670 research outputs found
A next generation measurement of the electric dipole moment of the neutron at the FRM II
In this paper we discuss theoretical motivations and the status of experimental searches to find time-reversal symmetry-violating electric dipole moments (EDM). Emphasis is given to a next generation search for the EDM of the
neutron, which is currently being set up at the FRM II neutron source in Garching, with an ultimate sensitivity goal of 5 Ă 10â28 cm (3Ï). The layout of the apparatus
allows for the detailed investigation of systematic effects by combining various means of magnetic field control and polarized UCN optics. All major components of the
installations are portable and can be installed at the strongest available UCN beam
The High-Acceptance Dielectron Spectrometer HADES
HADES is a versatile magnetic spectrometer aimed at studying dielectron
production in pion, proton and heavy-ion induced collisions. Its main features
include a ring imaging gas Cherenkov detector for electron-hadron
discrimination, a tracking system consisting of a set of 6 superconducting
coils producing a toroidal field and drift chambers and a multiplicity and
electron trigger array for additional electron-hadron discrimination and event
characterization. A two-stage trigger system enhances events containing
electrons. The physics program is focused on the investigation of hadron
properties in nuclei and in the hot and dense hadronic matter. The detector
system is characterized by an 85% azimuthal coverage over a polar angle
interval from 18 to 85 degree, a single electron efficiency of 50% and a vector
meson mass resolution of 2.5%. Identification of pions, kaons and protons is
achieved combining time-of-flight and energy loss measurements over a large
momentum range. This paper describes the main features and the performance of
the detector system
Effects of Brazil's political crisis on the science needed for biodiversity conservation.
The effects of Brazil's political crisis on science funding necessary for biodiversity conservation are likely to be global. Brazil is not only the world?s most biodiverse nation, it is responsible for the greater part of the Amazon forest, which regulates the climate and provides rain to much of southern South America. Brazil was a world leader in satellite monitoring of land-use change, in-situ biodiversity monitoring, reduction in tropical-forest deforestation, protection of indigenous lands, and a model for other developing nations. Coordinated public responses will be necessary to prevent special-interest groups from using the political crisis to weaken science funding, environmental legislation and law enforcement
Putative genes involved in muscle functioning are differentially expressed in Nelore steers divergent for sodium and potassium concentration.
Editores: Luiz Lehmann Coutinho, ESALQ/USP; Luciana Correia de Almeida Regitano, Embrapa PecuĂĄria Sudeste; Gerson Barreto MourĂŁo, ESALQ/USP; Aline Silva Mello Cesar, ESALQ/USP; BĂĄrbara Silva Vignato, FZEA/USP; Mirele Daiana Poleti, ESALQ/USP; Wellison Jarles da Silva Diniz, UFSCar
Application of remote sensing to the study of the pelagic spiny lobster larval transport in the Tropical Atlantic
Hemispheric reconfigurations in Northern Amazonia: The âThree Guianasâ amid regional change and Brazilian hegemony
© 2016 Southseries Inc., www.thirdworldquarterly.com. Regional and hemispheric reconfigurations in Latin America and the Caribbean are increasingly mediated by Brazilian power, and the engagement of Guyana, Suriname and French Guiana with this emerging context is intriguing. They are tentatively moving away from a Caribbean region with which they are culturally contiguous, towards a South American continent in which they are geographically located. This is partly a reflection of the gradual opening up of the Northern Amazonian space that they share collectively, and also with Venezuela and Brazil. These processes are occurring as cause and effect of Brazilâs emergence as a regionalâand even regionally hegemonicâpower. With reference to wider debates on regionalism and hegemony, we analyse the uncertain consequences of these shifts
Dynamic Measurements of Membrane Insertion Potential of Synthetic Cell Penetrating Peptides
