253 research outputs found
Replication factory activation can be decoupled from the replication timing program by modulating Cdk levels
In the metazoan replication timing program, clusters of replication origins located in different subchromosomal domains fire at different times during S phase. We have used Xenopus laevis egg extracts to drive an accelerated replication timing program in mammalian nuclei. Although replicative stress caused checkpoint-induced slowing of the timing program, inhibition of checkpoint kinases in an unperturbed S phase did not accelerate it. Lowering cyclin-dependent kinase (Cdk) activity slowed both replication rate and progression through the timing program, whereas raising Cdk activity increased them. Surprisingly, modest alteration of Cdk activity changed the amount of DNA synthesized during different stages of the timing program. This was associated with a change in the number of active replication factories, whereas the distribution of origins within active factories remained relatively normal. The ability of Cdks to differentially effect replication initiation, factory activation, and progression through the timing program provides new insights into the way that chromosomal DNA replication is organized during S phase
Interpreting Reactor Antineutrino Anomalies with STEREO data
Anomalies in past neutrino measurements have led to the discovery that theseparticles have non-zero mass and oscillate between their three flavors whenthey propagate. In the 2010's, similar anomalies observed in the antineutrinospectra emitted by nuclear reactors have triggered the hypothesis of theexistence of a supplementary neutrino state that would be sterile i.e. notinteracting via the weak interaction. The STEREO experiment was designed tostudy this scientific case that would potentially extend the Standard Model ofParticle Physics. Here we present a complete study based on our full set ofdata with significantly improved sensitivity. Installed at the ILL (InstitutLaue Langevin) research reactor, STEREO has accurately measured theantineutrino energy spectrum associated to the fission of 235U. Thismeasurement confirms the anomalies whereas, thanks to the segmentation of theSTEREO detector and its very short mean distance to the core (10~m), the samedata reject the hypothesis of a light sterile neutrino. Such a directmeasurement of the antineutrino energy spectrum suggests instead that biases inthe nuclear experimental data used for the predictions are at the origin of theanomalies. Our result supports the neutrino content of the Standard Model andestablishes a new reference for the 235U antineutrino energy spectrum. Weanticipate that this result will allow to progress towards finer tests of thefundamental properties of neutrinos but also to benchmark models and nucleardata of interest for reactor physics and for observations of astrophysical orgeo-neutrinos.<br
"Snowflake" H Mode in a Tokamak Plasma
An edge-localized mode (ELM) H-mode regime, supported by electron cyclotron heating, has been successfully established in a snowflake (second-order null) divertor configuration for the first time in the TCV tokamak. This regime exhibits 2 to 3 times lower ELM frequency and 20%30% increased normalized ELM energy () compared to an identically shaped, conventional single-null diverted H mode. Enhanced stability of mid- to high-toroidal-mode-number ideal modes is consistent with the different snowflake ELM phenomenology. The capability of the snowflake to redistribute the edge power on the additional strike points has been confirmed experimentally
TCV divertor upgrade for alternative magnetic configurations
The Swiss Plasma Center (SPC) is planning a divertor upgrade for the TCV tokamak. The upgrade aims at extending the research of conventional and alternative divertor configurations to operational scenarios and divertor regimes of greater relevance for a fusion reactor. The main elements of the upgrade are the installation of an in-vessel structure to form a divertor chamber of variable closure and enhanced diagnostic capabilities, an increase of the pumping capability of the divertor chamber and the addition of new divertor poloidal field coils. The project follows a staged approach and is carried out in parallel with an upgrade of the TCV heating system. First calculations using the EMC3-Eirene code indicate that realistic baffles together with the planned heating upgrade will allow for a significantly higher compression of neutral particles in the divertor, which is a prerequisite to test the power dissipation potential of various divertor configurations
Status, scientific results and technical improvements of the NBH on TCV tokamak
