468 research outputs found
Use of Antidepressants in Children and Adolescents
Depression is a serious disorder that can cause significant problems in mood, thinking, and behavior at home, in school, and with peers. It is estimated that major depressive disorder (MDD) affects about 5% of adolescents. Research has shown that, as in adults, depression in children and adolescents is treatable. Certain antidepressant medications, called selective serotonin reuptake inhibitors (SSRIs), can be beneficial to children and adolescents with MDD. Certain types of psychological therapies also have been shown to be effective. However, our knowledge of antidepressant treatments in youth, though growing substantially, is limited compared to what we know about treating depression in adults. The U.S. Food and Drug Administration (FDA) issued a public warning in October 2004 about an increased risk of suicidal thoughts or behavior (suicidality) in children and adolescents treated with SSRI antidepressant medications. However, SSRI medications are considered to have an improvement over older antidepressant medications and they have been shown to be safe and effective for adults. In this chapter we provide an updated and well-documented review of the current scientific evidence on this topic
Reseña: Estepa Maestre, F. (2017). Las Rentas Mínimas de Inserción: una aproximación sociológica al "Programa de Solidaridad de los Andaluces", en la provincia de Cádiz. (Tesis doctoral) Universidad de Cádiz, España
Es una investigación aplicada que analiza y explica la articulación delas Rentas Mínimas de Inserción dentro de la estructura de los Servicios Sociales Comunitarios. El estudio comprende una dimensión jurídica, sociológica y social de las políticas sociales de protección social y, en concreto, el análisis de los elementos que afectan a la eficiencia y eficacia del sistema de protección, en cuanto a la coherencia entre la intencionalidad de dichas políticas y los resultados de integración consolidada de los colectivos excluidos
Optimización de un procedimiento de digestión en muestras ambientales con horno microondas y su aplicación a la separación radioquímica del Po-210
[ES] En el presente Trabajo fin de Grado, se optimizó el procedimiento de digestión de muestras ambientales con horno microondas, para la posterior separación radioquímica ligada a la determinación de isótopos radiactivos, en concreto a la separación radioquímica del Po-210. En relación al proceso de digestión se han estudiado las posibles alternativas en cuanto a cantidad de muestra, mezcla de reactivos y ciclo de calentamiento, eligiendo el más adecuado en función del tipo de muestra a digerir.
Puesto a punto el proceso de digestión de las diversas muestras ambientales, se evaluó la actividad de Polonio-210 presente en dichas muestras.[EN] In this study, the procedure of digestion of environmental samples with microwave oven was optimized for the subsequent radiochemical separation linked to the determination of radioactive isotopes, specifically to the radiochemical separation of Po-210. In relation to the digestion process, the possible alternatives in terms of sample quantity, reagent mixture and heating cycle have been studied, choosing the most appropriate depending on the type of sample to be digested.
Once the digestion process of the various environmental samples was finalized, the activity of Polonium-210 present in these samples was evaluated.[CAT/VA] En el present Treball fi de Grau, es va optimitzar el procediment de digestió de mostres
ambientals amb forn micrones, per a la posterior separació radioquímica lligada a la
determinació d’isòtops radioactius, en concret a la separació radioquímica del Po-210. En relació
al procés de digestió s’han estudiar les posibles alternatives quant a quantitat de mostra, mescla
de reactius i cicle de calfament, triant el més adequat en funció del tipus de mostra a digerir.
Una vegada aconseguida la digestió de les diverses mostres ambientals, es va avaluar la activitat
de Polonio-210 present en les dites mostres.Lafuente Hernández, L. (2017). Optimización de un procedimiento de digestión en muestras ambientales con horno microondas y su aplicación a la separación radioquímica del Po-210. http://hdl.handle.net/10251/90691TFG
El valor del cliente en relaciones contractuales con estimaciones inciertas.
The Customer Lifetime Value (CLV ) concept has been highly used in the marketing area over the years. In this paper the authors present some useful extensions for the case of uncertain data. In particular, a CLV estimation with triangular fuzzy numbers (TFN) is introduced.valor del cliente, valor del consumidor, relaciones contractuales, subconjuntos borrosos, números borrosos triangulares, incertidumbre.
Triangular Matting con patrones temporales en pantallas retroreflectivas
La técnica propuesta permite evitar de forma sencilla las limitaciones de color en la filmación, basándose en la composición cromática de llaves de vídeo mediante una pantalla retroreflectiva y un anillo emisor de luz con diodos Led que están acoplados al mismo. Se aplica un patrón temporal asíncrono a la lona para generar el Chroma-Key y por procesamiento de imagen se consigue detectar el color del fondo sin restricciones en los colores presentes en la escena a grabar.
La técnica elimina por completo las limitaciones técnicas en la composición artística que existían en la etapa de procesado de un Chroma-Key. Es perfectamente compatible con todos los dispositivos que se emplean en los estudios de televisión y cine hasta la fecha para realizar la extracción, pero con una pequeña modificación electrónica de muy bajo coste en el anillo de diodos LED.A simple technique to avoid color limitations in filming based on Chroma key video composition using retroreflective screens and light-emitting diodes (LED) rings is proposed and demonstrated. An asynchronous temporal pattern is applied to the Chroma ring and through simple image processing; the background color can be substituted by any image or video without the usual restrictions on scene colors for still and moving objects in the foreground.