This document is the Accepted Manuscript version of a Published Work that appeared in final form in Langmuir, copyright © American Chemical Society after peer review and technical editing by the publisher. To access the final edited and published work see http://doi.org/10.1021/la403370p.Cell penetrating peptides (CPPs) have been established as excellent candidates for mediating drug delivery into cells. When designing synthetic CPPs for drug delivery applications, it is important to understand their ability to penetrate the cell membrane. In this paper, anionic or zwitterionic phospholipid monolayers at the air-water interface are used as model cell membranes to monitor the membrane insertion potential of synthetic CPPs. The insertion potential of CPPs having different cationic and hydrophobic amino acids were recorded using a Langmuir monolayer approach that records peptide adsorption to model membranes. Fluorescence microscopy was used to visualize alterations in phospholipid packing due to peptide insertion. All CPPs had the highest penetration potential in the presence of anionic phospholipids. In addition, two of three amphiphilic CPPs inserted into zwitterionic phospholipids, but none of the hydrophilic CPPs did. All the CPPs studied induced disruptions in phospholipid packing and domain morphology, which were most pronounced for amphiphilic CPPs. Overall, small changes to amino acids and peptide sequences resulted in dramatically different insertion potentials and membrane reorganization. Designers of synthetic CPPs for efficient intracellular drug delivery should consider small nuances in CPP electrostatic and hydrophobic properties
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Globalisation from Above? Corporate Social Responsibility, the Workers' Party and the Origins of the World Social Forum
In its assessment of the origins and early development of the World Social Forum this article challenges traditional understandings of the Forum as representing âglobalisation from belowâ. By tracing the intricate relations among elements of business, civil society, and the Workersâ Party in the first years of the Forum, this article reveals the major role played by a corporate movement stemming from the Brazilian democratisation process in the 1980s, and how this combined with the transformed agenda of the Workersâ Party as it gained higher political offices to constrain the Forumâs activities from the outset. In so doing, this article challenges not only widespread conceptions of the Forum as a counterâhegemonic alternative but also current critiques concerning its subsequent limitations. Furthermore, it reveals how traditional understandings of the World Social Forum and of global civil society are underpinned by flawed assumptions which typecast political activities in the global âSouthâ
Independent-Trajectories Thermodynamic-Integration Free-Energy Changes for Biomolecular Systems: Determinants of H5N1 Avian Influenza Virus Neuraminidase Inhibition by Peramivir
Free-energy changes are essential physicochemical quantities for understanding most biochemical processes. Yet, the application of accurate thermodynamic-integration (TI) computation to biological and macromolecular systems is limited by finite-sampling artifacts. In this paper, we employ independent-trajectories thermodynamic-integration (IT-TI) computation to estimate improved free-energy changes and their uncertainties for (bio)molecular systems. IT-TI aids sampling statistics of the thermodynamic macrostates for flexible associating partners by ensemble averaging of multiple, independent simulation trajectories. We study peramivir (PVR) inhibition of the H5N1 avian influenza virus neuraminidase flexible receptor (N1). Binding site loops 150 and 119 are highly mobile, as revealed by N1-PVR 20-ns molecular dynamics. Due to such heterogeneous sampling, standard TI binding free-energy estimates span a rather large free-energy range, from a 19% underestimation to a 29% overestimation of the experimental reference value (â62.2 ± 1.8 kJ molâ1). Remarkably, our IT-TI binding free-energy estimate (â61.1 ± 5.4 kJ molâ1) agrees with a 2% relative difference. In addition, IT-TI runs provide a statistics-based free-energy uncertainty for the process of interest. Using âŒ800 ns of overall sampling, we investigate N1-PVR binding determinants by IT-TI alchemical modifications of PVR moieties. These results emphasize the dominant electrostatic contribution, particularly through the N1 E277âPVR guanidinium interaction. Future drug development may be also guided by properly tuning ligand flexibility and hydrophobicity. IT-TI will allow estimation of relative free energies for systems of increasing size, with improved reliability by employing large-scale distributed computing
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