context, the interaction with content
combined with interactive/multimedia search capabilities across distributed repositories, opportunistic P2P
networks and the dynamic adaptation to the characteristics of diverse mobile terminals are expected to
contribute towards such a vision.
Based on work that has taken place in a number of EC co-funded projects, in Framework Program 6 (FP6)
and Framework Program 7 (FP7), a group of experts and technology visionaries have voluntarily
contributed in this white paper aiming to describe the status, the state-of-the art, the challenges and the way
ahead in the area of Content Aware media delivery platforms
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Evolution of the subsurface of 67P/Churyumov-Gerasimenkoâs Abydos Site
On November 12, 2014, Rosetta's descent module Philae landed on the Abydos site of comet 67P/Churyumov-Gerasimenko (67P). Here we investigate the structure of the subsurface of the Abydos site by making use of a cometary nucleus model [1] employing an updated set of thermodynamic parameters relevant for 67P and an appropriated parameterization of the illumination of the Abydos site. The model considers an initially homogeneous sphere composed of a predefined porous mixture of crystalline ices (H2O, CO and CO2) and dust in specified proportions, and uses parameters derived from recent 67P studies [2], [3] and [4]. The comparison of the production rates derived from our model with those of the main molecules measured by Ptolemy (the mass spectrometer performing the analysis of several samples collected from the surface and atmosphere of the comet) should allow us to place important constraints on the structure (layering and composition) of the subsurface of Philaeâs landing site
Dust observations of Comet 9P/Tempel 1 at the time of the Deep Impact
On 4 July 2005 at 05:52 UT, the impactor of NASA's Deep Impact (DI) mission
crashed into comet 9P/Tempel 1 with a velocity of about 10 km/s. The material
ejected by the impact expanded into the normal coma, produced by ordinary
cometary activity.
The characteristics of the non-impact coma and cloud produced by the impact
were studied by observations in the visible wavelengths and in the near-IR. The
scattering characteristics of the "normal" coma of solid particles were studied
by comparing images in various spectral regions, from the UV to the near-IR.
For the non-impact coma, a proxy of the dust production has been measured in
various spectral regions. The presence of sublimating grains has been detected.
Their lifetime was found to be about 11 hours. Regarding the cloud produced by
the impact, the total geometric cross section multiplied by the albedo was
measured as a function of the color and time. The projected velocity appeared
to obey a Gaussian distribution with the average velocity of the order of 115
m/s. By comparing the observations taken about 3 hours after the impact, we
have found a strong decrease in the cross section in J filter, while that in Ks
remained almost constant. This is interpreted as the result of sublimation of
grains dominated by particles of sizes of the order of some microns.Comment: Accepted by A&
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