The technique removes technical constrains in stage composition allowing its design purely based on artistic grounds using off-the-self components widely used in TV and filming studios and low-cost electronics.Lafuente Hernández, JA. (2012). Triangular Matting con patrones temporales en pantallas retroreflectivas. Universitat Politècnica de València. http://hdl.handle.net/10251/19147Archivo delegad
Hydrogen Peroxide in Biocatalysis. A Dangerous Liaison
Hydrogen peroxide is a substrate or side-product in many enzyme-catalyzed reactions. For example, it is a side-product of oxidases, resulting from the re-oxidation of FAD with molecular oxygen, and it is a substrate for peroxidases and other enzymes. However, hydrogen peroxide is able to chemically modify the peptide core of the enzymes it interacts with, and also to produce the oxidation of some cofactors and prostetic groups (e.g., the hemo group). Thus, the development of strategies that may permit to increase the stability of enzymes in the presence of this deleterious reagent is an interesting target. This enhancement in enzyme stability has been attempted following almost all available strategies: site-directed mutagenesis (eliminating the most reactive moieties), medium engineering (using stabilizers), immobilization and chemical modification (trying to generate hydrophobic environments surrounding the enzyme, to confer higher rigidity to the protein or to generate oxidation-resistant groups), or the use of systems capable of decomposing hydrogen peroxide under very mild conditions. If hydrogen peroxide is just a side-product, its immediate removal has been reported to be the best solution. In some cases, when hydrogen peroxide is the substrate and its decomposition is not a sensible solution, researchers coupled one enzyme generating hydrogen peroxide “in situ” to the target enzyme resulting in a continuous supply of this reagent at low concentrations thus preventing enzyme inactivation. This review will focus on the general role of hydrogen peroxide in biocatalysis, the main mechanisms of enzyme inactivation produced by this reactive and the different strategies used to prevent enzyme inactivation caused by this “dangerous liaison”.This work has been supported by grant CTQ2009-07568 from Spanish Ministerio de Ciencia e Innovación. A. Berenguer-Murcia thanks the Spanish Ministerio de Ciencia e Innovación for a Ramon y Cajal fellowship (RyC-2009-03813). Mr. Hernandez is a holder of a MAEC-AECID fellowship
Multi-Physics Tool for Electrical Machine Sizing
Society is turning to electrification to reduce air pollution, increasing electric machine demand. For industrial mass production, a detailed design of one machine is usually done first, then a design of similar machines, but different ratings are reached by geometry scaling. This design
process may be highly time-consuming, so, in this paper, a new sizing method is proposed to reduce this time, maintaining accuracy. It is based on magnetic flux and thermal maps, both linked with an algorithm so that the sizing process of an electrical machine can be carried out in less than one minute. The magnetic flux maps are obtained by Finite Element Analysis (FEA) and the thermal maps are obtained by analytical models based on Lumped Parameter Circuits (LPC), applying a time-efficient procedure. The proposed methodology is validated in a real case study, sizing 10 different industrial machines. Then, the accuracy of the sizing tool is validated performing the experimental test over the 10 machines. A very good agreement is achieved between the experimental results and the performances calculated by the sizing tools, as the maximum error is around 5%
Bottom-up control of sardine and anchovy population cycles in the canary current: insights from an end-to-end model simulation
Sardine and anchovy can exhibit dramatic decadal-scale shifts in abundance in
response to climate variability. Sharpe declines of these populations entail particularly
serious commercial and ecological consequences in eastern boundary current ecosystems,
where they sustain major world fisheries and provide the forage for a broad variety of
predators. Understanding the mechanisms and environmental forcing that drive the
observed fish variability remains a challenging problem. The modelling study presented
here provides an approach that bridges a comprehensive database with an end-to-end
modelling framework enabling the investigation of the sources of variability of sardine and
anchovy in the Canary Current System. Different biological traits and behaviour
prescribed for sardine and anchovy gave rise to different distribution and displacements of
the populations, but to a rather synchronous variability in terms of abundance and biomass,
in qualitative agreement with historical landing records. Analysis of years with
anomalously high increase and decline of the adult population points to food availability
(instead of temperature or other environmental drivers) as the main environmental factor
determining recruitment for both sardine (via spawning and survival of feeding age-0
individuals) and anchovy (via survival of feeding age-0). Consistent with this, the two
species thrive under enhanced upwelling-favourable winds, but only up to some threshold
of the wind velocity beyond which larval drift mortality exceeds the positive effect of the
extra food supply. Based on the analysis of the simulation, we found that anchovy larvae are
particularly vulnerable to enhanced wind-driven advection, and as such do better with
more moderate upwelling than sardines.Universidad de Málaga. Campus de Excelencia Internacional Andalucía Tech
pVT behaviour of hydrophilic and hydrophobic eutectic solvents
Among the basic principles of green chemistry is the search for less harmful alternative solvents than conventional solvents. Knowing the thermophysical properties of fluids under different pressure and temperature conditions is essential to propose them. Herein, we present data on the densities at several pressures (from 0.1 to 65 MPa) and temperatures (from 283.15 to 338.15 K) of two deep eutectic solvents with hydrophilic characteristics (choline chloride + ethylene glycol or glycerol) and two eutectic solvents with hydrophobic characteristics (camphor + thymol or menthol). We used the Tait equation of state to correlate and calculate derived properties. Moreover, we modelled the mixtures with the PC-SAFT equation of state. The results showed that the hydrophilic solvents were more compact than the hydrophobic ones. The former exhibited an abnormal thermal behaviour of the isobaric thermal expansibility. The deviations in the correlation of densities with the thermodynamic model were between 0.5 and 3%. They were lower for the mixtures with weaker interactions
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