Liquid bridging of cylindrical colloids in near-critical solvents

Within mean field theory, we investigate the bridging transition between a pair of parallel cylindrical colloids immersed in a binary liquid mixture as a solvent which is close to its critical consolute point $T_c$. We determine the universal scaling functions of the effective potential and of the force between the colloids. For a solvent which is at the critical concentration and close to $T_c$, we find that the critical Casimir force is the dominant interaction at close separations. This agrees very well with the corresponding Derjaguin approximation for the effective interaction between the two cylinders, while capillary forces originating from the extension of the liquid bridge turn out to be more important at large separations. In addition, we are able to infer from the wetting characteristics of the individual colloids the first-order transition of the liquid bridge connecting two colloidal particles to the ruptured state. While specific to cylindrical colloids, the results presented here provide also an outline for identifying critical Casimir forces acting on bridged colloidal particles as such, and for analyzing the bridging transition between them.Comment: 23 pages, 12 figure

Tour d'horizon du potentiel de développement de l'aquaponie en France : présentation et regard critique sur cette voie de développement alternative pour les productions piscicoles et horticoles

L'aquaponie repose sur l'intégration de process de production aquacole et hydroponique permettant le recyclage et la valorisation des nutriments émis par l'élevage aquacole par des cultures végétales. Cette démarche innovante attire à la fois les filières aquacoles, car la co-production permet de réutiliser l'eau en permanence pour l'élevage ; mais également les filières horticoles en réduisant l'emploi d'intrants chimiques dans la conduite de production végétale. Le projet APIVA® (Aquaponie Innovation Végétale et Aquaculture) vise à développer et caractériser des pilotes aquaponiques fonctionnels, d'étudier leur faisabilité économique, leur impact environnemental et la qualité des produits obtenus, tout en modélisant les flux se produisant entre les compartiments (bassins d'élevage, surfaces de culture, filtre biologique). Après une rapide présentation de l'origine de l'aquaponie, cet article vise à définir les avantages et inconvénients de cette pratique innovante, les différentes formes qu'elle peut prendre, les diverses modalités de conception envisageables, ainsi que les aspects techniques à appréhender. En France, très peu de systèmes d'aquaponie commerciale sont actifs, mais beaucoup de projets émergent depuis quelques années, notamment en milieu urbain. Des exemples d'entreprises d'aquaponie commerciale à l'international sont présentés, avant de définir une typologie des porteurs de projet français. (Résumé d'auteur

Hepatitis C Virus Infection in Guinea-Bissau: A Sexually Transmitted Genotype 2 with Parenteral Amplification?

BACKGROUND: Sub-Saharan Africa is the continent with the highest prevalence of Hepatitis C virus (HCV) infection. Genotype 2 HCV is thought to have originated from West Africa several hundred years ago. Mechanisms of transmission remain poorly understood. METHODOLOGY/PRINCIPAL FINDINGS: To delineate mechanisms for HCV transmission in West Africa, we conducted a cross-sectional survey of individuals aged ≥50 years in Bissau, Guinea-Bissau. Dried blood spots were obtained for HCV serology and PCR amplification. Prevalence of HCV was 4.4% (47/1066) among women and 5.0% (27/544) among men. In multivariate analysis, the independent risk factors for HCV infection were age (baseline: 50–59 y; 60–69 y, adjusted odds ratio [AOR]: 1.67, 95% CI: 0.91–3.06; ≥70 y, AOR: 3.47, 95% CI: 1.89–6.39), belonging to the Papel, Mancanha, Balanta or Mandjako ethnic groups (AOR: 2.45, 95% CI:1.32–4.53), originating from the Biombo, Cacheu or Oio regions north of Bissau (AOR: 4.16, 95% CI: 1.18–14.73) and having bought or sold sexual services (AOR: 3.60, 95% CI: 1.88–6.89). Of 57 isolates that could be genotyped, 56 were genotype 2. CONCLUSIONS: Our results suggest that transmission of HCV genotype 2 in West Africa occurs through sexual intercourse. In specific locations and subpopulations, medical interventions may have amplified transmission parenterally

CANDELS multi-wavelength catalogs: source identification and photometry in the CANDELS COSMOS survey field