The TCV tokamak contributes to physics understanding in fusion reactor research by a wide set of experimental tools, like flexible shaping and high power ECRH. A 1MW, 25 keV deuterium heating neutral beam (NB) has been installed in 2015 and it was operated from 2016 in SPC-TCV domestic and EUROfusion MST1 experimental campaigns ((similar to)50/50%). The rate of failures of the beam is less than 5%. Ion temperatures up to 3.5 keV have been achieved in ELMy H-mode, with a good agreement with ASTRA predictive simulations. The NB enables TCV to access ITER-like beta(N) values (1.8) and T-e/T-i (similar to)1, allowing investigations of innovative plasma features in ITER relevant ELMy H-mode. The advanced Tokamak route was also pursued, with stationary, fully non-inductive discharges sustained by ECCD and NBCD reaching beta(similar to)(N)1.4-1.7. Real-time control of the NB power has been implemented in 2018 and presented together with the statistics of NB operation on the TCV. During commissioning, the NB showed unacceptable heating of the TCV beam duct, indicating a higher power deposition than expected on duct walls. A high beam divergence has been found by dedicated measurement of 3-D beam power density distribution with an expressly designed device (IR measurement on tungsten target)
Interpreting Reactor Antineutrino Anomalies with STEREO data
Anomalies in past neutrino measurements have led to the discovery that these
particles have non-zero mass and oscillate between their three flavors when
they propagate. In the 2010's, similar anomalies observed in the antineutrino
spectra emitted by nuclear reactors have triggered the hypothesis of the
existence of a supplementary neutrino state that would be sterile i.e. not
interacting via the weak interaction. The STEREO experiment was designed to
study this scientific case that would potentially extend the Standard Model of
Particle Physics. Here we present a complete study based on our full set of
data with significantly improved sensitivity. Installed at the ILL (Institut
Laue Langevin) research reactor, STEREO has accurately measured the
antineutrino energy spectrum associated to the fission of 235U. This
measurement confirms the anomalies whereas, thanks to the segmentation of the
STEREO detector and its very short mean distance to the core (10~m), the same
data reject the hypothesis of a light sterile neutrino. Such a direct
measurement of the antineutrino energy spectrum suggests instead that biases in
the nuclear experimental data used for the predictions are at the origin of the
anomalies. Our result supports the neutrino content of the Standard Model and
establishes a new reference for the 235U antineutrino energy spectrum. We
anticipate that this result will allow to progress towards finer tests of the
fundamental properties of neutrinos but also to benchmark models and nuclear
data of interest for reactor physics and for observations of astrophysical or
geo-neutrinos.Comment: 21 pages, 13 figure
Helical core tokamak MHD equilibrium states
Bifurcated magnetohydrodynamic tokamak equilibrium states with axisymmetric or helical core structure are computed. When a peaked pressure profile is chosen, the helical core structures appear like the {em snakes} that are observed in the JET tokamak. They also have the allure of saturated ideal internal kinks. The existence of a magnetic island is not a requisite condition. Novel equilibrium states that can model the snake are obtained for a JET configuration when the -profile has weak reversed magnetic shear with minimum values in the range of to . At the lower end of this range, the equilibrium {em snake} structure lies radially well inside the domain for which . Free boundary equilibria computed for the TCV tokamak develop helical cores when exceeds and have a significant axis excursion for . At fixed , the distortion of the magnetic axis is large in the range . The plasma-vacuum interface is not significantly altered by the internal helical deformations
Improved FIFRELIN de-excitation model for neutrino applications
The precise modeling of the de-excitation of Gd isotopes is of great interest
for experimental studies of neutrinos using Gd-loaded organic liquid
scintillators. The FIFRELIN code was recently used within the purposes of the
STEREO experiment for the modeling of the Gd de-excitation after neutron
capture in order to achieve a good control of the detection efficiency. In this
work, we report on the recent additions in the FIFRELIN de-excitation model
with the purpose of enhancing further the de-excitation description.
Experimental transition intensities from EGAF database are now included in the
FIFRELIN cascades, in order to improve the description of the higher energy
part of the spectrum. Furthermore, the angular correlations between {\gamma}
rays are now implemented in FIFRELIN, to account for the relative anisotropies
between them. In addition, conversion electrons are now treated more precisely
in the whole spectrum range, while the subsequent emission of X rays is also
accounted for. The impact of the aforementioned improvements in FIFRELIN is
tested by simulating neutron captures in various positions inside the STEREO
detector. A repository of up-to-date FIFRELIN simulations of the Gd isotopes is
made available for the community, with the possibility of expanding for other
isotopes which can be suitable for different applications.Comment: Corrected typos on author names on arXiv metadat
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