Principles of chromosomal organization: lessons from yeast

The spatial organization of genes and chromosomes plays an important role in the regulation of several DNA processes. However, the principles and forces underlying this nonrandom organization are mostly unknown. Despite its small dimension, and thanks to new imaging and biochemical techniques, studies of the budding yeast nucleus have led to significant insights into chromosome arrangement and dynamics. The dynamic organization of the yeast genome during interphase argues for both the physical properties of the chromatin fiber and specific molecular interactions as drivers of nuclear order

Impaired IL-23-dependent induction of IFN-gamma underlies mycobacterial disease in patients with inherited TYK2 deficiency

Human cells homozygous for rare loss-of-expression (LOE) TYK2 alleles have impaired, but not abolished, cellular responses to IFN-alpha/beta (underlying viral diseases in the patients) and to IL-12 and IL-23 (underlying mycobacterial diseases). Cells homozygous for the common P1104A TYK2 allele have selectively impaired responses to IL-23 (underlying isolated mycobacterial disease). We report three new forms of TYK2 deficiency in six patients from five families homozygous for rare TYK2 alleles (R864C, G996R, G634E, or G1010D) or compound heterozygous for P1104A and a rare allele (A928V). All these missense alleles encode detectable proteins. The R864C and G1010D alleles are hypomorphic and loss-of-function (LOF), respectively, across signaling pathways. By contrast, hypomorphic G996R, G634E, and A928V mutations selectively impair responses to IL-23, like P1104A. Impairment of the IL-23-dependent induction of IFN-gamma is the only mechanism of mycobacterial disease common to patients with complete TYK2 deficiency with or without TYK2 expression, partial TYK2 deficiency across signaling pathways, or rare or common partial TYK2 deficiency specific for IL-23 signaling.ANRS Nord-Sud ; CIBSS ; CODI ; Comité para el Desarrollo de la Investigación ; Fulbright Future Scholarshi

Emmanuelle Lainé [Curatorial Project]

MOT International is delighted to present an exhibition of new work by Emmanuelle Lainé. Bringing together sculpture, photography and installation, the show explores the notion of trompe-l’oeil and invites the viewer to question their relationships to the objects and images exhibited. Over the past few years, Lainé has extended her sculptural practice to photography, which she uses as both a tool for documentation and a backdrop for her installations. From her studio, she constructs complex environments comprised of images, sculptures and found objects that are then photographed, recreated and augmented within the exhibition space. Despite their seemingly chaotic appearance, these compositions are in fact meticulously arranged. Examining the ambiguous relationships between 2D and 3D, they offer a singular experience that combines physical immersion with optical illusion. This exhibition announces a turning point in the artist’s work. Here, the photographic medium takes on a new role and reveals itself as a sculptural element. Derived from previous installations, the images are printed on transparent materials and take the form of receptacles. From the vinyls covering the gallery’s windows to the translucent tarps filled with bibelots, residues and other hybrid objects, these impressions go beyond their surface-like quality and reach the status of recipients. Taking over the interior, as well as the exterior spaces of the gallery, Lainé proposes a body of work that utilises the architecture of the place as the primary material. The artist therefore redefines a certain conception of the void that she presents as a dense installation, a work of art in its own right. Emmanuelle Lainé (b. 1973, Paris) lives and works in Marseille. Recent exhibitions include Copenhagen Art Festival, Copenhagen; La Galerie, Noisy-le-Sec (both 2015); Fondation d’Entreprise Ricard, Paris; C-o-m-p-o-s-i-t-e, Brussels (both 2014); La Loge, Brussels (2013). She is currently exhibiting at Casa de Francia, Mexico and at Musée d’art contemporain de Lyon on the occasion of the 13th Biennal of Lyon

Forums de consommation sur Internet. Un modèle évolutionniste

Curien Nicolas, Fauchart Emmanuelle, Laffond Gilbert, Lainé Jean, Lesourne Jacques, Moreau François. Forums de consommation sur Internet. Un modèle évolutionniste. In: Revue économique. Numéro Hors Série, 2001. Economie de l'Internet. pp. 119-135

Forums de consommation sur Internet

International audienc

Surfing on the Net as a source of market segmentation: a self‐organization approach

International audienc

Forums de consommation sur Internet

International audienc

Surfing on the Net as a source of market segmentation: a self‐organization approach

International audienc

Forums de consommation sur Internet. Un modèle évolutionniste

The purpose of the model is to analyse the genesis and evolution of consumption oriented chat rooms in the Web space. We study an endogeneous consumption dynamics in which individuals make their buying decisions on the basis of a threefold information: their own consumption past experience (private information); an index of best sales (public information); advices that are available on evolutive Internet chat rooms (collective information). We discuss the properties of such a system as regards auto-organization: under which conditions chat rooms do they allow individual experiences to converge and aggregate into a genuine common knowledge leading to the emergence of an auto-organized pattern of consumption? Classification JEL : D1, D3, D7