We present a multi-wavelength photometric catalog in the COSMOS field as part of the observations by the Cosmic Assembly Near-infrared Deep Extragalactic Legacy Survey. The catalog is based on Hubble Space Telescope Wide Field Camera 3 (HST/WFC3) and Advanced Camera for Surveys observations of the COSMOS field (centered at R.A.: 10h00m28s, Decl.:+02h12m21s). The final catalog has 38671 sources with photometric data in 42 bands from UV to the infrared (~0.3-8 μm). This includes broadband photometry from HST, CFHT, Subaru, the Visible and Infrared Survey Telescope for Astronomy, and Spitzer Space Telescope in the visible, near-infrared, and infrared bands along with intermediate- and narrowband photometry from Subaru and medium-band data from Mayall NEWFIRM. Source detection was conducted in the WFC3 F160W band (at 1.6 μm) and photometry is generated using the Template FITting algorithm. We further present a catalog of the physical properties of sources as identified in the HST F160W band and measured from the multi-band photometry by fitting the observed spectral energy distributions of sources against templates

Structural basis for inhibition of Plasmodium vivax invasion by a broadly neutralizing vaccine-induced human antibody.

The most widespread form of malaria is caused by Plasmodium vivax. To replicate, this parasite must invade immature red blood cells through a process requiring interaction of the P. vivax Duffy binding protein (PvDBP) with its human receptor, the Duffy antigen receptor for chemokines. Naturally acquired antibodies that inhibit this interaction associate with clinical immunity, suggesting PvDBP as a leading candidate for inclusion in a vaccine to prevent malaria due to P. vivax. Here, we isolated a panel of monoclonal antibodies from human volunteers immunized in a clinical vaccine trial of PvDBP. We screened their ability to prevent PvDBP from binding to the Duffy antigen receptor for chemokines, and their capacity to block red blood cell invasion by a transgenic Plasmodium knowlesi parasite genetically modified to express PvDBP and to prevent reticulocyte invasion by multiple clinical isolates of P. vivax. This identified a broadly neutralizing human monoclonal antibody that inhibited invasion of all tested strains of P. vivax. Finally, we determined the structure of a complex of this antibody bound to PvDBP, indicating the molecular basis for inhibition. These findings will guide future vaccine design strategies and open up possibilities for testing the prophylactic use of such an antibody

Are resistances to acute hyperthermia or hypoxia stress similar and consistent between early and late ages in rainbow trout using isogenic lines?

International audienceGlobal warming is expected to increase the frequency and intensity of heatwaves, resulting in more common combined acute hyperthermia and hypoxia conditions in fish farms. Such poor thermal and oxygenation conditions induce problems, including growth losses, increased pathogens pressure and mortality. Selective breeding is a promising solution to improve resistance to non-optimal water quality. Indeed, genetic variability to survive in acute hyperthermia or hypoxia conditions has been proved in fish. However, the characterization of these traits is not yet detailed enough to include them in a selection program. Here, we investigated the ranking stability of genotypes for acute hyperthermia or hypoxia resistances over age and between acute hyperthermia and acute hypoxia resistances. To this end, we established rankings of six isogenic lines of rainbow trout (Oncorhynchus mykiss) for their resistance to acute hyperthermia and hypoxia stress factors at 6 and 15 months. The experimental design was robust with more than a hundred fish per line and age. There were statistically significant resistance variations among lines confirming the potential of genetic selection for these traits. Hyperthermia and hypoxia resistance rankings were found stable 1 year apart for most genotypes. Therefore, it would be possible to select for resistance to hyperthermia and hypoxia at an early stage. No overall relationship was found between acute hyperthermia and hypoxia resistance traits: some lines were resistant to both stress factors while others were resistant to one but sensitive to the other. This indicates no strong antagonistic genetic effects between acute hyperthermia and hypoxia resistance traits in rainbow trout

Innate immune response triggered by triacyl lipid A is dependent on phospholipid transfer protein (PLTP) gene expression

International audienceHexaacyl lipopolysaccharide (LPS) aggregates in aqueous media, but its partially deacylated lipid A moiety forms monomers with weaker toxicity. Because plasma phospholipid transfer protein (PLTP) transfers hexaacyl LPS, its impact on metabolism and biological activity of triacyl lipid A in mice was addressed. Triacyl lipid A bound readily to plasma highdensity lipoproteins (HDLs) when active PLTP was expressed [HDL-associated lipid A after 4.5 h: 59.1؎16.0% of total in wild-type (WT) vs. 32.5؎10.3% in PLTP-deficient mice, P80% of the untreated WT, untreated PLTP-deficient, or lipid A-treated PLTP-deficient animals bore tumors (P<0.05 in all cases). It is concluded that PLTP is essential in mediating the association of triacyl lipid A with lipoproteins, leading to extension of its residence time and to magnification of its proinflammatory and anticancer properties

Sanitary prescriptions and procedures for transfer and safety standards - Aquaexcel (D3.1)

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